基本情報
- CAS
3239-45-0- 標準SMILES
CCN[C@@H](C)Cc1cccc(C(F)(F)F)c1.Cl- InChIKey
ZXKXJHAOUFHNAS-FVGYRXGTSA-N- 分子式
- C12H17ClF3N
- 平均分子量
- 267.72 g/mol
- 単同位体質量
- 267.1001617
概要
Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. It was for some years in the mid-1990s approved by the United States Food and Drug Administration for the purposes of weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was withdrawn.
名称と識別子
- 優先名称
- (+)-Fenfluramine hydrochloride
- IUPAC
- (2S)-N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine;hydrochloride
名称と別名
DEXFENFLURAMINE HYDROCHLORIDE3239-45-0AdifaxAdipomind-Fenfluramine hydrochloride(+)-Fenfluramine hydrochlorideGlypolixDexfenfluramine HClS 5614 HClS-5614 HYDROCHLORIDEDTXSID7048871PM28L0FHNP
名称をさらに表示
(+)-(S)-N-Ethyl-alpha-methyl-m-(trifluoromethyl)phenethylamine hydrochlorideFENFLURAMINE D-FORM HYDROCHLORIDES-5614 HCLDTXCID0028797CHEBI:59730RefChem:132388Hydrochloride, Dexfenfluramine221-806-0
データベース識別子
- CAS
3239-45-0- PubChem CID
- 66264
- DTXSID
DTXSID7048871- ChEMBL
CHEMBL1887891- UNII
- PM28L0FHNP
- EC Number
- 221-806-0
物性
構造計算による物性
- 極性表面積
- 12 Ų
- 水素結合供与体数
- 2
- 水素結合受容体数
- 4
- 回転可能結合数
- 4
- 重原子数
- 17
- 形式電荷
- 0
- 複雑度
- 203
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
GHS分類
GHS Classification
Danger
H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
P261, P262, P264, P270, P271, P280, P301+P316, P302+P352, P304+P340, P316, P321, P330, P361+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 40 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
危険有害性情報
Hazard Classes and CategoriesAcute Tox. 3 (100%)
毒性情報
Treatment
General supportive measures for oral drug overdose should be instituted. Measures that have been used in dexfenfluramine overdose cases include aspiration of gastric contents, gastric lavage with activated charcoal, osmotic diuresis, forced acid diuresis, and careful monitoring of CNS or respiratory depression. The effectiveness of dialysis is not known. Patients should be followed closely until there is no further evidence of drug-related CNS effects. No specific therapy for dexfenfluramine overdose is known. (L1712)
Exposure RoutesWell-absorbed from the gastrointestinal tract.
Toxicity Summary
Dexfenfluramine binds to the serotonin reuptake pump. This causes inhbition of serotonin reuptake. The increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates.
Signs and SymptomsSymptoms of overdose include respiratory failure and cardiac arrest leading to death.
化学と産業
薬理情報
Metabolism/MetabolitesHalf Life: 17-20 hours
MeSH Pharmacological ClassificationEndogenous compounds and drugs that bind to and activate SEROTONIN RECEPTORS. Many serotonin receptor agonists are used as ANTIDEPRESSANTS; ANXIOLYTICS; and in the treatment of MIGRAINE DISORDERS.
用途と製造
UsesA serotoninergic anorectic drug once used for the purposes of weight loss, but pulled out from the global market following multiple concerns about the cardiovascular side-effects of the drug. [Wikipedia]
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