4,4'-オキシビス(ベンゼンスルホノヒドラジド)

When heated to decomposition it emits very toxic fumes of /nitroxides/ and /sulfoxides/.

Decomposes below boiling point at 140-160 °C.

Other Solid; Dry Powder

White odorless solid; [HSDB] Fine, white powder; [ACGIH]

Danger

H242: Heating may cause a fire [Danger Self-reactive substances and mixtures; Organic peroxides]

P210, P234, P235, P240, P273, P280, P370+P378, P391, P403, P410, P411, P420, and P501 (click each P-code to see the statement)

This chemical does not meet GHS hazard criteria for 2.8% (13 of 458) of reports.

Danger

H228 (33.6%): Flammable solid [Danger Flammable solids]

Chemical: Benzenesulfonic acid, 4,4'-oxybis-, dihydrazide

Benzenesulfonic acid, 4,4'-oxybis-, 1,1'-dihydrazide is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Benzenesulfonic acid, 4,4'-oxybis-, 1,1'-dihydrazide are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

REACH registered substance: 4,4'-oxydi(benzenesulphonohydrazide) (EC: 201-286-1)

Benzenesulphonic acid, 4,4'-oxybis-, dihydrazide: HSNO Approval: HSR007572 Approved with controls

A skin, eye, and mucous membrane irritant; Moderately toxic by inhalation, ingestion, and skin absorption; [CAMEO] Health effects of exposure to the substance have not been investigated adequately. [ICSC] An irritant; [MSDSonline] Limited toxicology data available; Oral LD50 (rats) = 2.3 g/kg; Dermal LD50 (rabbits) >200 mg/kg; By analogy to the TLV for hydrazine, the recommended TLV for OBSH is sufficiently low to protect against ocular irritation and suspected genotoxicity and carcinogenicity; TLV Basis: Teratogenic effect; [ACGIH]

Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. p , p '-Oxybis(benzenesulfonylhydrazide) is included on this list. Effective date 9/30/91; Sunset date: 6/30/98.

Flam. Sol. 1 (33.6%)

Self-reactive substances and mixtures - Type D

Acute toxicity (Oral) - Category 5

Self-reactive substances and mixtures - Type D

Self-react. D

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

0.1 [mg/m3], inhalable fraction

8 hr Time-Weighted Avg (TWA): 0.1 mg/cu m. Inhalable fraction.

Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded.

Protective gloves. Safety spectacles.

Personal protection: P1 filter respirator for inert particles.

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 880(SRC), determined from a structure estimation method(2), indicates that p,p'-oxybis(benzenesulfonyl hydrazide) is expected to have low mobility in soil(SRC). Volatilization of p,p'-oxybis(benzenesulfonyl hydrazide) from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.26X10-17 atm-cu m/mole(SRC), using a fragment constant estimation method(3). p,p'-Oxybis(benzenesulfonyl hydrazide) is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 6.91X10-11 mm Hg at 25 °C(SRC), determined from a fragment constant method(4). A 2% of theoretical BOD using activated sludge in the Japanese MITI test(5) suggests that biodegradation is not an important environmental fate process in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 880(SRC), determined from a structure estimation method(2), indicates that p,p'-oxybis(benzenesulfonyl hydrazide) is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 1.26X10-17 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), BCF values of less than 3.0(6), suggest bioconcentration in aquatic organisms is low(SRC). A 2% of theoretical BOD using activated sludge in the Japanese MITI test(6) suggests that biodegradation is not an important environmental fate process in water(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), p,p'-oxybis(benzenesulfonyl hydrazide), which has an estimated vapor pressure of 6.91X10-11 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase p,p'-oxybis(benzenesulfonyl hydrazide) may be removed from the air by wet or dry deposition(SRC). p,p'-Oxybis(benzenesulfonyl hydrazide) does not contain chromophores that absorb at wavelengths >290 nm(3), and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

Reproductive Toxin - A chemical that is toxic to the reproductive system, including defects in the progeny and injury to male or female reproductive function. Reproductive toxicity includes developmental effects. See Guidelines for Reproductive Toxicity Risk Assessment.

Using a structure estimation method based on molecular connectivity indices(1), the Koc of p,p'-oxybis(benzenesulfonyl hydrazide) can be estimated to be 880(SRC). According to a classification scheme(2), this estimated Koc value suggests that p,p'-oxybis(benzenesulfonyl hydrazide) is expected to have low mobility in soil.

/GENOTOXICITY/ The test substance was evaluated for its ability to induce chromosomal aberrations in primary human lymphocyte cells in the presence and absence of a rat liver homogenate metabolic activation system. The test article was tested at the following concentrations: Neat and 1:2, 1:4, 1:8, 1:16, 1:32, and 1:64 dilutions of the neat extract. The concentrations chosen to be scored for the activated assay were neat and 1:2 and 1:4 dilutions of the test extract. The results indicate that the test substance did not cause a statistically significant increase in the number of chromosome aberrations (p < 0.05). This was observed for both activated and non-activated system. In addition, there was no detectable dose response in the number of aberrations of both activated and non-activated systems, verifying the validy of the test system. In conclusion, the test substance did not induce aberrations in primary cultured human lymphocytes and is considered non-clastogenic.

AEROBIC: p,p'-Oxybis(benzenesulfonyl hydrazide), present at 100 ppm, reached 2% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 ppm in the Japanese MITI test(1,2), indicating that biodegradation is not expected to be an important environmental fate process(SRC).

BCF values of <0.3 and <3.0 were calculated in carp (Cyprinus carpio) for p,p'-oxybis(benzenesulfonyl hydrazide), exposed over a 6 week test period to 1 mg/L and 0.1 mg/L, respectively(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Henry's Law constant for p,p'-oxybis(benzenesulfonyl hydrazide) is estimated as 1.26X10-17 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that p,p'-oxybis(benzenesulfonyl hydrazide) is expected to be essentially nonvolatile from water surfaces(2). p,p'-Oxybis(benzenesulfonyl hydrazide) is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 6.91X10-11 mm Hg(SRC), determined from a fragment constant method(3).

/LABORATORY ANIMALS: Acute Exposure/ There is limited evidence that 4,4'-oxybis(benzenesulphonyl hydrazide) irritated the skin and eyes of laboratory animals. A moderate to low acute oral toxicity was seen in rats and mice; effects on the nervous system were observed.

/LABORATORY ANIMALS: Acute Exposure/ Following repeated oral exposure, liver, kidney and adrenal effects were seen in limited studies in rats.

/LABORATORY ANIMALS: Acute Exposure/ Mutagenic activity was demonstrated in bacterial assays, including an Ames test, and DNA damage was induced in cultures of rat and mouse cells. No evidence of genotoxic potential was found in mice treated by intraperitoneal administration.

/GENOTOXICITY/ Bacterial reverse mutation assay. Benzenesulfonic acid, 4, 4'-oxybis-, dihydrazide was mutagenic in Salmonella typhimurium (Ames test) in the presence or absence of a liver metabolic activation system. In a test with one strain of Escherichia coli, a liver metabolic activation system was required for the hydrazide to exhibit mutagenic potential, although tests with other strains found no evidence of mutagenicity in the presence or absence of a liver metabolic fraction.

For more Non-Human Toxicity Excerpts (Complete) data for p,p'-Oxybis(benzenesulfonyl hydrazide) (7 total), please visit the HSDB record page.

p,p'-Oxybis(benzenesulfonyl hydrazide) is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(1). p,p'-Oxybis(benzenesulfonyl hydrazide) does not contain chromophores that absorb at wavelengths >290 nm(1), and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

According to the 2006 TSCA Inventory Update Report, the number of persons reasonably likely to be exposed in the industrial manufacturing, processing, and use of p,p'-oxybis(benzenesulfonyl hydrazide) is 1,000 or greater; the data may be greatly underestimated(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 5,939 workers (282 of these were female) were potentially exposed to p,p'-oxybis(benzenesulfonyl hydrazide) in the US(1). Occupational exposure to p,p'-oxybis(benzenesulfonyl hydrazide) may occur through inhalation of dust and dermal contact with this compound at workplaces where p,p'-oxybis(benzenesulfonyl hydrazide) is produced or used. Exposure to the general population is limited(SRC).

p,p'-Oxybis(benzenesulfonyl hydrazide)'s production and use as a blowing agent for sponge rubber and expanded plastics may result in its release to the environment through various waste streams. If released to air, an estimated vapor pressure of 6.91X10-11 mm Hg at 25 °C indicates p,p'-oxybis(benzenesulfonyl hydrazide) will exist solely in the particulate phase in the atmosphere. Particulate-phase p,p'-oxybis(benzenesulfonyl hydrazide) will be removed from the atmosphere by wet or dry deposition. p,p'-Oxybis(benzenesulfonyl hydrazide) does not contain chromophores that absorb at wavelengths >290 nm, and therefore is not expected to be susceptible to direct photolysis by sunlight. If released to soil, p,p'-oxybis(benzenesulfonyl hydrazide) is expected to have low mobility based upon an estimated Koc of 880. Volatilization from moist soil surfaces is not expected to be an important fate process based upon an estimated Henry's Law constant of 1.26X10-17 atm-cu m/mole. If released into water, p,p'-oxybis(benzenesulfonyl hydrazide) is expected to adsorb to suspended solids and sediment based upon the estimated Koc. Utilizing the Japanese MITI test, 2% of the theoretical BOD was reached in 2 weeks indicating that biodegradation is not an important environmental fate process. Volatilization from water surfaces is not expected to be an important fate process based upon this compound's estimated Henry's Law constant. BCF values of less than 3.0 suggest bioconcentration in aquatic organisms is low. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions. Occupational exposure to p,p'-oxybis(benzenesulfonyl hydrazide) may occur through inhalation of dust and dermal contact with this compound at workplaces where p,p'-oxybis(benzenesulfonyl hydrazide) is produced or used. Exposure to the general population is limited. (SRC)

Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. p , p '-Oxybis(benzenesulfonylhydrazide) is included on this list. Effective date 9/30/91; Sunset date: 6/30/98.

Used as a blowing agent for sponge rubber and expanded plastics; [HSDB] Used as an additive to polymers to make sponge rubber cosmetic puffs, electrostatographic toners, buoyant seats, insulation and packing materials, rubber products (insoles, gaskets, and stoppers), adhesives, sealants, and leather substitutes; Used as a blowing agent--releases nitrogen when heated; [ACGIH]

Working with Glues and Adhesives [Category: Other]

Blowing agent for sponge rubber and expanded plastics

2023: 601,810 lb

Benzenesulfonic acid, 4,4'-oxybis-, dihydrazide is listed as a High Production Volume (HPV) chemical (65FR81686). Chemicals listed as HPV were produced in or imported into the U.S. in >1 million pounds in 1990 and/or 1994. The HPV list is based on the 1990 Inventory Update Rule. (IUR) (40 CFR part 710 subpart B; 51FR21438).

Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#5300]

Production volume for non-confidential chemicals reported under the 2006 Inventory Update Rule. Chemical: Benzenesulfonic acid, 4,4'-oxybis-, 4,4'-dihydrazide. Aggregated National Production Volume: 1 to < 10 million pounds.

Computer and Electronic Product Manufacturing

Benzenesulfonic acid, 4,4'-oxybis-, 1,1'-dihydrazide: ACTIVE