Arry-382 (HCID 67259771)

基本情報

標準SMILES: Cc1cccc(Cn2nc(C3CC3)c3c(NC(=O)c4cnc5cc(OCCN6CCN(C)CC6)ccn45)cccc32)n1
InChIKey: JUPOTOIJLKDAPF-UHFFFAOYSA-N
分子式: C32H36N8O2
平均分子量: 564.7 g/mol

概要

cFMS Tyrosine Kinase Inhibitor ARRY-382 is a small molecule and orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R; cFMS) with potential antineoplastic activity. cFMS tyrosine kinase inhibitor ARRY-382 binds to and inhibits the activity of cFMS. By preventing colony-stimulating factor-1 (CSF-1)-cFMS signaling, this agent may inhibit tumor cell proliferation in cFMS-overexpressing tumor cells. cFMS, a tyrosine kinase receptor, is overexpressed in certain tumor cell types and plays an essential role in macrophage differentiation and regulation of cell proliferation.

名称と識別子

優先名称: Arry-382
IUPAC: N-[3-cyclopropyl-1-[(6-methyl-2-pyridinyl)methyl]indazol-4-yl]-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridine-3-carboxamide

名称と別名

ARRY-382c-Fms-IN-12ARRY382ARRY 382N-[3-cyclopropyl-1-[(6-methylpyridin-2-yl)methyl]indazol-4-yl]-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridine-3-carboxamidePF-07265804PF07265804N-(3-cyclopropyl-1-((6-methylpyridin-2-yl)methyl)indazol-4-yl)-7-(2-(4-methylpiperazin-1-yl)ethoxy)imidazo(1,2-a)pyridine-3-carboxamideRefChem:114168cFMS Tyrosine Kinase Inhibitor ARRY-3821313407-95-2N-(3-cyclopropyl-1-((6-methylpyridin-2-yl)methyl)-1H-indazol-4-yl)-7-(2-(4-methylpiperazin-1-yl)ethoxy)imidazo[1,2-a]pyridine-3-carboxamide

名称をさらに表示

N-[3-Cyclopropyl-1-[(6-methylpyridin-2-yl)methyl]-1H-indazol-4-yl]-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridine-3-carboxamideGTPL9108orb1304109SCHEMBL2048345CHEMBL3644252SCHEMBL29370287SCHEMBL30772280JUPOTOIJLKDAPF-UHFFFAOYSA-N

データベース識別子

PubChem CID: 67259771
ChEMBL: CHEMBL3644252

物性

構造計算による物性

XLogP: 3.9
極性表面積: 92.8 Å²
水素結合供与体数: 1
水素結合受容体数: 7
回転可能結合数: 9
重原子数: 42
形式電荷: 0
複雑度: 913

化合物ノート

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