4-Aminoquinoline (HCID 68476)

名称と識別子

優先名称: 4-Aminoquinoline
IUPAC: quinolin-4-amine
現地名: キノリン-4-アミン
英語名: 4-Aminoguinoline
分子式: C9H8N2
分子量: 144.17

名称と別名

4-Aminoquinoline578-68-74-QuinolinamineGTE5P5L97NDTXSID70206491RefChem:518302DTXCID70128982640-116-4quinolin-4-amine4-AminoguinolineQuinoline, 4-amino-MFCD00463448

名称をさらに表示

キノリン-4-アミン4-アミノキノリン4-キノリンアミン4(1H)-Quinolinimine4-Aminoquinoline 95+%4-Aminoquinoline ,98%4-Aminoquinoline, 97.5%

4-quinolylamine139266-00-5Quinolin-4-ylamineCCRIS 1679UNII-GTE5P5L97N4(1H)-Quinolinimine(9CI)4-quinolinylamine4-amino quinoline

データベース識別子

CAS: 578-68-7
PubChem CID: 68476
DTXSID: DTXSID70206491
ChEMBL: CHEMBL58146
UNII: GTE5P5L97N
EC Number: 640-116-4
Nikkaji: J1.803.795E、J79.669G

物性

構造計算による物性

XLogP: 1.6
極性表面積: 38.9 Å²
水素結合供与体数: 1
水素結合受容体数: 2
回転可能結合数: 0
重原子数: 11
形式電荷: 0
複雑度: 136

物理化学的性質

融点: 151 and · 151.0 and le 155.0 °C
沸点: 312.78 °C · 312.78°C (estimate)
比重(密度): 1.1148 · 1.1148 (estimate)
屈折率: 1.708 · 1.7080 (estimate)
貯蔵温度: Keep in dark place,Sealed in dry,Room Temperature
外見: powder to crystalline
酸解離定数(Pka): 9.17 · 9.17(at 20℃)
色: White to Yellow to Orange
InChI: InChI=1S/C9H8N2/c10-8-5-6-11-9-4-2-1-3-7(8)9/h1-6H,(H2,10,11)
InChIKey: FQYRLEXKXQRZDH-UHFFFAOYSA-N
SMILES: N1C2C(=CC=CC=2)C(N)=CC=1
CAS データベース: 578 · 578-68-7(CAS DataBase Reference)

化学的性質

化学的特性Light brown to grey solid

安全と法規制

GHS分類

GHS Classification · 5 件

Warning

H302 (93%): Harmful if swallowed [Warning Acute toxicity, oral]；H315 (11.6%): Causes skin irritation [Warning Skin corrosion/irritation]；H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

P264, P264+P265, P270, P280, P301+P317, P302+P352, P305+P351+P338, P321, P330, P332+P317, P337+P317, P362+P364, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 43 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

危険有害性情報

Hazard Classes and CategoriesAcute Tox. 4 (93%)；Skin Irrit. 2 (11.6%)；Eye Irrit. 2A (100%)

安全データ

wgk: WGK 3
ridadr: 2811
hs_code: 29334900
risk_code: 20/21/22-36/37/38-36-22-41
hazard_code: Xn
safety_code: 26-36/37/39-39
Hazard Classifications: Acute Tox. 4 OralEye Irrit. 2
ストレージクラス: 11 - Combustible Solids

化学と産業

薬理情報

MeSH Pharmacological ClassificationAgents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585)

応用分野

使用4-Quinolinamine and its derivatives are commonly used as anti-malarial drugs and also have potential therapeutic effects on patients afflicted with arthritis (and/or related diseases).

調製方法 · 1 件

純化方法It has been purified by zone refining and recrystallisation from *C6H6, EtOH or H2O. The hydrochloride has m 308o (from MeOH), and the picrate has m 277o (from EtOH). [Albert et al. J Chem Soc 2240 1948, Beilstein 22 III/IV 4611, 22/10 V 341.]

上流・下流製品情報

上流原料

キノリンエタノールアセトンオキシドール硫酸ナトリウムクロロホルムジエチルエーテル (無水)硝酸酢酸水酸化ナトリウム鉄粉硫酸水素

下流製品

キノリン-4-ボロン酸 4-アミノ-3-ブロモキノリン 4-ブロモキノリン

サプライヤー50 社

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

郑州阿尔法化工有限公司+86-18530059196 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

毕佳索（上海毕得医药科技股份有限公司）400-6005915 · [email protected]

上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]

キノリン-4-アミン

基本情報