Procainamide Hydrochloride

HCID 66068CAS 614-39-1

基本情報

標準SMILES: CCN(CC)CCNC(=O)c1ccc(N)cc1.Cl
InChIKey: ABTXGJFUQRCPNH-UHFFFAOYSA-N
分子式: C13H22ClN3O
平均分子量: 271.78 g/mol
単同位体質量: 271.14514

概要

Procainamide Hydrochloride is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procaine. Procainamide hydrochloride reversibly binds to and blocks activated (open) voltage-gated sodium channels, thereby blocks the influx of sodium ions into the cell, which leads to an increase in threshold for excitation and inhibit depolarization during phase 0 of the action potential. In addition, the effective refractory period (ERP), action potential duration (APD), and ERP/APD ratios are increased, resulting in decreased impulse conduction velocity. The lasting action potential may also be due to blockage of outward K+ currents. The result is a decrease in automaticity, increase in refractory period and slowing of impulse conduction.

名称と識別子

優先名称: Procainamide Hydrochloride
IUPAC: 4-amino-N-[2-(diethylamino)ethyl]benzamide;hydrochloride

名称と別名

procainamide hydrochloride614-39-1Procainamide HclProcanbidProcapanProcan SRPronestyl-SrAmidoprocaineCardiorytminBenzamide, 4-amino-N-[2-(diethylamino)ethyl]-, monohydrochlorideNovocamid hydrochlorideDTXSID2049422

名称をさらに表示

NSC-757279SI4064O0LXProcainamidi hydrochloridumBenzamide, 4-amino-N-(2-(diethylamino)ethyl)-, monohydrochlorideCHEBI:8429DTXCID10293824-Amino-N-(2-(diethylamino)ethyl)benzamide monohydrochloride4-Amino-N-[2-(diethylamino)ethyl]benzamide monohydrochloride

データベース識別子

CAS: 614-39-1
PubChem CID: 66068
DTXSID: DTXSID2049422
ChEMBL: CHEMBL605
UNII: SI4064O0LX
EC Number: 210-381-7

物性

構造計算による物性

極性表面積: 58.4 Å²
水素結合供与体数: 3
水素結合受容体数: 3
回転可能結合数: 6
重原子数: 18
形式電荷: 0
複雑度: 221

実験および物理化学的性質

Solubility>40.8 [ug/mL] (The mean of the results at pH 7.4)

Human Drugs · 2 件

FDA approved drugs -> Active ingredient

Collision Cross Section155.8 Å² [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

安全と法規制

GHS分類

GHS Classification · 4 件

Warning

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 47 reports by companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Other Safety InformationIMAP assessments - Benzamide, 4-amino-N-[2-(diethylamino)ethyl]-, monohydrochloride: Environment tier I assessment

Hazard Classes and CategoriesAcute Tox. 4 (100%)

毒性情報

Drug Induced Liver Injury · 6 件

Drug Induced Liver Injury Rank (DILIrank 2.0)

Procainamide hydrochloride

vLess-DILI-concern

Adverse reactions

DOI:10.1016/j.drudis.2016.02.015

化学と産業

薬理情報

FDA Pharmacological Classification · 4 件

PROCAINAMIDE HCI

Antiarrhythmic [EPC]

PROCAINAMIDE HYDROCHLORIDE

Antiarrhythmic [EPC]

MeSH Pharmacological Classification · 2 件

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.

A class of drugs that inhibit the activation of VOLTAGE-GATED SODIUM CHANNELS.

用途と製造

General Manufacturing InformationBenzamide, 4-amino-N-[2-(diethylamino)ethyl]-, hydrochloride (1:1): ACTIVE