基本情報
- CAS
1098-60-8- 標準SMILES
CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21.Cl- InChIKey
FTNWXGFYRHWUKG-UHFFFAOYSA-N- 分子式
- C18H20ClF3N2S
- 平均分子量
- 388.9 g/mol
- 単同位体質量
- 388.098782
名称と識別子
- 優先名称
- 10H-Phenothiazine-10-propanamine, N,N-dimethyl-2-(trifluoromethyl)-, monohydrochloride
- IUPAC
- N,N-dimethyl-3-[2-(trifluoromethyl)phenothiazin-10-yl]propan-1-amine;hydrochloride
- 現地名
- トリフルプロマジン·塩酸塩
- 英語名
- Triflupromazine hydrochloride
- 分子式
- C18H20ClF3N2S
- 分子量
- 388.88
名称と別名
Triflupromazine hydrochloride1098-60-8Triflupromazine HClFluopromazine monohydrochlorideTriflupromazine monohydrochlorideTrifluopromazine hydrochlorideDTXSID8045804NSC-14959NSC-174739E75N4A5HM10H-Phenothiazine-10-propanamine, N,N-dimethyl-2-(trifluoromethyl)-, monohydrochlorideMC-4703
名称をさらに表示
N,N-ジメチル-2-トリフルオロメチル-10H-フェノチアジン-10-プロパン-1-アミン·塩酸塩塩酸トリフルプロマジントリフルプロマジン塩酸塩2-(トリフルオロメチル)-10-[3-(ジメチルアミノ)プロピル]-10H-フェノチアジン·塩酸トリフルプロマジン·塩酸塩10-[3-(ジメチルアミノ)-1-プロピル]-2-(トリフルオロメチル)フェノチアジン塩酸塩トリフルプロマジン 塩酸塩塩酸トリフルプロマジン (JAN)N,N-ジメチル-2-トリフルオロメチル-10H-フェノチアジン-10-プロパン-1-アミン・塩酸塩トリフルプロマジン・塩酸塩2-(トリフルオロメチル)-10-[3-(ジメチルアミノ)プロピル]-10H-フェノチアジン・塩酸NeoprinFlumazinFluorofentriflupromazineHClLABOTEST-BB LT00772332TRIFLUPROMAZINE HCL IP/USPFluopromazine hydrochloride
物性
構造計算による物性
- 極性表面積
- 31.8 Ų
- 水素結合供与体数
- 1
- 水素結合受容体数
- 6
- 回転可能結合数
- 4
- 重原子数
- 25
- 形式電荷
- 0
- 複雑度
- 416
実験および物理化学的性質
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Animal DrugsFDA approved animal drugs -> Active ingredient
Collision Cross Section175.6 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
物理化学的性質
- 融点
- 174 to · 174.0 to 179.0 °C
- 貯蔵温度
- Keep in dark place,Inert atmosphere,Room temperature
- 水溶解度
- Soluble in water
- 溶解性
- 5 mg/mL; · DMF: 5mg/mL; DMSO: 3mg/mL; Ethanol: 5mg/mL; Ethanol:PBS (pH 7.2) (1:10): 0.09mg/mL
- 色
- White to Light yellow
- Merck
- 14 · 14,9685
- BRN
- 3801519 · 3801519
- 安定性
- Hygroscopic
- 主な用途
- 医薬品（低分子化合物）
- InChI
- 1S/C18H19F3N2S.ClH/c1-22(2)10-5-11-23-14-6-3-4-7-16(14)24-17-9-8-13(12-15(17)23)18(19,20)21;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H
- InChIKey
- FTNWXGFYRHWUKG-UHFFFAOYSA-N
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
GHS分類
GHS Classification
Danger
H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
P261, P264, P270, P271, P280, P301+P316, P302+P352, P304+P340, P317, P321, P330, P362+P364, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 39 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
危険有害性情報
Regulatory Information10H-Phenothiazine-10-propanamine, N,N-dimethyl-2-(trifluoromethyl)-, monohydrochloride: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - 10H-Phenothiazine-10-propanamine, N,N-dimethyl-2-(trifluoromethyl)-, monohydrochloride: Human health tier I assessment
Hazard Classes and CategoriesAcute Tox. 3 (100%)
安全データ
- wgk
- 3
- rtecs
- SO8925000
- ridadr
- UN 2811 6.1/PG 3
- hs_code
- 2934302300
- risk_code
- 20/21/22
- 化審法
- (9)-927
- hazard_code
- Xn
- safety_code
- 36
- hazard_class
- 6.1
- packing_group
- III
- Hazard Classifications
- Acute Tox. 3 OralAcute Tox. 4 DermalAcute Tox. 4 Inhalation
化学と産業
応用分野
説明Triflupromazine is a phenothiazine with diverse biological activities. It binds to muscarinic receptors in isolated rat corpus striatum (IC50 = 100 μM in a radioligand binding assay). Triflupromazine inhibits serotonin (5-HT) uptake by isolated rat brainstem synaptosomes (IC50 = 0.8 μM). It inhibits T. cruzi infection in mouse peritoneal macrophages when used at a concentration of 12.5 μM. Triflupromazine is active against S. aureus, shigellae, and vibrios (MICs = 2-100 μg/ml) in vitro and is protective against S. typhimurium infection in mice when administered at a dose of 30 μg per animal. Formulations containing triflupromazine were previously used as antipsychotics.
使用analgesic, antiinflammatory, antipyretic, COX-II inhibitor
一般的な説明Triflupromazinehydrochloride, 10-[3-(dimethylamino)propyl]-2-(trifluoromethyl)phenothiazine monohydrochloride (Vesprin), has agreater milligram potency as an antipsychotic, higher EPS,but lower sedative and hypotensive effects than chlorpromazine.The 2-CF3 versus the 2-Cl is associated with thesechanges. Overall, the drug has uses analogous to those ofchlorpromazine.
上流・下流製品情報
上流原料
サプライヤー56 社
国药集团化学试剂有限公司86-21-63210123 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
艾吉析科技（上海）有限公司
関連反応
0 件
現在のフィルター条件では反応記録がありません。
化合物ノート
読み込み中…