ガリウムトリニトラート
GALLIUM NITRATE
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名称と識別子
- 優先名称
- GALLIUM NITRATE
- 現地名
- ガリウムトリニトラート
- 英語名
- GALLIUM NITRATE
- 分子式
- GaH4NO3
- 分子量
- 135.76
名称と別名
硝酸ガリウム(III)ガリウムトリニトラート三硝酸ガリウム硝酸ガリウム（ＩＩＩ）（１：３）硝酸ガリウム(Ⅲ)n水和物硝酸ガリウム(III)N水和物, 99.9%硝酸ガリウム(III)N水和物硝酸ガリウム(III) solution, Ga 9-10% w/wganitensc-15200Ga(NO3)3nH2OGa(NO3)3?5H2O
名称をさらに表示
Wln: ga N-o3*3GALLIUM NITRATEgalliumtrinitrateGallium(Ⅲ) nitrateGALLIUM (III) NITRATENitricacid,galliumsalt
データベース識別子
- CAS
13494-90-1- PubChem CID
- 6711183
物性
物理化学的性質
- 融点
- 110 °C · 110°C (dec.)
- 闪点
- Not applicable
- 溶解性
- 2 O, · soluble in H2O, ethanol, ethyl ether
- 外見
- solution
- 色
- white crystals, crystalline powder
- 水溶解度
- 水に溶けます。
- InChI
- 1S/Ga.3NO3/c;3*2-1(3)4/q+3;3*-1
- InChIKey
- CHPZKNULDCNCBW-UHFFFAOYSA-N
- SMILES
- [Ga+3].[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O
- EPAの化学物質情報
- Gallium nitrate (13494-90-1)
化学的性質
化学的特性The structural formula of gallium nitrate is Ga(NO3)3. Gallium nitrate is an anhydrate salt that is very soluble in water and soluble in 95% ethanol. It is stable in commonly used intravenous fluids for 14 days at room temperature and at 5 ℃, and physically compatible for injection with selected drug products, with the exception of diazepam injection.This chemical is an oxidizer, and is probably combustible
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
安全データ
- wgk
- WGK 3
- tsca
- TSCA listed
- ridadr
- 1477
- risk_code
- 8-36/37/38
- safety_code
- 17-26-36/37/39
- hazard_class
- 5.1
- packing_group
- III
- Hazard Classifications
- Eye Irrit. 2Ox. Liq. 2Skin Irrit. 2
- ストレージクラス
- 5.1B - Oxidizing hazardous materials
化学と産業
応用分野
用途分析におけるガリウムイオン供給源。
用途高純度金属化合物。
説明Gallium nitrate, initially developed as an anticancer agent, was introduced by Fujisawa as an orphan drug for the treatment of cancer-related hypercalcemia and bone metastases that do not respond to adequate hydration. The compound acts specifically on bone by inhibiting calcium resorption and also possibly by stimulating bone formation. Compared with calcitonin and etidronate, gallium nitrate is more potent and substantially longer acting. Other potential uses could be in the treatment of osteoporosis and Paget’s disease.
使用Gallium is the second metal ion with clinical activity used in cancer treatment. Gallium nitrate has demonstrated antitumor activity in a variety of murine tumor models, including Walker 256 carcinosarcoma, fibrosarcoma M-89, leukemia K-1964, adenocarcinoma 755, mammary carcinoma YMC, reticulum cell sarcoma A-RCS, lymphoma P1798, and osteosarcoma 124F. It was, however, ineffective in ascites, leukemias, plasma cell tumors, or Ehrlich carcinoma. In phase II evaluation studies, gallium nitrate has shown antitumor activity in patients with either refractory lymphomas or small-cell lung carcinomas or bladder cancer, with total objective response rates of 28% and 11%, respectively. This drug has displayed its strongest antineoplastic activity in the treatment of non-Hodgkin’s lymphoma and bladder cancer. In addition, according to two phase III comparative trials,thanks to an inhibitory effect on calcium reabsorption from bone, gallium nitrate is superior to alternative therapies in the treatment of hypercalcemia associated with malignancy and related disease states. Based on its clinical efficacy, gallium nitrate (Ganite ) was approved by the Food and Drug Administration (FDA) for the treatment of cancerassociated hypercalcemia.Apart from its ability to control hypercalcemia, gallium nitrate has been shown to inhibit bone turnover and decrease osteolysis in patients with multiple myeloma and in patients with bone metastases from a variety of different cancers.
一般的な説明White crystals.
上流・下流製品情報
上流原料
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