Pilocarpine Nitrate (HCID 657349)

概要

See also: Pilocarpine (has active moiety); Pilocarpine Hydrochloride (related).

名称と識別子

優先名称: Pilocarpine Nitrate
IUPAC: (3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one;nitric acid
現地名: 硝酸ピロカルピン
英語名: Pilocarpine nitrate
分子式: C11H17N3O5
分子量: 271.27

名称と別名

Pilocarpine nitrate148-72-1PilaganPilocarpine mononitratePilocarpini nitrasPilocarpinum nitricumPilocarpine subnitrateNSC-757282M20T465H6JPilocarpine nitrate (USP)Pilocarpine nitrate [USP]2(3H)-Furanone, 3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-, (3S-cis)-, mononitrate

名称をさらに表示

硝酸ピロカルピン硝酸ピロカルピンピロカルピン·硝酸塩ピロカルピン硝酸塩ピロカルピン硝酸塩NitratPilocarpine nitrate for system suitability CRSPilocarpinnitratEinecs 205-723-7Pilocarpin Nitratep.v.carpineliquifilm

2(3H)-Furanone, 3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-, (3S,4R)-, mononitratePiloc nitRefChem:863282205-723-7Pilocarpine (nitrate)PilofrinPilocarpine nitrate salt(3S,4R)-3-Ethyl-4-((1-methyl-1H-imidazol-5-yl)methyl)dihydrofuran-2(3H)-one nitrate

データベース識別子

CAS: 148-72-1
PubChem CID: 657349
DTXSID: DTXSID80883277
ChEMBL: CHEMBL1213136
UNII: M20T465H6J
EC Number: 205-723-7

物性

構造計算による物性

極性表面積: 110 Å²
水素結合供与体数: 1
水素結合受容体数: 6
回転可能結合数: 3
重原子数: 19
形式電荷: 0
複雑度: 269

実験および物理化学的性質

Collision Cross Section146.4 Å² [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

物理化学的性質

融点: 173 · 173,5-174°C
比旋光度: 77 to · D +77 to +83° (c = 10)
屈折率: 81 ° · 81 ° (C=2, H2O)
貯蔵温度: 2 · 2-8°C
溶解性: 2 O: · H2O: 0.1 g/mL、透明、微かに黄色
外見: 粉
色: 白い
水溶解度: 2 O: · H2O: 100mg/mL
Merck: 14 · 14,7424
BRN: 4171406 · 4171406
主な用途: 医薬品（低分子化合物）
InChI: 1S/C11H16N2O2.HNO3/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;2-1(3)4/h5,7-8,10H,3-4,6H2,1-2H3;(H,2,3,4)/t8-,10-;/m0./s1
InChIKey: PRZXEPJJHQYOGF-GNAZCLTHSA-N
SMILES: O[N+]([O-])=O.CC[C@H]1[C@H](COC1=O)Cc2cncn2C
CAS データベース: 148 · 148-72-1(CAS DataBase Reference)
EPAの化学物質情報: Pilocarpine nitrate (148-72-1)

化学的性質

化学的特性White or almost white, crystalline powder or colourless crystals, sensitive to light.

安全と法規制

GHS分類

GHS Classification · 4 件

Danger

H300 (99.1%): Fatal if swallowed [Danger Acute toxicity, oral]

P260, P264, P270, P271, P284, P301+P316, P304+P340, P316, P320, P321, P330, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 113 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Regulatory InformationPilocarpine nitrate: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - 2(3H)-Furanone, 3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, (3S-cis)-, mononitrate: Environment tier I assessment

Hazard Classes and CategoriesAcute Tox. 2 (99.1%)

安全データ

F: 3-10
wgk: 3
tsca: TSCA listed
rtecs: TK1455000
ridadr: 3087
毒性: LD50 oral in rat: 911mg/kg
hs_code: 2939800000
risk_code: 22-26/28
hazard_code: Xn,T+
safety_code: 1-25-45
hazard_class: 6.1(b)
packing_group: III
Hazard Classifications: Acute Tox. 2 InhalationAcute Tox. 4 OralOx. Sol. 2
ストレージクラス: 5.1B - Oxidizing hazardous materials

化学と産業

薬理情報

MeSH Pharmacological Classification · 2 件

Agents causing contraction of the pupil of the eye. Some sources use the term miotics only for the parasympathomimetics but any drug used to induce miosis is included here.

Drugs that bind to and activate muscarinic cholinergic receptors (RECEPTORS, MUSCARINIC). Muscarinic agonists are most commonly used when it is desirable to increase smooth muscle tone, especially in the GI tract, urinary bladder and the eye. They may also be used to reduce heart rate.

用途と製造

General Manufacturing Information2(3H)-Furanone, 3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, (3S,4R)-, nitrate (1:1): INACTIVE

応用分野 · 2 件

使用Pilocarpine nitrate salt has been used to measure bronchoconstriction and M2 and M3 muscarinic receptor function in vivo. It has also been used to induce electrographic and behavioral seizures and to study the different patterns of neuronal activation and neurodegeneration in Proechimys rats and Wistar rats.

一般的な説明Pilocarpine mononitrate occursas shining white crystals that are not hygroscopic butare light sensitive. It is soluble in water (1:4) and alcohol(1:75) but insoluble in chloroform and ether. Aqueoussolutions are slightly acid to litmus and may be sterilizedin the autoclave. The alkaloid is incompatible with alkalies,iodides, silver nitrate, and reagents that precipitatealkaloids.

上流・下流製品情報

上流原料

ピロカルピン硝酸

サプライヤー50 社

北京华美互利生物化工010-56205725 · [email protected]

成都超九八生物科技有限公司13348960310 13348960310 · [email protected]

成都健腾生物技术有限公司028-85159085 · [email protected]

Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]

LGM Pharma1-(800)-881-8210 · [email protected]

硝酸ピロカルピン

基本情報

概要