Sodium Citrate Dihydrate (HCID 71474)

概要

Sodium citrate dihydrate is the dihydrate of trisodium citrate. It has a role as an anticoagulant. It contains a sodium citrate.

名称と識別子

優先名称: Sodium Citrate Dihydrate
IUPAC: trisodium;2-hydroxypropane-1,2,3-tricarboxylate;dihydrate
現地名: くえん酸三ナトリウム二水和物
英語名: Trisodium citrate dihydrate
分子式: C6H9Na3O9
分子量: 294.1

名称と別名

Trisodium citrate dihydrateSodium citrate dihydrate6132-04-3Sodium citrate hydrateB22547B95KCitric acid, trisodium salt, dihydrateSodium citrate hydrousEmetrol Chewables OrangeNauzeneDTXSID1049437CHEBI:32142N-1560

名称をさらに表示

くえん酸三ナトリウム二水和物クエン酸ナトリウム水和物(U‐E)くえん酸三ナトリウム,2水和物くえん酸三ナトリウム(2水和物)第三くえん酸ナトリウム二水和物クエン酸ナトリウム水和物「製造専用」TRISODIUM CITRATE 二水和物クエン酸三ナトリウム二水和物クエン酸ナトリウム水和物クエン酸ナトリウム水和物 (JP17)くえん酸トリナトリウム・2水和物くえん酸三ナトリウム・2水和物クエン酸ナトリウム・2水和物クエン酸ナトリウム水和物(U-E)クエン酸三ナトリウム(結晶)くえん酸三ナトリウム二水和物(くえん酸ナトリウム,第三)CITRIC ACID MONOSODIUM CITRATE TRIBASIC DIHYDRATETRI-SODIUM CITRATE DIHYDRATESODIUM CITRATE, DIHYDRATESodiuM Citrate (AS)SODIUM CITRATE TRISODIUM SALT DIHYDRATENATRII CITRASTRI-SODIUM CITRATE 2H2OSodiumCitrateTribasicUspACIDUM CITRICUM MONOHYDRICUM

Natrii citras, dehydrateAnticoagulant Sodium CitrateTricitrasolEmetrol PowderEmetrol ChewablesNauzene ChewablesCVS HealthRefChem:6335

データベース識別子

CAS: 6132-04-3
PubChem CID: 71474
DTXSID: DTXSID1049437
ChEBI: CHEBI:32142
UNII: B22547B95K
EC Number: 612-118-5

物性

構造計算による物性

極性表面積: 143 Å²
水素結合供与体数: 3
水素結合受容体数: 9
回転可能結合数: 2
重原子数: 18
形式電荷: 0
複雑度: 211

実験および物理化学的性質

Chemical ClassesMetals -> Organic Acids, Metal Salts

SolubilitySolubility in water, g/100ml: 77

Animal DrugsPharmaceuticals -> UK Veterinary Medicines Directorate List

Decomposition150 °C

Physical Description · 2 件

White odorless solid; [Merck Index] Colorless odorless crystalline powder; [Alfa Aesar MSDS]

WHITE SOLID IN VARIOUS FORMS.

物理化学的性質

融点: 300 °C · >300 °C(lit.)
比重(密度): 1.76 · 1.76
FEMA: 3026 · 3026 | SODIUM CITRATE
闪点: 173.9 °C · 173.9 °C
貯蔵温度: 5 °C · Store at +5°C to +30°C.
溶解性: 2 O: · H2O: 100 mg/mL
外見: 粉
酸解離定数(Pka): 6.4 · 6.40
色: 白い
臭い (Odor): 無臭
PH: 7 · 7.0-9.0 (25℃, 50mg/mL in H2O)
由来生物: synthetic
水溶解度: 720 g/L · 720g/L(25℃)
Merck: 14 · 14,8602
BRN: 6104939 · 6104939
安定性: 安定。塩基、還元剤、酸化剤と相容れない。
化粧品成分の機能: キレート化香料バッファリング
InChI: 1S/C6H8O7.3Na.2H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;;2*1H2/q;3*+1;;/p-3
InChIKey: NLJMYIDDQXHKNR-UHFFFAOYSA-K
SMILES: O.O.[Na+].[Na+].[Na+].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O
LogP: -1.72 · -1.72
CAS データベース: 6132 · 6132-04-3(CAS DataBase Reference)
EPAの化学物質情報: 1 · 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, trisodium salt, dihydrate (6132-04-3)
Absorption: 0.015 at · ≤0.015 at 260nm≤0.015 at 280nm

化学的性質

化学的特性white powder or colourless crystals

安全と法規制

GHS分類

GHS Classification · 3 件

This chemical does not meet GHS hazard criteria for 97% (520 of 536) of all reports.

Not Classified

Aggregated GHS information provided per 536 reports by companies from 4 notifications to the ECHA C&L Inventory.

危険有害性情報

Regulatory Information · 2 件

Chemical: 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, trisodium salt, dihydrate

Trisodium citrate dihydrate: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, trisodium salt, dihydrate: Human health tier I assessment

Fire HazardsCombustible.

Hazards SummaryAn eye and respiratory tract irritant; [ICSC] May cause irritation; [Alfa Aesar MSDS] See Sodium citrate, anhydrous.

EPA Safer ChemicalChemical: Sodium citrate, dihydrate

Chemical DangersThe solution in water is a weak base.

安全と保護具

Fire FightingUse water spray, powder.

First Aid Measures · 4 件

Fresh air, rest.

Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth.

Spillage DisposalSweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water.

Eye PreventionWear safety spectacles.

Fire PreventionNO open flames.

Inhalation RiskEvaporation at 20 °C is negligible; a nuisance-causing concentration of airborne particles can, however, be reached quickly when dispersed.

毒性情報

Exposure RoutesThe substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Signs and Symptoms · 2 件

Cough. Sore throat.

Redness.

安全データ

wgk: 1
tsca: Yes
rtecs: GE7810000
毒性: LD50 orally in Rabbit: > 8000 mg/kg
hs_code: 2918 15 00
risk_code: 37/38-41-36/37/38
hazard_code: Xi
safety_code: 26-36/37/39-24/25-36
ストレージクラス: 11 - Combustible Solids

化学と産業

薬理情報

FDA Pharmacological Classification · 4 件

SODIUM CITRATE DIHYDRATE

Anti-coagulant [EPC]; Acidifying Activity [MoA]; Calculi Dissolution Agent [EPC]; Decreased Coagulation Factor Activity [PE]; Calcium Chelating Activity [MoA]

TRISODIUM CITRATE DIHYDRATE

Anti-coagulant [EPC]; Acidifying Activity [MoA]; Calculi Dissolution Agent [EPC]; Calcium Chelating Activity [MoA]; Decreased Coagulation Factor Activity [PE]

MeSH Pharmacological Classification · 3 件

Agents that prevent BLOOD CLOTTING.

A chemical system that functions to control the levels of specific ions in solution. When the level of hydrogen ion in solution is controlled the system is called a pH buffer.

Substances capable of inhibiting, retarding or arresting the process of fermentation, acidification or other deterioration of foods.

用途と製造

Uses · 2 件

Used in blood collection (anticoagulant), photography, and food production (sequestering agent, emulsifier, and acidulant); [Merck Index] Permitted for use as an inert ingredient in non-food pesticide products; [EPA]

Photographic Processing [Category: Other]

Household ProductsInformation on 307 consumer products that contain Sodium citrate dihydrate in the following categories is provided:

Use Classification · 2 件

EPA Safer Chemical Functional Use Classes -> Chelating Agents;Preservatives and Antioxidants;Processing Aids and Additives

Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern

応用分野 · 4 件

用途pH緩衝剤、医薬品原料、写真材料。

用途製薬、製剤原料。

使用Trisodium citrate dihydrate, is widely applied in food, beverages and fillers as a buffering, sequestering or an emulsifying agent. It used as an anticoagulant in blood transfusions, osmotic laxative, functional fluids, solvents cleaning, furnishing care products, laundry dishwashing products and cleaning automobile radiators.

一般的な説明Sodium citrate tribasic dihydrate is the tribasic dihydrate sodium salt of citric acid.

調製方法

Sodium citrate is prepared by adding sodium carbonate to a solution of citric acid until effervescence ceases. The resulting solution is filtered and evaporated to dryness.

純化方法Crystallise the salt from warm water by cooling to 0o. [Beilstein 3 III 1100, 3 IV 1274.]