D-Tyrosine (HCID 71098)

名称と識別子

優先名称: D-Tyrosine
IUPAC: (2R)-2-amino-3-(4-hydroxyphenyl)propanoic acid
現地名: D-チロシン
英語名: D-Tyrosine
分子式: C9H11NO3
分子量: 181.19

名称と別名

D-tyrosine556-02-5(2R)-2-amino-3-(4-hydroxyphenyl)propanoic acidD-TyrD-Tyrosin(R)-TYROSINEWQ5G9JQ7GCCHEBI:28479(R)-3-(p-Hydroxyphenyl)alanineEINECS 209-112-6D-4-HYDROXYPHENYLALANINEDTXSID50883441

名称をさらに表示

D-チロシンDチロシンD‐チロシンD(+)-チロシンチロシン, D-Ｄ-3-(4-ヒドロキシフェニル)アラニンD-Tyr-OHD-THREONINOLD(+)-TYROSINED-thyrosineTYROSINE, D-D-p-TyrosineD-Tyrosine98%

(R)-2-Amino-3-(p-hydroxyphenyl)propionic acid2-amino-3-(4-hydroxyphenyl)-propanoic acidRefChem:585118DTXCID601022972(2R)-2-azaniumyl-3-(4-hydroxyphenyl)propanoate209-112-6H-D-Tyr-OH(R)-2-amino-3-(4-hydroxyphenyl)propanoic acid

データベース識別子

CAS: 556-02-5
PubChem CID: 71098
DTXSID: DTXSID50883441
ChEMBL: CHEMBL1076637
ChEBI: CHEBI:28479
UNII: WQ5G9JQ7GC
EC Number: 209-112-6
Nikkaji: J9.196K

物性

構造計算による物性

XLogP: -2.3
極性表面積: 83.6 Å²
水素結合供与体数: 3
水素結合受容体数: 4
回転可能結合数: 3
重原子数: 13
形式電荷: 0
複雑度: 176

実験および物理化学的性質

Solubility453

物理化学的性質

融点: 300 °C · >300 °C (lit.)
比旋光度: 11.3 · 11.3 º (c=5, 1N HCl)
沸点: 314.29 °C · 314.29°C (rough estimate)
比重(密度): 1.2375 · 1.2375 (rough estimate)
屈折率: 11.2 ° · 11.2 ° (C=5, 1mol/L HCl)
貯蔵温度: Store at RT.
溶解性: 水性酸（わずかに）、メタノール（わずかに）、水（わずかに）
酸解離定数(Pka): 2.25 · 2.25±0.10(Predicted)
外見: 結晶または粉末
色: ホワイトからオフホワイト
水溶解度: 溶ける
Merck: 14 · 14,9839
BRN: 2212157 · 2212157
主な用途: ペプチド合成
化粧品成分の機能: 香料ヘアコンディショニング帯電防止スキンコンディショニング
InChI: 1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m1/s1
InChIKey: OUYCCCASQSFEME-UHFFFAOYSA-N
SMILES: N[C@H](Cc1ccc(O)cc1)C(O)=O
LogP: -0.418 · -0.418 (est)
CAS データベース: 556 · 556-02-5(CAS DataBase Reference)
EPAの化学物質情報: D-Tyrosine (556-02-5)

化学的性質

化学的特性white to off-white powder

安全と法規制

GHS分類

GHS Classification · 6 件

This chemical does not meet GHS hazard criteria for 82.4% (42 of 51) of all reports.

Warning

H315 (17.6%): Causes skin irritation [Warning Skin corrosion/irritation]；H319 (17.6%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H335 (15.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 51 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Reported as not meeting GHS hazard criteria per 42 of 51 reports by companies.；There are 6 notifications provided by 9 of 51 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

危険有害性情報

Regulatory InformationChemical: D-Tyrosine

Other Safety InformationIMAP assessments - D-Tyrosine: Environment tier I assessment；Evaluation - Chemicals that are unlikely to require further regulation to manage risks to human health

Hazard Classes and CategoriesSkin Irrit. 2 (17.6%)；Eye Irrit. 2 (17.6%)；STOT SE 3 (15.7%)

法規制情報

Regulatory InformationChemical: D-Tyrosine

安全データ

wgk: 3
tsca: TSCA listed
hs_code: 29225000
risk_code: 36/37/38
化審法: (9)-1596 届出不要化学物質
hazard_code: Xi
safety_code: 26-36-24/25
ストレージクラス: 13 - Non Combustible Solids

化学と産業

用途と製造

General Manufacturing InformationD-Tyrosine: INACTIVE

応用分野 · 1 件

使用D-Tyrosine, the stereoisomer to L-Tyrosine (T899975), is an amino acid used in various organic syntheses for antibiotics. It is used in the synthesis of (-)-anisomycin, as well as BATSI (boronic acid transition state inhibitors) which act on β-lactamases. It has also been studied as an inhibitor of microbial growth on surfaces, reducing microbial attachment to hydrophillic glass and hydrophobic po lypropylene surfaces.

上流・下流製品情報

上流原料

クロロアセチルクロリド DL-チロシン

下流製品

N-BOC-O-ベンジル-D-チロシン 3,5-ジブロモ-D-チロシン N,O-ジ-BOC-D-チロシン 3-Bromo-D-Tyrosine

サプライヤー50 社

国药集团化学试剂有限公司86-21-63210123 · [email protected]

北京华美互利生物化工010-56205725 · [email protected]

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

INTATRADE GmbH+49 3493/605464 · [email protected]

補足説明 · 2 件

定義本品は、次の化学式で表されるアミノ酸である。

定義ChEBI: D-tyrosine is an optically active form of tyrosine having D-configuration. It has a role as an Escherichia coli metabolite. It is a tyrosine and a D-alpha-amino acid. It is a conjugate base of a D-tyrosinium. It is a conjugate acid of a D-tyrosinate(1-). It is an enantiomer of a L-tyrosine. It is a tautomer of a D-tyrosine zwitterion.