rac-(R*)-α-メチルベンジルアルコール

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

General First Aid:

General First Aid:

General First Aid:

General First Aid:

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear positive pressure self-contained breathing apparatus (SCBA).

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

Immediate precautionary measure

Immediate precautionary measure

Immediate precautionary measure

Immediate precautionary measure

Small Fire

Small Fire

Small Fire

Small Fire

TERRESTRIAL FATE: Based on a recommended classification scheme(1), measured Koc values of <5-52, with higher values corresponding to soils with a greater organic content(2), indicate that alpha-methylbenzyl alcohol will have very high mobility in soil(SRC). Biodegradation is expected to be a major fate process for this compound(SRC). Alpha-methylbenzyl alcohol was completely biodegraded within 2-3 weeks under aerobic conditions using an activated sludge inoculum(3). Under anaerobic conditions, this compound had a half-life of 7 days(3). Acetophenone was reported as a major metabolite for both oxygen conditions(3). Volatilization of alpha-methylbenzyl alcohol from either moist surfaces will not be a major fate process(SRC) based on estimated values for Henry's Law constant (2.9X10-7 atm-cu m/mole)(4,SRC). Volatilization from dry soil surfaces should not be significant based on an estimated vapor pressure (0.058 mm Hg)(5,SRC).

AQUATIC FATE: Based on a recommended classification scheme(1), experimental Koc values of <5 to 52(2) indicate that alpha-methylbenzyl alcohol will not adsorb to suspended solids and sediment(SRC) in the water column. Biodegradation is expected to be a major fate process for this compound(SRC). Alpha-methylbenzyl alcohol was completely biodegraded within 2-3 weeks under aerobic conditions using an activated sludge inoculum(3). Under anaerobic conditions, this compound had a half-life of 7 days(3). Acetophenone was reported as the major metabolite for both oxygen conditions(3). Retention pond and aerated lagoon systems reported 12 and 17% biodegradation after 260 hours(3) indicating that under some conditions, biodegradation may not occur rapidly(SRC). Alpha-methylbenzyl alcohol should not volatilize from water surfaces based on an estimated Henry's Law constant of 2.9X10-7 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). An estimated BCF value of 9(3,SRC), from a measured water solubility(2), suggests that alpha-methylbenzyl alcohol will not bioconcentrate in aquatic organisms(SRC), according to a recommended classification scheme(5).

ATMOSPHERIC FATE: According to a suggested classification scheme(1), an estimated vapor pressure of 0.058 mm Hg at 25 °C(2,SRC) indicates that alpha-methylbenzyl alcohol will mainly exist in the vapor phase in the ambient atmosphere. Vapor-phase alpha-methylbenzyl alcohol is degraded in the atmosphere by reaction with photochemically produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 1.1 days(3,SRC).

The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical. [http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=98-85-1]

Alpha-methylbenzyl alcohol was detected once in the wastewater from a mechanical products industry(1). Wastewater from a petrochemical company contained alpha-methylbenzyl alcohol at unreported concentrations(2). Alpha-methylbenzyl alcohol was detected in finished water from the Blue Plains Advanced Waste Treatment Plant in Washington, DC in September, 1974(3).

Koc values for alpha-methylbenzyl alcohol were determined for three subsoils: Apison (organic content = 0.11%) had a Koc of 37, Fullerton (organic content = 0.06%) had a Koc of <5, and Dormont (organic content = 1.2%) had a Koc of 52(1). According to a recommended classification scheme(2), these Koc values suggest that alpha-methylbenzyl alcohol has very high mobility in soil, although increasing organic content will act to reduce mobility slightly(SRC).

In an aerobic, sewage die-away screening test alpha-methylbenzyl alcohol (at 6000 ppm) biodegraded rapidly with 78.2% of the theoretical BOD reached in 8-10 days(1). Phenol-adapted cultures grown without alpha-methylbenzyl alcohol, with alpha-methylbenzyl alcohol (at 100 mg/L), and with both phenol and alpha-methylbenzyl alcohol consumed 69, 75, and 320 ul O2, respectively, over a 210 minute period(2). An Arthrobacter strain initially dehydrogenates alpha-methylbenzyl alcohol to acetophenone which is then converted to an ester, producing phenyl acetate which is then hydrolysed to phenol and acetate(3). A Nocardia strain first oxygenates the benzene nucleus to give 3-(1'-hydroxyethyl)-3,5-cyclo-hexadiene-1,2-diol which is then reduced and subjected to extra-diol cleavage(3). This same strain is also able to degrade alpha-methylbenzyl alcohol using the same pathway as described above for Arthrobacter(3). Alpha-methylbenzyl alcohol, inoculated with a mixed microbial culture, was readily biodegraded from 550 ppm to 20 ppm over 32 days(4). Nitrosomonas europaea degraded 2.5% of alpha-methylbenzyl alcohol (initially present at 200 nmol) over a 15 hour period(5). Alpha-methylbenzyl alcohol had a BOD of 1.0 g/g alpha-methylbenzyl alcohol after a 10 day incubation with a sewage inoculum(6).

Loss of alpha-methylbenzyl alcohol was monitored in four systems. In an aerobic, screening test using an activated sludge inoculum, alpha-methylbenzyl alcohol (at 100 ppm) was nearly completely biodegraded within either 14 or 20 days, depending on the inoculum size(heavy or light, respectively); acetophenone was the major metabolite(1). In an aerobic, retention pond system, 12% biodegradation was measured over 260 hours (alpha-methylbenzyl alcohol initially present at 300 ppm)(1). 17% degradation of alpha-methylbenzyl alcohol (at 300 ppm) was reported in an aerated lagoon system after 240 hours(1). Alpha-methylbenzyl alcohol had a half-life of 7 days under anaerobic conditions using a digester sludge inoculum; acetophenone was formed as a metabolite(1).

Alpha-Methylbenzyl Alcohol

TR-369: Toxicology and Carcinogenesis Studies of alpha-Methylbenzyl Alcohol (CASRN 98-85-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies) (1990 )

03/13/89

Some Evidence

No Evidence

No Evidence

An estimated BCF value of 9 was calculated for alpha-methylbenzyl alcohol(SRC), using a measured water solubility of 1950 mg/L at 25 °C(1) and a recommended regression-derived equation(2). According to a recommended classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms will not be an important fate process(SRC).

alpha-Methylbenzyl alcohol is a food additive permitted for direct addition to food for human consumption as a synthetic flavoring substance and adjuvant in accordance with the following conditions: 1) the quantity added to food does not exceed the amount reasonably required to accomplish its intended physical, nutritive, or other technical effect in food, and 2) when intended for use in or on food it is of appropriate food grade and is prepared and handled as a food ingredient.