基本情報
- CAS
1304-85-4- 標準SMILES
O=[N+]([O-])[O-].O=[N+]([O-])[O-].O=[N+]([O-])[O-].O=[N+]([O-])[O-].[Bi+3].[Bi+3].[Bi+3].[Bi+3].[Bi+3].[O-2].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-]- InChIKey
QGWDKKHSDXWPET-UHFFFAOYSA-E- 分子式
- Bi5H9N4O22
- 平均分子量
- 1,461.99 g/mol
- 単同位体質量
- 1,461.87284
概要
Bismuth subnitrate, also referred to as bismuth oxynitrate or bismuthyl nitrate, is a highly water-soluble crystalline compound that has been used as a treatment for duodenal ulcers and anti-diarrheic agent. The use of bismuth substrate as an active ingredient in over-the-counter antacids is approved by the FDA.
名称と識別子
- 優先名称
- Bismuth Subnitrate
- IUPAC
- pentabismuth;oxygen(2-);nonahydroxide;tetranitrate
- 現地名
- 次硝酸ビスマス
- 英語名
- Bismuth subnitrate
- 分子式
- Bi5H9N4O22
- 分子量
- 1461.99
名称と別名
Bismuth nitrate, basicBasic bismuth nitrateNovismuthVicalinVikalineBismuth paintBismuth SynlabBismuth WhiteCosmetic WhiteSpanish WhiteFlake WhitePaint White
名称をさらに表示
オキシ硝酸ビスマス硝酸ビスマス(塩基性)硝酸水酸化ビスマス(III)塩基性硝酸ビスマス塩基性.硝酸ビスマス(III)次硝酸ビスマス (AS)硝酸水酸化ビスマス(III), 99.9%次硝酸ビスマス(III)次硝酸ビスマス (JP17)亜硝酸ビスマス（III）次硝酸ビスマス「純生」硝ビスビスミット硝ビス硝酸ビスマス(塩基性硝酸ビスマス)BISMUTH OXYNITRATEc.i.77169flakewhitepaintwhitesnowcal5swblancdefardbismuthpaint
Blanc de fardBismuth magisteryBismuthyl nitrateBismuth subnitricumSnowcal 5SWSnowcal 5 SWBismuthum subnitricumMagistery of bismuth
データベース識別子
物性
構造計算による物性
- 極性表面積
- 262 Ų
- 水素結合供与体数
- 9
- 水素結合受容体数
- 22
- 回転可能結合数
- 0
- 重原子数
- 31
- 形式電荷
- 0
- 複雑度
- 18.8
実験および物理化学的性質
Chemical ClassesMetals -> Metals, Inorganic Compounds
CosmeticsOpacifying; Absorbent
pHSHOWS ACID TO MOISTENED LITMUS PAPER
OdorODORLESS
TasteTASTELESS
Density4.928
Color/Form
HEAVY, MICROCRYSTALLINE POWDER
WHITE POWDER
Solubility
Insoluble
PRACTICALLY INSOL IN WATER, ALC; SOL IN DILUTE HYDROCHLORIC ACID & NITRIC ACID
PRACTICALLY INSOL IN ORGANIC SOLVENTS
Animal DrugsPharmaceuticals -> UK Veterinary Medicines Directorate List
Boiling Point
Decomposes at 260
BOILING POINT: 260 °C -HNO3 /BIONO3.H2O/
DecompositionDecomposes to Bi2O3 and nitrogen oxides when heated to red heat.
Melting Point
安全と法規制
GHS分類
GHS Classification
This chemical does not meet GHS hazard criteria for 58.1% (115 of 198) of all reports.
Danger
H272 (24.2%): May intensify fire; oxidizer [Danger Oxidizing liquids; Oxidizing solids]
P210, P220, P260, P261, P264, P264+P265, P270, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 198 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Danger
危険有害性情報
Regulatory Information
Chemical: Bismuth hydroxide nitrate oxide, (Bi5(OH)9(NO3)4O)
Bismuth hydroxide nitrate oxide (Bi5(OH)9(NO3)4O) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Bismuth hydroxide nitrate oxide (Bi5(OH)9(NO3)4O) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
REACH registered substance: Bismuth hydroxide nitrate oxide (EC: 215-136-8)
Bismuth hydroxide nitrate oxide: HSNO Approval: HSR001433 Approved with controls
Fire PotentialHAZARD: OXIDIZING MATERIAL; FIRE RISK NEAR ORGANIC MATERIALS.
Hazards SummaryAn irritant; Oxidizing agent--keep away from combustible materials; [MSDSonline] See Bismuth. See NITRATES and NITRITES.
Hazard Classes and Categories
Ox. Sol. 2 (24.2%)
Specific target organ toxicity - Single exposure - Category 2 (central nervous system, blood)
Hazardous Reactivities and IncompatibilitiesIncompatible with alkaline bicarbonates, soluble iodides, gallic acid, calomel, salicylic acid, tannin, and sulfur.
化学と産業
薬理情報
ATC Code
A - Alimentary tract and metabolism
QA - Alimentary tract and metabolism
Protein BindingUpon accumulation in the kidneys, bismuth may bind to a bismuth-metal binding protein in the kidney.
Pharmacodynamics
Bismuth subnitrate acts as an antacid that exert protective effects on the gastric mucosa. In a double-blind endoscopically controlled study, bismuth substrate was demonstrated to be effective for symptomatic relief in duodenal ulcers. In the alcohol model of mucosal injury in the rat, bismuth substrate was shown to be cytoprotective. In a randomized clinical study consisting of patients with _H. pylori_-associated duodenal ulcer, adjunctive use of colloidal bismuth subnitrate in a short treatment regimen with omeprazole and clarithromycin resulted in improved eradication rate of _H. pylori_.
Mechanism of Action
Based on the findings of a clinical investigation in patients with duodenal ulcer disease and healthy volunteers receiving oral bismuth subnitrate tablets, the protective effects of bismuth subnitrate may be secondary to endogenous mucosal prostaglandin (PGE2) production, which is one of the deficient factors observed in peptic ulcer disease. Antacid neutralizing activity of bismuth subnitrate was demonstrated to have a significant postprandial effect on gastric pH.
Biological Half-LifeThe distribution half-life of bismuth is approximately 1 to 4 hours, and the elimination half-life is 5 to 11 days.
Metabolism/MetabolitesNo pharmacokinetic data available.
FDA Pharmacological Classification
BISMUTHUM SUBNITRICUM
Bismuth [CS]; Bismuth [EPC]
BISMUTH SUBNITRATE
Bismuth [CS]; Bismuth [EPC]
MeSH Pharmacological ClassificationSubstances that counteract or neutralize acidity of the GASTROINTESTINAL TRACT.
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