基本情報
- CAS
3847-29-8- 標準SMILES
CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O.O=C(O)[C@H](O)[C@@H](O)[C@H](O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)[C@H](O)CO- InChIKey
NNRXCKZMQLFUPL-WBMZRJHASA-N- 分子式
- C49H89NO25
- 平均分子量
- 1,092.2 g/mol
- 単同位体質量
- 1,091.57236735
概要
Erythromycin Lactobionate is the lactobionate salt form of erythromycin, a broad-spectrum, topical macrolide antibiotic with antibacterial activity. Erythromycin lactobionate diffuses through the bacterial cell membrane and reversibly binds to the 50S subunit of the bacterial ribosome. This prevents bacterial protein synthesis. Erythromycin lactobionate may be bacteriostatic or bactericidal in action, depending on the concentration of the drug at the site of infection and the susceptibility of the organism involved.
名称と識別子
- 優先名称
- Erythromycin Lactobionate
- IUPAC
- (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione;(2R,3R,4R,5R)-2,3,5,6-tetrahydroxy-4-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexanoic acid
- 現地名
- エリスロマイシンラクトビオン酸塩
- 英語名
- ERYTHROMYCIN LACTOBIONATE (200 MG)
- 分子式
- C37H67NO13.C12H22O12
- 分子量
- 1092.22
名称と別名
erythromycin lactobionate3847-29-833H58I7GLQErythromycini lactobionasErythromycin mono(4-O-beta-D-galactopyranosyl-D-gluconate) (salt)DTXSID801009322Erythrocin LactobionateRefChem:55127DTXCID401436149(2R,3S,4S,5R,6R,8R,10R,11R,12S,13R)-5-(3,4,6-Trideoxy-3-dimethylamino-beta-D-xylo-hexopyranosyloxy)-3-(2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyloxy)-6,11,12-trihydroxy-2,4,6,8,10,12-hexamethyl-9-oxopentadecan-13-olide mono(4-O-beta-D-galactopyranosyl-D-gluconate)223-348-7n-2,10-dion(1:1)
名称をさらに表示
4-O-β-D-ガラクトピラノシル-D-グルコン酸/エリトロマイシン,(1:1)ラクトビオン酸エリスロマイシンエリスロマイシン·4-O-β-D-ガラクトピラノシル-D-グルコン酸エリスロマイシンラクトビオン酸塩エリスロマイシンラクトビオン酸塩 (JP17)エリスロマイシン・4-O-β-D-ガラクトピラノシル-D-グルコン酸Azithromycin lactobionateERYTHROMYCIN LACTOBIONATE USP(CRM STANDARD)Lactose azithroMycinC37H67NO13.C12H22O12Erythomycin lactobionateMoxifloxacin Impurity 146Erythromycin lactobionate CRS
Erythromycin lactobionate (1:1) (salt)Erythromycin lactobionate [JAN]EINECS 223-348-7Erythrocin Lactobionate IVUNII-33H58I7GLQErythromycin A Lactobionate; (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-4-[(2,6-dideoxy-3-C-methyl-3-O-methyl-a-l-ribo-hexopyranosyl)oxy]-14-ethyl-7,12,13-trihydroxy-3,5,7,9,11,13-hexamethyl-6-[[3,4,6-trideoxy-3-(dimethylamino)-ss-d-xylo-hexopyranosyl]oxy]oxacyclotetradecane-2,10-dione 4-O-ss-d-galactopyranosyl-d-gluconateErythromycin lactobionate [USP:BAN:JAN]Erythromycin iactobionate
データベース識別子
- CAS
3847-29-8- PubChem CID
- 71469
- DTXSID
DTXSID801009322- ChEMBL
CHEMBL1200506- UNII
- 33H58I7GLQ
- EC Number
- 223-348-7
物性
構造計算による物性
- 極性表面積
- 412 Ų
- 水素結合供与体数
- 14
- 水素結合受容体数
- 26
- 回転可能結合数
- 15
- 重原子数
- 75
- 形式電荷
- 0
- 複雑度
- 1,580
実験および物理化学的性質
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
物理化学的性質
- 融点
- 145 · 145-150°
- 比重(密度)
- 0.9083 · 0.9083 (rough estimate)
- 屈折率
- 1.53 · 1.5300 (estimate)
- 貯蔵温度
- Refrigerator
- 溶解性
- 水に溶けやすく、無水エタノールとメタノールに溶けやすく、アセトンとジクロロメタンに非常に溶けにくい。
- 外見
- 個体
- 色
- ホワイトからオフホワイト
- 水溶解度
- 20 g/L · >20g/L(21℃)
- 主な用途
- USPバイオ医薬品医薬品（低分子化合物）
- InChIKey
- NNRXCKZMQLFUPL-FACXKIDONA-N
化学的性質
化学的特性White or slightly yellow hygroscopic, powder.
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
危険有害性情報
Other Safety InformationIMAP assessments - D-Gluconic acid, 4-O-.beta.-D-galactopyranosyl-, compound with erythromycin (1:1): Environment tier I assessment
安全データ
- wgk
- WGK 3
- hs_code
- 2941500000
- ストレージクラス
- 11 - Combustible Solids
化学と産業
薬理情報
FDA Pharmacological Classification
ERYTHROMYCIN LACTOBIONATE
Macrolides [CS]; Decreased Sebaceous Gland Activity [PE]; Macrolide [EPC]; Macrolide Antimicrobial [EPC]
MeSH Pharmacological Classification
Drugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility and water flow, and improve digestion.
Substances that inhibit the growth or reproduction of BACTERIA.
応用分野
説明Erythromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by targeting the 50S ribosomal subunit, blocking the progression of nascent polypeptide chains. It is effective against a host of bacterial genera, including Streptococcus, Staphylococcus, and Haemophilus (MIC90s range from 0.015-2.0 mg/l). Erythromycin is known to potently inhibit the cytochrome P450 isoform CYP3A4, which can affect the metabolism of numerous clinically relevant medications. Erythromycin lactobionate is a soluble salt of erythromycin that is typically used for intraperitoneal or intravenous injections.
使用Macrolide antibacterial.
一般的な説明Erythromycin lactobionate is a water-soluble salt preparedby reacting erythromycin base with lactobiono-σ-lactone. Itoccurs as an amorphous powder that is freely soluble inwater and alcohol and slightly soluble in ether. It is intended,after reconstitution in sterile water, for intravenousadministration to achieve high plasma levels in the treatmentof serious infections.
上流・下流製品情報
上流原料
サプライヤー88 社
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