基本情報
- CAS
1197-21-3- 標準SMILES
CC(C)(N)Cc1ccccc1.Cl- InChIKey
NCAIGTHBQTXTLR-UHFFFAOYSA-N- 分子式
- C10H16ClN
- 平均分子量
- 185.69 g/mol
- 単同位体質量
- 185.0971272
名称と識別子
- 優先名称
- Phentermine Hydrochloride
- IUPAC
- 2-methyl-1-phenylpropan-2-amine;hydrochloride
名称と別名
Phentermine hydrochloride1197-21-3Phentermine HClFastinOby-TrimToraOna-MastObestin-30SuprenzaWilpoZantrylLomaira
名称をさらに表示
Phenyl-t-butylamine hydrochloridePhentermine hydrochloride civNSC-440901-Phenyl-2-methyl-2-aminopropane hydrochloride0K2I505OTVPhentermine hydrochloride [USP]Benzeneethanamine, alpha,alpha-dimethyl, hydrochloridePhentermine hydrochloride (USP)
データベース識別子
- CAS
1197-21-3- PubChem CID
- 70969
- DTXSID
DTXSID20152550- ChEMBL
CHEMBL1200912- UNII
- 0K2I505OTV
- EC Number
- 214-821-9
物性
構造計算による物性
- 極性表面積
- 26 Ų
- 水素結合供与体数
- 2
- 水素結合受容体数
- 1
- 回転可能結合数
- 2
- 重原子数
- 12
- 形式電荷
- 0
- 複雑度
- 112
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
GHS分類
GHS Classification
Danger
H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
P264, P270, P301+P316, P321, P330, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 79 reports by companies from 1 notifications to the ECHA C&L Inventory.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
危険有害性情報
Regulatory InformationBenzeneethanamine, .alpha.,.alpha.-dimethyl-, hydrochloride: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Other Safety InformationIMAP assessments - Benzeneethanamine, .alpha.,.alpha.-dimethyl-, hydrochloride: Environment tier I assessment；IMAP assessments - Benzeneethanamine, .alpha.,.alpha.-dimethyl-, hydrochloride: Human health tier I assessment
Hazard Classes and CategoriesAcute Tox. 3 (100%)
毒性情報
Treatment
Management of acute phentermine intoxication is largely symptomatic and includes lavage and sedation with a barbiturate. Acidification of the urine increases phentermine excretion. Intravenous phentolamine (REGITINE) has been suggested for possible acute, severe hypertension, if this complicates phentermine overdosage. (L1712)
Health Effects
化学と産業
薬理情報
Metabolism/MetabolitesHepatic.
Half Life: 16 to 31 hours
FDA Pharmacological Classification
PHENTERMINE HCL C-IV
Sympathomimetic Amine Anorectic [EPC]; Appetite Suppression [PE]; Increased Sympathetic Activity [PE]
PHENTERMINE HYDROCHLORIDE
Appetite Suppression [PE]; Sympathomimetic Amine Anorectic [EPC]; Increased Sympathetic Activity [PE]
MeSH Pharmacological Classification
A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here.
Agents that are used to suppress appetite.
Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.
Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters.
用途と製造
UsesFor the treatment and management of obesity.
関連反応
9 件
化合物ノート
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