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化工社化工社 化学情報印刷レポート · 研究参考用
HCID 7240作成日：2026年10月27日

2-クロロアニリン

2-クロロアニリン · C.I.アゾイックジアゾコンポーネント44【ベース】 · 2-クロロベンゼンアミン · ファーストイエローGCベース · ミツイイエローGCベース · o-クロロアニリン · ファーストイエローベースGC · アゾイックDC44(ベース)

https://huagongshe.com/ja/chemical/7240

2-クロロアニリン の分子構造式

識別子と物理属性

CAS No.95-51-2
分子式C6H6ClN
平均分子量127.57 g/mol
単同位体質量127.01887687 g/mol
SMILESNc1ccccc1Cl
InChIKeyAKCRQHGQIJBRMN-UHFFFAOYSA-N
PubChem CID7240
ChEMBLCHEMBL389885
EC No.202-426-4
DTXSIDDTXSID2021810
現地名2-クロロアニリン

化学・物理的性質

XLogP1.9
極性表面積26
水素結合供与体数1
水素結合受容体数1
回転可能結合数0
重原子数8
形式電荷0
複雑度74.9
物質分類Nitrogen Compounds -> Amines, AromaticTextile
SpringerMaterials Properties15N nuclear magnetic resonance spectrum
LogP（分配係数）log Kow = 1.901.921.74
臭いCharacteristic sweet odorAmine odor特有の臭い
密度1.213 at 68 °F (NTP, 1992) - Denser than waterwill sink1.2114 at 22 °C/4 °C1.213 g/cm³Relative density of the vapour/air-mixture at 20 °C (air = 1): 1.001.213 g/mL at 25 °C(lit.)
Viscosity2.9157 cP at 20 °C
Color/FormAmber liquidWater-white to tan liquidColorless liquid
溶解度less than 1 mg/mL at 68 °F (NTP, 1992)Soluble in acid and in most organic solvents.Miscible in alcohol and etherSoluble in alcohol, ether, benzene, and acetone.In water, 8165 mg/L at 25 °CSolubility in water, g/100ml at 20 °C: 0.5水：20℃で可溶5.13g/L5.13g/L（20℃）
引火点208 °F (NTP, 1992)103 °C103 °C (closed cup)108 °C98 °C
沸点406 to 410 °F at 760 mmHg (NTP, 1992)208.8 °C209 °C208-210 °C(lit.)
DecompositionWhen heated to decomposition, it emits toxic fumes of /hydrogen chloride and nitrogen oxides/.
融点28.5 °F (NTP, 1992)-14 °C-2 °C0-3 °C
蒸気密度4.41 (vs air)
蒸気圧0.5 hPa (20 °C)
屈折率n20/D 1.589
貯蔵条件Store below +30°C.
外観・状態液体
pKa（酸解離定数）2.65(at 25℃)
色澄んだ淡黄色～褐色
爆発限界2.4-14.2%(V)
Merck14,2118
BRN606077
ヘンリー定数1.9×100 mol/(m3Pa) at 25℃, Brockbank (2013)
誘電率13.4
InChI1S/C6H6ClN/c7-5-3-1-2-4-6(5)8/h1-4H,8H2
InChIKeyAKCRQHGQIJBRMN-UHFFFAOYSA-N
SMILESNc1ccccc1Cl
LogP（分配係数）1.72 at 20℃ and pH6-8
CAS データベース95-51-2(CAS DataBase Reference)
NISTの化学物質情報o-Chloroaniline(95-51-2)
EPAの化学物質情報o-Chloroaniline (95-51-2)

化学的特性

clear pale yellow to brown liquid with ammonia odor. darkens on exposure to air. almost insoluble in water, soluble in acids and most common organic solvents.

安全性と法規制

GHS 分類DangerH301+H311+H331 (78.9%): Toxic if swallowed, in contact with skin or if inhaled [Danger Acute toxicity, oralacute toxicity, dermalacute toxicity, inhalation]P203, P260, P261, P262, P264, P264+P265, P270, P271, P273, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P316, P318, P319, P321, P330, P337+P317, P361+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 204 reports by companies from 20 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.H302: Harmful if swallowed [Warning Acute toxicity, oral]
規制情報Chemical: Benzenamine, 2-chloro-Benzenamine, 2-chloro- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Benzenamine, 2-chloro- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 15-04-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/137852-Chloroaniline: Does not have an individual approval but may be used under an appropriate group standard
その他の安全情報IMAP assessments - 2-Chloroaniline and its hydrochloride: Human health tier II assessment
輸送ラベル（DOT）Poison
火災危険This chemical is combustible. (NTP, 1992)Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
健康有害性SYMPTOMS: Symptoms of exposure to this compound may include headache, nausea, vomiting, jaundice, convulsions, severe kidney damage, liver damage, methemoglobin formation and in sufficient concentrations, cyanosisskin and eye irritationand dermatitis. Onset may be delayed 2-4 hours or longer.
有害性の概要o-Chloroaniline is listed in a table Examples of Industrial Chemicals for Which Methemoglobin Formation is the Principal Cause of Toxicity[ACGIH] In the United Kingdom between 1961 and 1980, chloroaniline, p-toluidine, nitrobenzene, and nitrochlorobenzene were the most common industrial causes of methemoglobinemia. Dermal exposure was a more frequent route of toxicity than inhalation with these compounds. (Ellenhorn, M.J. and D.G. Barceloux. Medical Toxicology - Diagnosis and Treatment of Human Poisoning. New York, NY: Elsevier Science Publishing Co., Inc. 1988.) An eye irritant

用途

用途

有機合成原料(染料、医薬、農薬)。

使用

2-Chloroaniline used as petroleum solvents. It is used in biological studies to evaluate the mutagenicity and carcinogenicity of Salmonella typhimurium. Used as a Intermediates for dyestuff, pigment and specialty chemicals. 2-Chloroaniline is widely used in polymer, rubber, pharmaceutical and dye industries.

一般的な説明

Clear amber liquid with an amine odor. Occurs in both alpha and beta forms.

製法・合成法

製造方法

The synthesis method of 2-chloroaniline is to reflux 2-nitrochlorobenzene with iron filings, dilute hydrochloric acid and water for 6~8h, distill to get crude product, and then distill to get finished product.

純化方法

Free it from small amounts of the p-isomer by dissolving in one equivalent of H2SO4 and steam distilling. The p-isomer remains behind as the sulfate. [Sidgwick & Rubie J Chem Soc 1013 1921.] An alternative method is to dissolve it in warm 10% HCl (11mL/g of amine) and on cooling, o-chloroaniline hydrochloride separates out. The latter can be recrystallised until the acetyl derivative has a constant melting point (m 90o). (In this way, yields are better than via the recrystallisation of the picrate from EtOH or of the acetyl derivative from pet ether.) [King & Orton J Chem Soc 1377 1911]. [Beilstein 12 III 1281, 12 IV 1115.]

Can induce methemoglobinemia
[ICSC] Negative results for skin sensitizer from guinea pig testing
[Reference #2]
反応性グループAryl Halides
EC 分類Symbol: T, NR: 23/24/25-33-50/53S: (1/2)-28-36/37-45-60-61Note: C
UN 分類UN Hazard Class: 6.1UN Pack Group: II
TSCA 要件Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Benzenamine, 2-chloro- is included on this list.
Reactivity ProfileO-CHLOROANILINE is incompatible with acids, acid chlorides, acid anhydrides, chloroformates and strong oxidizing agents. (NTP, 1992)
大気基準This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. o-chloroaniline is produced, as an intermediate or a final product, by process units covered under this subpart.
消火Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)Use powder. Use foam. Use carbon dioxide.
応急処置措置Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Give one or two glasses of water to drink. Refer for medical attention .
応急処置EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
安全保管Separated from food and feedstuffs. Keep in the dark. Well closed.
暴露管理・個人防護Biological Exposure Indices (BEI) [ACGIH] - Methemoglobin in blood = 1.5% of hemoglobin during or end of shift
消火手順Water, dry chemical, foam or carbon dioxide /4-chloroaniline/
非火災時の漏出対応SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
処分方法SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal, aquatic, and plant lifeand conformance with environmental and public health regulations.
漏出処分Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
Preventive MeasuresImmediately wash contaminated areas of body with concentrated soap solution. Remove contaminated clothing, dry, then wash with concentrated soap solution or dispose as waste. Contaminated shoes may be disposed in an incinerator.Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
Isolation and EvacuationExcerpt from ERG Guide 152 [Substances - Toxic (Combustible)]:
Eye PreventionWear safety goggles or face shield.
生態毒性値EC50 Daphnia magna (Daphnidsability to swim) 4.2 mg/L/24 hr /Conditions of bioassay not specified in source examined/ability to swim) 1.8 mg/L/48 hr /Conditions of bioassay not specified in source examined/LC50 Tubifex (Worm) 130-220 mg/L/48 hrLC50 Oryzia latipes (Medaka) 6.4 mg/L/48 hr /Conditions of bioassay not specified in source examined/For more Ecotoxicity Values (Complete) data for 2-CHLOROANILINE (9 total), please visit the HSDB record page.
環境中動態TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 260(SRC), determined from a log Kow of 1.90(2) and a regression-derived equation(3), indicates that 2-chloroaniline is expected to have moderate mobility in soil(SRC). However, aromatic amines are expected to bind strongly to humus or organic matter in soils due to the high reactivity of the aromatic amino group(4,5), suggesting that mobility may be much lower in some soils(SRC). The pKa of 2-chloroaniline is 2.66(6), indicating that this compound will primarily exist in its nonionic form in the environment. Volatilization of 2-chloroaniline from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 5.4X10-6 atm-cu m/mole(SRC), derived from its vapor pressure, 0.20 mm Hg(7), and water solubility, 8.2X10+3 mg/L(8). However, adsorption to soil is expected to attenuate volatilization(SRC). 2-Chloroaniline is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 0.20 mm Hg(7). Biodegradation screening tests suggest that 2-chloroaniline is slightly to non-biodegradable(9,10). 100% loss of UV absorbance by microbial degradation in a mineral salts solution, with a soil inoculum, required an excess of 64 days(11). When 2-chloroaniline (3-ppm) was incubated in Guelph loam with water added to 60% water-holding capacity, levels declined rapidly for 2 weeks after which time the rate of loss decreased(12). The percent of 2-chloroaniline remaining in soil after 2 and 8 weeks were 40 and 20%, respectively(12). Experiments using 2-chloroaniline show that it undergoes photolysis in aqueous solution when irradiated by light with wavelengths above 290 nm (13,14)2-chloroaniline may also be susceptible to direct photolysis by sunlight in soil surfaces(SRC).AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 260(SRC), determined from a log Kow of 1.90(2) and a regression-derived equation(3), indicates that 2-chloroaniline is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 5.4X10-6 atm-cu m/mole(SRC), derived from its vapor pressure, 0.20 mm Hg(4), and water solubility, 8.2X10+3 mg/L(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 7.8 days and 60 days, respectively(SRC). However, aromatic amines are expected to bind strongly to humus or organic matter in soils due to the high reactivity of the aromatic group(6,7), and volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column(SRC). The pKa of 2-chloroaniline is 2.66(8), indicating that this compound will primarily exist in its nonionic form in the environment. According to a classification scheme(9), an estimated BCF of 5.8(SRC), from an estimated log Kow(2) and a regression-derived equation(10), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Biodegradation screening tests suggest that 2-chloroaniline is generally resistant to biodegradation or biodegrades slowly(11,12). 2-Chloroaniline (2 mg/L) was found to be not readily biodegradable with a 10% BOD observed after 5 days in a mixed inoculum of river water collected from the Songhua River in China(13). Irradiation of an aqueous solution of 2-chloroaniline in a quartz tube with a fluorochemical lamp (wavelengths above 300 nm) resulted in a photodegradation half-life of 11.5 hours(14). When aqueous solutions of 2.5X10-3 mol/L 2-chloroaniline in a photochemical reactor were irradiated by a mercury lamp (wavelengths 254, 297, and 365 nm), the concentration of 2-chloroaniline decreased exponentially with time, and the rate of disappearance approximated a first-order process with a rate constant of 0.107/hour(15).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 2-chloroaniline, which has a vapor pressure of 0.20 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 2-chloroaniline is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 12 hours(SRC), calculated from its rate constant of 3.1X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). 2-Chloroaniline absorbs ultraviolet light above 290 nm(4). Experiments using 2-chloroaniline show that it undergoes photolysis in aqueous solution when irradiated by light with wavelengths above 290 nm (5,6)2-chloroaniline may also be susceptible to direct photolysis by sunlight in air(SRC).
食品調査値2-Chloroaniline has been qualitatively identified as a volatile flavor component of Idaho Russet baked potatoes(1).
有害作用Methemoglobinemia - The presence of increased methemoglobin in the bloodthe compound is classified as primary toxic effect.
暴露経路The substance can be absorbed into the body by inhalation, through the skin and by ingestion.
生態毒性抜粋/AQUATIC SPECIES/ 21 day Daphnia reproduction tests were conducted in line with the provisional procedure proposed by the Federal Environmental Agency (Umweltbundesamt, FRG), as of Jan 1, 1984. Groups of 20, 24-hr old Daphnia magna Straus were exposed to 0.001 to 3.16 mg/L 2-chloroaniline in semi-static test vessels. Parent animals in the test and control vessels had to be pipetted 3 times/wk in freshly prepared test and control media at the corresponding concentration level. The no observed effect concentration (NOEC) was determined from the parameters of mortality of the parent animals, reproduction rate and appearance of the first offspring during the test period. In preliminary acute Daphnia tests, the 24-hr EC50 was 6.0 mg/L for 2-chloroaniline, the EC0 was 1.4 mg/L. The nominal 21-day no observed effect concentration was 0.032 mg/L./AQUATIC SPECIES/ Twenty-nine day old fathead minnows were exposed to an 80 mg/L concentration of 2-chloroaniline. Test conditions were as follows: Exposure temperature: 24.9 °CpH: 7.60. Average concentration/chamber of 2-chloroaniline ranged from 2.00-25.9 mg/L. Affected fathead minnows lost schooling behavior and swam near the tank surface. They were hyperactive and overreactive to external stimuli, were darkly colored, and hemorrhagic. Equilibrium loss was not observed prior to death.
Signs and SymptomsBlue lips, fingernails and skin. Dizziness. Headache. Shortness of breath. Nausea. Vomiting. Convulsions. Weakness. Confusion. Unconsciousness.MAY BE ABSORBED! Further see Inhalation.Redness. Pain.Abdominal pain. Further see Inhalation.
Ongoing Test StatusThe following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical. [http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=95-51-2]
Effluent Concentrations2-Chloroaniline was detected at an average concentration of 42.58 ug/L and a 76.5% frequency of detection in sewage treatment effluents in England and Wales collected in 1995(1). In a comprehensive survey of wastewater from 4,000 industrial and publicly owned treatment works sponsored by the Effluent Guidelines Division of the US EPA, 2-chloroaniline was identified in discharges of the following industrial categories (positive occurrences, median concentration in ppb): pharmaceuticals (4588.1) and organic chemicals (357.1)(2). The highest effluent concentration was 2564.1 ppb in the pharmaceutical industry(2). Wastewater discharges from the commercial manufacture of 4,4'-methylenebis(2-chloroaniline) can contain 2-chloroaniline(3). 2-Chloroaniline was qualitatively detected in effluent discharges from chemical production facilities along the Upper Catawba River in North Carolina in 1973 and 1974(4). Sludge from the Muskegon County, Michigan wastewater treatment system was found to contain 48.3 mg/kg 2-chloroaniline(5).
ICSC Environmental DataThe substance is toxic to aquatic organisms.
Medical SurveillanceConsider the points of attack (blood, heart, lung and liver) in preplacement and periodic physical examinations. /4-Nitroaniline/
Soil Adsorption/MobilityThe Koc of 2-chloroaniline is estimated as 260(SRC), using a log Kow of 1.9(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that 2-chloroaniline is expected to have moderate mobility in soil. However, aromatic amines are expected to bind strongly to humus or organic matter in soils due to the high reactivity of the aromatic amino group(4,5), suggesting that mobility may be much lower in some soils(SRC).
F8-10-23
水環境危害等級（WGK）2
TSCA 収載状態TSCA listed
RTECS 番号BX0525000
輸送番号（UN）UN 2019 6.1/PG 2
PRTR法第一種指定化学物質
税関コード29214210
危険文句（R）23/24/25-33-50/53-39/23/24/25-11-52/53
化審法(3)-194 優先評価化学物質
消防法危-4-3-III
危険表示T,N,F
安全措置（S）28-36/37-45-60-61-28A-16
危険等級6.1Acute Tox. 3 DermalAcute Tox. 3 InhalationAcute Tox. 3 OralAquatic Acute 1Aquatic Chronic 1Eye Irrit. 2Muta. 2STOT RE 2
包装等級II
毒劇物取締法劇物
自然発火温度>500 °C
環境リスク評価o-クロロアニリン(95-51-2)
貯蔵分類6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials
有害物質データ95-51-2(Hazardous Substances Data)