ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
化工社オープンプロジェクト:[email protected]AIアクセス:llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.7.8
  1. ホーム
  2. /化合物

トリメチルアルサン

Trimethylarsine

HCID 68978
ノート反応
基本情報概要名称と識別子物性安全と法規制化学と産業関連反応化合物ノート
部分構造検索類似構造を探す

基本情報

CAS
593-88-4
標準SMILES
C[As](C)C
InChIKey
HTDIUWINAKAPER-UHFFFAOYSA-N
分子式
C3H9As
平均分子量
120.03 g/mol
単同位体質量
119.99202

概要

Trimethylarsine is an arsine that is arsane in which each of the hydrogens is substituted by a methyl group. It derives from a hydride of an arsane.

名称と識別子

優先名称
Trimethylarsine
IUPAC
trimethylarsane
現地名
トリメチルアルサン
英語名
TRIMETHYLARSINE
分子式
C3H9As
分子量
120.03

名称と別名

Trimethylarsinetrimethylarsane593-88-4TrimethylarsenicArsine, trimethyl-AsMe3(CH3)3AsMQ83UQ8A1QDTXSID4073203trimethylarsane;trimethylarsenicCHEBI:27130RefChem:191775
名称をさらに表示
トリメチルひ素トリメチルアルサントリメチルアルシントリメチル砒素トリメチルアルシン, elec. gr. (99.995%-As) PURATREMトリメチルアルシン, 99%trimethyl-arsinarsine,trimethyl-Trimethylarsine,99%TrimethylarsineelecgrcolorlessliqTRIMETHYLARSINE 99.999% METAL PURITYTrimethylarsine,elec.gr.(99.995%-As)PURATREM
DTXCID1042603209-815-8C3H9AsMFCD00014838Trimethylarsine, elec. gr.4-04-00-03665 (Beilstein Handbook Reference)EINECS 209-815-8UNII-MQ83UQ8A1Q

データベース識別子

CAS
593-88-4
PubChem CID
68978
DTXSID
DTXSID4073203
ChEBI
CHEBI:27130
UNII

物性

構造計算による物性

極性表面積
0 Ų
水素結合供与体数
0
水素結合受容体数
0
回転可能結合数
0
重原子数
4
形式電荷
0
複雑度
8

実験および物理化学的性質

Chemical ClassesMetals -> Arsenic Compounds, Organic
Physical DescriptionColorless liquid; [Sigma-Aldrich MSDS]

物理化学的性質

融点
-87 · -87,3°C
沸点
51 °C · 51°C
比重(密度)
1 · 1,124 g/cm3
闪点
-25 °C · -25°C
貯蔵温度
Refrigerator, under inert atmosphere
溶解性
ベンゼン
外見
液体
色
無色
比重
1.124 · 1.124
安定性
揮発性
EPAの化学物質情報
Arsine, trimethyl- (593-88-4)

安全と法規制

安全情報は参考情報です。供給元の安全データシート(SDS)、適用法令、専門家による評価に代わるものではありません。

GHS分類

GHS Classification · 4 件

Danger

H225 (41.5%): Highly Flammable liquid and vapor [Danger Flammable liquids]

P210, P223, P231+P232, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P273, P280, P301+P316, P302+P335+P334, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P316, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P391, P402+P404, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 94 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Regulatory Information · 2 件

PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.

Restricted substance: Trimethylarsine

Hazards SummaryCauses somnolence, tremor, and ataxia in inhalation lethal-concentration studies of mice; [RTECS] May cause irritation; [Sigma-Aldrich MSDS] See Triphenylarsine, Diethylarsine, and tert-Butylarsine.
Hazard Classes and CategoriesFlam. Liq. 2 (41.5%)

安全と保護具

Minimum Risk LevelAcute Oral: 0.005 mg/kg/day (L134) Chronic Oral: 0.0003 mg/kg/day (L134) Chronic Inhalation: 0.01 mg/m3 (L134)
Permissible Exposure Limit (PEL)0.5 [mg/m3], as As

毒性情報

Treatment · 1 件

化学と産業

薬理情報

Metabolism/Metabolites · 1 件

Arsenic is absorbed mainly by inhalation or ingestion, as to a lesser extent, dermal exposure. It is then distributed throughout the body, where it is reduced into arsenite if necessary, then methylated into monomethylarsenic (MMA) and dimethylarsenic acid (DMA) by arsenite methyltransferase. Arsenic and its metabolites are primarily excreted in the urine. Arsenic is known to induce the metal-binding protein metallothionein, which decreases the toxic effects of arsenic and other metals by binding them and making them biologically inactive, as well as acting as an antioxidant. (L20)

用途と製造

UsesTrimethylarsine is used in the microelectronics industry, the production of other organoarsenic compounds, and as a ligand in coordination chemistry. (L388)
General Manufacturing InformationArsine, trimethyl-: ACTIVE

応用分野

使用Trimethylarsine is an environmental pollutant found in lake sediment. Trimethylarsine is toxic to mammalian cells.

サプライヤー9 社

上海源象化学有限公司17312431727 · [email protected]
Aladdin Scientific[email protected]
上海迈瑞尔生化科技有限公司4006356688 18621169109 · [email protected]
上海阿拉丁生化科技股份有限公司6206333 13167063860 · [email protected]
陕西缔都医药化工有限公司029-029-81120477 17792793610 · [email protected]

関連反応

0 件
反応記録を作成

現在のフィルター条件では反応記録がありません。

化合物ノート

読み込み中…

このページの内容基本情報概要名称と識別子物性安全と法規制化学と産業関連反応化合物ノート
MQ83UQ8A1Q
EC Number
209-815-8
Nikkaji
J459F

Arsenic poisoning can be treated by chelation therapy, using chelating agents such as dimercaprol, EDTA or DMSA. Charcoal tablets may also be used for less severe cases. In addition, maintaining a diet high in sulfur helps eliminate arsenic from the body. (L20)

Health EffectsArsenic poisoning can lead to death from multi-system organ failure, probably from necrotic cell death, not apoptosis. Arsenic is also a known carcinogen, esepcially in skin, liver, bladder and lung cancers. (T1, L20)
Exposure RoutesOral (L2) ; inhalation (L2); dermal (L2)
Toxicity Summary · 1 件

Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. Arsenic's carginogenicity is influenced by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. The binding of other arsenic protein targets may also cause altered DNA repair enzyme activity, altered DNA methylation patterns and cell proliferation. (T1, A17)

Signs and SymptomsExposure to lower levels of arsenic can cause nausea and vomiting, decreased production of red and white blood cells, abnormal heart rhythm, damage to blood vessels, and a sensation of burn (T1).
Carcinogen Classification3, not classifiable as to its carcinogenicity to humans. (L135)
Toxicity Data · 2 件

LC50 (mouse) = 20,500 ppm/4hr

LD50: 7870 mg/kg (Oral, Rouse) LC50: 20 500 ppm over 4 hours (Inhalation, Mouse) (L934)

安全データ

tsca
TSCA listed
rtecs
CH8800000
ridadr
1992
risk_code
11-23/25-50/53-14/15
hazard_code
T,N,F
safety_code
3/7-9-23-45-61-60-28-20/21
hazard_class
4.2
packing_group
I
上海源叶生物科技有限公司18916372613 · [email protected]
北京百灵威科技有限公司18210857532 18210857532 · [email protected]
DAYANG CHEM (HANGZHOU) CO.,LTD+86-88938639 +86-17705817739 · [email protected]
陕西缔都医药化工有限公司+86-29-87569266 +86-17392581500 · [email protected]

補足説明

定義ChEBI: An arsine that is arsane in which each of the hydrogens is substituted by a methyl group.