フェンチクロール

Fenticlor

HCID 7329CAS 97-24-5

基本情報

標準SMILES
Oc1ccc(Cl)cc1Sc1cc(Cl)ccc1O
InChIKey
ANUSOIHIIPAHJV-UHFFFAOYSA-N
分子式
C12H8Cl2O2S
平均分子量
287.2 g/mol
単同位体質量
285.9622061

名称と識別子

優先名称
Fenticlor
IUPAC
4-chloro-2-(5-chloro-2-hydroxyphenyl)sulfanylphenol
現地名
フェンチクロール
英語名
BIS(2-HYDROXY-5-CHLOROPHENYL) SULFIDE
分子式
C12H8Cl2O2S
分子量
287.16

名称と別名

Fenticlor97-24-52,2'-THIOBIS(4-CHLOROPHENOL)Bis(2-hydroxy-5-chlorophenyl) sulfideFentichlorNovexOvitrolPhentichlorumMeflorinOksidBis(2-hydroxy-5-chlorophenyl)sulfideFenticloro
名称をさらに表示
ビス(2-ヒドロキシ-5-クロロフェニル)スルフィドフェンチクロルノベックス2,2'-チオビス(4-クロロフェノール)フェンチクーロルオビトロールフェンチクロ-ル2,2'-チオビス(5-クロロフェノール) スルフィド 塩化物2,2'-ジヒドロキシ-5,5'-ジクロロジフェニルスルフィドビス(5-クロロ-2-ヒドロキシフェニル)スルフィド2,2'-チオビス(5-クロロフェノール)フェンチクロール4-クロロ-2-[(5-クロロ-2-ヒドロキシフェニル)スルファニル]フェノール2,2′-チオビス(4-クロロフェノール)d25D 25cr305HL 1050
D 25-AntimykotikumS 7 (antimycotic)FenticlorumPhenol, 2,2'-thiobis[4-chloro-2,2'-Dihydroxy-5,5'-dichlorodiphenyl sulfidePh 549CR 3052,2'-sulfanediylbis(4-chlorophenol)

データベース識別子

CAS
97-24-5
PubChem CID
7329
DTXSID
DTXSID4026137
ChEMBL
CHEMBL473535
ChEBI
CHEBI:556580
UNII
D61659OVD0
EC Number
202-568-7
Nikkaji
J4.947F

物性

構造計算による物性

XLogP
4.5
極性表面積
65.8 Ų
水素結合供与体数
2
水素結合受容体数
3
回転可能結合数
2
重原子数
17

実験および物理化学的性質

Solubilityless than 1 mg/mL at 72 °F (NTP, 1992)
Melting Point348.4 to 368.2 °F (NTP, 1992)
Physical Description · 2 件

2,2'-thiobis(4-chlorophenol) appears as white to cream-colored solid or pale yellow powder. White crystalline solid melting from 175.8-186.8 °C. Odorless and insoluble in water.

White to cream-colored solid or pale yellow powder; [CAMEO]

物理化学的性質

融点
175 °C · 175°C
沸点
416.7 · 416.7±45.0 °C(Predicted)
比重(密度)
1.4186 · 1.4186 (estimate)
貯蔵温度
Sealed in dry,Room Temperature
外見
powder to crystal
酸解離定数(Pka)
7.91 · 7.91±0.48(Predicted)

化学的性質

化学的特性white to pale yellow powder

安全と法規制

GHS分類

GHS Classification · 5 件

Danger

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation];H317 (97.5%): May cause an allergic skin reaction [Warning Sensitization, Skin];H318 (97.5%): Causes serious eye damage [Danger Serious eye damage/eye irritation];H335 (97.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation];H413 (97.5%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard]

P261, P264, P264+P265, P271, P272, P273, P280, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P332+P317, P333+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 40 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

危険有害性情報

Regulatory InformationPhenol, 2,2'-thiobis[4-chloro-: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Other Safety InformationIMAP assessments - Phenol, 2,2'-thiobis[4-chloro-: Human health tier I assessment;IMAP assessments - Phenol, 2,2'-thiobis[4-chloro-: Environment tier I assessment
Fire HazardsFlash point data are not available for this chemical, but it is probably combustible. (NTP, 1992)
Health HazardsSYMPTOMS: This material may cause skin irritation.;ACUTE/CHRONIC HAZARDS: This material may cause irritation of the skin on contact. Hazardous products are emitted when this chemical is heated to decomposition. (NTP, 1992)
Hazards SummaryMay be irritating to the skin; [CAMEO] A photosensitizer reported in Canada, Britain, and Australia; [Marks, p. 231-2]
Reactive GroupSulfides, Organic;Phenols and Cresols;Aryl Halides

安全と保護具

Fire FightingFires involving this compound should be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
First Aid · 1 件

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.;SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.;INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.;INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

Nonfire Spill Response · 1 件

SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.;STORAGE PRECAUTIONS: You should store this material in a refrigerator. (NTP, 1992)

Personal Protective Equipment (PPE) · 1 件

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

毒性情報

Adverse EffectsDermatotoxin - PACD (photoallergic contact dermatitis).

法規制情報

Regulatory InformationPhenol, 2,2'-thiobis[4-chloro-: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

安全データ

rtecs
SN0350000
毒性
LDLo intraperitoneal in mouse: 250mg/kg
hs_code
2930.90.2900
risk_code
36/37/38
safety_code
26-36/37/39
hazard_class
IRRITANT

化学と産業

用途と製造

Uses · 2 件

Classification Code: Anti-infective, topical ; Antifungal agents [NLM, ChemIDplus] Used as a preservative in water circulation systems to prevent the growth of algae and slime; it has antimicrobial activity against bacteria, fungi, and algae; [Ullmann] Used in cosmetics (hair dressings and antifungal creams) sold outside the United States; also reported in workers handling thermoplastic resins; [Marks, p. 231]

Metal Machining [Category: Heat or Machine];Plastic Composites Manufacturing [Category: Industry];Dressing Hair [Category: Other]

Use ClassificationCosmetics -> Antimicrobial

応用分野

使用Fungicide; especially used against Monosporium apiospermum: Reifferscheid, Seeliger, Dtsch. Med. Wochenschr. 80, 1841, 1850 (1955).

一般的な説明White to cream-colored solid or pale yellow powder. White crystalline solid melting from 175.8-186.8°C. Odorless and insolbule in water.

調製方法 · 1 件

製造方法Fenticlor is produced (1) by the reaction of 4-chlorophenol with sulfur dichloride in the presence of AlCl3 or (2) by chlorination of 2,2'-thiobisphenol with chlorine in glacial acetic acid or with SO2Cl2 in dichlorobenzene. It shows a tendency to discoloration. Fenticlor has a broad range of antimicrobial action; it is, e.g., effective against bacteria, fungi, yeasts, and algae. Fenticlor is therefore used as a preservative for aqueous functional fluids and to control algae and slime in process water circulation systems.

サプライヤー44 社

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
爱斯特(成都)生物制药股份有限公司+86-28-85122536 85324413 · [email protected]
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]
Aladdin Scientific[email protected]

補足説明

定義ChEBI: An aryl sulfide having two 5-chloro-2-hydroxyphenyl groups attached to sulfur; an antiinfective drug mostly used in veterinary medicine.

関連反応

1 件

関連ノート

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