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化工社化工社 化学情報印刷レポート · 研究参考用
HCID 6979作成日：2026年10月27日

4-クロロ-2-ニトロアニリン

4-クロロ-2-ニトロアニリン · アゾイックDC9(ベース) · ファーストレッド3GLスペシャル · 2-ニトロ-4-クロロアニリン · 4-クロロ-6-ニトロアニリン · ファーストレッド3GLベース · C.I.アゾイックジアゾコンポーネント9(ベース) · 4-クロロ-2-ニトロベンゼンアミン

https://huagongshe.com/ja/chemical/6979

4-クロロ-2-ニトロアニリン の分子構造式

識別子と物理属性

CAS No.89-63-4
分子式C6H5ClN2O2
平均分子量172.57 g/mol
単同位体質量172.00395508 g/mol
SMILESNc1ccc(Cl)cc1[N+](=O)[O-]
InChIKeyPBGKNXWGYQPUJK-UHFFFAOYSA-N
PubChem CID6979
ChEMBLCHEMBL166405
EC No.201-925-4
DTXSIDDTXSID4030384
現地名4-クロロ-2-ニトロアニリン

化学・物理的性質

XLogP2.7
極性表面積71.8
水素結合供与体数1
水素結合受容体数3
回転可能結合数0
重原子数11
形式電荷0
複雑度159
物質分類Nitrogen Compounds -> Nitroanilines
SpringerMaterials Properties15N nuclear magnetic resonance spectrum
LogP（分配係数）log Kow = 2.72
Color/FormOrange crystalsDark orange-yellow prisms from dil alc
溶解度less than 1 mg/mL at 72 °F (NTP, 1992)Very soluble in ethanol, ether, acetic acidslightly soluble in acetone, ligandInsoluble in water, methanol, and etherIn water, 5,003 mg/L at 25 °C0.5g/l（無水物）不溶性
DecompositionWhen heated to decomposition ... emits toxic vapors of /nitrogen oxides and hydrogen chloride/.
融点241 to 243 °F (NTP, 1992)116.5 °C117-119 °C(lit.)
蒸気圧0.000485 [mmHg]4.85X10-4 mm Hg at 25 °C (wat)
Physical Description4-chloro-2-nitroaniline is a bright orange powder. (NTP, 1992)Orange solid[Hawley] Orange powder[MSDSonline]
Ionization EfficiencyPositive2.322.7Agilent XCTElectrospray ionizationformic acid (5.3nM)
Dissociation ConstantspKa = -1.02 (conjugate acid)
沸点200°C (rough estimate)
密度1.37
屈折率1.6460 (estimate)
引火点191 °C
貯蔵条件room temp
pKa（酸解離定数）pK1: 1.10(+1) (25°C)
外観・状態結晶性粉末またはチャンク
色オレンジ
pH7 (0.5g/l, H2O, 20℃)
BRN512436
ヘンリー定数8.2×101 mol/(m3Pa) at 25℃, HSDB (2015)
安定性安定。可燃性。強力な酸化剤とは相容れない。
InChI1S/C6H5ClN2O2/c7-4-1-2-5(8)6(3-4)9(10)11/h1-3H,8H2
InChIKeyPBGKNXWGYQPUJK-UHFFFAOYSA-N
SMILESNc1ccc(Cl)cc1[N+]([O-])=O
CAS データベース89-63-4(CAS DataBase Reference)
NISTの化学物質情報Aniline, 4-chloro-2-nitro-(89-63-4)
EPAの化学物質情報4-Chloro-2-nitroaniline (89-63-4)

化学的特性

bright orange powder

安全性と法規制

GHS 分類DangerH300 (99.4%): Fatal if swallowed [Danger Acute toxicity, oral]P260, P262, P264, P270, P271, P273, P280, P284, P301+P316, P302+P352, P304+P340, P316, P319, P320, P321, P330, P361+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 179 reports by companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.WarningH302: Harmful if swallowed [Warning Acute toxicity, oral]
規制情報Chemical: Benzenamine, 4-chloro-2-nitro-Status: Active Update: 14-05-2013 https://echa.europa.eu/registration-dossier/-/registered-dossier/79154-Chloro-2-nitroaniline: Does not have an individual approval but may be used under an appropriate group standard
その他の安全情報IMAP assessments - Benzenamine, 4-chloro-2-nitro-: Human health tier II assessment
輸送ラベル（DOT）Poison
火災危険This compound is probably combustible. (NTP, 1992)
健康有害性SYMPTOMS: Exposure to this material can cause local irritation, headache, cyanosis, jaundice, methemoglobinemia, weight loss, anemia, weakness and irritability.
有害性の概要A mutagenActs as general anesthetic in lethal-dose feeding studies of guinea pigs[RTECS] Emergency treatment: MethemoglobinemiaMay caused severe damage to eyes[HSDB] An irritantMay induce methemoglobinemiaMay be absorbed through skin[MSDSonline]
反応性グループNitro, Nitroso, Nitrate, and Nitrite Compounds, Organic
TSCA 要件Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Benzenamine, 4-chloro-2-nitro- is included on this list. Effective date 10/4/82Sunset date 10/4/92.

用途

用途

染料?顔料中間体

用途

有機合成原料。

使用

4-Chloro-2-nitroaniline is used almost exclusively as an intermediate in the synthesis of pigments. The greatest potential for human exposure to 4-chloro-2- nitroaniline is in production and use of pigments made from the compound.

一般的な説明

Bright orange powder.

製法・合成法

製造方法

4-Chloro-2-nitrobenzenamine of chlorine.

調製方法

1,4-Dichloro-2-nitrobenzene is aminated at 165 ℃ by using a process similar to that described for 2- nitroaniline.

純化方法

Crystallise the aniline from hot H2O (m 115.8-116o), EtOH, EtOH/H2O or *C6H6, and dry it for 10hours at 60o in vacuo. It has m 115.5-116o after sublimation. [Beilstein 12 H 729, 12 I 355, 12 II 396, 12 III 1649, 12 IV 1669.]

Reactivity Profile4-CHLORO-2-NITROANILINE forms explosive products on reaction with nitric acid. Can react with oxidizing agents. (NTP, 1992)
DOT Emergency Guidelines/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Health: TOXICinhalation, ingestion, or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. /Chloronitroanilines//GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Fire or Explosion: Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards. Those substances designated with a "P" may polymerize explosively when heated or involved in a fire. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. /Chloronitroanilines//GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate enclosed areas. /Chloronitroanilines//GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLYit is not effective in spill situations where direct contact with the substance is possible. /Chloronitroanilines/For more DOT Emergency Guidelines (Complete) data for 4-CHLORO-2-NITROANILINE (8 total), please visit the HSDB record page.
Air and Water ReactionsInsoluble in water.
Hazard Classes and CategoriesAcute Tox. 2 (99.4%)Acute toxicity (ingestion) - category 4Specific target organ toxicity - Repeated exposure - Category 2 (blood system)Self-reactive substances and mixtures - Type G
消火Fires involving this chemical can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
応急処置EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
消火手順If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use foam, dry chemical, or carbon dioxide. Keep run-off water out of sewers and water sources.Suitable extinguishing media: Use dry chemical, CO2, water spray or "alcohol" foam. As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear. Water mist may be used to cool closed containers.
保管条件Keep containers tightly closed in a cool, well-ventilated place.
清掃方法Prevent product from entering drains. Sweep up and shovel into suitable containers for disposal.
非火災時の漏出対応SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, you should dampen the solid spill material with alcohol, then transfer the dampened material to a suitable container. Use absorbent paper dampened with alcohol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with alcohol followed by washing with a strong soap and water solution. Do not reenter the contaminate area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
処分方法SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal, aquatic, and plant lifeand conformance with environmental and public health regulations.
Preventive MeasuresIf material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Do not use water.Personnel protection: Avoid breathing vapors. Keep upwind. ... Avoid bodily contact with the material. ... Do not handle broken packages unless wearing appropriate personal protective equipment.Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice.Eye contact: In the case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Ingestion: Do not induce vomiting without medical advice. Never give anything by mouth to an unconscious person. Consult a physician.
Isolation and EvacuationExcerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:
Personal Protective Equipment (PPE)RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)Personnel protection: ... Wear positive pressure self-contained breathing apparatus. ... Wear appropriate chemical protective clothing Do not handle broken packages unless wearing appropriate personal protective equipment.PERSONAL PROTECTIVE EQUIPMENT. Respiratory protection: Breathing apparatus only if aerosol or dust is formed. Hand protection: PVC or other plastic material gloves. Skin and body protection: Usual safety precautions while handling the product will provide adequate protection against this potential effect. Eye protection: Safety glasses with side-shields.
生態毒性値LC50Species: Daphnia magna (Water flea, age 6-24 hr)Conditions: freshwater, static, 20 °C, pH > or =7.0Concentration: 3700 ug/L for 24 hrConcentration: 3200 ug/L for 48 hr (95% confidence interval: 2900-3500 ug/L)EC50Photobacterium phosphorem (19.8 ug/L)Condition: 15 degree C) for 30 min /Conditions of bioassay not specified in source examined/Water flea (3.2 mg/L) for 48 hr /Conditions of bioassay not specified in source examined/
環境中動態TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 720(SRC), determined from a log Kow of 2.72(2) and a regression-derived equation(3), indicates that 4-chloro-2-nitroaniline is expected to adsorb to suspended solids and sediment(SRC). Volatilization of 4-chloro-2-nitroaniline from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.2X10-7 atm-cu m/mole(SRC), using a fragment constant estimation method(4). 4-Chloro-2-nitroaniline is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 4.8X10-4 mm Hg(SRC), determined from a fragment constant method(5). A 0% theoretical BOD using an activated sludge inoculum and the Japanese MITI test(6) indicates that biodegradation is not an important environmental fate process in soil(SRC).AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 720(SRC), determined from a log Kow of 2.72(2) and a regression-derived equation(3), indicates that 4-chloro-2-nitroaniline is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 1.2X10-7 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), BCF values of 7.5-13.4(6), suggest bioconcentration in aquatic organisms is low(SRC). A 0% theoretical BOD using an activated sludge inoculum and the Japanese MITI test(6) indicates that biodegradation is not an important environmental fate process in water(SRC).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 4-chloro-2-nitroaniline, which has an estimated vapor pressure of 4.8X10-4 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 4-chloro-2-nitroaniline is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 4 days(SRC), calculated from its rate constant of 3.9X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). The compound contains chromophores that absorb at wavelengths >290 nm(4) and therefore may be susceptible to direct photolysis by sunlight(SRC).
有害作用Neurotoxin - Other CNS neurotoxin
Ongoing Test StatusThe following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical. [http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=89-63-4]
Effluent Concentrations4-Chloro-2-nitroaniline was identified in one industrial wastewater extract of an organic and plastic industry at a concentration of 246 ng/uL extract(1). 4-Chloro-2-nitroaniline was identified at a concentration of 11 ug/mL in hazardous waste incineration effluents from four different test sites(2). 4-Chloro-2-nitroaniline was qualitatively detected in advanced waste treatment concentrate from Lake Tahoe, CA on October 24, 1974(3).
Medical SurveillanceRoutine checking of lips, tongue and nail beds of exposed personnel for signs of cyanosis. /Protect/ from exposure those individuals with anemia, cardiovascular or pulmonary diseases.
Soil Adsorption/MobilityThe Koc of 4-chloro-2-nitroaniline is estimated as 720(SRC), using a log Kow of 2.72(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that 4-chloro-2-nitroaniline is expected to have low mobility in soil. Anilines are expected to bind strongly to humus or organic matter in soils due to the high reactivity of the aromatic amino group(4,5), suggesting that mobility may be much lower in some soils(SRC). The log Koc of 4-chloro-2-nitroaniline was measured as 2.30 in Yangtze river sediment (37.1% sand, 49.3% silt, 13.6% clay, 1.28% organic carbon, pH 7.44)(6). The log Koc was also measured as 3.68 in modified clay(7). These values give Koc values of 200 and 4800, respectively(SRC).
Human Toxicity Excerpts/SIGNS AND SYMPTOMS/ Chronic toxicity: Chronic exposure may cause nausea and vomiting, higher exposure causes unconsciousness. Local effects: Symptoms of overexposure may be headache, dizziness, tiredness, nausea and vomiting. Specific effects: May include moderate to severe erythema (redness) and moderate edema (raised skin), nausea, vomiting, headache./OTHER TOXICITY INFORMATION/ Harmful by inhalation, in contact with skin and if swallowed. ... Risk of serious damage to eyes
Artificial Pollution Sources4-Chloro-2-nitroaniline's production and use as a dye and pigment intermediate(1) may result in its release to the environment through various waste streams(SRC).
Environmental BiodegradationAEROBIC: 4-Chloro-2-nitroaniline, present at 100 ppm, reached 0% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 ppm and the Japanese MITI test(1).
Environmental BioconcentrationA 6 week bioconcentration study obtained BCF values of 7.5-13.2 and 8.0-13.4 in carp (Cyprinus carpio) for concentrations of 4-chloro-2-nitroaniline of 100 and 10 ppb, respectively(1). According to a classification scheme(2), these BCF values suggest bioconcentration in aquatic organisms is low(SRC).
Volatilization from Water/SoilThe Henry's Law constant for 4-chloro-2-nitroaniline is estimated as 1.2X10-7 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that 4-chloro-2-nitroaniline is expected to be essentially nonvolatile from water surfaces(2). 4-Chloro-2-nitroaniline is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 4.8X10-4 mm Hg(SRC), determined from a fragment constant method(3).
水環境危害等級（WGK）2
TSCA 収載状態TSCA listed
RTECS 番号BX1575000
輸送番号（UN）UN 2237 (CHLORONITROANILINES)
税関コード29214210
危険文句（R）26/27/28-33-51/53
化審法(3)-407, (5)-2303
安衛法変異原性物質
消防法危-5-II
危険表示T+,N,T
hazard_noteVery Toxic
安全措置（S）28-36/37-45-61-28A
危険等級6.1Acute Tox. 1 DermalAcute Tox. 2 InhalationAcute Tox. 2 OralAquatic Acute 1Aquatic Chronic 2STOT RE 2
包装等級III
自然発火温度964 °F
貯蔵分類6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials
有害物質データ89-63-4(Hazardous Substances Data)