リコリン

解説リコリンはいヒガンバナの主アルカロイド．各種ヒガンバナ科植物中に広く分布する．"分解点276 ℃．[α]D "－120°(エタノール)．エタノール，石油エーテル，クロロホルムに可溶．アメーバ赤痢に有効であるといわれており，細胞分裂に対してはコルヒチン様の細胞分裂促進作用をもつ．毒性がやや強い．LD50 41 mg/kg(イヌ，静注)．[CAS 476-28-8]森北出版「化学辞典（第2版）

説明Lycoris radiate, a traditional Chinese medicine (TCM), is the bulb of the amaryllidaceous Lycoris radiata herb. It has been applied for clinical purposes for centuries. It is firstly recorded in Tujing Bencao and mainly used for the pyogenic infections. According to A Supplement to Compendium of Materia Medica, lycoris radiate may be used for treating acute throat trouble, phlegm node, baihuodan, and pulmonary abscess.There are about 20 Lycoris species in the world, which are widely distributed in China and Japan. Lycoris radiate is an amazing horticultural plant with a graceful shape and a bright color. In TCM, it is acrid in taste and neutral in nature, with functions of detoxication, easy expectoration, and diuresis and emesis promotion. According to the modern medicine, lycoris radiate is considered to be in favor of the central nervous system and cardiovascular system.The main active ingredients extracted from the lycoris herbs are about 40 alkaloids with various contents. Pharmacological tests indicate that galanthamine, lycorine, lycoramine, lycorenine, and crinine are the major effective medicinal ingredients. Lycorine may be used to treat amebic dysentery and against cancer. Moreover, galanthamine, dihydrogalanthamine, and lycoramine may be used to treat infantile paralysis and restore nerve functions and against traumatic paraplegia, etc. Lycoris radiate is famous because galanthamine has been approved by FDA as an anti-Alzheimer disease drug. Lycoris radiate is the only natural source for galanthamine with extremely low content (

来歴In 1895, Morishima successfully extracted lycorine from the bulb of Lycoris radiata. However, its structure was unidentified until in 1935. In 1959, its stereochemical structure was dissected by monocrystal.The solvent extraction method, chromatographic separation, and resin absorption are commonly used for lycorine extraction. However, lycorine obtained from these techniques is not pure enough and often mixed with other alkaloids. The great differences in the efficacies of different alkaloids prevent such blending from being directly used. Furthermore, the separation and purification process so required has an adverse effect on and limits the development and utilization of the medicinal value of lycorine.

使用Lycorine is an analgesic, more so than aspirin, and a hypotensive, as are caranine and galanthine . The analgesic activity exhibited by the Amaryllidaceae alkaloids is attributed to their resemblance to the morphine and codeine skeletons. Lycorine also has antiarrhythmic action, and lycorine hydrochloride is a strong broncholytic. In fact, lycorine shows a relaxant effect on an isolated epinephrine-precontracted pulmonary artery and increases contractility and the rate of an isolated perfused heart. These effects are mediated by stimulation of b-adrenergic receptors.Lycorine also has a strong inhibitory effect on parasite (Encephalitozoon intestinalis) development and antifungal activity against Candida albicans. Additionally, lycorine has antifeedant, antimalarial, emetic, anti-inflammatory, antiplatelet , as well as antifertility activities. Galanthine, in turn, shows mild in vitro activity against Tripanosoma brucei rhodesiense and Plasmodium falciparum.