CAS 22832-87-7 Miconazole Nitrate (HCID 68553)

概要

Miconazole is an antifungal prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of mucocutaneouscandidiasis, including:

名称と識別子

優先名称: Miconazole Nitrate
IUPAC: 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole;nitric acid
現地名: 硝酸ミコナゾール
英語名: Miconazole nitrate
分子式: C18H14Cl4N2O.HNO3
分子量: 479.14

名称と別名

Miconazole nitrate22832-87-7DermonistatMicatinMonistat-DermMiconazole 7Monistat 3Monistat 5Monistat 7M-zole 7 Dual PackPriconazoleM-zole 3 Combination Pack

名称をさらに表示

硝酸ミコナゾールミカチンMCZニトラート1-[2,4-ジクロロ-β-[(2,4-ジクロロベンジル)オキシ]フェネチル]-1H-イミダゾール·硝酸塩1-[2-(2,4-ジクロロフェニル)-2-[(2,4-ジクロロフェニル)メトキシ]エチル]-1H-イミダゾール·硝酸塩ミコナゾール硝酸塩硝酸ミコナゾ-ル1-[2-(2,4-ジクロロベンジルオキシ)-2-(2,4-ジクロロフェニル)エチル]-1H-イミダゾール硝酸塩硝酸ミコナゾール SALT, (+/-)-(±)-ミコナゾール硝酸塩ミコナゾール硝酸塩 (JP17)1-[2-(2,4-ジクロロフェニル)-2-[(2,4-ジクロロフェニル)メトキシ]エチル]-1H-イミダゾール・硝酸塩1-[2,4-ジクロロ-β-[(2,4-ジクロロベンジル)オキシ]フェネチル]-1H-イミダゾール・硝酸塩monistatTocris BioscienceIsoconazole IMpurity C Nitrate (Miconazole Nitrate)EcobiVodolDaktarFloridAflorixBrentanHi-Pick

Miconazole 1Miconazole 3Monistat Dual-pakMonistat 3 Combination PackMonistat 7 Combination PackMonistat-3 Combination PackBaza cream antifungalBaza cream

データベース識別子

CAS: 22832-87-7
PubChem CID: 68553
DTXSID: DTXSID50996767
ChEMBL: CHEMBL1559
UNII: VW4H1CYW1K
EC Number: 245-256-6、922-010-2

物性

構造計算による物性

極性表面積: 93.1 Å²
水素結合供与体数: 1
水素結合受容体数: 5
回転可能結合数: 6
重原子数: 29
形式電荷: 0
複雑度: 441

実験および物理化学的性質

Solubility26.3 [ug/mL] (The mean of the results at pH 7.4)

Human Drugs · 2 件

FDA approved drugs -> Active ingredient

Animal Drugs · 2 件

FDA approved animal drugs -> Active ingredient

Pharmaceuticals -> UK Veterinary Medicines Directorate List

Collision Cross Section189.4 Å² [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

物理化学的性質

融点: 170 · 170-185 C
比重(密度): 1.5 · 1.5000 (rough estimate)
屈折率: 1.62 · 1.6200 (estimate)
貯蔵温度: 2 · 2-8°C
溶解性: 50 mg/mL · ピリジン：可溶50mg/mL
外見: Solid
色: ホワイトからオフホワイト
水溶解度: 水にわずかに溶ける。プロピレングリコールまたはピリジンに可溶。
Merck: 14 · 14,6178
主な用途: 医薬品（低分子化合物）
化粧品成分の機能: 抗菌剤
InChI: InChI=1S/C18H14Cl4N2O.HNO3/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22;2-1(3)4/h1-8,11,18H,9-10H2;(H,2,3,4)
InChIKey: MCCACAIVAXEFAL-UHFFFAOYSA-N
SMILES: C(C1C=CC(=CC=1Cl)Cl)(OCC1C=CC(=CC=1Cl)Cl)CN1C=NC=C1.N(O)(=O)=O
CAS データベース: 22832 · 22832-87-7(CAS DataBase Reference)

化学的性質

化学的特性White Solid

安全と法規制

GHS分類

GHS Classification · 4 件

Warning

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

P261, P264, P264+P265, P270, P272, P273, P280, P301+P317, P302+P352, P305+P351+P338, P321, P330, P333+P317, P337+P317, P362+P364, P391, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 161 reports by companies from 14 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Regulatory Information · 2 件

REACH registered substance: Miconazole nitrate (EC: 245-256-6)

Miconazole nitrate: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - 1H-Imidazole, 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-, mononitrate: Environment tier I assessment

Hazard Classes and CategoriesAcute Tox. 4 (100%)

毒性情報

Exposure RoutesTopical

Toxicity Summary · 1 件

Miconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Miconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.

Signs and SymptomsIngestion of the amounts of the components contained in a tube of cream are unlikely to produce overdosage and toxic effects.

Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).

Toxicity DataLD50: 3800 mg/kg (Oral, Mouse) (A308) LD50: 3 gm/kg (Oral, Rat) (A308)

安全データ

wgk: 3
rtecs: NI4771000
ridadr: 3249
hs_code: 2933290000
risk_code: 22-43-40
hazard_code: Xn
safety_code: 36/37
hazard_class: 6.1(b)
packing_group: III
Hazard Classifications: Acute Tox. 4 OralSkin Sens. 1
ストレージクラス: 11 - Combustible Solids

化学と産業

薬理情報

FDA Pharmacological Classification · 6 件

2% MICONAZOLE NITRATE CREAM

Azoles [CS]; Azole Antifungal [EPC]

ANTI-FUNGAL MICONAZOLE ATHLETES FOOT SPRAY TALC FREE

Azole Antifungal [EPC]; Azoles [CS]

ANTI-FUNGAL POWDER MICONAZOLE NITRATE TALC FREE

Azoles [CS]; Azole Antifungal [EPC]

MeSH Pharmacological Classification · 4 件

Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.

Compounds that specifically inhibit STEROL 14-DEMETHYLASE. A variety of azole-derived ANTIFUNGAL AGENTS act through this mechanism.

Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 CYP2C9.

Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 CYP3A.

用途と製造

Uses · 1 件

For topical application in the treatment of tinea pedis (athlete’s foot), tinea cruris, and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum, in the treatment of cutaneous candidiasis (moniliasis), and in the treatment of tinea versicolor.

Household ProductsInformation on 1 consumer products that contain Miconazole Nitrate in the following categories is provided:

応用分野 · 5 件

用途薬理研究用

用途イミダゾール系抗菌剤です。広い抗菌スペクトルを示し、各種真菌に対して強い抗菌作用を示します。

説明Miconazole is a widely used antifungal imidazole that acts by inhibiting the 14α-demethylation of lanosterol, which consequently leads to the inhibition of ergosterol synthesis in fungal cell membranes. Additionally, miconazole has been shown to induce reactive oxygen species in fungal biofilms, demonstrating a MIC value of ≥256 μM against Candida spp.

使用Antifungal (topical).

一般的な説明Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Miconazole nitrate is an imidazole derivative and a broad spectrum antifungal drug used in the management of fungal outbreak in humans and veterinary animals.

上流・下流製品情報

上流原料

アセトンアルミニウムイソプロポキシドトルエンアセトフェノンアルミニウム亜硝酸ナトリウムイミダゾールイソプロピルアルコール 3-クロロアニリン 2,4-ジクロロベンジルクロリド 4-クロロフェナシルクロリド

サプライヤー100 社

国药集团化学试剂有限公司86-21-63210123 · [email protected]

北京华美互利生物化工010-56205725 · [email protected]

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

湖北威德利化学试剂有限公司181-6332-1995 18062128043 · [email protected]

化合物ノート

読み込み中…

硝酸ミコナゾール

基本情報

概要