N,N-ジエチルアニリン

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

Use water spray, foam, powder, carbon dioxide.

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Give one or two glasses of water to drink. Give a slurry of activated charcoal in water to drink. Refer for medical attention .

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

General First Aid:

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

If material not on fire and not involved in fire: Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without undue personnel hazard.

Personnel protection: Keep upwind. Avoid breathing vapors. ... Do not handle broken packages unless wearing appropriate personal protective equipment. Avoid bodily contact with the material.

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

Immediate precautionary measure

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1,500(SRC), determined from a log Kow of 3.31(2) and a regression-derived equation(3), indicates that N,N-diethylaniline is expected to have low mobility in soil(SRC). A pKa value of 6.57(4) suggests that N,N-diethylaniline will exist partially in the protonated form in moist soils and the protonated form of N,N-diethylaniline is expected to bind strongly to soil surfaces(SRC). Volatilization of N,N-diethylaniline from moist soil surfaces is expected to be an important fate process for the neutral species(SRC) given an estimated Henry's Law constant of 1.9X10-4 atm-cu m/mole(SRC), derived from its vapor pressure of 0.14 mm Hg(5) and water solubility of 139 mg/l(6) at 25 °C. N,N-Diethylaniline is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(5). N,N-Diethylaniline achieved 0% of the theoretical BOD in a sewage sludge test during a 5 day incubation period and was considered persistent(7).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1,500(SRC), determined from a log Kow of 3.31(2) and a regression-derived equation(3), indicates that N,N-diethylaniline is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 1.9X10-4 atm-cu m/mole(SRC), derived from its vapor pressure of 0.14 mm Hg(4) and water solubility of 139 mg/l(5) at 25 °C. Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 5 hours and 6.5 days, respectively(SRC). A pKa of 6.57(6) suggests that N,N-diethylaniline will exist partially in the protonated form in aqueous environments and the protonated form of N,N-diethylaniline is not expected to volatilize from water. According to a classification scheme(7), BCF values of 17-161 measured in carp(8) suggest bioconcentration in aquatic organisms is low to high. N,N-Diethylaniline achieved 0% of the theoretical BOD in a sewage sludge during a 5 day incubation period and was considered persistent(9). Using the Japanese MITI test, N,N-diethylaniline achieved 0% of theoretical BOD in an acclimated study during a 4 week incubation(8).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), N,N-diethylaniline, which has a vapor pressure of 0.14 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase N,N-diethylaniline is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 2 hours(SRC), calculated from its estimated rate constant of 1.6X10-10 cu cm/molecule-sec at 25 °C(3) determined using a structure estimation method(3).

Blue lips, fingernails and skin. Convulsions. Dizziness. Laboured breathing. Vomiting. Symptoms may be delayed.

Redness. MAY BE ABSORBED! Further see Inhalation.

Redness. Pain.

See Inhalation.

The substance is toxic to aquatic organisms. Bioaccumulation of this chemical may occur along the food chain. It is strongly advised not to let the chemical enter into the environment. The substance may cause long-term effects in the aquatic environment.

A pKa value of 6.57(1) suggests that N,N-diethylaniline will exist partially in the protonated form in moist soils and the protonated form of N,N-diethylaniline is expected to bind strongly to soil surfaces(SRC). The Koc of N,N-diethylaniline is estimated as 1,500(SRC), using a log Kow of 3.31(2) and a regression-derived equation(3). According to a classification scheme(4), this estimated Koc value suggests that N,N-diethylaniline is expected to have low mobility in soil.

Developmental toxicity of diethylaniline was evaluated in groups of 24 pregnant CD rats fed dose levels of 0, 50, 250, or 500 mg/kg bw/day, by gavage, on gestation days 6-15, followed by fetal examination on gestation day 20. The treatment killed 0, 0, and 5 rats in the low-, mid-, and high-dose groups, respectively. Symptoms of maternal toxicity that were observed in all dose groups included decreased body weight gain and food consumption, and excessive salivation; rats in the mid- and high- dose groups also had excessive lacrimation and staining of the skin/fur in the ano-genital region. The treatment was fetotoxic (reduced fetal weight gain and retarded sternebral ossification), but not embryotoxic or teratogenic, at the high-dose level. The treatment was not embryotoxic, fetotoxic, or teratogenic at the low- and mid-dose levels.

Developmental toxicity of diethylaniline was evaluated in groups of 5 pregnant Sprague-Dawley CD rats fed dose levels of 0, 100, 250, 500, 750, 1000, 1500, or 2000 mg/kg bw/day, by gavage, on gestation days 6-15, followed by fetal examination on gestation day 20. The treatment killed 0, 0, 0, and 4 rats in the 100, 250, 500, and 750 mg/kg dose groups, respectively. All rats in the 1000, 1500, and 2000 mg/kg dose groups died by gestation day 7, after receiving 1-2 treatments; embryotoxic, fetotoxic, and teratogenic effects could not be evaluated in those groups. Symptoms of maternal toxicity in surviving dams included decreased body weight gain and food consumption (100, 250, 500, and 750 mg/kg), and staining of the fur in the ano-genital region (250, 500, and 750 mg/kg). Gross necropsy revealed discolored lungs in some dams at all dose levels. The treatment was not embryotoxic (rate of uterine implantation was normal) or teratogenic at any dose level, but was fetotoxic (reduced fetal weight gain) at 500 and 750 mg/kg.

N,N-Diethylaniline, present at 100 mg/l, reached 0% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/l and the Japanese MITI test(1). N,N-Diethylaniline achieved 0% of the theoretical BOD in a sewage sludge during a 5 day incubation period and was considered persistent(2).

BCF values of 44-161 were measured for carp exposed to 0.2 mg/l of N,N-diethylaniline for 8 weeks and BCF values of 17-125 were measured for carp exposed to 0.02 mg/l(1). According to a classification scheme(2), this BCF data suggests the potential for bioconcentration in aquatic organisms is low to high.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 1000 lb or 454 kg. The toll free number of the NRC is (800) 424-8802; In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).