L-2-フェニルグリシン

解説L-フェニルグリシンは抗生物質の構成成分，D-フェニルグリシンの誘導体はアヤメ属Iris tingitana，ゴウダソウ属Lunaria annua，モクセイ属Reseda luteolaに見いだされている．α-アミノベンゾニトリルの加水分解により合成できる．DL-フェニルグリシンは光輝ある小板状結晶．255 ℃(昇華)．酸，アルカリに易溶，有機溶媒に不溶．L-フェニルグリシンは融点305～310 ℃．[α]20D－157.8°(希塩酸)．セファロスポリン，セファレキシン，ペニシリンなどの合成原料．(b)はアニリノ酢酸，N-フェニルグリシンにあたる．インジゴの合成中間体として，モノクロロ酢酸とアニリンから合成される．融点127～128 ℃．水に可溶．

説明L-Phenylglycine is an amide that belongs to the group of pyridoxal phosphate analogues. It has been shown to be a response element for enzymes and natural compounds in Escherichia coli and Saccharomyces cerevisiae. It inhibits aminotransferase activity, dopamine synthesis, and microbial metabolism in these organisms. This compound also has a structural analysis that includes x-ray diffraction data, which can be used to identify its three-dimensional structure.

使用L-(+)-2-Phenylglycine is a derivative of Glycine (G615990), the smallest of all the amino acids, and is also used to treat schizophrenia, stroke, and benign prostatic hyperplasia. L-(+)-2-Phenylglycine is also used as an N-linked side chain of an SMTP (Stachybotrys microspora tripenyl phenols) congener, which was potent in enhancing plasminogen activation in S. microspora.