基本情報
- CAS
59625-89-7- 標準SMILES
O.O.O=C([O-])[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.O=C([O-])[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.[Mg+2]- InChIKey
HJWFTNWQKDPLAS-ACMDZETANA-L- 分子式
- C12H26MgO16
- 平均分子量
- 450.63 g/mol
- 単同位体質量
- 450.1071264
概要
Magnesium gluconate is a magnesium salt of gluconate. It demonstrates the highest oral bioavailability of magnesium salts and is used as a mineral supplement. Magnesium is ubiquitous in the human body, and is naturally present in many foods, added to other food products, available as a dietary supplement and used as an ingredient in some medicines (such as antacids and laxatives). Although magnesium is available in the form of sulphates, lactate, hydroxide, oxide and chloride, only magnesium gluconate is recommended for magnesium supplementation as it appears to be better absorbed and causes less diarrha. This drug has been studied in the prevention of pregnancy-induced hypertension, and has displayed promising results. In addition, it has been studied for its effects on premature uterine contractions.
名称と識別子
- 優先名称
- Magnesium Gluconate
- IUPAC
- magnesium;bis((2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate);dihydrate
- 現地名
- グルコン酸マグネシウム
- 英語名
- MAGNESIUM GLUCONATE, DIHYDRATE
- 分子式
- C12H26MgO8
- 分子量
- 322.64
名称と別名
Magnesium gluconate59625-89-7Magnesium D-gluconate (1:2) hydrateT42NAD2KHCMagnesium D-gluconate (1:2) dihydrateMagnesium gluconicumMagnesium gluconate,dihydrateMagnesium (as gluconate)E-580(magnesium gluconate)Ins-580(magnesium gluconate)D-Gluconic acid, magnesium salt (2:1), hydrateIns no.580(magnesium gluconate)
名称をさらに表示
ビス(D-グルコン酸)マグネシウム・2水和物グルコン酸マグネシウムMagnesium gluconate 2 HydrateMAGNESIUM GLUCONATE, DIHYDRATEMagnesium D-gluconate dihydrateMAGNESIUMGLUCONATE,DIHYDRATE,FCCMANGANESE(II) GLUCONATE DIHYDRATEMAGNESIUMGLUCONATE,DIHYDRATE,PURIFIEDMAGNESIUM GLUCONATE DIHYDRATE GRANULAR USPD-Gluconic acid hydrate magnesium salthigh qualtiy Magnesium Gluconate, DihydrateMAGNESIUM GLUCONATE DIHYDRATE GRANULAR USP (G)
RefChem:800525UNII-T42NAD2KHCMagnesium gluconate [EP]Magnesium gluconate [USP]magnesium gluconate dihydrateMagnesium (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate dihydratemagnesium;(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate;dihydrateSCHEMBL3411059
物性
構造計算による物性
- 極性表面積
- 285 Ų
- 水素結合供与体数
- 12
- 水素結合受容体数
- 16
- 回転可能結合数
- 8
- 重原子数
- 29
- 形式電荷
- 0
- 複雑度
- 165
実験および物理化学的性質
Food AdditivesNUTRIENT SUPPLEMENT -> FDA Substance added to food
SolubilitySoluble in cold water
物理化学的性質
- 融点
- 200 °C · 200 °C (dec.)(lit.)
- 主な用途
- 医薬品（低分子化合物）医薬品
- InChI
- InChI=1/2C6H12O7.Mg.2H2O/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;;;/h2*2-5,7-11H,1H2,(H,12,13);;2*1H2/q;;+2;;/p-2/t2*2-,3-,4+,5-;;;/s3
- InChIKey
- HJWFTNWQKDPLAS-ACMDZETANA-L
- SMILES
- [Mg+2].C([O-])(=O)[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O.C([O-])(=O)[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O.[H]O[H].[H]O[H] |&1:4,5,6,7,17,18,19,20,r|
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
GHS分類
GHS ClassificationNot Classified
危険有害性情報
Regulatory InformationMagnesium gluconate dihydrate: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Hazard Classes and CategoriesNot Classified
安全データ
- wgk
- 3
- ストレージクラス
- 11 - Combustible Solids
化学と産業
薬理情報
ATC Code
A - Alimentary tract and metabolism
QA - Alimentary tract and metabolism
Protein BindingApproximately 25-30%. Of the protein bound fraction, 60–70% is associated with albumin and the rest is bound to other globulins.
Pharmacodynamics
Magnesium is a cofactor in over 300 enzyme systems that regulate a variety of biochemical reactions in the body, including protein synthesis, muscle and nerve function, blood glucose control, and blood pressure regulation. Magnesium is necessary for energy production, oxidative phosphorylation, and glycolysis.
Mechanism of Action
Replaces deficient circulating levels of magnesium. By competing with calcium for membrane binding sites and by stimulating calcium sequestration by sarcoplasmic reticulum, magnesium helps in the maintenance of a low resting intracellular free calcium ion concentration, which is essential in various cellular functions. The electrical properties of membranes and their permeability characteristics are also affected by magnesium. Magnesium is essential to many enzymatic reactions in the body, serving as a cofactor in protein synthesis and in carbohydrate metabolism. Magnesium contributes to the structural development of bone and is also essential in the synthesis of DNA, RNA, and the antioxidant glutathione. Magnesium also plays an important role in the active transport of calcium and potassium ions across cell membranes, a process which is important to nerve impulse conduction, muscle contraction, and normal heart rhythm. In addition to the above, magnesium is an essential mineral required for the regulation of body temperature, nucleic acid and protein synthesis, and in preserving nerve and muscle cell electrical potentials. Magnesium supplementation during pregnancy may help to reduce fetal growth restriction and pre-eclampsia, as well to increase birth weight.
Absorption, Distribution and Excretion
A high-fat diet may decrease the amount of magnesium absorbed in the diet. Over-cooking food also may decrease the amount of magnesium absorbed from dietary sources. About 1/3 of magnesium is absorbed from the small intestine. The fraction of magnesium absorbed is inversely proportional to amount ingested. Oral absorption is estimated to be 15% to 30%.
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