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化工社化工社 化学情報印刷レポート · 研究参考用
HCID 6917作成日：2026年10月27日

ポリビニルポリピロリドン

ポリビニルポリピロリドン · ポリビニルピロリドン, 架橋結合 · クロスポビドン (JP17) · クロスポビドン · PVPP · POLYVINYLPOLYPYRROLIDONE · PLASDONE · Polyplasdone

https://huagongshe.com/ja/chemical/6917

ポリビニルポリピロリドン の分子構造式

識別子と物理属性

CAS No.25249-54-1
分子式C6H9NO
平均分子量111.14 g/mol
単同位体質量111.06841391 g/mol
SMILESC=CN1CCCC1=O
InChIKeyWHNWPMSKXPGLAX-UHFFFAOYSA-N
PubChem CID6917
ChEMBLCHEMBL1878943
ChEBICHEBI:82551
EC No.201-800-4
DTXSIDDTXSID2021440
現地名ポリビニルポリピロリドン

化学・物理的性質

XLogP0.4
極性表面積20.3
水素結合供与体数0
水素結合受容体数1
回転可能結合数1
重原子数8
形式電荷0
複雑度120
医薬品Pharmaceuticals
PolymersPlastics & Rubber -> Other Monomers
化粧品Emulsion stabilizingAntistaticBindingFilm formingHair fixing
SpringerMaterials PropertiesChemical shift
LogP（分配係数）log Kow = 0.370.4
食品添加物PROCESSING AID, SURFACE-FINISHING AGENT -> FDA Substance added to food
密度1.04 @ 24 °C/4 °CRelative density (water = 1): 1.041..041.04 @25 °C
Viscosity2.07 cps @ 25 °C2.07 cP at 25 °C
Color/FormClear to light straw colored liquid
溶解度Soluble in water and many organic solventsIn water, 5.2X10+4 mg/L @ 25 °C /Estimated/Solubility in water: very good水、酸、アルカリに不溶。
引火点95 °C100.5 °C (213 °F) open cup95 °C closed cup93 °C199.4 °F
沸点96 °C @ 14 mm Hg193 °C @ 400 mm Hgat 1.3kPa: 90-93 °C194 °F
融点~165 °C (dec.)(lit.)
外観・状態粉
色ホワイトからオフホワイト
InChIInChI=1S/C6H9NO/c1-2-7-5-3-4-6(7)8/h2H,1,3-5H2
InChIKeyWHNWPMSKXPGLAX-UHFFFAOYSA-N
SMILESN1(C=C)CCCC1=O
CAS データベース25249-54-1

化学的特性

white to off-white micro-crystalline powder

安全性と法規制

GHS 分類DangerH302: Harmful if swallowed [Warning Acute toxicity, oral]P203, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P354+P338, P317, P318, P319, P321, P330, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)This chemical does not meet GHS hazard criteria for 0.1% (1 of 963) of reports.H302 (97.2%): Harmful if swallowed [Warning Acute toxicity, oral]
規制情報Chemical: Poly[1-(2-oxo-1-pyrrolidinyl)-1,2-ethanediyl]Chemical: 2-Pyrrolidinone, 1-ethenyl-2-Pyrrolidinone, 1-ethenyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 2-Pyrrolidinone, 1-ethenyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 26-04-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/15035Polyvinylpyrrolidone: Does not have an individual approval but may be used under an appropriate group standardVinylpyrrolidone: Does not have an individual approval but may be used under an appropriate group standard
その他の安全情報PEC / SN / Other assessments - N-vinyl-2-pyrrolidone (NVP): Health and EnvironmentIMAP assessments - Poly[1-(2-oxo-1-pyrrolidinyl)-1,2-ethanediyl]: Human health tier I assessment
火災危険Combustible.
有害性の概要No health effects found in a study of 94 production workersAnimal studies show evidence of liver damage in acute and chronic studies[ACGIH] An eye and respiratory tract irritantMay cause liver injury[ICSC] See N-Methyl-2-pyrrolidone.
EC 分類Symbol: XnR: 20/21/22-37-40-41-48/20S: 26-36/37/39Note: D
Special ReportsEuropean Union/European Chemicals BureauRisk Assessment Report: 1-Vinyl-2-pyrrolidone (88-12-0) V39 (2003).NICNASPriority existing chemical assessment report on N-vinyl-2-pyrrolidone (NVP) 11: 134 (2000)

用途

解説

略称PVDF．表されるフッ化ビニリデンの重合体．ポリビニルポリピロリドン, 高温高圧下で，過酸化物を触媒として得られる．融点170 ℃，熱分解温度300 ℃ 以上のため加熱溶融による射出，押出，圧縮の各種成形法が適用できる．結晶性の熱可塑性樹脂で，機械的性質，熱安定性，耐候性，耐放射線性および低温特性にすぐれている．化学機器関係のバルブ，ポンプ部品，タンクやパイプのライニング，軸受，耐熱電線被覆，ソケット，コネクターに用いられる．また，エレクトレットおよび圧電体としてコンデンサーマイクロホン，そのほか音響製品などに使用されている．[CAS 25249-54-1]森北出版「化学辞典（第2版）

使用

PVP (polyvinylpyrrolidone) is a chemical ingredient that, depending on the formulatory requirement, can act as a binder, viscosity controller, emulsion stabilizer, or film former. Its benefits include water and wear resistance, pigment dispersion, a non-greasy feel, and improved stick integrity. PVP is commonly found in waterproof sunscreens, mascaras, and lipsticks in order to improve their wear.

Chemical DangersThe substance may polymerize in the presence of air due to warming, under the influence of light and acids. Decomposes on burning. This produces toxic and corrosive gases of nitrogen oxides.
Hazard Classes and CategoriesAcute Tox. 4 (97.2%)Carcinogenicity - category 2Acute toxicity (Oral) - Category 4Carc. 2
Explosive Limits and PotentialExplosion limits in air: 1.4-10.0 Vol. %Explosive limits , vol% in air: 1.4-10
Hazardous Reactivities and IncompatibilitiesHeat develops during polymerization when mixed with acids.Can react vigorously with oxidizing materials...
消火Use water spray, powder, foam, carbon dioxide.
応急処置措置Fresh air, rest. Refer for medical attention.Remove contaminated clothes. Rinse and then wash skin with water and soap.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Give one or two glasses of water to drink. Refer for medical attention .
安全保管Separated from strong acids. Keep in the dark. Cool. Store only if stabilized.
暴露管理・個人防護0.01 [ppm]
消火手順To fight fire use alcohol foam, carbon dioxide or dry chemical.
処分方法SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal, aquatic, and plant lifeand conformance with environmental and public health regulations.
漏出処分Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
Eye PreventionWear safety goggles or eye protection in combination with breathing protection.
Fire PreventionNO open flames.
Inhalation RiskA harmful contamination of the air will be reached quickly on evaporation of this substance at 20 °C.
Skin PreventionProtective gloves.
Exposure PreventionSTRICT HYGIENE!
生態毒性値LC50 Salmo gairdneri/ renamed Oncorhyncus mykiss (Rainbow trout) 913 mg/L/96 hrstaticLC50 Salmo gairdneri/ renamed Oncorhyncus mykiss (Rainbow trout) 976 mg/L/72 hrEC50 Daphnia magna (immobilization) 130 mg/L/24 hr45 mg/L/48 hr /Conditions of bioassay not specified in source examined/EC50 Scenedesmus subscpicatus (Algaebiomass) 780 mg/L/72 hr /Conditions of bioassay not specified in source examined/growth rate) >1000 mg/L/72 hr /Conditions of bioassay not specified in source examined/
有害作用Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.
暴露経路The substance can be absorbed into the body by inhalation, through the skin and by ingestion.
生態毒性抜粋/AQUATIC SPECIES/ Four groups of five animals /(Daphnia magna)/ were used at each dose level of 0.7, 1.6, 3.8, 8.0, 17.9, 40.0, 89.4, 200.0, 447.0 and 1,000 mg/L. Only one control group was used. An EC50 of 45.04 mg/L and a NOEC of 3.6 mg/L after 48 hours were derived from the results. An EC100 of 447 mg/L after 48 hours was also reported.
Signs and SymptomsCough. Sore throat.Redness. Pain. Severe deep burns.Abdominal pain. Diarrhoea. Nausea. Vomiting.
Human Toxicity Excerpts/HUMAN EXPOSURE STUDIES/ Only one study has been conducted to examine the health of N-VP production workers, a cross-sectional morbidity study. The study included comprehensive medical examinations of the majority of the workforce and no signs of ill health related to N-VP exposure were identified. However, the actual levels of N-VP to which the workforce was exposed are unclear./OTHER TOXICITY INFORMATION/ In liver biopsies from people who had received polyvinyl pyrrolidone iv, basophilic globular deposits were observed in Kupffer cells, occasionally accompanied by mild inflammation. Thesaurismosis (a foam-cell storage phenomenon characterized by swollen cells with reticulated nuclei loaded with vacuoles or deposits of polyvinyl pyrrolidone) has been observed after inhalation of hair sprays containing polyvinyl pyrrolidone and may be accompanied by pulmonary fibrosis and pneumonia. /Polyvinyl pyrrolidone/
Carcinogen ClassificationN-Vinyl-2-pyrrolidoneGroup 3: Not classifiable as to its carcinogenicity to humansVolume 19: (1979) Some Monomers, Plastics and Synthetic Elastomers, and Acrolein19991998
Non-Human Toxicity Excerpts/LABORATORY ANIMALS: Acute Exposure/ A 4-hr LC50 value of 3,070 mg/cu m (3.07 mg/L) has been obtained from a study in which groups of 10 male and 10 female Sprague-Dawley rats were exposed head only to aerosols of around 800, 2,000, 2,800, 5,200 or 5,600 mg/cu m N-VP (purity >99%, stabilized with 10 ppm Kerobit, particle size not stated). Following exposure, rats were observed for 14 days and underwent gross necropsy at the end of the study. Deaths occurred in all but the lowest dose group within 2-4 days of exposure, and clinical signs of toxicity including increased respiration rates, ataxia, /CNS depression/, bloodshot eyes and nasal secretions were observed in all dose groups. Necropsy revealed changes in decedents only. In the lungs, isolated areas of edema were recordedin the heart, acute hyperemic obstruction and acute dilation of the fore chambers occurredthe liver had a sandy grey appearancemultiple bloody ulcerations were apparent in the stomach and blood was apparent in intestinal contents suggesting irritation of the gastrointestinal tract. There was also some discoloration of the kidneys. No details on the severity of these changes were provided. No deaths occurred in earlier studies in which cats, rabbits, guinea pigs, rats and mice or rats alone were exposed for 6 or 8 hr to air saturated with N-VP vapor. Signs of toxicity during exposure were limited to salivation and nasal secretion, and at necropsy, slight irritation of the mucous membranes was occasionally observed. Based on the reported vapor pressure of 0.12 hPa, the saturated vapor concentration would be 0.6 mg/L (600 mg/cu m)./LABORATORY ANIMALS: Acute Exposure/ A dermal LD50 value of 560 mg/kg has been estimated from a study in which groups of 5 rabbits were given 200, 375, 800, 1,000 or 2,000 mg/kg on intact skin. The conditions of exposure were not stated. Deaths occurred in all but the lowest dose group within 5 days of dosing and all animals in the top two groups died. No information on local skin effects or systemic toxicity was provided./LABORATORY ANIMALS: Acute Exposure/ Results from a study in the rat indicated that the dermal LD50 value for this species lay between 1,043 and 4,127 mg/kg. Groups of 2 male and 2 female CFY rats were given 0, 668, 1,043, 4,127 or 10,430 mg/kg N-VP over an area approximately 10% of body surface under an occlusive dressing for 24 hr. There was no evidence of irritation at the site of application. Deaths occurred in all but the low dose group within three days of dosing and non-specific signs of toxicity were seen in all rats given 1,043 mg/kg or more. Signs of toxicity in the lowest dose group were limited to slight diarrhea in the two males. Autopsy of decedents revealed congestion of the lungs, pallor of the liver, kidneys and spleen and injection of the blood vessels into the subcutaneous tissue at the site of application. Body weight gains of treated rats were reduced during the first week of observation but were normal during the second week. No abnormalities were seen in survivors at necropsy./LABORATORY ANIMALS: Acute Exposure/ The effects of single oral gavage doses of N-VP ... in aqueous solution have also been studied in guinea pigs, cats and rabbits. One out of a group of 4 guinea pigs given 520 mg/kg, died. All animals showed a lack of appetite, apathy, slight atony and one developed enteritis after 3 days. Groups of 3 rabbits received 417 or 1,043 mg/kg. No deaths occurred. At both dose levels, slight weight loss and lack of appetite were recorded. Groups of two cats received 100, 210 or 520 mg/kg N-VP. One top dose cat died 3 days after dosing. Salivation and emesis were apparent at all dose levels, accompanied by a lack of appetite, slight weight loss and loss of balance at the top dose level, which persisted until the surviving cat was sacrificed 28 days post exposure.For more Non-Human Toxicity Excerpts (Complete) data for 2-PYRROLIDINONE,1-ETHENYL- (38 total), please visit the HSDB record page.
Evidence for CarcinogenicityEvaluation: No epidemiological data relevant to the carcinogenicity of N-vinyl-2-pyrrolidone ... were available. There is limited evidence for the carcinogenicity of N-vinyl-2-pyrrolidone in experimental animals. Overall evaluation N-Vinyl-2-pyrrolidone is not classifiable as to its carcinogenicity to humans (Group 3).A3Confirmed animal carcinogen with unknown relevance to humans.
Toxicity DataLC50 (rat) = 3,200 mg/m3/4h
Non-Human Toxicity ValuesLD50 Rat oral 1470 mg/kgLD50 Rabbit dermal 560 mg/kgLD50 Mouse oral about 940 mg/kg bwLC50 Rat inhalation 3.07 mg/L/4 hrFor more Non-Human Toxicity Values (Complete) data for 2-PYRROLIDINONE,1-ETHENYL- (9 total), please visit the HSDB record page.
水環境危害等級（WGK）1
RTECS 番号TR8370000
税関コード39059900
安全措置（S）22-24/25
貯蔵分類11 - Combustible Solids