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化工社化工社 化学情報印刷レポート · 研究参考用
HCID 7019作成日：2026年10月27日

アクリジン-9-アミン

9-アクリジンアミン · アクラミジン · アクリフレックス · アミノアクジリン · アクリジン-9-アミン · モナクリン · アミナクリン · イゾアクリジナ

https://huagongshe.com/ja/chemical/7019

アクリジン-9-アミン の分子構造式

識別子と物理属性

CAS No.90-45-9
分子式C13H10N2
平均分子量194.23 g/mol
単同位体質量194.08439833 g/mol
SMILESNc1c2ccccc2nc2ccccc12
InChIKeyXJGFWWJLMVZSIG-UHFFFAOYSA-N
PubChem CID7019
ChEMBLCHEMBL43184
ChEBICHEBI:74789
EC No.201-995-6
DTXSIDDTXSID2024456
現地名アクリジン-9-アミン

化学・物理的性質

XLogP2.8
極性表面積38.9
水素結合供与体数1
水素結合受容体数2
回転可能結合数0
重原子数15
形式電荷0
複雑度207
溶解度less than 1 mg/mL at 68 °F (NTP, 1992)エタノール: かすんでいる11.65mg/L(24℃)
融点466 °F (NTP, 1992)238-240℃
Physical Description9-aminoacridine appears as yellow needles. Free soluble in alcohol.
Kovats Retention Index2240
Collision Cross Section139.3 Ų [M-H]- [CCS Type: DTBuffer gas: N2Ionization: ESI-Dataset: TOXCASTSource Identifier: DTXSID7024457]138.9 Ų [M+H]+ [CCS Type: DTIonization: ESI+139.0 Ų [M]+ [CCS Type: DTIonization: APCI+138.8 Ų [M+H]+ [CCS Type: DT136.8 Ų [M+H]+ [CCS Type: TWMethod: calibrated with polyalanine and drug standards]147.66 Ų [M+K]+ [CCS Type: TW131.39 Ų [M+H-H2O]+ [CCS Type: TW135 Ų [M+H]+ [CCS Type: TW
沸点320.68°C (rough estimate)
密度1.268
屈折率1.5014 (estimate)
貯蔵条件Store below +30°C.
pKa（酸解離定数）9.99(at 20℃)
外観・状態個体
色黄色
Merck14,407
安定性安定。強力な酸化剤とは相容れない。
InChI1S/C13H10N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1-8H,(H2,14,15)
InChIKeyXJGFWWJLMVZSIG-UHFFFAOYSA-N
SMILESNc1c2ccccc2nc3ccccc13
CAS データベース90-45-9(CAS DataBase Reference)
EPAの化学物質情報9-Aminoacridine (90-45-9)

化学的特性

yellow crystals or powder

安全性と法規制

GHS 分類WarningH315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]H335 (97.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposureRespiratory tract irritation]P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 40 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
規制情報Chemical: 9-Acridinamine9-Aminoacridine: Does not have an individual approval but may be used under an appropriate group standard
その他の安全情報Evaluation - Chemicals not considered for in depth evaluation - Not commercially active in Australia
火災危険Flash point data for this chemical are not availablehowever, it is probably combustible. (NTP, 1992)
健康有害性SYMPTOMS: Symptoms of exposure to this compound may include gastrointestinal mucosa irritation, nausea and vomiting.ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes of NOx. (NTP, 1992)
反応性グループAmines, Phosphines, and PyridinesHydrocarbons, Aromatic
Reactivity Profile9-AMINOACRIDINE is a moderately strong base. Neutralizes acids to form salts plus water in exothermic reactions. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides.
Air and Water ReactionsInsoluble in water.

用途

使用

Acridine analog. DNA intercalating agent.

一般的な説明

Yellow needles. Free soluble in alcohol.

製法・合成法

純化方法

It crystallises from EtOH or acetone and sublimes at 170-180o/0.04mm [Albert & Ritchie Org Synth Coll Vol III 53 1955, for hydrochloride, see below]. [Beilstein 22 H 463, 21 II 280, 21 III/IV 4174.]

Hazard Classes and CategoriesSkin Irrit. 2 (100%)Eye Irrit. 2 (100%)STOT SE 3 (97.5%)
消火Fires involving this material can be controlled using a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
応急処置EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.INHALATION: IMMEDIATELY leave the contaminated areatake deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be usedif not available, use a level of protection greater than or equal to that advised under Protective Clothing.INGESTION: If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Generally, the induction of vomiting is NOT recommended outside of a physician's care due to the risk of aspirating the chemical into the victim's lungs. However, if the victim is conscious and not convulsing and if medical help is not readily available, consider the risk of inducing vomiting because of the high toxicity of the chemical ingested. Ipecac syrup or salt water may be used in such an emergency. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)
非火災時の漏出対応SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.STORAGE PRECAUTIONS: You should store this material under ambient temperatures. (NTP, 1992)
Personal Protective Equipment (PPE)RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). (NTP, 1992)
水環境危害等級（WGK）3
RTECS 番号AR7300000
輸送番号（UN）2811
毒性LD50 intraperitoneal in mouse: 68mg/kg
税関コード2933 99 80
危険文句（R）36/37/38
危険表示Xi
安全措置（S）26-36
危険等級6.1(b)Acute Tox. 4 OralAquatic Acute 1Aquatic Chronic 1Eye Irrit. 2Skin Irrit. 2STOT SE 3
包装等級III
貯蔵分類11 - Combustible Solids