基本情報
- CAS
7060-74-4- 標準SMILES
CO[C@H]1C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@@H](C)C[C@@]3(CO3)C(=O)[C@H](C)[C@@H](O)[C@@H](C)[C@@H](C)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O.O=P(O)(O)O- InChIKey
RLPCJGKQKFMBEI-UOBLTHIJSA-N- 分子式
- C35H64NO16P
- 平均分子量
- 785.9 g/mol
- 単同位体質量
- 785.39627195
概要
Oleandomycin Phosphate is the phosphate salt form of oleandomycin, a macrolide antibiotic similar to erythromycin with antimicrobial activity. Oleandomycin targets and reversibly binds to the 50S subunit of bacterial ribosomes. This prevents translocation of peptidyl tRNA leading to an inhibition of protein synthesis.
名称と識別子
- 優先名称
- Oleandomycin Phosphate
- IUPAC
- (3R,5S,6S,7R,8S,9R,12R,13R,14S,15R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-hydroxy-8-[(2R,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-5,7,9,12,13,15-hexamethyl-1,11-dioxaspiro[2.13]hexadecane-10,16-dione;phosphoric acid
- 現地名
- オレアンドマイシン·りん酸塩
- 英語名
- OLEANDOMYCIN PHOSPHATE
- 分子式
- C35H64NO16P
- 分子量
- 785.85
名称と別名
oleandomycin phosphate7060-74-4Oleandomycin, phosphate (1:1) (salt)Oleandomycin phosphate (1:1)8681H0C27PDTXCID7025398RefChem:168081230-351-7DTXSID9045398Matromycin (TN)Oleandomycin phosphate [JAN]Oleandomycin (phosphate)
名称をさらに表示
オレアンドマイシン·りん酸塩マトロマイシンりん酸オレアンドマイシンオレアンドマイシンりん酸塩二水和物標準液オレアンドマイシンりん酸塩標準液リン酸オレアンドマイシン (JAN)オレアンドマイシン・りん酸塩matromycinbambusamycinPhosphacyclidine ≥97%OLEANDOMYCIN PHOSPHATE SALTLJQRWAWAOFAOCL-UOESYEISSA-NOleandomycin, phosphate (1:1)oleandomycin standard solution
Oleandomycin phosphate (JAN)Oleandomycin phosphate 100 |Ig/mL in AcetonitrileEINECS 230-351-7UNII-8681H0C27POleandomycin phosphate [JAN:NF]Oleandomycin, phosphate (1:1) (salt); Oleandomycin phosphate (6CI); 1,9-Dioxaspiro[2.13]hexadecane, oleandomycin deriv.; Matromycinorb3134475SCHEMBL5033021
物性
構造計算による物性
- 極性表面積
- 244 Ų
- 水素結合供与体数
- 6
- 水素結合受容体数
- 17
- 回転可能結合数
- 6
- 重原子数
- 53
- 形式電荷
- 0
- 複雑度
- 1,140
物理化学的性質
- 融点
- 145 · 145-147℃
- 貯蔵温度
- 0 · 0-6°C
- 溶解性
- DMSO (Slightly), Methanol (Slightly)
- 外見
- Solid
- 色
- White to Off-White
- CAS データベース
- 7060 · 7060-74-4
- EPAの化学物質情報
- Oleandomycin phosphate (7060-74-4)
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
GHS分類
GHS Classification
Danger
H300 (97.7%): Fatal if swallowed [Danger Acute toxicity, oral]
P264, P270, P301+P316, P321, P330, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 43 reports by companies from 2 notifications to the ECHA C&L Inventory.
危険有害性情報
Regulatory InformationOleandomycin phosphate: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Hazard Classes and CategoriesAcute Tox. 2 (97.7%)
安全データ
- rtecs
- RJ9800000
- ridadr
- UN2811 6.1/PG 2
- 毒性
- LD50 ivn-rat: 480 mg/kg ANTCAO 7,419,57
- PRTR法
- 1-13
- risk_code
- 28
- 安衛法
- 57,57-2
- 消防法
- 危-4-1-S-II
- hazard_code
- T+
- safety_code
- 22-24/25-45-36/37-28
- 毒劇物取締法
- II
化学と産業
薬理情報
MeSH Pharmacological ClassificationSubstances that inhibit the growth or reproduction of BACTERIA.
応用分野
説明Oleandomycin is a macrolide antibiotic with a 14-membered lactone constituent. It was found in the culture broth of Streptomyces antibioticus by Pfizer Research Laboratories in 1954. Oleandomycin shows almost the same antimicrobial spectrum and activity as the other macrolide antibiotics. Its serum concentration is low, but its tissue concentration is high enough to provide a therapeutic effect. Oleandomycin phosphate is used orally or intravenously to treat pyoderma, sepsis, meningitis, surgical and abdominal infections, respiratory tract and urinary tract infections, and other infections caused by Staphylococci, Streptococci, Corynebacterium, Neisseria, and Mycoplasma. Oleandomycin is also used as a feed additive and therapeutic agent for animals.
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