フタル酸ジシクロヘキシル

This compound is not very flammable but any fire involving this compound may produce dangerous vapors. You should evacuate the area. All firefighters should wear full-body protective clothing and use self-contained breathing apparatuses. You should extinguish any fires involving this chemical with a dry chemical, carbon dioxide, foam, or halon extinguisher. (NTP, 1992)

Use water spray, foam, powder, carbon dioxide.

Fresh air, rest.

Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Wear self-contained breathing apparatus for firefighting if necessary.

Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

ACCIDENTAL RELEASE MEASURES Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions: Do not let product enter drains. Methods and materials for containment and cleaning up: Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.

SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, you should dampen the solid spill material with alcohol, then transfer the dampened material to a suitable container. Use absorbent paper dampened with alcohol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with alcohol followed by washing with a strong soap and water solution. Do not reenter the contaminate area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

Product Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Contaminated packaging Dispose of as unused product.

Increased /room/ ventilation and /SRP: decreased/ aspiration of vapors and dusts. /Phathalic esters/

SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

SRP: Contaminated protective clothing should be segregated in a manner such that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. The completeness of the cleaning procedures should be considered before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at the end of shift, but should remain at employee's place of work for cleaning.

SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants. Ensure that the local ventilation moves the contaminant away from the worker.

For more Preventive Measures (Complete) data for DICYCLOHEXYL PHTHALATE (7 total), please visit the HSDB record page.

The degradation product of dicyclohexyl phthalate, monocyclohexyl phthalate (MCHP), was detected (detection limit 0.7 ug/L) in <16% of 2540 urine samples collected in the United States National Health and Nutrition Examination Survey (1999-2000)(1). MCHP was not detected in the serum of 501 female and 502 male seniors from Uppsala, Sweden(2). MCHP was detected in <20% of the urine samples collected from 3236 people (ages 6-49 years old) during the Canadian Health Measures Survey 2007-2009(3).

Phthalate esters are endocrine disruptors. Animal studies have shown that they disrupt reproductive development and can cause a number of malformations in affected young, such as reduced anogenital distance (AGD), cryptorchidism, hypospadias, and reduced fertility. The combination of effects associated with phthalates is called 'phthalate syndrome’. (A2883)

TERRESTRIAL FATE: Based on a classification scheme(1), estimated log Koc values of 4.12-4.47(2-3), indicate that dicyclohexyl phthalate is expected to be immobile in soil(SRC). Volatilization of dicyclohexyl phthalate from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.0X10-7 atm-cu m/mole(SRC), based upon its vapor pressure, 8.69X10-7 mm Hg(4), and water solubility, 4 mg/L(5). Dicyclohexyl phthalate is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(4). Dicyclohexyl phthalate reached 68.5% of its theoretical BOD in the Japanese MITI test(6), suggesting that biodegradation is an important environmental fate process in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), estimated log Koc values of 4.12-4.47(2-3), indicate that dicyclohexyl phthalate is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(4) based upon an estimated Henry's Law constant of 1.0X10-7 atm-cu m/mole(SRC), derived from its vapor pressure, 8.69X10-7 mm Hg(5), and water solubility, 4 mg/L(6). Dicyclohexyl phthalate is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(4). According to a classification scheme(7), an estimated BCF of 5750(SRC), from an estimated log Kow of 6.2(2) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is very high(SRC). However, bioconcentration studies on compounds which are structurally similar suggest that bioconcentration may be lower than that indicated by the regression-derived equations due to the ability of aquatic organisms to readily metabolize this class of compounds(8). Hydrolysis is not expected to be an important process(SRC) based on estimated hydrolysis half-lives of 12 and 1.2 years at pHs 7 and 8, respectively(2). Dicyclohexyl phthalate had average biodegradation half-lives of 11.1 and 26.4 days under aerobic and anaerobic conditions, respectively, in river sediment samples(9), suggesting that biodegradation is an important environmental fate process in water(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), dicyclohexyl phthalate, which has a vapor pressure of 8.69X10-7 mm Hg at 25 °C(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase dicyclohexyl phthalate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 16 hours(SRC), calculated from its rate constant of 2.4X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase dicyclohexyl phthalate may be removed from the air by wet and dry deposition(SRC). Dicyclohexyl phthalate contains chromophores that absorb at wavelengths >290 nm(4) and, therefore, may be susceptible to direct photolysis by sunlight(SRC).

In April 2011, 72 commonly consumed foods were purchased from super markets in Albany, NY; dicyclohexyl phthalate was not detected (detection limit 0.2 ng/g) in beverages, milk, fish, fruits/vegetables, grain, beef, pork, poultry or meat and meat products(1). It was detected in 1 of 9, 1 of 3, 1 of 6 and 1 of 7 samples of other dairy, vegetable oils, condiments and infant food, respectively(1). Dicyclohexyl phthalate was detected in 11% of foods and beverages purchased from Norwegian grocery stores(2). Dicyclohexyl phthalate was detected at <0.01-18.6 mg/kg in 47 confectionary, snack products and biscuits wrapped in printed polypropylene film; a good correlation was found between the ink concentration and the food products(3). Dicyclohexyl phthalate was not detected in raw cow's milk collected from farms in Belgium(4).

Dicyclohexyl phthalate was not detected (detection limit 0.2 ng/g) in 2 milk samples purchased from super markets in Albany, NY in April 2011(1). Dicyclohexyl phthalate was not detected in raw cow's milk collected from farms in Belgium(2).

This survey determined the levels of eight phthalates - i.e. dimethyl phthalate (DMP), diethyl phthalate (DEP), diisobutyl phthalate (DiBP), di-n-butyl phthalate (DnBP), benzylbutyl phthalate (BzBP), di(2-ethylhexyl) phthalate (DEHP), dicyclohexyl phthalate (DCHP) and di-n-octyl phthalate (DnOP) - in several Belgian milk and dairy products. Samples were obtained from various farms, a dairy factory and from different shops in order to investigate phthalate contamination "from farm to fork". At several stages in the milk chain, product contamination with phthalates - mostly DiBP, DnBP, BzBP and DEHP - was observed. At farm level, the mechanical milking process and the intake of phthalate containing feed by the cattle were found to be possible contamination sources. At industry and retail level, contact materials including packaging materials were additional contamination sources for phthalates in milk and dairy products.

This study investigated the occurrence of dimethyl phthalate (DMP), diethyl phthalate (DEP), diisobutyl phthalate (DiBP), di-n-butyl phthalate (DnBP), benzylbutyl phthalate (BBP), di(2-ethylhexyl) phthalate (DEHP), dicyclohexyl phthalate (DCHP) and di-n-octyl phthalate (DnOP) in raw cow's milk and feed from Belgian farms in order to determine their most relevant contamination pathways in milk. Measurable levels of DMP, DEP, DnBP, DCHP and DnOP were found in various feed samples, although they were not observed in milk. A plausible explanation for this is that they are rapidly metabolised in cows. DEHP and in a smaller degree also DiBP and BBP levels in milk seemed to vary across seasons and farms. DiBP and BBP levels were lower in summer than in winter milk, which was in contrast with what was observed for DEHP. This is possibly due to another feed composition during summer and winter. Comparing BBP and DEHP concentrations in manually with those in mechanically obtained milk revealed that, besides environmental contamination via feed ingestion, contact materials used during the mechanical milking process is another important contamination pathway. Concentrations observed in this study confirm the decreasing trend of DEHP in European cow's milk owing to the substitution of DEHP by other plasticisers.

IDENTIFICATION AND USE: Dicyclohexyl phthalate(DCHP) is a white granular solid. It is used as a plasticizer to modify the properties of synthetic resins, in alkyd resins and cellulose nitrate to increase their stability to light and weathering, and to improve the chemical and physical properties of plastics by preventing creep. It is very stable to heat and light and imparts a glossy finish to extruded materials. It is also used in paper finishes and makes printers ink water-resistant. HUMAN EXPOSURE AND TOXICITY: There is limited evidence that occupational exposure to DCHP fumes may have caused asthma. In vitro DCHP effectively inhibit the calcium signaling of human nicotinic acetylcholine receptors. In vitro assay of human breast cancer MCF-7 cell proliferation demonstrated DCHP estrogenic activities. People exposed to DCHP will excrete mono-cyclohexyl phthalate (MCHP) in their urine. ANIMAL STUDIES: Neat dicyclohexyl phthalate (DCHP) was slightly irritant to the skin of guinea-pigs and rabbits, and the eyes of rabbits. Liver and testicular effects were seen following repeated administration in oral studies in rats. It was of low acute oral toxicity in rats and mice. DCHP gave no indication of genotoxicity in studies using bacteria, including Ames tests. Prolonged estrous cycle length was found in rats exposed to 6000 ppm DCHP in diet. A decrease in the survival of pups was seen after rats were exposed to 500 mg/kg/d during gestation. DCHP may have antiandrogenic effects on male reproductive development before and after birth. DCHP affected the developing rat brain, resulting in hyperactivity, probably as a result of degeneration of mesencephalic tyrosine hydroxylase rather than alteration of the level of gene expression. ECOTOXICITY STUDIES: DCHP significantly inhibited activities of antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) in liver of freshwater goldfish Carassius.

Phthalate esters are endocrine disruptors. They decrease foetal testis testosterone production and reduce the expression of steroidogenic genes by decreasing mRNA expression. Some phthalates have also been shown to reduce the expression of insulin-like peptide 3 (insl3), an important hormone secreted by the Leydig cell necessary for development of the gubernacular ligament. Animal studies have shown that these effects disrupt reproductive development and can cause a number of malformations in affected young. (A2883)

The average daily intake of dicyclohexyl phthalate was estimated as 0.008 ug/kg/day based on a food survey conducted in Albany, NY in 2011(1). The average daily intake of dicyclohexyl phthalate was estimated as 10-20 ng/kg body weight/day in studies of foods and beverages purchased from Norwegian grocery stores(2).

/AQUATIC SPECIES/ Phthalates (PAEs) are chemical agents typically used as plasticizers in numerous industrial products. They have become ubiquitous contaminants due to their tendency to release into the environment. The present study was conducted to investigate the comparative antioxidant responses in liver of freshwater goldfish Carassius auratus injected intraperitoneally with 17 different PAEs at a concentration of 10 mg/kg for 10 days. The results indicated that these PAEs can adversely affect the antioxidant status, confirmed by the significantly inhibited activities of antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase). Especially, the latter two enzymes constituted the most affected antioxidant enzymes after the exposure, and the lowest values were recorded for the catalase activity. The toxicity order was proposed via the integrated biomarker response, with dicyclohexyl phthalate the most toxic and diethyl phthalate the least. Overall, these findings may contribute to the risk assessments of these chemicals on aquatic species.

EPA has released the first beta version (version 0.5) of the Interactive Chemical Safety for Sustainability (iCSS) Dashboard. The beta version of the iCSS Dashboard provides an interactive tool to explore rapid, automated (or in vitro high-throughput) chemical screening data generated by the Toxicity Forecaster (ToxCast) project and the federal Toxicity Testing in the 21st century (Tox21) collaboration. /The title compound was tested by ToxCast and/or Tox21 assays; Click on the "Chemical Explorer" button on the tool bar to see the data./[USEPA; ICSS Dashboard Application; Available from, as of December 8, 2014: http://actor.epa.gov/dashboard/]

The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical.[Available from: http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=84-61-7]

Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. 1,2-Benzenedicarboxylic acid,dicyclohexyl ester is included on this list. Effective date 10/04/82; Sunset date 10/04/92.

Used as plasticizer for nitrocellulose, ethyl cellulose, chlorinated rubber, polyvinyl acetate, polyvinyl chloride, and other polymers; Also used as a heat sealer for cellulose, in paper finishes, and to make printers ink water-resistant; [HSDB]

Pulp and Paper Processing [Category: Industry]

Plasticizer for nitrocellulose, ethyl cellulose, chlorinated rubber, polyvinyl acetate, polyvinyl chloride, and other polymers.

Dicyclohexyl phthalate is used as a plasticizer to modify the properties of synthetic resins, in alkyd resins and cellulose nitrate to increase their stability to light and weathering, and to improve the chemical and physical properties of plastics by preventing creep. It is very stable to heat and light and imparts a glossy finish to extruded materials. It is also used in paper finishes and makes printers ink water-resistant.

Use resulting in inclusion into or onto matrix ... Paint, lacquers and varnishes industry ...

Phthalate esters are mainly used as plasticizers, primarily used to soften polyvinyl chloride. They are found in a number of products, including glues, building materials, personal care products, detergents and surfactants, packaging, children's toys, paints, pharmaceuticals, food products, and textiles. Phthalates are used in a variety of household applications such as shower curtains, vinyl upholstery, adhesives, floor tiles, food containers and wrappers, and cleaning materials. Personal care items containing phthalates include perfume, eye shadow, moisturizer, nail polish, liquid soap, and hair spray. (L1903)

2023: 250,000 - <550,000 lb

The 1977 TSCA inventory listed 4 companies which manufactured dicyclohexyl phthalate, with a total production volume of 12.2 million pounds.

Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#5303]

1,2-Benzenedicarboxylic acid, dicyclohexyl ester is listed as a High Production Volume (HPV) chemical (65FR81686). Chemicals listed as HPV were produced in or imported into the U.S. in >1 million pounds in 1990 and/or 1994. The HPV list is based on the 1990 Inventory Update Rule. (IUR) (40 CFR part 710 subpart B; 51FR21438).

Production volume for non-confidential chemicals reported under the 2006 Inventory Update Rule. Chemical: 1,2-Benzenedicarboxylic acid, 1,2-dicyclohexyl ester. Aggregated National Production Volume: < 500,000 pounds.

Non-confidential 2012 Chemical Data Reporting (CDR) information on the production and use of chemicals manufactured or imported into the United States. Chemical: 1,2-Benzenedicarboxylic acid, 1,2-dicyclohexyl ester. National Production Volume: 500,000 - 1,000,000 lb/yr.

... Prepared from the reaction of phthalic anhydride with cyclohexanol in an inert solvent like toluene at about 130 °C.

Cyclohexanol + phthalic anhydride (esterification)

Other (requires additional information)

1,2-Benzenedicarboxylic acid, 1,2-dicyclohexyl ester: ACTIVE