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HCID 7276作成日：2026年10月27日

スチレンオキシド

スチレンオキシド · フェネチレンオキシド · オキシラニルベンゼン · 1-フェニル-1,2-エポキシエタン · エポキシスチレン · スチレン-7,8-オキシド · スチレンエポキシド · 1-(オキシラニル)ベンゼン

https://huagongshe.com/ja/chemical/7276

スチレンオキシド の分子構造式

識別子と物理属性

CAS No.96-09-3
分子式C8H8O
平均分子量120.15 g/mol
単同位体質量120.05751488 g/mol
SMILESc1ccc(C2CO2)cc1
InChIKeyAWMVMTVKBNGEAK-UHFFFAOYSA-N
PubChem CID7276
ChEMBLCHEMBL1605493
ChEBICHEBI:17907
EC No.202-476-7
DTXSIDDTXSID2021286
現地名スチレンオキシド

化学・物理的性質

XLogP1.6
極性表面積12.5
水素結合供与体数0
水素結合受容体数1
回転可能結合数1
重原子数9
形式電荷0
複雑度94.7
物質分類Hazardous Air Pollutants (HAPs)Carcinogens
PolymersPlastics & Rubber -> Epoxides
LogP（分配係数）log Kow = 1.611.84
臭いSweet, pleasant
密度1.0523 at 61 °F (NTP, 1992) - Denser than waterwill sink1.0490 g/ cu cm at 25 °CStyrene oxide (98 mole % pure) is available in USA with following specifications: density, 1.0490-1.0515 (25/25 °C)distillation range at 760 mm: fraction between 5 and 95% by vol shall boil within 3.0 °C range, which includes temp 194.1 °Cwater, 0.25% by wt.Relative density (water = 1): 1.051.046 @25 °C1.054 g/mL at 25 °C (lit.)
Viscosity1.99 cP at 20 °C
Color/FormColorless to pale straw-colored liquid
溶解度less than 1 mg/mL at 67.1 °F (NTP, 1992)Completely soluble in acetone, benzene, carbon tetrachloride, ethyl ether, heptane, methanol0.3% wt in waterSolubility in water, g/100ml at 25 °C: 0.3 (poor)3g/リットル3g/L（20℃）
引火点175 °F (NTP, 1992)76 °C165 °F (74 °C) (Open cup)76 °C c.c.
沸点381 °F at 760 mmHg (NTP, 1992)194.1 °C194 °C194.2 °C @760 [mm Hg]194 °C (lit.)
融点-35 °F (NTP, 1992)-35.6 °C-36.7 °C-37 °C (lit.)
蒸気密度4.14 (NTP, 1992) - Heavier than airwill sink (Relative to Air)4.30 (Air = 1)Relative vapor density (air = 1): 4.304.14 (vs air)
蒸気圧<1 mm Hg ( 20 °C)
屈折率n20/D 1.535(lit.)
貯蔵条件Store below +30°C.
外観・状態液体
色無色透明～微黄色透明
由来生物synthetic
爆発限界1.1-22%(V)
BRN108582
ヘンリー定数6.2×10-1 mol/(m3Pa) at 25℃, HSDB (2015)
安定性不安定 - 酸、塩基、または特定の塩の存在下で、酸やアルコールなどの不安定な水素を持つ化合物と容易に重合します。可燃性。強力な酸化剤、酸、塩基とは相容れない。
主な用途フレーバーそして香料
InChI1S/C8H8O/c1-2-4-7(5-3-1)8-6-9-8/h1-5,8H,6H2
InChIKeyAWMVMTVKBNGEAK-UHFFFAOYSA-N
SMILESC1OC1c2ccccc2
LogP（分配係数）1.61
CAS データベース96-09-3(CAS DataBase Reference)
NISTの化学物質情報Oxirane, phenyl-(96-09-3)
EPAの化学物質情報Styrene oxide (96-09-3)

化学的特性

Styrene oxide is a colorless to pale strawcolored liquid. Pleasant, sweet odor.

安全性と法規制

GHS 分類DangerH312: Harmful in contact with skin [Warning Acute toxicity, dermal]P203, P264+P265, P280, P302+P352, P305+P351+P338, P317, P318, P321, P337+P317, P362+P364, P405, and P501 (click each P-code to see the statement)This chemical does not meet GHS hazard criteria for 4.3% (16 of 374) of reports.H311 (15%): Toxic in contact with skin [Danger Acute toxicity, dermal]
規制情報Chemical: Oxirane, phenyl-Hazard Traits - CarcinogenicityDermatotoxicityHepatotoxicity and Digestive System ToxicityNeurotoxicityOcular ToxicityReproductive ToxicityRespiratory ToxicityStatus: Active Update: 10-06-2020 https://echa.europa.eu/registration-dossier/-/registered-dossier/14585Phenylethylene oxide: Does not have an individual approval but may be used under an appropriate group standardThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)
その他の安全情報IMAP assessments - Oxirane, phenyl-: Environment tier I assessment
輸送ラベル（DOT）Poison
火災危険This chemical is combustible. (NTP, 1992)Combustible. Above 76 °C explosive vapour/air mixtures may be formed.
火災の可能性On ... basis /of flash point/, it presents hazard of flammability similar to that encountered with ... o-cresol, o-dichlorobenzene, naphthalene, phenol, and dimethylaniline. Definite hazard exists whenever ... /it/ is heated to temperatures at and above the flash point.
健康有害性SYMPTOMS: Symptoms of exposure to this compound may include severe irritation of the skin and eyes, and skin sensitization. It can cause corrosion of tissues. Other symptoms may include burns, irritation of mucous membranes and upper respiratory tract, nausea, vomiting and headaches. Exposure may also cause central nervous system depression, hepatic lesions and pain to the eyes. Symptoms of exposure to a related compound include drying and cracking of the skin on contact, primary irritation to mucosal surfaces, fatigue, weakness, depression, unsteadiness, feeling of drunkenness, abnormal electroencephalograms and one case of toxic retrobulbar neuritis. Chronic exposure to a related compound has caused peripheral neuropathies (distal hypesthesia and decreased nerve conduction velocities).

用途

用途

フェニルエチルアルコール?フェニルアラニンなどの原料?合成樹脂原料?香料

用途

有機合成原料。

使用

Styrene oxide is is an important intermediate for organic synthesis and is widely used in organic synthesis, pharmaceutical preparation, and perfume production. For example, styrene oxide is added to hydrogen to produce monophenylethanol under the action of a catalyst. Styrene oxide has a wide range of uses, and can be used in floral fragrances for daily use, as well as in food. Styrene oxide is also an important intermediate for the synthesis of levamisole hydrochloride. L-imidazole hydrochloride is a broad-spectrum intestinal repellent that can be used by humans and animals.

一般的な説明

Styrene oxide is a clear colorless straw-colored liquid with a sweet pleasant odor. (NTP, 1992)

製法・合成法

純化方法

Fractional distillation under reduced pressure does not remove phenylacetaldehyde. If this material is present, the styrene oxide is treated with hydrogen under 3 atmospheres pressure in the presence of platinum oxide. The aldehyde, but not the oxide, is reduced to .-phenylethanol, and separation is now readily achieved by fractional distillation. [Schenck & Kaizermen J Am Chem Soc 75 1636 1953, Beilstein 17/1 V 577.]

有害性の概要Styrene oxide is used as a reactive plasticizer or diluent for epoxy resins and in the production of phenethyl alcohol and styrene glycol and its derivatives. Acute (short-term) exposure to styrene oxide causes skin and eye irritation in humans. Corneal injury, liver, and neurological effects have been reported in acutely exposed animals. No information is available on the chronic (long-term), reproductive, developmental, or carcinogenic effects of styrene oxide in humans. Maternal toxicity and increased fetal mortality have been observed in rats and rabbits exposed to styrene oxide by inhalation. Several studies have reported an increased incidence of forestomach tumors in rats and mice exposed via gavage (experimentally placing the chemical in the stomach). The International Agency for Research on Cancer (IARC) has classified styrene oxide as a Group 2A, a probable human carcinogen.There are no data linking styrene oxide exposure to effects in humans, so the TLV-TWA is based on animal studies. TLV Basis = upper respiratory tract irritation and blood changes. [ACGIH, 2020] A skin and eye irritantInhalation of high concentrations may cause CNS depression[ICSC] Toxic by ingestion and inhalation[Hawley] Repeated exposure may lead to skin sensitization[HSDB] May cause skin burns, sensitization, liver injury, and CNS depression[CAMEO] An eye irritant and lachrymatorMay cause CNS depressionTargets the CNS and liver[MSDSonline]The major hazards encountered in the use and handling of styrene-7,8-oxide stem from its toxicologic properties. Exposure to this sweet-smelling, colorless-to-pale straw-colored liquid may occur from its use in the manufacture of styrene glycol, beta-phenylethyl alcohol, surface coatings, and epoxy resins, and in the treatment of fibers and textiles. Effects from exposure may include skin, eye, and respiratory irritation, pulmonary edema, nausea, and central nervous system depression. Also, the International Agency for Research on Cancer (IARC) has classified styrene-7,8-oxide as a Group 2A carcinogen (defined as an agent that is probably carcinogenic to humans). Mechanical exhaust ventilation should be used to minimize exposure. In activities and situations where over-exposure may occur, wear chemical protective clothing and a self-contained breathing apparatus. Smoking, drinking, and eating should be prohibited in styrene-7,8-oxide work areas. Styrene-7,8-oxide must be moderately heated before ignition will occur. For fires involving styrene-7,8-oxide, extinguish with water spray, which acts by lowering the substance to below its flash point. Styrene-7,8-oxide should be stored in unbreakable, watertight containers, away from heat and sources of ignition. Before implementing land disposal of styrene-7,8-oxide waste, consult with environmental regulatory agencies for guidance.
反応性グループHydrocarbons, Aromatic
EC 分類Symbol: TR: 45-21-36S: 53-45Note: E
Special ReportsBarale RMutat Res 257 (2): 107-26 (1991). The genetic toxicology of styrene and styrene oxide is reviewed.National Toxicology Program. Eleventh Report on Carcinogens (2005). The Report on Carcinogens is an informational scientific and public health document that identifies and discusses substances (including agents, mixtures, or exposure circumstances) that may pose a carcinogenic hazard to human health. Styrene-7,8-oxide (96-09-3) is listed as reasonably anticipated to be a human carcinogen.[Available from, as of July 31, 2009: http://ntp.niehs.nih.gov/ntp/roc/eleventh/profiles/s165styr.pdf]
Reactivity AlertsPolymerizable
Reactivity ProfileSTYRENE OXIDE is incompatible with oxidizing agents. Also incompatible with acids and bases. Reacts with 4-(4'-nitrobenzyl)pyridine. Polymerizes exothermally and reacts vigorously with compounds possessing a labile hydrogen (e.g. alcohols and amines) in the presence of catalysts such as acids, bases and certain salts (NTP, 1992).
消火Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used. (NTP, 1992)Use powder, foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water. NO direct contact with water.
応急処置措置Fresh air, rest.Remove contaminated clothes. Rinse and then wash skin with water and soap.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Refer for medical attention .
応急処置EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
安全保管Separated from acids, bases and food and feedstuffs. Ventilation along the floor.
Firefighting Hazards... /Styrene oxide/ is a corrosive chemical that reacts vigorously with water ... .
保管条件... PRECAUTIONS SHOULD BE TAKEN TO PREVENT EXCESSIVE PRESSURE UNDER STORAGE OR REACTION CONDITIONS & TO RELIEVE SUCH PRESSURE SHOULD IT OCCUR.PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practicable to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/
清掃方法PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. /Chemical Carcinogens/
非火災時の漏出対応SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
処分方法SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal, aquatic, and plant lifeand conformance with environmental and public health regulations.Incineration: Liquids should be atomized into an incinerator and combustion may be improved by mixing with a more flammable solvent (acetone or benzene). Solids should be combined with paper or other flammable material. An alternate procedure is to dissolve the solid in a flammable solvent and spray the soln into the fire chamber.PRECAUTIONS FOR "CARCINOGENS": There is no universal method of disposal that has been proved satisfactory for all carcinogenic compounds & specific methods of chem destruction ... published have not been tested on all kinds of carcinogen-containing waste. ... summary of avail methods & recommendations ... /given/ must be treated as guide only. /Chemical Carcinogens/PRECAUTIONS FOR "CARCINOGENS": ... Incineration may be only feasible method for disposal of contaminated laboratory waste from biological expt. However, not all incinerators are suitable for this purpose. The most efficient type ... is probably the gas-fired type, in which a first-stage combustion with a less than stoichiometric air:fuel ratio is followed by a second stage with excess air. Some ... are designed to accept ... aqueous & organic-solvent solutions, otherwise it is necessary ... to absorb soln onto suitable combustible material, such as sawdust. Alternatively, chem destruction may be used, esp when small quantities ... are to be destroyed in laboratory. /Chemical Carcinogens/For more Disposal Methods (Complete) data for STYRENE-7,8-OXIDE (8 total), please visit the HSDB record page.
漏出処分Personal protection: chemical protection suit including self-contained breathing apparatus. Collect leaking liquid in covered containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
Preventive MeasuresPRECAUTIONS FOR "CARCINOGENS": Smoking, drinking, eating, storage of food or of food & beverage containers or utensils, & the application of cosmetics should be prohibited in any laboratory. All personnel should remove gloves, if worn, after completion of procedures in which carcinogens have been used. They should ... wash ... hands, preferably using dispensers of liq detergent, & rinse ... thoroughly. Consideration should be given to appropriate methods for cleaning the skin, depending on nature of the contaminant. No standard procedure can be recommended, but the use of organic solvents should be avoided. Safety pipettes should be used for all pipetting. /Chemical Carcinogens/PRECAUTIONS FOR "CARCINOGENS": In animal laboratory, personnel should remove their outdoor clothes & wear protective suits (preferably disposable, one-piece & close-fitting at ankles & wrists), gloves, hair covering & overshoes. ... clothing should be changed daily but ... discarded immediately if obvious contamination occurs ... /also,/ workers should shower immediately. In chemical laboratory, gloves & gowns should always be worn ... however, gloves should not be assumed to provide full protection. Carefully fitted masks or respirators may be necessary when working with particulates or gases, & disposable plastic aprons might provide addnl protection. If gowns are of distinctive color, this is a reminder that they should not be worn outside of lab. /Chemical Carcinogens/SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.PRECAUTIONS FOR "CARCINOGENS": ... operations connected with synth & purification ... should be carried out under well-ventilated hood. Analytical procedures ... should be carried out with care & vapors evolved during ... procedures should be removed. ... Expert advice should be obtained before existing fume cupboards are used ... & when new fume cupboards are installed. It is desirable that there be means for decreasing the rate of air extraction, so that carcinogenic powders can be handled without ... powder being blown around the hood. Glove boxes should be kept under negative air pressure. Air changes should be adequate, so that concn of vapors of volatile carcinogens will not occur. /Chemical Carcinogens/For more Preventive Measures (Complete) data for STYRENE-7,8-OXIDE (12 total), please visit the HSDB record page.
Isolation and EvacuationExcerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:
体内負荷Styrene oxide has been detected in the venous blood of 4 workers exposed to styrene of unspecified purity(1).
相互作用Doses of 0.8 umol/egg styrene oxide (purity, 97%) dissolved in vegetable oil were injected into the air space of White-Leghorn "mittari" & SK 12 chicken eggs on day 3 of incubation. In addnl groups, 0.1 umol trichloropropylene oxide, an inhibitor of epoxide hydrolyase, was injected simultaneously with styrene oxide as a check on the effects of metabolism on embryotoxicity. Embryos were examined on day 14 of incubation. Styrene oxide treatment alone resulted in embryolethality & malformationsaddition of trichloropropylene oxide to the styrene oxide treatment augmented these effects.
生態毒性値EC50Species: Scenedesmus abundans (Green algae, 10+4 cells/mL)Conditions: freshwater, static, 22 °CConcentration: 32000 ug/L for 96 hrEffect: growth, general /97.0% purity/LC50Species: Daphnia magna (Water flea, age <24 hr neonate)Conditions: freshwater, renewal, 23.7 (23-24.5) °C, pH 8.34 (7.67-8.63), hardness 287.2 mgL CaCO3 (168-437 mg/L), alkalinity 174.2 mg/L CaCO3 (104-261 mg/L), dissolved oxygen 82.6% (75.9-95.3%)Concentration: 11600 ug/L for 48 hr (95% confidence interval: 10200-13100 ug/L) /97% purity/Species: Pimephales promelas (Fathead minnow, age 30 days, length 17 mm, weight 0.082 g)Conditions: freshwater, flow through, 23.3 (22.5-24.8) °C, pH 6.9 (6.75-7.04), hardness 53.4 mgL CaCO3 (51.9-53.9 mg/L), alkalinity 40.5 mg/L CaCO3 (40-42 mg/L), dissolved oxygen 85.5% (72.9-92.3%)Concentration: 4540 ug/L for 96 hr /97% purity/Species: Pimephales promelas (Fathead minnow, age 30 days, length 17 mm, weight 0.074 g)Conditions: freshwater, static, 22.3 (22-22.6) °C, pH 6.82 (6.53-7.12), hardness 53.2 mgL CaCO3 (49.9-57.9 mg/L), alkalinity 38 mg/L CaCO3 (31-42 mg/L), conductivity 120 (118-120) umhos/cm, dissolved oxygen 59.4% (25.6-73%)Concentration: 10700 ug/L for 96 hr /97% purity/
環境中動態TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 53(SRC), determined from a water solubility of 3,000 mg/L(2) and a regression-derived equation(3), indicates that styrene-7,8-oxide is expected to have very high mobility in soil(SRC). Volatilization of styrene-7,8-oxide from moist soil surfaces is expected(SRC) given an estimated Henry's Law constant of 1.6X10-6 atm-cu m/mole(SRC), derived from its vapor pressure, 0.3 mm Hg(2), and water solubility, 3,000 mg/L(2). Styrene-7,8-oxide is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 0.3 mm Hg(2). Hydrolytic half-lives of 0.17, 28 and 40.9 hours have been reported for styrene-7,8-oxide at pH 3, 7, and 9, respectively(4). Hydrolysis is likely to be a more important fate than volatilization from moist soil or transport through soils, particularly in acidic soils(SRC). Styrene-7,8-oxide (100 mg/L) reached 80-82% of its theoretical BOD in 2 weeks using an activated sludge inoculum (30 mg/L) in the Japanese MITI test(5), suggesting that biodegradation is likely to be an important fate process for styrene-7,8-oxidehowever, the test results might be for the hydrolysis product, styrene glycol(SRC).AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 53(SRC), determined from a water solubility of 3,000 mg/L(2) and a regression-derived equation(3), indicates that styrene-7,8-oxide is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected for styrene-7,8-oxide(3) based upon an estimated Henry's Law constant of 1.6X10-5 atm-cu m/mole(SRC), derived from its vapor pressure, 0.3 mm Hg(2), and water solubility, 3,000 mg/L(2). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 64 hours and 23 days, respectively(SRC). According to a classification scheme(4), an estimated BCF of 3.5(SRC), from its log Kow of 1.61(5) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Hydrolytic half-lives of 0.17, 28 and 40.9 hours have been reported for styrene-7,8-oxide at pH 3, 7, and 9, respectively(7). Hydrolysis is likely to be a more important fate than volatilization from water or bioconcentration in aquatic organisms, particularly in acidic water(SRC). Styrene-7,8-oxide (100 mg/L) reached 80-82% of its theoretical BOD in 2 weeks using an activated sludge inoculum (30 mg/L) in the Japanese MITI test(8), suggesting that biodegradation is likely to be an important fate process for styrene-7,8-oxideATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), styrene-7,8-oxide, which has a vapor pressure of 0.3 mm Hg at 20 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase styrene-7,8-oxide is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 3.2 days(SRC), calculated from its rate constant of 5.1X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Styrene-7,8-oxide does not contain chromophores that absorb at wavelengths >290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).
有害作用Neurotoxin - Other CNS neurotoxin
暴露経路The substance can be absorbed into the body by inhalation, through the skin and by ingestion.
Signs and SymptomsDizziness. Drowsiness. Unconsciousness. Vomiting.Redness. Pain.Abdominal pain. Further see Inhalation.
Ongoing Test StatusThe following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical.[Available from: http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=96-09-3]
Effluent ConcentrationsIn a comprehensive survey of wastewater from 4000 industrial and publicly owned treatment works (POTWs) sponsored by the Effluent Guidelines Division of the US EPA, styrene-7,8-oxide was identified in one discharge of the rubber processing industry at a level of 46.2 ppb(1). Styrene-7,8-oxide was also identified in effluent from a latex manufacturing plant in Louisville, KY and chemical manufacturing plants in Louisville and Memphis, TN(2).
Medical SurveillancePRECAUTIONS FOR "CARCINOGENS": Whenever medical surveillance is indicated, in particular when exposure to a carcinogen has occurred, ad hoc decisions should be taken concerning ... /cytogenetic and/or other/ tests that might become useful or mandatory. /Chemical Carcinogens/
Soil Adsorption/MobilityThe Koc of styrene-7,8-oxide is estimated as 53(SRC), using a water solubility of 3,000 mg/L(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that styrene-7,8-oxide is expected to have very high mobility in soil. Hydrolytic half-lives of 0.17, 28 and 40.9 hours have been reported for styrene-7,8-oxide at pH 3, 7, and 9, respectively(4). Hydrolysis is likely to be a more important fate than transport through soils, particularly in acidic soils(SRC).
Atmospheric ConcentrationsStyrene-7,8-oxide has been tentatively detected, but not quantified, in air samples in the Los Angeles Basin as well as other, unspecified areas of the USA(1).SOURCE DOMINATED: Concentrations of styrene-7,8-oxide ranging from <0.2 to 190 ppb were reported in air from various polymerization facilities(1).
大気基準Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Styrene-7,8-oxide is included on this list.
CERCLA 報告数量Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 100 lb or 45.4 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).
水環境危害等級（WGK）3
TSCA 収載状態TSCA listed
RTECS 番号CZ9625000
輸送番号（UN）UN 2810 6.1/PG 3
PRTR法第一種指定化学物質
税関コード29109000
危険文句（R）45-21-36-43-36/38-20/21-46
化審法(3)-1033
安衛法変異原性物質
消防法危-4-3-III
危険表示T
安全措置（S）53-45-36/37-26
危険等級6.1Acute Tox. 3 InhalationAcute Tox. 4 DermalCarc. 1BEye Irrit. 2Muta. 1BSkin Irrit. 2Skin Sens. 1
包装等級III
自然発火温度928 °F
環境リスク評価スチレンオキシド(96-09-3)
貯蔵分類6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
有害物質データ96-09-3(Hazardous Substances Data)