基本情報
- CAS
157-06-2- 標準SMILES
NC(N)=NCCC[C@@H](N)C(=O)O- InChIKey
ODKSFYDXXFIFQN-SCSAIBSYSA-N- 分子式
- C6H14N4O2
- 平均分子量
- 174.2 g/mol
- 単同位体質量
- 174.1116757
概要
D-arginine is a D-alpha-amino acid that is the D-isomer of arginine. It has a role as an EC 4.1.1.19 (arginine decarboxylase) inhibitor and a mouse metabolite. It is a D-alpha-amino acid and an arginine. It is a conjugate base of a D-argininium(1+). It is a conjugate acid of a D-argininate. It is an enantiomer of a L-arginine.
名称と識別子
- 優先名称
- D-Arginine
- IUPAC
- (2R)-2-amino-5-(diaminomethylideneamino)pentanoic acid
- 現地名
- D-(-)-アルギニン
- 英語名
- D(-)-Arginine
- 分子式
- C6H14N4O2
- 分子量
- 174.2
名称と別名
D-Arginine157-06-2D-Arginin(R)-2-amino-5-guanidinopentanoic acidArginine, d-D-2-Amino-5-guanidinovaleric acid(2R)-2-amino-5-carbamimidamidopentanoic acid(-)-D-Arginine hydrateEINECS 205-866-5(2R)-2-amino-5-(diaminomethylideneamino)pentanoic acid(2R)-2-amino-5-guanidinopentanoic acidR54Z304Z7C
名称をさらに表示
D-(-)-アルギニンD-アルギニン(R)-2-アミノ-5-グアニジノペンタン酸(R)-2-アミノ-5-(アミジノアミノ)吉草酸(-)-D-アルギニン(-)-アルギニンD(-)-アルギニンアルギニン, D-D-ARGH-D-ARG-OHD-Arg-OHD-(-)-ARGININEH-D-ArginineR-(-)-ARGININED-Arginine，98%
(2R)-2-amino-5-[(diaminomethylidene)amino]pentanoic acidCHEBI:15816DTXSID40883354(2R)-2-amino-5-(carbamimidamido)pentanoic acid(2R)-2-amino-5-((diaminomethylidene)amino)pentanoic acidRefChem:582678DTXCID601022891InChI=1/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m1/s
物性
構造計算による物性
- XLogP
- -4.2
- 極性表面積
- 128 Ų
- 水素結合供与体数
- 4
- 水素結合受容体数
- 4
- 回転可能結合数
- 5
- 重原子数
- 12
- 形式電荷
- 0
- 複雑度
- 176
実験および物理化学的性質
SpringerMaterials PropertiesChemical shift
Physical DescriptionSolid
物理化学的性質
- 融点
- 226 °C · 226 °C (dec.) (lit.)
- 比旋光度
- -28.5 · -28.5 º (c=8, 6 N HCl)
- 沸点
- 305.18 °C · 305.18°C (rough estimate)
- 比重(密度)
- 1.2297 · 1.2297 (rough estimate)
- 屈折率
- -23 ° · -23 ° (C=8, 6mol/L HCl)
- 貯蔵温度
- Keep in dark place,Inert atmosphere,Room temperature
- 溶解性
- 水性酸（わずかに）、水（わずかに）
- 外見
- 個体
- 酸解離定数(Pka)
- 2.49 · 2.49±0.24(Predicted)
- 色
- ホワイトからオフホワイト
- 水溶解度
- 溶ける
- 比熱容量
- 1.33 J/ · Cp(crystal): 1.33 J/(g·K), at 25℃
- BRN
- 1725412 · 1725412
- 主な用途
- ペプチド合成
- InChI
- 1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m1/s1
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
GHS分類
GHS Classification
This chemical does not meet GHS hazard criteria for 82.6% (38 of 46) of all reports.
Warning
H319 (17.4%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
P264+P265, P280, P305+P351+P338, and P337+P317 (click each P-code to see the statement)
Aggregated GHS information provided per 46 reports by companies from 4 notifications to the ECHA C&L Inventory.
危険有害性情報
Hazard Classes and CategoriesEye Irrit. 2A (17.4%)
安全データ
- F
- 9
- wgk
- 3
- tsca
- TSCA listed
- rtecs
- CF1934220
- hs_code
- 29252000
- risk_code
- 36-36/37/38-20/21/22
- hazard_code
- Xi,Xn
- safety_code
- 26-36
- hazard_class
- IRRITANT
- ストレージクラス
- 11 - Combustible Solids
化学と産業
薬理情報
Tissue LocationsEpidermis
Cellular LocationsPeroxisome
Metabolite PathwaysD-Arginine and D-Ornithine Metabolism
用途と製造
General Manufacturing InformationD-Arginine: ACTIVE
応用分野
用途アミノ酸研究用、D-体ペプチド合成原料。
説明D-arginine is the D-form of arginine, which is a kind of amino acids. It can be reacted with hydrogen peroxide for non-enzymatic synthesis of nitric oxide. It has certain pharmacological activities. For example, its derivative, 1-deamino-8-D-arginine vasopressin is useful for the management of haemophilia and von Willebrand’s disease. It also has the potential to inhibit the proliferation of certain cancer cells. In biological research, D-arginine is frequently used in the studies of L-arginine/nitric oxide pathway as an inactive form of L-arginine.
使用Arginine is an essential amino acid found in food and plant sources, and many biological systems. D-Arginine is extensively used in studies on L-arginine/nitric oxide pathway as an inactive form of L-arginine, even in man. D-Arginine is slightly soluble (in water) and a moderately acidic compound (based on its pKa). D-Arginine can be found in human epidermis and platelet tissues. Within the cell, D-arginine is primarily located in the peroxisome. D-Arginine specifically can inhibit arginine decarboxylase enzymes and also functions as a metabolite.
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