Lufenuron (HCID 71777)

名称と識別子

優先名称: Lufenuron
IUPAC: N-[[2,5-dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl]carbamoyl]-2,6-difluorobenzamide
現地名: ルフェヌロン
英語名: Lufenuron
分子式: C17H8Cl2F8N2O3
分子量: 511.15

名称と別名

Lufenuron103055-07-8FluphenacurLufenuroneLufenuronumDTXSID5034357Program flavor tabsPROGRAMN-((2,5-Dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl)carbamoyl)-2,6-difluorobenzamideCGA-1846991-(2,5-Dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl)-3-(2,6-difluorobenzoyl)ureaNSC-759097

名称をさらに表示

ルフェヌロン標準品ルフェヌロン（ＲＳ）-１-［２,５-ジクロロ-４-（１,１,２,３,３,３-ヘキサフルオロプロポキシ）フェニル］-３-（２,６-ジフルオロベンゾイル）ウレア(RS)-1-[2?5-ジクロロ-4-(1?1?2?3?3?3-ヘキサフルオロプロポキシ)フェニル]-3-(2?6-ジフルオロベンゾイル)ウレアCS_N-12325-100MG_ルフェヌロンルフェヌロン STANDARDルフェヌロン標準物質ルフェヌロン Standard, 100 µg/mL in MethanolN-[2,5-ジクロロ-4-(1,1,2,3,3,3-ヘキサフルオロプロポキシ)フェニルカルバモイル]-2,6-ジフルオロベンズアミドマッチ3-[2,5-ジクロロ-4-(1,1,2,3,3,3-ヘキサフルオロプロポキシ)フェニル]-1-(2,6-ジフルオロベンゾイル)尿素1-[2,5-ジクロロ-4-(1,1,2,3,3,3-ヘキサフルオロプロポキシ)フェニル]-3-(2,6-ジフルオロベンゾイル)尿素Lufenuron for peak identificationLufenuron 97%Lufenuron@1000 μg/mL in AcetoneLufenurincga-184,699

N-[[2,5-dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl]carbamoyl]-2,6-difluorobenzamide1R754M4918DTXCID3014357CHEBI:39384N-{[2,5-dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl]carbamoyl}-2,6-difluorobenzamideN-({[2,5-dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl]amino}carbonyl)-2,6-difluorobenzamideN-(((2,5-DICHLORO-4-(1,1,2,3,3,3-HEXAFLUOROPROPOXY)PHENYL)AMINO)CARBONYL)-2,6-DIFLUOROBENZAMIDEProgram Suspension

データベース識別子

CAS: 103055-07-8、130841-22-4、130841-26-8
PubChem CID: 71777
DTXSID: DTXSID5034357
ChEMBL: CHEMBL1364906
ChEBI: CHEBI:39384
UNII: 1R754M4918、4629851K7Q、9CR45YMS74
EC Number: 410-690-9
Nikkaji: J481.190I

物性

構造計算による物性

XLogP: 6.4
極性表面積: 67.4 Å²
水素結合供与体数: 2
水素結合受容体数: 11
回転可能結合数: 5
重原子数: 32
形式電荷: 0
複雑度: 677

実験および物理化学的性質

Collision Cross Section · 4 件

205.4 Å² [M-H]- [CCS Type: DT; Buffer gas: N2; Ionization: ESI-; Dataset: TOXCAST; Source Identifier: DTXSID5034357]

198.53 Å² [M+H]+ [CCS Type: TW]

209.11 Å² [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

211.45 Å² [M+Na]+；196.94 Å² [M+H]+

物理化学的性質

融点: 174.1 ° · 174.1°
比重(密度): 1.631 · 1.631±0.06 g/cm3(Predicted)
蒸気圧: 0.4 x10 · <0.4 x10 -3 Pa (25 °C)
闪点: 170 °C · 170 °C
貯蔵温度: 0 · 0-6°C
溶解性: 100 mg/L · 100mg/L in organic solvents at 20 ℃
外見: Solid
水溶解度: -1 · -1 (25 °C)
酸解離定数(Pka): 8.49 · 8.49±0.46(Predicted)
色: Off-white to light yellow
JECFA Number: 85 · 85
BRN: 8398291 · 8398291
InChI: 1S/C17H8Cl2F8N2O3/c18-6-5-11(32-17(26,27)14(22)16(23,24)25)7(19)4-10(6)28-15(31)29-13(30)12-8(20)2-1-3-9(12)21/h1-5,14H,(H2,28,29,30,31)
InChIKey: PWPJGUXAGUPAHP-UHFFFAOYSA-N
SMILES: FC(C(F)(F)F)C(F)(F)Oc1cc(Cl)c(NC(=O)NC(=O)c2c(F)cccc2F)cc1Cl
LogP: 5.12 at · 5.12 at 25℃
CAS データベース: 103055 · 103055-07-8(CAS DataBase Reference)
EPAの化学物質情報: 2 · Benzamide, N-[[[2,5-dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl]amino]carbonyl]-2,6-difluoro- (103055-07-8)

安全と法規制

GHS分類

GHS Classification · 6 件

Warning

H317: May cause an allergic skin reaction [Warning Sensitization, Skin]；H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]；H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P261, P272, P273, P280, P302+P352, P321, P333+P317, P362+P364, P391, and P501 (click each P-code to see the statement)

Danger

危険有害性情報

Regulatory Information · 4 件

Commission Regulation (EC) No 1490/2002

2009/77/EC, Reg. (EU) 2022/801, Reg. (EU) No 540/2011

Status: Active Update: 06-01-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/32780；Status: No longer Valid Update: 10-11-2008 https://echa.europa.eu/registration-dossier/-/registered-dossier/3279

Lufenuron: Does not have an individual approval but may be used under an appropriate group standard

Hazard Classes and Categories · 5 件

Skin Sens. 1 (100%)；Repr. 1B (32.4%)；STOT RE 1 (32.4%)；Aquatic Acute 1 (100%)；Aquatic Chronic 1 (100%)

Skin sensitisation - category 1；Hazardous to the aquatic environment (acute) - category 1；Hazardous to the aquatic environment (chronic) - category 1

Reproductive toxicity - Category 2；Specific target organ toxicity - Repeated exposure - Category 2 (liver, nervous system)

Skin sensitization - Category 1B；Hazardous to the aquatic environment (Acute) - Category 1；Hazardous to the aquatic environment (Long-term) - Category 1

Skin Sens. 1；Aquatic Acute 1；Aquatic Chronic 1

法規制情報

Regulatory Information · 4 件

Commission Regulation (EC) No 1490/2002

2009/77/EC, Reg. (EU) 2022/801, Reg. (EU) No 540/2011

Status: Active Update: 06-01-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/32780；Status: No longer Valid Update: 10-11-2008 https://echa.europa.eu/registration-dossier/-/registered-dossier/3279

Lufenuron: Does not have an individual approval but may be used under an appropriate group standard

安全データ

wgk: 2
ridadr: 3077
毒性: LD50 in rats (mg/kg): >2000 orally; LC50 in rats (mg/m3): >2350 (Buholzer)
PRTR法: 第2種指定化学物質
hs_code: 29242990
risk_code: 43-50/53
hazard_code: Xi;N,N,Xi
safety_code: 2-24-37-60-61
hazard_class: 9
packing_group: III
Hazard Classifications: Aquatic Acute 1Aquatic Chronic 1Skin Sens. 1
ストレージクラス: 11 - Combustible Solids

化学と産業

薬理情報

ATC CodeQP - Antiparasitic products, insecticides and repellents；QP53 - Ectoparasiticides, insecticides and repellents；QP53B - Ectoparasiticides for systemic use；QP53BC - Chitin synthesis inhibitors；QP53BC01 - Lufenuron

MeSH Pharmacological ClassificationPesticides designed to control insects that are harmful to man. The insects may be directly harmful, as those acting as disease vectors, or indirectly harmful, as destroyers of crops, food products, or textile fabrics.

用途と製造

Use Classification · 5 件

Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

Veterinary Drug -> INSECTICIDE; Veterinary Drug -> -> JECFA Functional Classes

Environmental transformation -> Pesticides (parent, predecessor)

PFAS (per- and polyfluoroalkyl substances) -> OECD Category

Veterinary substances, Acaricides, Insecticides

応用分野 · 3 件

用途農薬(殺虫剤)

説明Lufenuron is an insect development inhibitor of the benzoylphenyl urea class. It demonstrates activity against fleas that have fed on treated cats and dogs and become exposed to lufenuron in the host’s blood. Lufenuron also has activity by virtue of its presence in adult flea feces, leading to its ingestion by flea larvae. Both activities result in the production of eggs that are unable to hatch, causing significant reductions in flea larvae populations. The lipophilicity of lufenuron leads to its deposition in adipose tissues of animals from where it is slowly released into the bloodstream. This permits effective blood concentrations to be maintained throughout the recommended oral dosing interval of 1 month.

使用Lufenuron is used for the control of Lepidoptera and Coleoptera larvae on cotton, maize and vegetables, and of citrus whitefly and rust mites on citrus fruit. It is also used to control fleas on pets and cockroaches in houses.

サプライヤー50 社

湖北博杰生物科技有限公司0713-2060728 15629612610

Shandong chuangyingchemical Co., Ltd.18853181302 · [email protected]

上海宇之诚医药科技有限公司13361818591 · [email protected]

武汉欣扬瑞和化学科技有限公司153-07155313 15307155313 · [email protected]

上海遐瑞医药科技有限公司+86-021-61551413 · [email protected]

ルフェヌロン

基本情報