基本情報
- CAS
56-89-3- 標準SMILES
[NH3+][C@@H](CSSC[C@H]([NH3+])C(=O)[O-])C(=O)[O-]- InChIKey
LEVWYRKDKASIDU-IMJSIDKUSA-N- 分子式
- C6H12N2O4S2
- 平均分子量
- 240.3 g/mol
- 単同位体質量
- 240.02384922
概要
L-cystine zwitterion is a cystine zwitterion. It is an enantiomer of a D-cystine zwitterion. It is a tautomer of a L-cystine.
名称と識別子
- 優先名称
- L-cystine zwitterion
- IUPAC
- (2R)-2-azaniumyl-3-[[(2R)-2-azaniumyl-2-carboxylatoethyl]disulfanyl]propanoate
- 現地名
- L-(-)-シスチン
- 英語名
- L-Cystine
- 分子式
- C6H12N2O4S2
- 分子量
- 240.3
名称と別名
24645-67-8L-cystine zwitterionL-(-)-3,3'-Dithiobis(2-aminopropanoic acid)CHEBI:35491(2R,2'R)-3,3'-dithiobis(2-ammoniopropanoate)(2R,2'R)-3,3'-disulfanediylbis(2-ammoniopropanoate)L-(-)-シスチンL-シスチン3,3'-ジチオビス[(R)-2-アミノプロパン酸]3,3'-ジチオビス[(2R)-2-アミノプロピオン酸]3,3'-ジチオビス(L-アラニン)(-)-シスチン
名称をさらに表示
シスチン(-)-L-シスチンLシスチンL(-)-シスチンL(-)‐シスチンL‐シスチン CRM6025‐Aシスチン, L-L-シスチン (JAN)シスチン 3Ｌ(-)-3,3′-ジチオビス(2-アミノプロピオン酸)Ｌ-3,3′-ジチオビス(2-アミノプロピオン酸) CRM6025-aＬ-シスチン CRM6025-a(H-CYS-OH)2l-cystin3,3’-dithiobis(2-aminopropanoicacid)(2R,2'R)-3,3'-Disulfanediylbis(2-aminopropanoic acid)(2R,2'R)-3,3'-disulfanediylbis(2-aminopropanoic acid)(CYS)2-Cystine1-cystineCystine CRSCystine acid
物性
構造計算による物性
- XLogP
- -5
- 極性表面積
- 186 Ų
- 水素結合供与体数
- 2
- 水素結合受容体数
- 6
- 回転可能結合数
- 5
- 重原子数
- 14
- 形式電荷
- 0
- 複雑度
- 181
実験および物理化学的性質
LogP-5.08
Solubility0.19 mg/mL
Melting Point260.5 °C
Physical DescriptionSolid
Dissociation Constants1
物理化学的性質
- 融点
- 240 °C · >240 °C (dec.) (lit.)
- 比旋光度
- -224 · -224 º(c=2 in 1M HCl)
- 沸点
- 468.2 · 468.2±45.0 °C(Predicted)
- 比重(密度)
- 1.68 · 1.68
- 屈折率
- -222.5 ° · -222.5 ° (C=1, 1mol/L HCl)
- 貯蔵温度
- 2 · 2-8°C
- 溶解性
- 1 M · 1M HCl: 100mg/mL
- 外見
- 粉体・固形
- 酸解離定数(Pka)
- 1 · 1.0, 2.1, 8.02, 8.71(at 25℃)
- 色
- 白い
- PH
- 4.6 · 4.60
- 由来生物
- plant
- 水溶解度
- 0.112 g/L · 0.112g/L (25℃)
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
安全データ
- wgk
- 3
- tsca
- TSCA listed
- rtecs
- HA2690000
- ridadr
- 2811
- hs_code
- 29309014
- risk_code
- 36/37/38-22
- 化審法
- (9)-1587, (2)-1468 届出不要化学物質
- hazard_code
- Xi,Xn
- hazard_note
- Irritant
- safety_code
- 26-36-24/25
- packing_group
- III
- ストレージクラス
- 11 - Combustible Solids
化学と産業
薬理情報
Pharmacodynamics
L-Cystine is a covalently linked dimeric nonessential amino acid formed by the oxidation of cysteine. Two molecules of cysteine are joined together by a disulfide bridge to form cystine. Cystine is a chemical substance which naturally occurs as a deposit in the urine, and can form a calculus (hard mineral formation) when deposited in the kidney. The compound produced when two cysteine molecules linked by a disulfide (S-S) bond. Cystine is required for proper vitamin B6 utilization and is also helpful in the healing of burns and wounds, breaking down mucus deposits in illnesses such as bronchitis as well as cystic fibrosis. Cysteine also assists in the supply of insulin to the pancreas, which is needed for the assimilation of sugars and starches. It increases the level of glutathione in the lungs, liver, kidneys and bone marrow, and this may have an anti-aging effect on the body by reducing age-spots etc.
Mechanism of ActionCertain conditions, e.g. an acetaminophen overdose, deplete hepatic glutathione and subject the tissues to oxidative stress resulting in loss of cellular integrity. L-Cystine serves as a major precursor for synthesis of glutathione.
Tissue LocationsAll Tissues
Cellular LocationsCytoplasm
応用分野
用途アミノ酸研究、ペプチド原料あるいは医・農薬の不斉骨格源。
使用L-Cystine is a non-essential amino acid for human development. L-Cystine is formed by the dimerization of two cysteines through the sulfur.
一般的な説明This Standard Reference Material (SRM) is intended primarily for use in validating microchemical procedures for the determination of carbon, hydrogen, nitrogen, and sulfur in organic matter. SRM 143d is pure crystalline cystine supplied in a 2 g unit size. For more information, please refer to the SDS and COA.SRM 143D_cert SRM 143D _SDS
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