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化工社化工社 化学情報印刷レポート · 研究参考用
HCID 6598作成日：2026年10月27日

ジメチルカルバモイルクロリド

ジメチルカルバモイルクロリド · ジメチルカルバミン酸クロリド · N,N-ジメチルクロロホルムアミド · N,N-ジメチルカルバモイルクロリド · ジメチルカルバミド酸クロリド · N,N-ジメチルカルバミン酸クロリド · N,N-ジメチルカルバミド酸クロリド · ジメチルカルバモイル=クロリド

https://huagongshe.com/ja/chemical/6598

ジメチルカルバモイルクロリド の分子構造式

識別子と物理属性

CAS No.79-44-7
分子式C3H6ClNO
平均分子量107.54 g/mol
単同位体質量107.01379149 g/mol
SMILESCN(C)C(=O)Cl
InChIKeyYIIMEMSDCNDGTB-UHFFFAOYSA-N
PubChem CID6598
ChEMBLCHEMBL1527556
ChEBICHEBI:82280
EC No.201-208-6
DTXSIDDTXSID1020512
現地名ジメチルカルバモイルクロリド

化学・物理的性質

XLogP0.8
極性表面積20.3
水素結合供与体数0
水素結合受容体数1
回転可能結合数0
重原子数6
形式電荷0
複雑度61.8
物質分類Hazardous Air Pollutants (HAPs)Toxic Gases & Vapors -> Acid HalidesCarcinogens
SpringerMaterials Properties15N nuclear magnetic resonance spectrum
密度1.168 at 68 °F (USCG, 1999) - Denser than waterwill sink1.168 g/cu cm @ 25 °C1.171.168 @25 °C1.168 g/mL at 25 °C(lit.)
Color/FormClear, colorless liquid.
溶解度Decomposes (NTP, 1992)ReactsChloroform (Soluble), DMSO (Sparingly)分解する
引火点155 °F (NTP, 1992)Flash point: not available
沸点329 to 333 °F at 760 mmHg (NTP, 1992)167 °C329 °F167 °C @760 [mm Hg]167-168 °C775 mm Hg(lit.)
DecompositionWHEN HEATED TO DECOMPOSITION IT EMITS VERY TOXIC FUMES OF /HYDROGEN CHLORIDE AND NITROGEN OXIDES/.Decomposes in water.
融点-27 °F (NTP, 1992)-33 °C−33 °C(lit.)
蒸気密度3.73 (NTP, 1992) - Heavier than airwill sink (Relative to Air)3.73 (Air = 1)
蒸気圧1.95 [mmHg]1.95 mm Hg @ 25 °C1.95 [mm Hg] @25 °C
屈折率Index of refraction: 1.4529 @ 20 °C/Dn20/D 1.453
外観・状態液体
pKa（酸解離定数）-1.85±0.70(Predicted)
色Colorless to Yellow
比重1.172
BRN878197
安定性Moisture Sensitive
InChI1S/C3H6ClNO/c1-5(2)3(4)6/h1-2H3
InChIKeyYIIMEMSDCNDGTB-UHFFFAOYSA-N
SMILESCN(C)C(Cl)=O
CAS データベース79-44-7(CAS DataBase Reference)
NISTの化学物質情報Carbamic chloride, dimethyl-(79-44-7)
EPAの化学物質情報Dimethylcarbamoyl chloride (79-44-7)

化学的特性

Dimethylcarbamoyl chloride is a colorless to light yellow or light brown, irritating oily liquid. The molecule contains two polar functional groups: a formyl group and a chlorine atom. These functional groups impart a certain polarity to the molecule, giving it strong polar solubility. It is soluble in organic solvents such as ether, carbon disulfide, and benzene.

安全性と法規制

GHS 分類DangerH302: Harmful if swallowed [Warning Acute toxicity, oral]P203, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P316, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]P203, P260, P261, P264, P264+P265, P270, P271, P273, P280, P284, P301+P317, P302+P352, P304+P340, P305+P351+P338, P316, P318, P319, P320, P321, P330, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)
規制情報Chemical: Carbamic chloride, dimethyl-Hazard Traits - CarcinogenicityDermatotoxicityHepatotoxicity and Digestive System ToxicityOcular ToxicityRespiratory ToxicityStatus: Active Update: 01-04-2011 https://echa.europa.eu/registration-dossier/-/registered-dossier/8335Dimethylcarbamyl chloride: Does not have an individual approval but may be used under an appropriate group standardThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)
その他の安全情報IMAP assessments - Carbamic chloride, dimethyl-: Human health tier II assessment
輸送ラベル（DOT）Corrosive
火災危険Special Hazards of Combustion Products: Toxic fumes of NO x and HCl (USCG, 1999)· Combustible material: may burn but does not ignite readily.
健康有害性Material is extremely destructive to the mucous membranes, upper respiratory tract, eyes, and skin. Symptoms of exposure include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting. (USCG, 1999)· TOXIC and/or CORROSIVEinhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death.
有害性の概要Dimethylcarbamoyl chloride is used as an intermediate in the production of pharmaceuticals, pesticides, and dyes. Acute (short-term) inhalation exposure to dimethylcarbamoyl chloride has been observed to result in damaged mucous membranes of the nose, throat, and lungs, and cause difficulty in breathing in rats. No information is available on the chronic (long-term), reproductive, developmental, or carcinogenic health effects of dimethylcarbamoyl chloride in humans. Nasal tract carcinomas have been observed in rats and male hamsters following inhalation exposure. EPA has not classified dimethylcarbamoyl chloride for potential carcinogenicity.

用途

用途

有機合成原料。

用途

有機合成中間体

使用

Dimethylcarbamoyl chloride has been used primarily as a chemical intermediate in the production of dyes, pharmaceuticals, pesticides, and rocket fuel (IARC 1999, HSDB 2009).

一般的な説明

Dimethylcarbamoyl chloride appears as a colorless to yellow liquid with a pungent odor. Burns to skin, eyes and mucous membranes. A lachrymator. Used to make dyes and pharmaceuticals.

製法・合成法

純化方法

It must be distilled under high vacuum to avoid decomposition. [Beilstein 4 IV 224.]

Liquid causes second or third degree burns after short contact. [CHRIS] A lachrymator
Inhalation exposure to HCl may cause chemical pneumonitis
[HSDB] DMCC reacts with tissue at the point of contact. DMCC hydrolyzes to dimethylamine, CO2, and HCl. Animals in feeding studies develop liver hemorrhages. Sprague-Dawley rats were exposed by inhalation 6 hours/day, 5 days/week for 6 weeks at 0.5, 1.0, or 2.0 ppm DMCC in an exposure chamber and held without further exposure for up to 2 years. A dose-response relationship for both the development of morphological lesions and for tumor incidences of the nasal cavity and nasopharyngeal areas was seen, ranging from 89% tumor incidence at 2 ppm to 4% incidence at 0.5 ppm. No tumors in these regions were reported in the controls. [ACGIH]
輸送番号・ガイド（DOT）2262 156
反応性グループAcyl Halides, Sulfonyl Halides, and Chloroformates
Special ReportsNational Toxicology Program. Eleventh Report on Carcinogens (2005). The Report on Carcinogens is an informational scientific and public health document that identifies and discusses substances (including agents, mixtures, or exposure circumstances) that may pose a carcinogenic hazard to human health. Dimethylcarbamoyl Chloride (79-44-7) is listed as reasonably anticipated to be a human carcinogen.[Available from, as of July 31, 2009: http://ntp.niehs.nih.gov/ntp/roc/eleventh/profiles/s076dime.pdf]
RCRA 要件U097As stipulated in 40 CFR 261.33, when dimethylcarbamoyl chloride, as a commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate, becomes a waste, it must be managed according to Federal and/or State hazardous waste regulations. Also defined as a hazardous waste is any residue, contaminated soil, water, or other debris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of this waste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5).
Reactivity AlertsWater-Reactive
Reactivity ProfileDIMETHYLCARBAMOYL CHLORIDE is water reactive. Incompatible with strong oxidizing agents, alcohols, bases (including amines). May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291]. Gives toxic fumes of NOx and HCl when burned (USCG, 1999).
消火Excerpt from ERG Guide 156 [Substances - Toxic and/or Corrosive (Combustible / Water-Sensitive)]:
漏出応急措置· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.
応急処置EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.General First Aid:(General first aid procedures)
暴露管理・個人防護· Wear positive pressure self-contained breathing apparatus (SCBA).
保管条件PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/
清掃方法PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. /Chemical Carcinogens/
非火災時の漏出対応Excerpt from ERG Guide 156 [Substances - Toxic and/or Corrosive (Combustible / Water-Sensitive)]:
処分方法Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U097, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.A potential candidate for rotary kiln incineration at a temperature range of 820 to 1,600 °C and residence times of seconds for liquids and gases, and hours for solids. A potential candidate for fluidized bed incineration at a temperature range of 450 to 980 °C and residence times of seconds for liquids and gases, and longer for solids.PRECAUTIONS FOR "CARCINOGENS": There is no universal method of disposal that has been proved satisfactory for all carcinogenic compounds & specific methods of chem destruction ... published have not been tested on all kinds of carcinogen-containing waste. ... Summary of avail methods & recommendations ... /given/ must be treated as guide only. /Chemical Carcinogens/PRECAUTIONS FOR "CARCINOGENS": ... Incineration may be only feasible method for disposal of contaminated laboratory waste from biological expt. However, not all incinerators are suitable for this purpose. The most efficient type ... is probably the gas-fired type, in which a first-stage combustion with a less than stoichiometric air:fuel ratio is followed by a second stage with excess air. Some ... are designed to accept ... aqueous & organic-solvent solutions, otherwise it is necessary ... to absorb soln onto suitable combustible material, such as sawdust. Alternatively, chem destruction may be used, esp when small quantities ... are to be destroyed in laboratory. /Chemical Carcinogens/For more Disposal Methods (Complete) data for DIMETHYLCARBAMOYL CHLORIDE (7 total), please visit the HSDB record page.
Preventive MeasuresTHE PROCESSES SHOULD ... TAKE PLACE IN WELL VENTILATED PREMISES UNDER A SLIGHT NEGATIVE PRESSURE TO AVOID ANY DIFFUSION OF POLLUTANTS. THE PROCESS PLANT SHOULD BE EQUIPPED WITH LOCAL EXHAUST DEVICES, IN PARTICULAR AT FLANGES, VALVES, ETC, WHERE LEAKS ARE MORE LIKELY TO ARISE.PRECAUTIONS FOR "CARCINOGENS": Smoking, drinking, eating, storage of food or of food & beverage containers or utensils, & the application of cosmetics should be prohibited in any laboratory. All personnel should remove gloves, if worn, after completion of procedures in which carcinogens have been used. They should ... wash ... hands, preferably using dispensers of liq detergent, & rinse ... thoroughly. Consideration should be given to appropriate methods for cleaning the skin, depending on nature of the contaminant. No standard procedure can be recommended, but the use of organic solvents should be avoided. Safety pipettes should be used for all pipetting. /Chemical Carcinogens/PRECAUTIONS FOR "CARCINOGENS": In animal laboratory, personnel should remove their outdoor clothes & wear protective suits (preferably disposable, one-piece & close-fitting at ankles & wrists), gloves, hair covering & overshoes. ... clothing should be changed daily but ... discarded immediately if obvious contamination occurs ... /also,/ workers should shower immediately. In chemical laboratory, gloves & gowns should always be worn ... however, gloves should not be assumed to provide full protection. Carefully fitted masks or respirators may be necessary when working with particulates or gases, & disposable plastic aprons might provide addnl protection. If gowns are of distinctive color, this is a reminder that they should not be worn outside of lab. /Chemical Carcinogens/PRECAUTIONS FOR "CARCINOGENS": ... Operations connected with synth & purification ... should be carried out under well-ventilated hood. Analytical procedures ... should be carried out with care & vapors evolved during ... procedures should be removed. ... Expert advice should be obtained before existing fume cupboards are used ... & when new fume cupboards are installed. It is desirable that there be means for decreasing the rate of air extraction, so that carcinogenic powders can be handled without ... powder being blown around the hood. Glove boxes should be kept under negative air pressure. Air changes should be adequate, so that concn of vapors of volatile carcinogens will not occur. /Chemical Carcinogens/For more Preventive Measures (Complete) data for DIMETHYLCARBAMOYL CHLORIDE (13 total), please visit the HSDB record page.
Isolation and EvacuationExcerpt from ERG Guide 156 [Substances - Toxic and/or Corrosive (Combustible / Water-Sensitive)]:Immediate precautionary measure
Respirator RecommendationsNIOSH
Threshold Limit Values (TLV)0.005 [ppm]8 hr Time Weighted Average (TWA): 0.005 ppm, skin.Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded.A2Suspected human carcinogen.0.005 ppm [2006]
Cancer Sites[in animals: nasal cancer]
標的器官Eyes, skin, respiratory system, liver
環境中動態TERRESTRIAL FATE: If dimethylcarbamoyl chloride is released to soil, it will be expected to rapidly hydrolyze if the soil is moist, based upon a half-life of 54 sec at 14 °C(SRC) calculated from a measured hydrolysis rate constant(1). Since it rapidly hydrolyzes, adsorption to and volatilization from moist soil are not expected to be significant processes, although no data specifically regarding the fate of dimethylcarbamoyl chloride in soil were located(SRC). The potential for volatilization of dimethylcarbamoyl chloride from dry soil surfaces may exist(SRC) based upon a vapor pressure of 1.95 mm Hg(2). Biodegradation should not be an important process since hydrolysis is such a rapid process(SRC).AQUATIC FATE: If dimethylcarbamoyl chloride is released to water, it will be expected to rapidly hydrolyze, based upon a half-life of 54 sec at 14 °C(SRC) calculated from a measured hydrolysis rate constant(1). The products of hydrolysis are dimethylamine, carbon dioxide, and hydrogen chloride(2). Since it rapidly hydrolyzes, bioconcentration, volatilization, and adsorption to sediment and suspended solids are not expected to be significant processes(SRC). No data were located concerning biodegradation, but dimethylcarbamoyl chloride probably abiotically degrades via hydrolysis significantly faster than via biodegradation(SRC).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), dimethylcarbamoyl chloride, which has a vapor pressure of 1.95 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere(SRC). Vapor-phase dimethylcarbamoyl chloride is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 24 hours(SRC), calculated from its rate constant of 16X10-12 cu cm/molecule-sec at 25 °C(SRC) determined using a structure estimation method(3). The hydrolysis half-life for dimethylcarbamoyl chloride is 54 sec(SRC), calculated from its rate constant of 12.76X10-3 sec-1(4), which suggests that vapor-phase dimethylcarbamoyl chloride will rapidly hydrolyze in fog and rain(SRC).
有害作用Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.
暴露経路inhalation, skin absorption, ingestion, skin and/or eye contact
Signs and Symptomsirritation eyes, skin, nose, throat, respiratory systemeye, skin burnscough, wheezing, larnygitis, dyspnea (breathing difficulty)headache, nausea, vomitingliver injury[potential occupational carcinogen]
Ongoing Test StatusThe following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical. [http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=79-44-7]
Medical SurveillancePRECAUTIONS FOR "CARCINOGENS": Whenever medical surveillance is indicated, in particular when exposure to a carcinogen has occurred, ad hoc decisions should be taken concerning ... /cytogenetic and/or other/ tests that might become useful or mandatory. /Chemical Carcinogens/
Soil Adsorption/MobilitySince dimethylcarbamoyl chloride rapidly hydrolyzes in water and moist soil(1), adsorption to soil is not expected to be an important environmental fate process(SRC).
Natural Pollution SourcesThere are no known natural sources of dimethylcarbamoyl chloride(1).
Human Toxicity ExcerptsONE CASE OF EYE IRRITATION & ONE OF LIVER DISTURBANCES HAVE BEEN OBSERVED IN WORKERS EXPOSED TO DIMETHYLCARBAMOYL CHLORIDE.NO CHROMOSOMAL ABERRATION WAS REPORTED IN 10 WORKERS EXPOSED TO THIS CMPD FOR 4-17 YEARS.AN ESTIMATE OF TOTAL NUMBER OF WORKERS AT RISK OF DMCC EXPOSURE, MADE IN 1976, WAS < 200. THIS DID NOT INCLUDE POTENTIAL EXPOSURES TO DMCC FORMED IN SIDE REACTIONS DURING THE SYNTHESIS OF OTHER PRODUCTS. NO CASES OF HUMAN CANCER ATTRIBUTABLE TO DMCC HAVE BEEN REPORTED. DUE TO HIGH TOXICITY, HOWEVER, EXPOSURES HAVE APPARENTLY BEEN WELL CONTROLLED.NO CANCER DEATHS (OUT OF A TOTAL OF SIX DEATHS) OR X-RAY INDICATIONS OF LUNG CANCER WERE REPORTED IN AN INVESTIGATION OF 39 DMCC PRODUCTION WORKERS...26 PROCESSING WORKERS & 42 EX-WORKERS, AGED 17-65 & EXPOSED FOR PERIODS RANGING FROM 6 MO TO 12 YR.Chromosomal analysis of peripheral lymphocytes from 10 people who had been occupationally exposed to dimethylcarbamoyl chloride (and diethylcarbamoyl chloride) for periods ranging from 4 to 17 years showed differences in the frequency of chromosomal aberrations (inclusive and exclusive gaps), when compared with a control group of 10 people matched for age, although statistical evaluation revealed no significant increase.
Artificial Pollution SourcesDimethylcarbamoyl chloride's production and former use as a chemical intermediate in the production of dyes, pharmaceuticals, and pesticides(1) may have resulted in its release to the environment through various waste streams(SRC).
大気基準Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Dimethyl carbamoyl chloride is included on this list.
CERCLA 報告数量Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 1 lb or 0.454 kg. The toll free number of the NRC is (800) 424-8802In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).
F9
水環境危害等級（WGK）3
TSCA 収載状態TSCA listed
RTECS 番号FD4200000
輸送番号（UN）UN 2262
毒性A designated animal carcinogen (IARC) and hazardous waste (EPA)a suspected carcinogen in humans. It is a liquid boiling at 165_x0003_C that is used primarily in the manufacture of drugs and pesticides. Dimethyl carbamoyl chloride is extremely toxic.
PRTR法第二種指定化学物質
税関コード29241990
危険文句（R）45-22-23-36/37/38
化審法(2)-2858
消防法危-4-3-III
危険表示T
安全措置（S）53-45-99
危険等級8Acute Tox. 3 InhalationAcute Tox. 4 OralCarc. 1BEye Irrit. 2Skin Irrit. 2STOT SE 3
包装等級II
貯蔵分類6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
有害物質データ79-44-7(Hazardous Substances Data)