メタクリルアミド
メタクリルアミド · 2-メチレンプロパンアミド · 2-メチルアクリルアミド · 2-メチル-2-プロペンアミド · 2-メチルプロペンアミド · メタクリル酸アミド · Methylacrylamide · 2-Methylacrylamide
識別子と物理属性
| CAS No. | 79-39-0 |
|---|---|
| 分子式 | C4H7NO |
| 平均分子量 | 85.1 g/mol |
| 単同位体質量 | 85.05276384 g/mol |
| SMILES | C=C(C)C(N)=O |
| InChIKey | FQPSGWSUVKBHSU-UHFFFAOYSA-N |
| PubChem CID | 6595 |
| ChEMBL | CHEMBL158237 |
| ChEBI | CHEBI:51759 |
| EC No. | 201-202-3 |
| DTXSID | DTXSID8029600 |
| 現地名 | メタクリルアミド |
化学・物理的性質
| XLogP | 0.1 |
|---|---|
| 極性表面積 | 43.1 |
| 水素結合供与体数 | 1 |
| 水素結合受容体数 | 1 |
| 回転可能結合数 | 1 |
| 重原子数 | 6 |
| 形式電荷 | 0 |
| 複雑度 | 85.5 |
| 物質分類 | Industrial compound |
| Polymers | Plastics & Rubber -> Other Monomers |
| SpringerMaterials Properties | Boiling point |
| 沸点 | 215 °C @760 [mm Hg] |
| 蒸気圧 | 0.1 [mmHg]0.0015 hPa (20 °C) |
| Food Contact Substances | FCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR |
| Physical Description | White crystalline solid[Alfa Aesar MSDS] |
| 融点 | 106-110 °C (lit.) |
| 密度 | 1,115 g/cm3 |
| 屈折率 | 1.3992 (estimate) |
| 引火点 | 215°C |
| 貯蔵条件 | Store below +30°C. |
| 溶解度 | 202g/リットル202g/L（20℃） |
| 外観・状態 | クリスタル |
| pKa（酸解離定数） | 15.46±0.50(Predicted) |
| 色 | 白色～わずかに黄色 |
| pH | 7.1 (100g/l, H2O, 20℃) |
| 爆発限界 | 2-15%(V) |
| BRN | 605397 |
| ヘンリー定数 | 8.8×103 mol/(m3Pa) at 25℃, Ebert et al. (2023) |
| InChI | 1S/C4H7NO/c1-3(2)4(5)6/h1H2,2H3,(H2,5,6) |
| InChIKey | FQPSGWSUVKBHSU-UHFFFAOYSA-N |
| SMILES | CC(=C)C(N)=O |
| CAS データベース | 79-39-0(CAS DataBase Reference) |
| NISTの化学物質情報 | Methacrylamide(79-39-0) |
| EPAの化学物質情報 | Methacrylamide (79-39-0) |
化学的特性
white to very slightly yellow crystals
安全性と法規制
| GHS 分類 | This chemical does not meet GHS hazard criteria for 0.9% (7 of 803) of reports.WarningH302 (99.1%): Harmful if swallowed [Warning Acute toxicity, oral]P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P304+P340, P305+P351+P338, P308+P316, P319, P330, P337+P317, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 803 reports by companies from 23 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| 規制情報 | Chemical: 2-Propenamide, 2-methyl-Status: Active Update: 14-04-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/15801Methacrylamide: Does not have an individual approval but may be used under an appropriate group standard |
| その他の安全情報 | Evaluation - 2-Propenamide, 2-methyl- (methacrylamide) |
| 有害性の概要 | An eye irritant in rabbitsNo to mild skin sensitization reactions seen in guinea pigsNeurotoxicity observed in repeated-dose animal studies[IUCLID] Marked developmental toxicity observed in mice at doses only slightly maternally toxic[NTP] An irritantModerately toxic by ingestion and inhalation (degenerative changes of the liver, kidney, and brain)Reproductive effects observed in experimental animals[Alfa Aesar MSDS] See Acrylamide. |
| Hazard Classes and Categories | Acute Tox. 4 (99.1%)Acute toxicity (Oral) - Category 4 |
| Protective Action Criteria (PAC) | 3.0 [mg/m3]15 [mg/m3]91 [mg/m3] |
| 有害作用 | Neurotoxin - Other CNS neurotoxin |
| 水環境危害等級（WGK） | 1 |
| TSCA 収載状態 | TSCA listed |
| RTECS 番号 | UC6475000 |
| 輸送番号（UN） | 3263 |
用途
用途
主な用途は織物の仕上げ剤、紙仕上げ剤、コーティング剤、縮合剤などに使用されるエマルジョンやラテックスのような重合物の原料である。
用途
有機合成原料。
使用
Methacrylamide is a reagent used in the production of polymers and copolymers. It is also used as a raw material in the production of chemicals for industrial and professional use such as textiles, leather, fur, bulk, large scale chemicals (including petroleum products), fine chemicals, formulation [mixing] of preparations and/or re-packaging (excluding alloys), building and construction work, electricity, steam, gas, water supply and sewage treatment.
製法・合成法
純化方法
Crystallise the amide from *benzene or ethyl acetate and dry it under vacuum at room temperature. [Beilstein 2 IV 1538.]