2-イソブチルキノリン

This chemical does not meet GHS hazard criteria for 98.2% (1385 of 1411) of all reports.

Not Classified

Aggregated GHS information provided per 1411 reports by companies from 3 notifications to the ECHA C&L Inventory.

Chemical: Quinoline, 2-(2-methylpropyl)-

Quinoline, 2-(2-methylpropyl)-: Does not have an individual approval but may be used under an appropriate group standard

The existing information was reviewed by the independent Expert Panel for Fragrance Safety and supports the use of 2-Isobutylquinoline as described in this fragrance ingredient safety assessment. Target data show that 2-isobutylquinoline is not genotoxic. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class III material, and the exposure to 2-isobutylquinoline is below the TTC (0.0015 mg/kg/day, 0.0015 mg/kg/day, and 0.47 mg/day, respectively). Data from read-across analog quinoline (CAS # 91-22-5) show that there are no safety concerns for 2-isobutylquinoline for skin sensitization under the current declared levels of use. The photoirritation endpoint was evaluated based on data and ultraviolet/visible (UV/Vis) spectra; 2-isobutylquinoline is not photoirritating. 2-isobutylquinoline is not photoallergenic based on the UV/Vis spectra.

The existing information was reviewed by the independent Expert Panel for Fragrance Safety and supports the use of 2-Isobutylquinoline as described in this fragrance ingredient safety assessment. It was determined not to be Persistent, Bioaccumulative, or Toxic (PBT) according to the International Fragrance Association (IFRA) Environmental Standards. The 2-Isobutylquinoline risk quotients (RQs), calculated based on its current volume of use (VoU) in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are less than 1.