化工社化工社 化学情報印刷レポート · 研究参考用
フェニルヒドラジン
フェニルヒドラジン · 1-フェニルヒドラジン · フェニルヒドラジド · 1-ヒドラジノベンゼン · ヒドラジノベンゼン · フェニルヒドラジン, 97% · Phenyl hydrazide · Fenilidrazina
識別子と物理属性
| CAS No. | 100-63-0 |
|---|---|
| 分子式 | C6H8N2 |
| 平均分子量 | 108.14 g/mol |
| 単同位体質量 | 108.06874826 g/mol |
| SMILES | NNc1ccccc1 |
| InChIKey | HKOOXMFOFWEVGF-UHFFFAOYSA-N |
| PubChem CID | 7516 |
| ChEMBL | CHEMBL456807 |
| ChEBI | CHEBI:27924 |
| EC No. | 202-873-5 |
| DTXSID | DTXSID8021147 |
| 現地名 | フェニルヒドラジン |
化学・物理的性質
| XLogP | 1.2 |
|---|---|
| 極性表面積 | 38.1 |
| 水素結合供与体数 | 2 |
| 水素結合受容体数 | 2 |
| 回転可能結合数 | 1 |
| 重原子数 | 8 |
| 形式電荷 | 0 |
| 複雑度 | 57.5 |
| 物質分類 | Nitrogen Compounds -> HydrazinesFlammable agents - 2nd degree |
| SpringerMaterials Properties | 13C nuclear magnetic resonance spectrum |
| LogP（分配係数） | log Kow= 1.25 |
| 臭い | Faint, aromatic odor. |
| 密度 | 1.0978 (USCG, 1999) - Denser than waterwill sink1.0978 at 20 °C/4 °CRelative density (water = 1): 1.11.0978 @ 20°C1.101.098 g/mL at 25 °C (lit.) |
| Color/Form | Monoclinic prisms or oilColorless to pale yellow liquid or solid (below 67 degrees F). |
| 溶解度 | Slight (NIOSH, 2024)Sparingly sol petroleum ether, sol in dil acids. Miscible in alcohol, ether, chloroform, and benzeneSoluble in oxygenated, chlorinated, and aromatic solvents.Very soluble in acetone.In water, 1.27X10+5 mg/L at 25 °CSolubility in water, g/100ml at 25 °C: 14.5希酸に可溶。145g/L(20℃) |
| 引火点 | 190 °F (USCG, 1999)88 °C190 °F, 88 °C (closed cup)88 °C c.c.192 °F |
| 沸点 | 471 °F at 760 mmHg (with decomposition) (USCG, 1999)243.5 °C, decomp (760 mm Hg)173.5 °C at 100 mm Hg148.2 °C at 40 mm Hg131.5 °C at 20 mm Hg115.8 °C at 10 mm Hg101.6 °C at 5 mm Hg71.8 °C at 1 mm Hg470 °F (decomposes)243.5 °C @760 [mm Hg]238-241 °C (lit.) |
| Decomposition | When heated to decomposition it emits highly toxic fumes of /nitrogen oxides/.243.5 °C |
| 融点 | 68 °F (USCG, 1999)19.5 °CMP: 243-6 °C, decomposesmolecular wt 144.60 /Phenylhydrazine hydrochloride/Liquid Molar Volume= 0.098820 cu m/kmolIG Heat of Formation= 2.0350X10+8 J/kmolHeat of Fusion at the Melting Point= 1.6429X10+7 J/kmol.67 °F18-21 °C (lit.) |
| 蒸気密度 | 3.7 (air= 1)Relative vapor density (air = 1): 3.74.3 (vs air) |
| 蒸気圧 | <0.1 mm Hg ( 20 °C) |
| 屈折率 | n20/D 1.607(lit.) |
| 貯蔵条件 | Store below +30°C. |
| 外観・状態 | 粉 |
| pKa（酸解離定数） | 8.79(at 15℃) |
| 色 | 白からやや青またはライトベージュ |
| 爆発限界 | 1.1%(V) |
| 比熱容量 | Cp(liquid): 2.01 J/(g·K), at 25℃ |
| Merck | 14,7293 |
| BRN | 606080 |
| ヘンリー定数 | 2.2×103 mol/(m3Pa) at 25℃, Duchowicz et al. (2020) |
| 誘電率 | 7.2(23℃) |
| 安定性 | 安定していますが、日光で分解する可能性があります。空気または光に敏感な場合があります。強力な酸化剤、金属酸化物とは相容れない。 |
| InChI | 1S/C6H8N2/c7-8-6-4-2-1-3-5-6/h1-5,8H,7H2 |
| InChIKey | HKOOXMFOFWEVGF-UHFFFAOYSA-N |
| SMILES | NNc1ccccc1 |
| CAS データベース | 100-63-0(CAS DataBase Reference) |
| NISTの化学物質情報 | Hydrazine, phenyl-(100-63-0) |
| EPAの化学物質情報 | Phenylhydrazine (100-63-0) |
化学的特性
Phenylhydrazine is a colorless to pale yellow liquid or solid with a weak aromatic odor. It is soluble in water (values ranging from 145 to 837 g/litre at 24 °C have been reported) and is miscible with alcohol, ether, chloroform, benzene, and acetone. The conversion factor for phenylhydrazine is 1 ppm = 4.5 mg/m3 (at 20 °C, 101 kPa).
安全性と法規制
| GHS 分類 | DangerH301: Toxic if swallowed [Danger Acute toxicity, oral]P203, P260, P261, P262, P264, P264+P265, P270, P271, P272, P273, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P316, P318, P319, P321, P330, P332+P317, P333+P317, P337+P317, P361+P364, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral] |
|---|---|
| 規制情報 | Chemical: Hydrazine, phenyl-Hydrazine, phenyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Hydrazine, phenyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 01-04-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/14149Phenylhydrazine: HSNO Approval: HSR003056 Approved with controlsThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
| その他の安全情報 | IMAP assessments - Phenylhydrazine and its monohydrochloride: Human health tier II assessment |
| 輸送ラベル（DOT） | Poison |
| 火災危険 | Special Hazards of Combustion Products: Irritating vapors and toxic gases, such as nitrogen oxides and carbon monoxide, may be formed when involved in fire.· Combustible material: may burn but does not ignite readily.Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Above 88 °C explosive vapour/air mixtures may be formed. |
| 火災の可能性 | Flammable when exposed to heat, flame, or oxidizers. |
| 健康有害性 | Material is corrosive to tissue. Exposure can cause vomiting, diarrhea, fatigue, headache, and irritation and itchiness of the eyes and skin. (USCG, 1999)· TOXIC and/or CORROSIVEinhalation, ingestion or skin contact with material may cause severe injury or death. |
| 有害性の概要 | Hemolytic anemia has been observed in workers after inhalation and dermal exposures. [ACGIH] Phenylhydrazine is a potent skin sensitizer and can cause hemolytic anemia by all routes of exposure. Toxic effects were observed in patients treated for polycythemia with doses of 0.2 G/day for 3 or 4 doses, then 0.1 G/day. Adverse effects included hemolytic anemia, liver injury, and methemoglobinemia. [HSDB] Can cause hemolytic anemia and skin sensitization[ICSC] Causes first-degree burns on short exposure and second-degree burns on prolonged exposure[CHRIS] |
| 輸送番号・ガイド（DOT） | 2572 153 |
| 反応性グループ | Azo, Diazo, Azido, Hydrazine, and Azide Compounds |
| EC 分類 | Symbol: T, NR: 45-23/24/25-36/38-43-48/23/24/25-68-50S: 53-45-61Note: E |
| UN 分類 | UN Hazard Class: 6.1UN Pack Group: II |
| Special Reports | International Programme on Chemical Safety's Concise International Chemical Assessment Documents. Available from http://www.inchem.org/pages/cicads.html Number 19: Phenyl hydrazine as of April 16, 2004. |
| 消火 | Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:Use water spray, alcohol-resistant foam, powder, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water. |
| 応急処置措置 | Fresh air, rest. Refer for medical attention.Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention . |
| 漏出応急措置 | · CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. |
| 応急処置 | Excerpt from NIOSH Pocket Guide for Phenylhydrazine:General First Aid:(General first aid procedures) |
| 安全保管 | Separated from strong oxidants and food and feedstuffs. Store in an area without drain or sewer access. |
| 暴露管理・個人防護 | · Wear positive pressure self-contained breathing apparatus (SCBA). |
| 保管条件 | Keep well closed and protected from lightSince they are strong reducing agents, they are hypergolic when in contact with strong oxidizers ... /Hydrazine derivatives/All hydrazines should be stored at temperatures well below their boiling points. Hydrazines that are ignitable shall be stored in electrically grounded containers and isolated from ignition sources and oxidants. All containers of hydrazines shall be kept tightly closed when not in use and stored in a cool ventilated room or sheltered outside space. In the containers, a blanket of nitrogen or other inert gas should be placed over the hydrazines. |
| 非火災時の漏出対応 | Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: |
| 処分方法 | SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal, aquatic, and plant lifeand conformance with environmental and public health regulations. |
| 漏出処分 | Evacuate danger area! Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. If liquid: collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. If solid: sweep spilled substance into containers. Carefully collect remainder. Then store and dispose of according to local regulations. |
| Preventive Measures | SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.... Should be used only in well ventilated premises and cumulative action of repeated small doses should be avoided.Inhalation of salt dusts should be avoided. /Hydrazine & derivatives/For more Preventive Measures (Complete) data for PHENYLHYDRAZINE (9 total), please visit the HSDB record page. |
| Isolation and Evacuation | Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:Immediate precautionary measure |
| Cancer Sites | [in animals: tumors of the lungs, liver, blood vessels & intestine] |
| 相互作用 | Erythrocytes (RBC) from phenylhydrazine treated mice are protective when injected into syngenic mice before x-ray irradiation. Evidence suggested that repair of hemopoietic stem cells was enhanced in mice injected with phenylhydrazine red blood cells before x-ray irradiation.The protective effect of phenylhydrazine hydrochloride (PHCL) against acute deaths resulting from whole body irradiation was examined in mice. Male (C3H/C57Bl)F1 mice received sc 1 mg PHCL in 0.1 mL water for 3 days. Controls received injections of water. Mice were injected ip with (59)iron as citrate 1 to 10 days after 3rd PHCL injection. Some mice were exposed to 800 roentgens at various intervals after 3rd injection. During the 1st five days, PHCL caused increases in spleen wt and (59)iron uptake in erthyrocytes and spleen, but a reduction in (59)iron uptake in femurs. All values returned to those of controls by 10 days after 3rd injection. Thirty-day survival of water injected control was 10%. Pretreatment with PHCL improved 30-day survival to almost 100% when mice were irradiated between 4 and 8 days after 3rd injection. Apparently the improved survival resulted from an increase in the number of hemopoietic stem cells at time of irradiation. /Phenylhydrazine hydrochloride/The peroxidation induced by phenylhydrazine in rats chronically exposed to lead was evaluated. Wistar-rats were exposed to lead in-utero and up to four months after birth via administration of distilled drinking water containing ...lead-acetate. The animals were then maintained in a closed desiccator system for analysis of exhaled hydrocarbons before or immediately after injection of phenylhydrazine. The effect of chronic lead pretreatment was assessed by measuring the production of the four main volatile hydrocarbons: ethane and pentane as indices of lipid peroxidationpropane as a marker of protein peroxidationand ethylene as an index of both lipid and protein peroxidations. Lead alone did not increase the physiological formation of alkanes. After phenylhydrazine injection, lipid peroxidation markers were not modified except for pentane in male lead treated rats. Ethylene and propane exhalation, on the other hand, were increased 45 minutes after phenylhydrazine injection in lead treated rats, indicating lead induced potentiation of the oxidative effect of phenylhydrazine. |
| 標的器官 | Blood, respiratory system, liver, kidneys, skin |
| 生態毒性値 | LC50 Brachydanio rerio (Zebrafish) 0.16-0.26 mg/L/96 hr /Conditions of bioassay not specified in source examined/EC50 Daphnia sp. (Water fleaintoxication, immobilization) <1200 ug/L 24 hrstaticLC50 Oryzias latipes (Medaka) 21,400 ug/L/24 hr, 15,700 ug/L/48 hr |
| 環境中動態 | TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 110(SRC), determined from a measured log Kow of 1.25(2) and a recommended regression-derived equation(3), indicates that phenylhydrazine will have high mobility in soil(SRC). Phenylhydrazine is a weak base with a pKa of 5.21(4), suggesting it will partially exist as a cation in moist soil, and the cationic form may adsorb to soil more than the free base(SRC). Phenylhydrazine is not expected to volatilize from moist soil surfaces(SRC)because cations do not volatilize and the Henry's Law constant of the free base is estimated as 2.9X10-8 atm-cu m/mole(SRC), calculated from experimental values for vapor pressure, 0.026 mm Hg(5), and water solubility, 1.27X10+5 mg/L(6). In the Zahn-Wellens aqueous screening test, 85% of this compound was biodegraded in 9-13 days(7). Phenylhydrazine may be susceptible to photolysis upon exposure to sunlight on soil surfaces as it strongly absorbs UV light in the environmentally significant range (wavelengths >290 nm)(8).AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 110(SRC), determined from a measured log Kow of 1.25(2) and a recommended regression-derived equation(3), indicates that phenylhydrazine should not adsorb to suspended solids and sediment in water(SRC). Phenylhydrazine is a weak base with a pKa of 5.21(4), suggesting it will partially exist as a cation in water, and the cationic form may adsorb to sediment more than the free base(SRC). Phenylhydrazine is not expected to volatilize from water surfaces(3)because cations do not volatilize and the Henry's Law constant of the free base is estimated as 2.9X10-8 atm-cu m/mole(SRC), calculated from experimental values for vapor pressure, 0.026 mm Hg(5), and water solubility, 1.27X10+5 mg/L(6). According to a classification scheme(7), an estimated BCF value of 2(SRC), from a measured log Kow(2) and regression derived equation(8), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Based on limited data, phenylhydrazine may biodegrade under aerobic conditions in natural water environments(SRC). In the Zahn-Wellens aqueous screening test, 85% of this compound was biodegraded in 9-13 days(9). Phenylhydrazine is not expected to undergo hydrolysis as it lacks hydrolyzable functional groups, but may be susceptible to photolysis upon exposure to sunlight in natural waters because it strongly absorbs UV light in the environmental UV spectrum (wavelengths >290 nm)(10).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), phenylhydrazine, which has a measured vapor pressure of 0.026 mm Hg at 25 °C(2), will exist solely as a vapor in the ambient atmosphere. Vapor-phase phenylhydrazine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be about 9 hours(SRC), calculated from its rate constant of 4.3X10-11 cu cm/molecule-sec at 25 °C(SRC) estimated with a structure estimation method(3). |
| 有害作用 | Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation. |
| 暴露経路 | The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.inhalation, skin absorption, ingestion, skin and/or eye contact |
| 毒性の概要 | IDENTIFICATION: Phenylhydrazine exists as yellow to brown crystals or as a yellowish oily liquid. This chemical is used world wide mainly as a chemical intermediate in the pharmaceutical, agrochemical and chemical industries. HUMAN EXPOSURE: The number of persons potentially exposed to phenylhydrazine or its hydrochloride salt is unknown, but is expected to be small. No personal exposure data were available. There is evidence that phenylhydrazine has skin sensitizing properties in humans. There are no adequate data available regarding the reproductive or developmental effects, hence, it is not possible to evaluate the risk to human health for these endpoints. The level of risk in occupational settings is uncertainas a result, there is a continuing requirement to reduce exposure levels with the technology currently available. The lack of available data to serve as a basis for estimation of indirect exposure of individuals to phenylhydrazine from the general environment precludes the characterization of potential cancer risks for the general population. ANIMAL/PLANT STUDIES: The limited data on the toxicokinetics indicate that phenylhydrazine is well absorbed by inhalation, oral and dermal routes and binds readily with hemoglobin in red blood cells. Metabolism seems to occur via ring hydroxylation and conjugation, probably with glucuronic acid. Excretion is primarily via the urine. Phenylhydrazine is toxic by single exposure via the oral route (LD50 80-188 mg/kg body weight) and is expected to be toxic by inhalation and dermal routes (data from these routes are less clear). Phenylhydrazine has potential for skin and eye irritation. Exposure to this chemical may cause damage to red blood cells, potentially resulting in anemia and consequential secondary involvement of other tissues such as the spleen and liver. Phenylhydrazine is mutagenic in vitro, and there is some evidence to indicate that it may express genotoxic activity in vivo. The substance is clearly carcinogenic in mice following oral dosing, inducing tumors of the vascular system. Phenylhydrazine is readily biodegradable. Phenylhydrazine is toxic to aquatic organisms, with the lowest reported no observed effect concentration (NOEC) in standard acute fish tests at 0.01 mg/lfish are generally more sensitive than either daphnids or bacteria. A NOEC of 0.49 ug/l has been reported for embryo larval stages of the zebra fish (Brachydanio rerio). |
| 生態毒性抜粋 | /AQUATIC SPECIES/ The toxicities of hydrazine and phenylhydrazine to embryos and larvae of zebrafish, Brachydanio rerio, were studied under standardized conditions. Exposures to the chemicals started at the blastula stage and the effect on hatching and survival were monitored for 15 days. The results showed that toxicities of phenylhydrazine to both embryos and larvae were more than those of hydrazine. The Lowest Observed Effect Concentration for hatching was 0.049 mg/L for hydrazine and 0.0078 mg/L for phenylhydrazine, the Lowest Observed Effects Concentration for survival of larvae was 0.0035 mg/L for hydrazine and 0.00098 mg/L for phenylhydrazine, respectively. The No Observed Effect Concentration for hatching was 0.0245 mg/L for hydrazine and 0.0039 mg/L for phenylhydrazine and the No Observed Effect Concentration for survival of larvae was 0.00175 mg/L for hydrazine and 0.00049 mg/L for phenylhydrazine, respectively./AQUATIC SPECIES/ In a study on the goldfish (Carassius auratus), 40% of fish died when exposed to phenylhydrazine at a nominal concentration of 1 mg/L for 48 h. Signs of toxicity included erratic swimming, sinking to the bottom of the test tank, and slowed and erratic respiration. No gross lesions were found following dissection, although all viscera showed focal hemorrhaging./AQUATIC SPECIES/ Effects on blood cells and the hematopoietic system, comparable to those found in mammals, were seen in fish injected with phenylhydrazine. Chinook salmon (Oncorhynchus tshawytscha) juveniles were injected with 12.5 mg phenylhydrazine/kg body weight. Red cell count, hemoglobin, and hematocrit fell to 1-5% of their normal values within 10 days of treatmenta slight improvement was reported 15 days following injection, and values had returned to normal 95 days after treatment. |
| Signs and Symptoms | Cough. Sore throat. Weakness. Dizziness.MAY BE ABSORBED! Dry skin. Redness. Pain.Redness. Pain. Blurred vision.Abdominal pain. Diarrhoea. Dizziness. Nausea. Vomiting. Weakness.Skin sensitization, hemolytic anemia, dyspnea (breathing difficulty), cyanosisjaundicekidney damagevascular thrombosis[potential occupational carcinogen] |
| ICSC Environmental Data | The substance is toxic to aquatic organisms. |
| Medical Surveillance | ... Situations in which air concentration ... approach 5 ppm and particularly where there is additional possibility of skin contact, workers should be under careful medical observation.It is essential that alcoholics or persons suffering from liver ailments or blood disorders are ... /protected/ from work with phenylhydrazine. Complete periodic medical exam should including blood tests, as well as biochemical tests (glycemia, cholesterolemia, bilirubinemia). Urine should be exam ... for the degradation products of phenylhydrazine. |
| TSCA 要件 | Section 8(a) of TSCA requires manufacturers of this chemical substance to report preliminary assessment information concerned with production, exposure, and use to EPA as cited in the preamble in 51 FR 41329.Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Phenylhydrazine is included on this list. |
| F | 8-10-23 |
| 職業暴露限界（OEL） | Ceiling: 0.14 ppm (0.6 mg/m3) [2-hr] [skin] |
| 水環境危害等級（WGK） | 3 |
| 生命健康即時危険濃度 | 15 ppm |
| TSCA 収載状態 | TSCA listed |
| RTECS 番号 | MV8925000 |
| 輸送番号（UN） | UN 2572 |
| 毒性 | LD50 orally in Rabbit: 188 mg/kg |
| PRTR法 | 第一種指定化学物質 |
| 税関コード | 2928 00 90 |
| 危険文句（R） | 45-23/24/25-36/38-43-48/23/24/25-50-68 |
| 化審法 | (3)-470 |
| 安衛法 | 変異原性物質 |
| 消防法 | 危-4-3-III |
| 危険表示 | T,N |
| 安全措置（S） | 53-45-61 |
| 危険等級 | 6.1Acute Tox. 3 DermalAcute Tox. 3 InhalationAcute Tox. 3 OralAquatic Acute 1Carc. 1BEye Irrit. 2Muta. 2Skin Irrit. 2Skin Sens. 1STOT RE 1 |
| 包装等級 | II |
| 自然発火温度 | 345 °F |
| 貯蔵分類 | 6.1A - Combustible, acute toxic Cat. 1 and 2very toxic hazardous materials |
| 有害物質データ | 100-63-0(Hazardous Substances Data) |
用途
解説
フェニルヒドラジン，ヒドラジノベンゼンともいう．ベンゼンジアゾニウム塩を亜硫酸塩あるいは塩化スズ(Ⅱ)などで還元すると得られる．融点23 ℃，沸点241～242 ℃，137～138 ℃(2.4 kPa)．d4201.0978．nD201.6081．空気中で酸化され褐色となる．エタノール，エーテル，ベンゼンに可溶．弱い塩基性を示し，普通，塩酸塩の形で用いられる．アルデヒドやケトンと反応してフェニルヒドラゾン，またα-ケトールと反応してオサゾンの結晶を生成するので，これら化合物の確認試薬として用いられる．また，ピラゾールやピリダジンなどの複素環化合物や染料の合成の原料にも用いられる．LD50 188 mg/kg(ラット，経口)．
用途
染料 医薬,医薬中間体 合成中間体 糖、アルデヒド、ケトンの検出用試薬,金属沈殿分析
使用
Phenylhydrazine is used in the manufactureof dyes and pharmaceuticals; as a stabilizerfor explosive; as a reagent for aldehydes,ketones, and sugars in chemical analysis; andin organic synthesis.
一般的な説明
Pale yellow crystals. Melting point 66°F. Becomes an oily liquid. Toxic by ingestion, inhalation and skin absorption. Flash point 192°F. Autoignition temperature 345°F. Soluble in alcohol.
使用用途
フェニルヒドラジンの主な用途には、 染料・医薬・農業用化学物質などの合成中間体や、糖・アルデヒド・ケトンの検出用試薬、金属沈殿分析などがあります。 合成用途では、特にインドール類の合成中間体として使用されることが多いです。
製法・合成法
純化方法
Purify phenylhydrazine by chromatography, then crystallise it from pet ether (b 60-80o)/*benzene. Store it in the dark under N2 as it turns yellow, then red, on exposure to air. It is best stored as the hydrochloride salt; see below. [Coleman Org Synth Coll Vol I 442 1941, Shaw & Stratton J Chem Soc 5004 1962, Beilstein 15 IV 50.]