Odm-203

HCID 71554322

基本情報

CAS: 1430723-35-5
標準SMILES: Cn1cc(-c2ccc3c(c2)ncn3-c2cc(NS(=O)(=O)C3CC3)cc(-c3ccc(F)cc3F)c2)cn1
InChIKey: ZJFCBQXPTQSTCZ-UHFFFAOYSA-N
分子式: C26H21F2N5O2S
平均分子量: 505.5 g/mol

概要

VEGFR/FGFR Inhibitor ODM-203 is an orally available inhibitor of the human vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs), with potential antiangiogenic and antineoplastic activities. VEGFR/FGFR inhibitor ODM-203 inhibits both VEGFRs and FGFRs, which may result in the inhibition of VEGFR- and FGFR-mediated signaling. This leads to an inhibition of angiogenesis and cell proliferation in tumor cells overexpressing VEGFR and/or FGFR. Both VEGFRs and FGFRs belong to the superfamily of receptor tyrosine kinases and are upregulated in various tumor cell types.

名称と識別子

優先名称: Odm-203
IUPAC: N-[3-(2,4-difluorophenyl)-5-[5-(1-methylpyrazol-4-yl)benzimidazol-1-yl]phenyl]cyclopropanesulfonamide
英語名: ODM203
分子式: C26H21F2N5O2S
分子量: 505.54

名称と別名

ODM-203ODM203Cyclopropanesulfonamide, N-(2',4'-difluoro-5-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzimidazol-1-yl)(1,1'-biphenyl)-3-yl)-N-(2',4'-Difluoro-5-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzimidazol-1-yl)(1,1'-biphenyl)-3-yl)cyclopropanesulfonamideRefChem:167937ODM-203 [WHO-DD]ODM 203VEGFR/FGFR Inhibitor ODM-2031430723-35-5N-[3-(2,4-difluorophenyl)-5-[5-(1-methylpyrazol-4-yl)benzimidazol-1-yl]phenyl]cyclopropanesulfonamideN-(2',4'-Difluoro-5-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-[1,1'-biphenyl]-3-yl)cyclopropanesulfonamideY7HJ4D4CRT

名称をさらに表示

ODM-203 ，S8882ODM-203, 10 mM in DMSON-[2',4'-Difluoro-5-[5-(1-methyl-1H-pyrazol-4-yl)-1H-benzimidazol-1-yl][1,1'-biphenyl]-3-yl]cyclopropanesulfonamideCyclopropanesulfonamide, N-[2',4'-difluoro-5-[5-(1-methyl-1H-pyrazol-4-yl)-1H-benzimidazol-1-yl][1,1'-biphenyl]-3-yl]-anti-tumor immunity,ODM-203,FGFR,HUVEC,H1581,Inhibitor,cancer,Vascular endothelial growth factor receptor,SNU16,ODM203,ODM 203,RT4,Fibroblast growth factor receptor,VEGFR,inhibit

MFCD320627831814961-19-7N-[2 inverted exclamation marka,4 inverted exclamation marka-difluoro-5-[5-(1-methyl-1H-pyrazol-4-yl)-1H-benzimidazol-1-yl][1,1 inverted exclamation marka-biphenyl]-3-yl]-cyclopropanesulfonamideUNII-Y7HJ4D4CRTorb1299661C26H21F2N5O2SCHEMBL3964954SCHEMBL16342978

データベース識別子

CAS: 1430723-35-5
PubChem CID: 71554322
ChEMBL: CHEMBL3964954
UNII: Y7HJ4D4CRT

物性

構造計算による物性

XLogP: 4.4
極性表面積: 90.2 Å²
水素結合供与体数: 1
水素結合受容体数: 7
回転可能結合数: 6
重原子数: 36
形式電荷: 0
複雑度: 886

物理化学的性質

沸点: 732.4 · 732.4±70.0 °C(Predicted)
比重(密度): 1.48 · 1.48±0.1 g/cm3(Predicted)
貯蔵温度: -20 °C · Store at -20°C
溶解性: 66.67 mg/mL · DMSO : 66.67 mg/mL (131.88 mM; Need ultrasonic)
外見: A crystalline solid
酸解離定数(Pka): 7.88 · 7.88±0.20(Predicted)
色: White to yellow

安全と法規制

安全データ

注意喚起語: 警告
危険有害性情報: コード危険有害性情報危険有害性クラス区分注意喚起語シンボル P コード H302

化学と産業

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上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]

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上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]

江苏艾康生物医药研发有限公司025-025-66113011 15955137747 · [email protected]

化合物ノート

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