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ペニシリンV

Penicillin V

HCID 6869
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基本情報概要名称と識別子物性安全と法規制化学と産業関連反応化合物ノート
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基本情報

CAS
87-08-1
標準SMILES
CC1(C)S[C@@H]2[C@H](NC(=O)COc3ccccc3)C(=O)N2[C@H]1C(=O)O
InChIKey
BPLBGHOLXOTWMN-MBNYWOFBSA-N
分子式
C16H18N2O5S
平均分子量
350.4 g/mol
単同位体質量
350.09364268

概要

Penicillin v is a white crystalline powder. (NTP, 1992)

名称と識別子

優先名称
Penicillin V
IUPAC
(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenoxyacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
現地名
ペニシリンV
英語名
PENICILLIN V
分子式
C16H18N2O5S
分子量
350.39

名称と別名

penicillin vPhenoxymethylpenicillin87-08-1OracillinVebecillinPenicillin phenoxymethylPhenopenicillinDistaquaine VMeropeninPhenomycillineV-CillinFenospen
名称をさらに表示
(2S,5R)-3,3-ジメチル-7-オキソ-6α-(フェノキシアセチルアミノ)-4-チア-1-アザビシクロ[3.2.0]ヘプタン-2β-カルボン酸(2S,5β)-3,3-ジメチル-7-オキソ-6α-[(フェノキシアセチル)アミノ]-4-チア-1-アザビシクロ[3.2.0]ヘプタン-2β-カルボン酸ペン-オラールベベシリンフェノスペン6α-(2-フェノキシアセチルアミノ)ペニシラン酸ペニシリンVフェナシリンジスタクアインVオスペンアシペン-Vオラシリンスタビシリン6α-[(フェノキシアセチル)アミノ]ペニシラン酸アポペンフェノペニシリンペン-ビー6α-[(2-フェノキシアセチル)アミノ]ペニシラン酸(6R)-6α-(フェノキシアセチルアミノ)ペニシラン酸V-シリン(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(2-phenoxyacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acidpen-vv-cilacipenvpen-vee
BeromycinFenacilinStabicillinApopenOratrenOspenEskacillin VPhenoxymethyl penicillin

データベース識別子

CAS
87-08-1
PubChem CID
6869
DTXSID
DTXSID3023429
ChEMBL
CHEMBL615
ChEBI
CHEBI:27446
UNII
Z61I075U2W
EC Number
201-722-0
Nikkaji
J9.743H

物性

構造計算による物性補完中

XLogP
2.1
極性表面積
121 Ų
水素結合供与体数
2
水素結合受容体数
6
回転可能結合数
5
重原子数
24
形式電荷
0
複雑度
547

実験および物理化学的性質

Drugs · 3 件

Pharmaceuticals -> Antibiotics

Pharmaceuticals -> Listed in ZINC15

Pharmaceuticals -> Used in Switzerland

pH2.5-4.0 (saturated solution)
SpringerMaterials PropertiesCrystal structure
LogP · 2 件

1.4

1.95

OdorOdorless
Color/Formwhite, crystalline powder
Solubility · 5 件

less than 1 mg/mL at 55 °F (NTP, 1992)

<0.1 g/100mL

In water at pH 1.8 (acidified with hydrochloric acid)= 24 mg/100 ml; soluble in polar organic solvents; practically insol in vegetable oils and in liquid petrolatum.

Sol in alcohol and acetone; insoluble in fixed oils

4.54e-01 g/L

Human Drugs · 4 件

Breast Feeding; Lactation; Anti-Infective Agents; Antibacterial Agents; Penicillins

FDA approved drugs -> Active ingredient

FDA approved drugs -> Active ingredient

Access group antibiotics

Melting Point · 2 件

安全と法規制

安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。

GHS分類

GHS Classification · 4 件

Danger

H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]

P233, P260, P261, P271, P272, P280, P284, P302+P352, P304+P340, P321, P333+P317, P342+P316, P362+P364, P403, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 3 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Other Safety InformationIMAP assessments - 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenoxyacetyl)amino]-, [2S-(2.alpha.,5.alpha.,6.beta.)]-: Human health tier I assessment
Fire HazardsFlash point data for this chemical are not available; however it is probably combustible. (NTP, 1992)
Health Hazards · 1 件

SYMPTOMS: Symptoms of exposure to this compound include hypersensitization, skin rashes, contact dermatitis, oral lesions, fever, eosinophilia, interstitial nephritis, angioedema, serum sickness, anaphylaxis, "Arthus" phenomenon; irritation of the Gastrointestinal tract; phlebitis; bronchoconstriction with severe asthma, or abdominal pain, nausea, vomiting, extreme weakness and fall in blood pressure, diarrhea, and purpuric skin eruptions. (NTP, 1992)

FDA Requirements · 3 件

Oral Dosage Form New Animal Drugs. Specifications and conditions of use provided for dogs and cats. /Penicillin V potassium for oral solution/

Oral Dosage Form New Animal Drugs. Specifications and conditions of use provided for dogs and cats. /Penicillin V potassium tablets/

Manufacturers, packers, and distributors of drug and drug products for human use are responsible for complying with the labeling, certification, and usage requirements as prescribed by the Federal Food, Drug, and Cosmetic Act, as amended (secs 201-902, 52 Stat. 1040 et seq., as amended; 21 U.S.C. 321-392).

化学と産業

薬理情報

ATC Code · 4 件

J01CE02

J - Antiinfectives for systemic use

QJ - Antiinfectives for systemic use

J01CE02

Protein BindingUpon oral administration, about 50-80% of the drug is bound to plasma proteins.
Pharmacodynamics · 1 件

Phenoxymethylpenicillin works against penicillin-sensitive microorganisms with bactericidal effects. It targets the bacteria during its active multiplication stage by interfering with bacterial cell wall peptidoglycan synthesis. _In vitro_, phenoxymethylpenicillin was shown to be active against staphylococci (except penicillinase-producing strains), streptococci (groups A, C, G, H, L and M), and pneumococci, as well as _Corynebacterium diphtheriae_, _Bacillus anthracis_, Clostridia, _Actinomyces bovis_, _Streptobacillus moniliformis_, _Listeria monocytogenes_, _Leptospira_, _Neisseria gonorrhoeae_, and _Treponema pallidum_.

Mechanism of Action · 5 件

Phenoxymethylpenicillin inhibits the biosynthesis of cell wall mucopeptide by binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which are critical in the cell wall synthesis and maintenance, as well as cell division. This disrupts the third and last stage of bacterial cell wall synthesis. This subsequently leads to cell lysis.

Penicillins and breakdown products of penicillins act as haptens after their covalent reaction with proteins. The most important antigenic intermediate of penicillin appears to be the penicilloyl moiety, which is formed when the beta-lactam ring is opened. This is considered to be the major (predominant) determinant of penicillin allergy. /Penicillins/

Penicillin is known to interfere with synthesis of N-acetylmuramic acid mucopeptides and teichoic acids which are part of cell-wall material. ... Under favorable conditions penicillin exerts direct bactericidal action, & successful penicillin therapy may be relatively independent of immunity mechanisms of the host. /Penicillins/

The penicillins and their metabolites are potent immunogens because of their ability to combine with proteins and act as haptens for acute antibody-mediated reactions. The most frequent (about 95 percent) or "major" determinant of penicillin allergy is the penicilloyl determinant produced by opening the beta-lactam ring of the penicillin. This allows linkage of the penicillin to protein at the amide group. "Minor" determinants (less frequent) are the other metabolites formed, including native penicillin and penicilloic acids. /Penicillins/

関連反応

12 件
反応記録を作成
HRID 28302 の反応式
HRID 28302反応物としてuspto-grants-2008_09
HRID 376567 の反応式
HRID 376567反応物としてuspto-grants-2000_02
HRID 612283 の反応式
HRID 612283反応物としてuspto-grants-1999_12
HRID 638677 の反応式
HRID 638677反応物としてuspto-grants-1985_12
HRID 1268423 の反応式
HRID 1268423反応物としてuspto-grants-2003_04
HRID 1421792 の反応式
HRID 1421792反応物としてuspto-grants-2000_06
HRID 1587641 の反応式
HRID 1587641反応物としてuspto-grants-1993_06
HRID 1657391 の反応式
HRID 1657391反応物としてuspto-grants-1976_06
1 / 2 ページ

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248 to 262 °F (Decomposes) (NTP, 1992)

120 - 128 °C

Optical RotationThe biologically active form is the dextrorotatory D-form; the DL-form is half as active. L-Penicillin V has little, if any, antibiotic activity. Maximum absorption: 268, 274 nm (E= 1330, 1100).
Physical Description · 2 件

Penicillin v is a white crystalline powder. (NTP, 1992)

Solid

Stability/Shelf Life · 5 件

Stable in air up to 37 °C; relatively stable to acid.

Following reconstitution, penicillin V potassium oral soln should be refrigerated @ 2-8 °C, and any unused soln should be discarded after 14 days. /Penicillin V potassium/

Penicillins are generally inactivated in the presence of heat, alkaline or acid pH, oxidizing agents, alcohols, glycols, and metal ions such as copper, mercury, or zinc. In currently available penicillins, cleavage at any point in the penicillin nucleus, including the beta-lactam ring, results in complete loss of antibacterial activity. The major cause of inactivation of penicillins is hydrolysis of the beta-lactam ring. The course of hydrolysis and nature of the degradation products can vary and are generally influenced by pH. /Penicillins/

In the dry state, natural penicillins and their salts are generally stable for several yr @ room temp; however, the drugs deteriorate more rapidly @ higher temp. /Natural penicillins/

Solutions of penicillin begin to deteriorate upon standing a few days, even in the cold. /Penicillin V potassium/

物理化学的性質

融点
120 · 120-1280C (dec)
沸点
681.4 · 681.4±55.0 °C(Predicted)
比重(密度)
1.3121 · 1.3121 (rough estimate)
屈折率
1.651 · 1.6510 (estimate)
貯蔵温度
20 °C · −20°C
溶解性
水に非常に溶けにくく、エタノールに溶けます (96%)。
酸解離定数(Pka)
2.44 · 2.44±0.50(Predicted)
外見
固体
安定性
安定。可燃性。強力な酸化剤とは相容れない。
EPAの化学物質情報
Penicillin V (87-08-1)

化学的性質

化学的特性Crystalline Solid

Reactive GroupAcids, Carboxylic
Reactivity Profile · 1 件

Stable in air up to 37%; relatively stable to acid. This compound is incompatible with acids, oxidizing agents (especially in the presence of trace metals), heavy metal ions such as copper, lead, zinc and mercury; glycerol, sympathomimetic amines, thiomersal, wood alcohols, cetostearyl alcohol, hard paraffins, macrogols, cocoa butter and many ionic an nonionic surface-active agents. It is also incompatible with alkalis, compounds leached from vulcanized rubber, hydrochlorides of tetracyclines and organic peroxides. Other incompatibilities include reducing agents, alcohols, other hydroxy compounds, self-emulsifying stearyl alcohol, emulsifying wax, lanolin, crude cholinesterated bases, glycol, sugars, amines, aminacrine hydrochloride, ephedrine, procaine, rubber tubing, thiamine hydrochloride, zinc oxide, oxidized cellulose, iodine, iodides, thiols, chlorocresol and resorcinol. It may also be incompatible with naphthalene oils and vitamin B. (NTP, 1992)

Air and Water ReactionsInsoluble in water.
Hazard Classes and CategoriesSkin Sens. 1 (100%)

安全と保護具

Fire FightingFires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
First Aid · 1 件

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Storage ConditionsCommercially available penicillin V ... tablets and powders for oral suspension or solution should be stored in tight containers at 15-30 °C.
Nonfire Spill Response · 1 件

SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. You should then dampen the solid spill material with ethanol, and transfer the dampened material to a suitable container. Use absorbent paper dampened with ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Disposal Methods · 1 件

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Personal Protective Equipment (PPE) · 1 件

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

毒性情報

Interactions · 5 件

Oral neomycin has been shown to decrease the absorption of penicillin V ... .

Since penicillin acts by inhibiting cell wall synthesis, agents which inhibit protein synthesis (eg, chloramphenicol) could ... mask the bactericidal effect of penicillin. /Penicillin/

Since penicillin acts by inhibiting cell wall synthesis, agents which inhibit protein synthesis (eg, erythromycin) could ... mask the bactericidal effect of penicillin. ... Clinical evidence exists for erythromycin-penicillin antagonism in patients with group A hemolytic streptococcal pharyngitis. ... The possibility of antagonism exists, but it has not been sufficiently documented in clinical studies. /Penicillin/

Tetracyclines ... may interfere with a bactericidal agent such as penicillin. /Penicillin/

For more Interactions (Complete) data for PENICILLIN V (16 total), please visit the HSDB record page.

Human Toxicity Excerpts · 5 件

Hypersensitivity reactions are one of the most frequent adverse reactions to penicillin G & penicillin V. In addition ... oral admin ... is frequently associated with adverse GI effects.

In addition to eosinophilia & hemolytic anemia ... other adverse hematologic effects including transient neutropenia, leukopenia, thrombocytopenia, & thrombocytopenic purpura have occurred rarely in patients receiving penicillin G or penicillin V. These hematologic reactions occur most frequently when high doses of penicillin G are admin IV & are generally reversible following discontinuance of the drugs. ... Some or the most frequent adverse reactions to orally admin penicillin ... V are GI effects including nausea, vomiting, epigastric distress & diarrhea.

Skin rashes of all types may be caused by allergy to penicillin. Scarlatiniform, morbilliform, urticarial, vesicular, and bullous eruptions may develop. Purpuric lesions are uncommon & are usually the result of a vasculitis ... Henoch-Schoenlein purpura with renal involvement has been a rare complication. ... The most serious hypersensitivity reactions produced by the penicillins are angioedema and anaphylaxis. Angioedema with marked swelling of the lips, tongue, face, & periorbital tissues, frequently accompanied by asthmatic breathing & "giant hives" ... observed after topical, oral or systemic admin of penicillins of various types. ... Anaphylactoid reactions may occur at any age. ... About 0.002% of patients treated with these agents die from anaphylaxis. It has been estimated that there are at least 300 deaths per yr due to this complication of therapy. /Penicillins/

Anaphylaxis has most often followed the injection of penicillin, although it has also been observed after oral ingestion of the drug, & has even resulted from the intradermal instillation of a very small quantity for the purpose of testing for the presence of hypersensitivity. ... The most dramatic /clinical picture/ is sudden, severe hypotension & rapid death. ... Bronchoconstriction with severe asthma, or abdominal pain, nausea, and vomiting, or extreme weakness & fall in blood pressure, or diarrhea & purpuric skin eruptions have characterized the anaphylactic episodes. Serum sickness varies from mild fever, rash, and leukopenia to severe arthralgia or arthritis, purpura, lymphadenopathy, splenomegaly, mental changes, ECG abnormalities suggestive of myocarditis, generalized edema, albuminuria, and hematuria. It is mediated by IgG antibodies. /Penicillins/

For more Human Toxicity Excerpts (Complete) data for PENICILLIN V (45 total), please visit the HSDB record page.

Drug Induced Liver Injury · 5 件

Drug-Induced Liver Injury Severity and Toxicity (DILIst)

penicillin v

DILI Negative

Oral

DOI:10.1016/j.drudis.2019.09.022

Probable Routes of Human ExposureVeterinarians, physicians, nurses, and pharmacists have occasionally experienced contact dermatitis after handling penicillin preparations.
Effects During Pregnancy and Lactation◉ Summary of Use during Lactation

法規制情報

FDA Requirements · 3 件

Oral Dosage Form New Animal Drugs. Specifications and conditions of use provided for dogs and cats. /Penicillin V potassium for oral solution/

Oral Dosage Form New Animal Drugs. Specifications and conditions of use provided for dogs and cats. /Penicillin V potassium tablets/

Manufacturers, packers, and distributors of drug and drug products for human use are responsible for complying with the labeling, certification, and usage requirements as prescribed by the Federal Food, Drug, and Cosmetic Act, as amended (secs 201-902, 52 Stat. 1040 et seq., as amended; 21 U.S.C. 321-392).

安全データ

rtecs
RY4025000
毒性
LD50 oral in rat: > 2220mg/kg
hs_code
29411094
risk_code
42/43
hazard_code
Xn
safety_code
22-36
有毒物質データの
87-08-1(Hazardous Substances Data)

Bactericidal; inhibit bacterial cell wall synthesis. Action is dependent on the ability of penicillins to reach and bind penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Penicillin-binding proteins (which include transpeptidases, carboxypeptidases, and endopeptidases) are enzymes that are involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Penicillins bind to, and inactivate, penicillin-binding proteins, resulting in the weakening of the bacterial cell wall and lysis. /Penicillins/

Biological Half-Life · 2 件

Upon oral administration, the half-life is about 30 minutes. It can last up to 4 hours in patients with renal impairment.

The serum half-life of penicillin V in adults with normal renal function is reportedly 0.5 hr.

Metabolism/Metabolites · 2 件

About 35-70% of an oral dose is metabolized to penicilloic acid, an inactive metabolite. Small amounts of 6-aminopenicillanic acid have been recovered in the urine of patients on penicillin G. A small percentage of the drug appears to be hydroxylated into one or more active metabolites, which are also excreted via urine.

Approximately 35-70% of an oral dose of penicillin V or penicillin V potassium is metabolized to penicilloic acid which is microbiologically inactive. Small amt of 6-aminopenicillanic acid (6-APA) have also been found in urine of patients receiving penicillin V. In addition, the drug appears to be hydroxylated to a small extent to one or more microbiologically active metabolites which are also excreted in urine.

FDA Pharmacological Classification · 5 件

Z61I075U2W

PENICILLIN V

Established Pharmacologic Class [EPC] - Penicillin-class Antibacterial

Chemical Structure [CS] - Penicillins

Penicillin v is a Penicillin-class Antibacterial.

MeSH Pharmacological ClassificationSubstances that inhibit the growth or reproduction of BACTERIA.
Absorption, Distribution and Excretion · 6 件

Upon oral administration, phenoxymethylpenicillin is rapidly but incompletely absorbed. The bioavailability of phenoxymethylpenicillin ranges from 25 to 60%. Compared to the free acid form of the drug, the calcium or potassium salts of phenoxymethylpenicillin displays better absorption profiles. It is reported that fasting state enhances the drug absorption. The peak plasma concentrations of 200 to 700 ng/mL are achieved in 2 hours following an oral dose of 125 mg. Following an oral dose of 500 mg, the peak plasma concentrations of 3 to 5 μg/mL are reached in 30 to 60 minutes post-dose.

While the drug is rapidly excreted, only 25% of the total dose is detected in the urine. Renal excretion may be delayed in neonates, young infants, and patients with renal impairment.

Following intravenous administration, the volume of distribution at steady state was 35.4 L. Small amounts of the drug can be found in various tissues, with the highest amount found in the kidneys, with lesser amounts in the liver, skin, and intes­ tines. Phenoxymethylpenicillin was found in the cerebrospinal fluid. Phenoxymethylpenicillin was detectable in the placenta and human breast milk.

A dose of 1,000,000 units of the acid gives peak plasma levels of about 2 to 3 ug/ml ...

Approx 60-73% of an oral dose of penicillin V or penicillin V potassium is absorbed from the GI tract in healthy, fasting adults. Following oral administration of a single dose of penicillin V or penicillin V potassium in fasting children or adults, peak serum concn of penicillin V are generally attained within 30-60 min. Peak serum penicillin V concn are attained sooner and are slightly higher following administration of the potassium salt than the free acid.

Following oral administration of a single 125-mg tablet of penicillin V potassium in healthy, fasting adults in one study, serum penicillin V concn averaged 1.2, 1.2, 0.5, and 0.1 ug/ml @ 30 min, 1 hr, 2 hr, and 4 hr, respectively, after the dose. Oral administration of a single 250-mg tablet of the drug in healthy, fasting adults results in serum penicillin V concn averaging 2.1-2.8, 2.3-2.7, 0.8-0.9, and 0.1-0.2 ug/ml @ 30 min, 1 hr, 2 hr, and 4 hr, respectively, after the dose. Following oral administration of a single 500-mg tablet of penicillin V potassium in healthy, fasting adults, serum penicillin V concn average 4.7-5, 4.9-6.3, 2.3-3, and 0.04-0.1 ug/ml @ 30 min, 1 hr, 2 hr, and 6 hr, respectively, after the dose.

Cellular LocationsCytoplasm

用途と製造

Uses · 4 件

Used to prepare 6-APA on a large scale by selective enzymatic hydrolysis

MEDICATION

MEDICATION (VET)

Use (kg; approx.) in Germany (2009): >25000

ImpuritiesCommercially available penicillin ... V preparations may contain small amounts of high molecular weight protein impurities that originate from the fermentation process used to produce the drugs.
U.S. Exports(1985) 1.28X10+9 g /Penicillins, NSPF/
U.S. Imports(1985) 3.44X10+7 g /Penicillins, NSPF/
U.S. Production(1985) /Data not reported/
Methods of Manufacturing · 2 件

Natural penicillins are produced by fermentation of mutant strains of Penicillium chrysogenum. ... Penicillin ... V /is/ produced by adding ... phenoxyacetic acid ... to the culture media.

Obtained by adding 2-phenoxyethanol to the Penicillium culture using yeast autolyzate as source of nitrogen.

Formulations/Preparations · 2 件

... Penicillin V is commercially available as the acid and its potassium salt.

Generic: Powder for oral solution (plain, buffered) and oral suspension 125 and 250 mg/5 ml; tablets 250 and 500 mg.

General Manufacturing Information · 3 件

Grade: NF

Although potency of penicillin V ... is generally expressed in terms of the weight of penicillin V, potency of the drugs may be expressed in terms of USP penicillin V units. For labeling purposes, each mg of penicillin V contained in penicillin V ... prepn is considered equivalent to 1695 penicillin V units.

The problem of antibiotic contamination of milk requires that the dairy operator, veterinarian, and milk processor be aware of the sensitizing ability of penicillin and the importance of adherence to drug withdrawal times. /Penicillins/

応用分野 · 2 件

使用Phenoxymethylpenicillin or penicillin V is acid-resistant and used instead of penicillin G for oral use. It is active with respect to Gram-positive (staphylococcus, streptococcus, pneumococcus), and Gram-negative (meningococcus, gonococcus) cocci, spirochaeta, clostridia, and corynebacteria. Phenoxymethylpenicillin is used for bronchitis, pneumonia, angina, scarlet fever, gonorrhea, syphilis, purulent skin and soft-tissue wounds, and other infectious diseases. Synonyms of this drug are bermycin, isocillin, cristapen, fenospen, uticillin, and others.

一般的な説明White crystalline powder.

上流・下流製品情報

下流製品

アモキシシリン6α-(フェノキシアセチルアミノ)ペニシラン酸ナトリウム