化工社化工社 化学情報印刷レポート · 研究参考用
4-tert-ブチルフェノール
4-tert-ブチルフェノール · ブチルフェン · 4-ターシャリ-ブチルフェノール · 4-(tert-ブチル)フェノール · 4-(1,1-ジメチルエチル)フェノール · p-tert-ブチルフェノール · 4-t-ブチルフェノル · ｐ－ｔ－ブチルフェノール
識別子と物理属性
| CAS No. | 98-54-4 |
|---|---|
| 分子式 | C10H14O |
| 平均分子量 | 150.22 g/mol |
| 単同位体質量 | 150.10446507 g/mol |
| SMILES | CC(C)(C)c1ccc(O)cc1 |
| InChIKey | QHPQWRBYOIRBIT-UHFFFAOYSA-N |
| PubChem CID | 7393 |
| ChEMBL | CHEMBL16217 |
| ChEBI | CHEBI:34444 |
| EC No. | 202-679-0 |
| DTXSID | DTXSID1020221 |
| 現地名 | 4-tert-ブチルフェノール |
化学・物理的性質
| XLogP | 3.3 |
|---|---|
| 極性表面積 | 20.2 |
| 水素結合供与体数 | 1 |
| 水素結合受容体数 | 1 |
| 回転可能結合数 | 1 |
| 重原子数 | 11 |
| 形式電荷 | 0 |
| 複雑度 | 115 |
| 物質分類 | Other Classes -> PhenolsAntioxidant |
| SpringerMaterials Properties | 13C nuclear magnetic resonance spectrum |
| 香料 | Fragrance substance (p-tert-Butylphenol) -> IFRA amendment 40 |
| LogP（分配係数） | log Kow = 3.312.4/3.43.16 |
| 臭い | Distinctive odorプロピレングリコール中1.00%。オークモスレザー |
| 食品添加物 | FLAVORING AGENT OR ADJUVANT -> FDA Substance added to food |
| 密度 | 0.908 at 176 °F (NTP, 1992) - Less dense than waterwill float1.037 at 25 °CDensity: 0.908 g/cu cm at 80 °C0.9 g/cm³1.037 @25 °C0.908 g/mL at 25 °C (lit.) |
| 香味料 | EU Flavoring substances |
| Viscosity | 2.4 mPa.s at 110 °C |
| Color/Form | Needles from waterNeedles from ligninWhite crystalsCrystals, needles, or practically white flakes |
| 溶解度 | Insoluble (NTP, 1992)In water, 580 mg/L at 25 °CIn water, 610 mg/L at 25 deg (OECD Guideline 105)In water, 607.2 mg/L at 25 °C (pH 6-7) National Standard ASTM E 1148 - 02, which is similar to OECD Guideline No. 105)Soluble in ethanol, ether, chloroform, alkalis0.58 mg/mL at 25 °Cエタノール：可溶50mg/mL 無色透明8.7g/L(20℃) |
| 引火点 | 235 °F (NTP, 1992)113 °C (235 °F) - closed cup115 °C o.c. |
| 融点 | 96-101 °C (lit.) |
| 沸点 | 236-238 °C (lit.) |
| 蒸気圧 | 1 mm Hg ( 70 °C) |
| 屈折率 | 1.4787 |
| FEMA | 3918 | P-TERT-BUTYLPHENOL |
| 貯蔵条件 | Store below +30°C. |
| 外観・状態 | フレークまたはトローチ |
| pKa（酸解離定数） | 10.23(at 25℃) |
| 色 | ホワイトからライトベージュ |
| 比重 | 0.908 |
| pH | 7 (10g/l, H2O, 20℃) |
| 爆発限界 | 0.8-5.3%(V) |
| においのタイプ | 革っぽい |
| 由来生物 | synthetic |
| JECFA Number | 733 |
| Merck | 14,1585 |
| BRN | 1817334 |
| ヘンリー定数 | 8.9×100 mol/(m3Pa) at 25℃, Parsons et al. (1972) |
| 安定性 | 安定。銅、鋼、塩基、酸塩化物、酸無水物、酸化剤とは混和しません。 |
| InChI | 1S/C10H14O/c1-10(2,3)8-4-6-9(11)7-5-8/h4-7,11H,1-3H3 |
| InChIKey | QHPQWRBYOIRBIT-UHFFFAOYSA-N |
| SMILES | CC(C)(C)c1ccc(O)cc1 |
| LogP（分配係数） | 3 at 23℃ |
| CAS データベース | 98-54-4(CAS DataBase Reference) |
| NISTの化学物質情報 | Phenol, p-tert-butyl-(98-54-4) |
| EPAの化学物質情報 | p-tert-Butylphenol (98-54-4) |
化学的特性
4-tert-Butylphenol is a white to pale yellow crystalline solid at room temperature and is sold in solid form as flakes or briquettes. 4-tert-butylphenol is employed in coating products, polymers, adhesives, sealants and for the synthesis of other substances. The major use is as a monomer in chemical synthesis, e.g. for the production of polycarbonate, phenolic resins, epoxy resins. PtBP is used as a chain terminator in the synthesis of polycarbonate polymers. The main uses of polycarbonate are in compact discs, DVD and CD Rom manufacture.
安全性と法規制
| GHS 分類 | DangerH315: Causes skin irritation [Warning Skin corrosion/irritation]P203, P264, P264+P265, P273, P280, P302+P352, P305+P354+P338, P317, P318, P321, P332+P317, P362+P364, P391, P405, and P501 (click each P-code to see the statement)This chemical does not meet GHS hazard criteria for 0.2% (7 of 3826) of reports.H314 (12.2%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation] |
|---|---|
| 規制情報 | Chemical: Phenol, 4-(1,1-dimethylethyl)-Hazard Traits - Endocrine ToxicityCommission Regulation (EC) No 1565/2000 (Repealed by Com. Implementing Reg. (EU) No 872/2012)Phenol, 4-(1,1-dimethylethyl)- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Phenol, 4-(1,1-dimethylethyl)- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 07-02-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/15260Substance: 4-tert-butylphenol |
| その他の安全情報 | IMAP assessments - Phenol, 4-(1,1-dimethylethyl)-: Human health tier II assessment |
| 輸送ラベル（DOT） | Corrosive |
| 火災危険 | Combustible. (NTP, 1992) |
| 火災の可能性 | Combustible when exposed to heat or flame. |
| 健康有害性 | SYMPTOMS: Irritating to eyes, noses and throat. If inhaled, will cause difficult breathing. |
| 有害性の概要 | A severe skin, eye, and respiratory tract irritantMay cause skin sensitization and dermatitis after prolonged contactMay cause skin depigmentationAfter chronic exposure, may cause effects on the liver and nervous system[ICSC] Danger of cutaneous absorptionDanger of skin sensitization[MAK] A corrosive substance that can cause injury to the skin, eyes, and respiratory tractNo sensitizing effects knownInhalation may cause chemical pneumonitisCan be absorbed through skin[MSDSonline] |
| 反応性グループ | Phenols and Cresols |
| UN 分類 | UN Hazard Class: 8UN Pack Group: III |
| TSCA 要件 | Section 8(a) of TSCA requires manufacturers of this chemical substance to report preliminary assessment information concerned with production, exposure, and use to EPA as cited in the preamble in 51 FR 41329. Effective date: 3/29/96Reporting date: 5/29/96.Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. 4-tert-Butylphenol is included on this list. Effective date: 3/29/96Reporting date: 6/30/98. |
| FIFRA 要件 | As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their continued use. Under this pesticide reregistration program, EPA examines newer health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether the use of the pesticide does not pose unreasonable risk in accordance to newer safety standards, such as those described in the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA '88 were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern than those on List C, and with List C containing pesticides of greater concern than those on List D. Butylphenol is found on List C. Case No: 3035Pesticide type: fungicide, antimicrobialCase Status: No products containing the pesticide are actively registered. Therefore, we are characterizing the case as "cancelled." Under FIFRA, pesticide producers may voluntarily cancel their registered products. EPA also may cancel pesticide registrations if registrants fail to pay required fees or make/meet certain reregistration commitments, or if EPA reaches findings of unreasonable adverse effects.Active ingredient (AI): butylphenolData Call-in (DCI) Date(s): NoneAI Status: The active ingredient is no longer contained in any registered products. Thus, we characterize it as "cancelled." |
| Reactivity Profile | Phenols, such as 4-TERT-BUTYL PHENOL, do not behave as organic alcohols, as one might guess from the presence of a hydroxyl (-OH) group in their structure. Instead, they react as weak organic acids. Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has pKa = 9.88). These materials are incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction between phenols and bases. Such heating may initiate polymerization of the organic compound. Phenols are sulfonated very readily (for example, by concentrated sulfuric acid at room temperature). The reactions generate heat. Phenols are also nitrated very rapidly, even by dilute nitric acid. |
| 消火 | A fire in your laboratory involving this chemical should be extinguished with a dry chemical, carbon dioxide or halon extinguisher. (NTP, 1992)Use alcohol-resistant foam, powder, carbon dioxide. |
| 応急処置措置 | Fresh air, rest.Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Give one or two glasses of water to drink. Rest. Refer for medical attention . |
| 応急処置 | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. |
| 安全保管 | Well closed. |
| 暴露管理・個人防護 | 0.08 [ppm] |
| 消火手順 | Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary. |
| 保管条件 | Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place. |
| 清掃方法 | ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal. |
| 非火災時の漏出対応 | SMALL SPILLS AND LEAKAGE: If you spill this chemical, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with alcohol followed by washing with a strong soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. |
| 処分方法 | SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in air, soil or watereffects on animal, aquatic and plant lifeand conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.Product: Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Contaminated packaging: Dispose of as unused product. |
| 漏出処分 | Personal protection: filter respirator for organic gases and particulates adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. |
| Preventive Measures | ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.Precautions for safe handling: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Further processing of solid materials may result in the formation of combustible dusts. The potential for combustible dust formation should be taken into consideration before additional processing occurs. Provide appropriate exhaust ventilation at places where dust is formed.Appropriate engineering controls: Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.For more Preventive Measures (Complete) data for p-tert-Butylphenol (6 total), please visit the HSDB record page. |
| 健康影響 | Leukoderma, vitiligo. |
| 生態毒性値 | LC50Species: Crangon septemspinosa (Bay Shrimp, Sand Shrimp) length 6.4-8.3 cm, weight 2.4-4.5 gConditions: saltwater, renewal, 10 °CConcentration: 1900 ug/L for 96 hrEC50Species: Daphnia magna (Water Flea) age 6-24 hrConditions: freshwater, static, 20 °C, pH > or =7.0Concentration: 4200 ug/L for 24 hr (95% confidence interval: 3800-4700 ug/L)Effect: intoxication, immobilization /formulated product/Concentration: 3900 ug/L for 48 hr (95% confidence interval: 3400-4500 ug/L)Species: Pimephales promelas (Fathead Minnow) age 31-35 days, weight 97 mgConditions: freshwater, flow through, 24.6 °C, pH 6.9-7.7, hardness 44.9 mg/L CaCO3 (42.4-46.6 mg//L CaCO3), alkalinity 42.9 mg/L CaCO3 (39.6-61.4 mg/L CaCO3), dissolved oxygen 7.4 mg/L (4.6-8.8 mg/L)Concentration: 6210 ug/L for 24 hr (95% confidence interval: 5780-6680 ug/L) />99% purity/For more Ecotoxicity Values (Complete) data for p-tert-Butylphenol (8 total), please visit the HSDB record page. |
| 環境中動態 | TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1290(SRC), determined from a structure estimation method(2), indicates that p-tert-butylphenol is expected to have low mobility in soil(SRC). The pKa of p-tert-butylphenol is 10.16(3), indicating that this compound will exist almost entirely in the neutral form in the environment. Volatilization of p-tert-butylphenol from moist soil surfaces is not expected to be an important fate process(SRC) given a Henry's Law constant of 1.19X10-6 atm-cu m/mole(4). p-tert-Butylphenol is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 0.00919 mm Hg at 25 °C(5). Results of biodegradation screen tests suggest p-tert-butylphenol can be readily biodegradable via adapted microorganisms and at concentrations below inhibitory effects(6). Therefore, biodegradation is expected to be an important fate process(SRC).AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1290(SRC), determined from a structure estimation method(2), indicates that p-tert-butylphenol is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon a Henry's Law constant of 1.19X10-6 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 38 and 279 days, respectively(SRC). According to a classification scheme(5), a measured BCF range of 20-120(6,7), suggests the potential for bioconcentration in aquatic organisms is low to moderate(SRC). Results of biodegradation screen tests suggest p-tert-butylphenol can be readily biodegradable via adapted microorganisms and at concentrations below inhibitory effects(8). Therefore, biodegradation is expected to be an important fate process(SRC). p-tert-Butylphenol was found to be stable to hydrolysis at pH 4, pH 7 and pH 9 using OECD Guideline 111(9).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), p-tert-butylphenol, which has a vapor pressure of 0.00919 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase p-tert-butylphenol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 9.5 hours(SRC), calculated from its rate constant of 4.1X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). p-tert-Butylphenol absorbs at wavelengths >290 nm(4,5) and, therefore, may be susceptible to direct photolysis by sunlight(SRC). |
| 食品調査値 | p-Butylphenol (isomers not specified) was qualitatively detected in cassava volatiles(1). |
| 有害作用 | Neurotoxin - Other CNS neurotoxin |
| 暴露経路 | The substance can be absorbed into the body by inhalation of its aerosol and through the skin.Dermal |
| 毒性の概要 | IDENTIFICATION AND USE: p-tert-Butylphenol (4-TBP) is a solid. It is used as a plasticizer for cellulose acetate, intermediate for antioxidants, special starches, oil-soluble phenolic resins, as a pour-point depressors and emulsion breakers for petroleum oils and some plastics, as a synthetic lubricants, industrial odorants, and motor-oil additives. It is no longer used as insecticide. HUMAN STUDIES: In a routine test series of the North American Contact Dermatitis Group in 1,900 patients with contact dermatitis revealed 1.9% positive reactions and the test series with 900-2,000 contact dermatitis patients revealed 1.1% positive reactions to 2% of 4-TBP. Ten shoemakers with eczema due to occupational exposure to 4-TBP containing glues were patch-tested for sensitization. Positive reactions to the glue, its ingredients and 4-TBP were observed in all patients. After 24 hours, reaction in the 4-TBP test was erythema, edema or papules, and some patients showed a few vesicles. After 48 hours, all patients showed these symptoms. In the search for environmental compounds responsible for contact or occupational vitiligo, it was found that the most potent was 4-TBP. In vitro 4-TBP induced oxidative stress that was more readily overcome by melanocytes from normally pigmented individuals than from two individuals with vitiligo. ANIMAL STUDIES: Sluggishness, unsteady gait, prostration, unkempt appearance, and nasal discharge were observed as the principal signs of toxicity in acute studies in rats. After inhalation exposure in rats, clinical signs observed on the day of exposure and up to 7 days after it included mucosal irritation and respiratory distress. Male hamsters given a 15 g/kg in a diet developed hyperplasia in the forestomach and papillomatous lesions. Male rats given a 15 g/kg in a diet for 51 weeks developed forestomach hyperplasia, but no tumors in the other organs. there were no treatment related toxic effects on pregnant and lactating females or their offspring in developmental studies in rats. 4-TBP did not induce gene mutation in S. Typhimurium TA100, TA98, TA1535, TA1537 and E. coli WP2 uvrA with and without exogenous metabolic activation system. However, 4-TBP induced both structural and numerical chromosome aberrations in vitro.4-Tert-butylphenol is structurally similar to the melanin precursor tyrosine, and acts as a substrate for tyrosinase. Tyrosinase oxidizes 4-tert-butylphenol to a quinone (4-tert-butylcyclohexa-3,5-diene-1,2-dione) which in turn rapidly reacts with glutathione (GSH). A depletion of the GSH defence system may allow the quinone to generate reactive oxygen species that damage melanocytes and induce apoptosis, leading to leukoderma/vitiligo. (A15209, A15210) |
| Animal Concentrations | p-tert-Butylphenol was not detected (detection limit not reported) in snails collected from the Fujima and Shiratori Rivers (near Lake Biwa, Japan) during 1999-2000(1). |
| Signs and Symptoms | Cough. Sore throat.Redness. Pain.Nausea. Vomiting.Loss of skin pigmentation. |
| Ongoing Test Status | EPA has released the Interactive Chemical Safety for Sustainability (iCSS) Dashboard. The iCSS Dashboard provides an interactive tool to explore rapid, automated (or in vitro high-throughput) chemical screening data generated by the Toxicity Forecaster (ToxCast) project and the federal Toxicity Testing in the 21st century (Tox21) collaboration. /The title compound was tested by ToxCast and/or Tox21 assays/[USEPAICSS Dashboard ApplicationAvailable from, as of August 9, 2018: http://actor.epa.gov/dashboard/] |
| Effluent Concentrations | Leachate samples collected at four landfills in the Gothenburg region, Sweden had a median p-tert-butylphenol concentration of 0.97 ug/L (range of 0.027-8.1 ug/L)(1). Leachate samples collected from a municipal landfill in Gryta, Sweden in May 1990 contained tert-butylphenol(2). p-tert-Butylphenol was qualitatively detected in trench leachate samples collected from low-level radioactive waster disposal sites at Maxey Flats, KY and West Valley, NY(3). p-tert-Butylphenol was detected in the influent to a waste treatment facility in North Carolina (possibly due to its use as a detergent constituent)(4). p-tert-Butylphenol was detected in emissions from incinerators(5). Untreated wastewater and septage samples from Cod Cod, MA (1996-1997 sampling) contained p-tert-butylphenol concentrations of 2.2-3.5 and 0.16-3.9 ug/L respectively(6). |
| ICSC Environmental Data | The substance is toxic to aquatic organisms. Bioaccumulation of this chemical may occur in fish. |
| 水環境危害等級（WGK） | 2 |
| TSCA 収載状態 | TSCA listed |
| RTECS 番号 | SJ8925000 |
| 輸送番号（UN） | UN 3077 9/PG 3 |
| 毒性 | LD50 orally in rats: 3.25 ml/kg (Smyth) |
| PRTR法 | 第一種指定化学物質 |
| 税関コード | 29071900 |
| 危険文句（R） | 37/38-41-51/53-62-38-37-34 |
| 化審法 | (3)-503 |
| 危険表示 | Xi,N |
| 安全措置（S） | 26-39-61-36/37/39-45 |
| 危険等級 | 8Aquatic Chronic 1Eye Dam. 1Repr. 2Skin Irrit. 2 |
| 包装等級 | III |
| 自然発火温度 | 475°C |
| 環境リスク評価 | 4-tert-ブチルフェノール(98-54-4) |
| 貯蔵分類 | 11 - Combustible Solids |
| 有害物質データ | 98-54-4(Hazardous Substances Data) |
用途
用途
合成樹脂変性(改質)剤、有機合成原料。
用途
環境試料中の内分泌攪乱物質の分析（HPLC）用標準品、GC-MS分析標準品。
用途
油溶性フェノール樹脂?農薬?紫外線吸収剤?界面活性剤原料
説明
Para-tertiary-butylphenol formaldehyde resin (PTBPF- R) is a polycondensate of para-tertiary-butylphenol and formaldehyde. Major occupational sources are neoprene glues and adhesives in industry, in the shoemaking and leather industry or in car production. It is also used as a box preservative in box and furniture manufacture, and in the production of casting moulds, car-brake linings, insulated electrical cables, adhesives, printing inks and paper laminates. Para-tertiary-butyl-phenol is the sensitizer.
天然物の起源
Reported found in origanum (Coridothymus cap. (L.) Richb.)
使用
4-tert-Butylphenol is a phenol derivative. Its contact with skin may lead to leukoderma. It is widely used in the polymer industry. Reaction of 4-tert-Butylphenol with mushroom tyrosinase has been reported to afford 4-t-butyl-o-benzoquinone and kinetics of this enzymatic reaction has been investigated.
一般的な説明
Crystals or practically white flakes. Has a disinfectant-like odor. May float or sink in water. Insoluble in water.
製法・合成法
製造方法
Prepared by heating phenol with isobutanol in the presence of zinc chloride; also from phenol, tert- butyl chloride and excess alkali in alcohol
純化方法
Crystallise the phenol to constant melting point from pet ether (b 60-80o). It sublimes in vacuo. Also purify it via the benzoate, as for phenol. The salicylate ester [87-18-30] has m 63-64o (from aqueous EtOH, or EtOH). [Beilstein 6 IV 3296.]