3-ヒドロキシプロピオン酸

解説3-ヒドロキシプロピオン酸，ヒドロキシプロピオンサン，3-hydroxypropanoic acid．C3H6O3(90.08)．HOCH2CH2COOH．ヒドロアクリル酸ともいう．3-ヒドロキシプロピオニトリルの加水分解で得られる．粘ちゅうな液体．pKa1 4.49(30 ℃)．水，エタノールに可溶．蒸留または硫酸脱水によりアクリル酸になる．酸化により，シュウ酸と二酸化炭素を生成する．生体内では，プロピオニルCoAカルボキシラーゼの欠損時に，プロピオニルCoAから生成し，さらに酵素作用を受けて，アセチルCoAになる．

用途アクリル酸の合成

説明3-Hydroxypropionic acid (3-HP) is considered as a potential building block either for organic synthesis or high performance polymers.It is a 3-carbon carboxylic acid, structural isomer of lactic acid, which naturally exists in some thermophilic archaea and bacteria. This organic compound has been pointed out by the US Department of Energy as a promising biomass derivate, which could potentially be used for the production of high added-value chemicals like1,3-propanediol, acrylic acid, acrylamide, and bioplastics. Being 3-HP a commercially valuable, important platform chemical, researches have been conducted about its production on commercial scale, mainly from renewable sources. The biological production of 3-HP from glycerol and glucose, both based on microbial fermentation, are among the main routes studied. More specifically, research activities have been devoted to goals such as identifying novel biochemical pathways, metabolic engineering of microbial strains for the production of 3-HP, and improvements of cultivation techniques to increase 3-HP production titers. Despite intense research efforts, there are still important bottlenecks for cost efficient, large scale biological production of 3-Hydroxypropionic Acid.

使用A three carbon non-chiral compound, 3-Hydroxypropionic acid can be used as a building block for industrial chemicals.