ポリグリコリド

ポリグリコリド · ポリグリコール酸 · POLY(GLYCOLIC ACID) · Polyglycolide,PGA · BP-0700 · Glycolaci · Glycol acid · POLYGLYCOLIDE

識別子と物理属性

CAS No.	26124-68-5
分子式	C2H4O3
平均分子量	76.05 g/mol
単同位体質量	76.01604399 g/mol
SMILES	O=C(O)CO
InChIKey	AEMRFAOFKBGASW-UHFFFAOYSA-N
PubChem CID	757
ChEMBL	CHEMBL252557
ChEBI	CHEBI:17497
EC No.	201-180-5
DTXSID	DTXSID0025363
現地名	ポリグリコリド

化学・物理的性質

XLogP	-1.1
極性表面積	57.5
水素結合供与体数	2
水素結合受容体数	3
回転可能結合数	1
重原子数	5
形式電荷	0
複雑度	40.2
物質分類	Other Classes -> Organic Acids
医薬品	Pharmaceuticals -> Listed in ZINC15
化粧品	Cosmetic ingredients (Glycolic Acid) -> CIR (Cosmetic Ingredient Review)Buffering
pH	pH = 2.5 (0.5%)2.33 (1.0%)2.16 (2.0%)1.91 (5.0%)1.73 (10.0%)
LogP（分配係数）	log Kow = -1.11
臭い	Odorless
密度	1.49 at 25 °C/4 °CRelative density (water = 1): 1.491.49 @25 °C1.53 g/mL at 25 °C(lit.)
Color/Form	Colorless, translucent solidSolid glycolic acid forms colorless, monoclinic, prismatic crystals.Orthorhombic needles from waterleaves from diethyl ether
溶解度	Soluble in ethanol, ethyl etherSoluble in methanol, acetone, acetic acidSolubility in water: very goodヘキサフルオロイソプロパノール：可溶
Corrosivity	Corrosive
Human Drugs	Breast FeedingLactationDermatologic AgentsKeratolytic Agents
沸点	100 °CBP: decomposes
融点	200-220 °C
貯蔵条件	2-8°C
外観・状態	solid
InChI	InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)
InChIKey	AEMRFAOFKBGASW-UHFFFAOYSA-N
SMILES	C(O)(=O)CO
EPAの化学物質情報	Acetic acid, hydroxy-, homopolymer (26124-68-5)

化学的特性

intrinsic viscosity 1.30-1.60

安全性と法規制

GHS 分類	This chemical does not meet GHS hazard criteria for 0.3% (10 of 3312) of reports.DangerH302 (82.6%): Harmful if swallowed [Warning Acute toxicity, oral]P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P363, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 3312 reports by companies from 35 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
規制情報	Chemical: Acetic acid, 2-hydroxy-Regulation (EC) No 1935/2004 (amended)Acetic acid, 2-hydroxy- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Acetic acid, 2-hydroxy- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 12-05-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/14561Glycolic acid: Does not have an individual approval but may be used under an appropriate group standard
その他の安全情報	PEC / SN / Other assessments - Glycolic acid in cosmetics: Health
火災危険	Combustible.
火災の可能性	Combustible.
有害性の概要	Corrosive to skin[Quick CPC] 70% technical solutions cause severe burns of the skin and eyes. [HSDB] Corrosive to skin and eyesA respiratory tract irritantMay have effects on kidneys, leading to kidney failure[ICSC] Causes burnsInhalation may cause corrosive injuries to upper respiratory tract and lungsHarmful by ingestion[Alfa Aesar MSDS]
FDA 要件	Hydroxyacetic acid is an indirect food additive for use as a component of adhesives.
UN 分類	UN Hazard Class: 8UN Pack Group: II
Special Reports	DHHS/NTPNTP Technical Report on the Photocarcinogenesis Study of Glycolic Acid and Salicylic Acid (CAS NOS. 79-14-1 and 69-72-7) in SKH-1 Mice (Simulated Solar LIght and Topical Application Study). NTP TR-524 244 pp. (September 2007)[Available from, as of July 31, 2008: http://ntp.niehs.nih.gov/files/524_web1.pdf]DHHS/NTP-CERHRMonograph on the Potential Human Reproductive and Developmental Effects. 51: (11): 1-III36. January 2004. NTP-CERHR monographs are available electronically in PDF format on the CERHR web site and in printed text or CD-ROM from the CERHR (National Institute of Environmental Health Sciences, P.O. Box 12233, MD EC-32, Research Triangle Park, NCfax: 919-316-4511).[Available from, as of July 3, 2008: http://cerhr.niehs.nih.gov]Cosmetic Ingredient ReviewFinal Report on the Safety Assessment of Glycolic Acid, Ammonium, Calcium, Potassium, and Sodium Glycolates, Methyl, Ethyl, Propyl, and Butyl Glycolates, and Lactic Acid, Ammonium, Calcium, Potassium, Sodium, and TEA-Lactates, Methyl, Ethyl, Isopropyl, and Butyl Lactate, and Lauryl, Myristyl, and Cetyl LactatesJournal of American College of Toxicology 17(Suppl 1):1-242 (1998)
FIFRA 要件	As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their continued use. Under this pesticide reregistration program, EPA examines newer health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether the use of the pesticide does not pose unreasonable risk in accordance to newer saftey standards, such as those described in the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA '88 were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern than those on List C, and with List C containing pesticides of greater concern than those on List D. Glycolic acid is found on List D. Case No: 4045Pesticide type: antimicrobialCase Status: No products containing the pesticide are actively registered ... The case /is characterized/ as "cancelled." Under FIFRA, pesticide producers may voluntarily cancel their registered products. EPA also may cancel pesticide registrations if registrants fail to pay required fees or make/meet certain reregistration commitments, or if EPA reaches findings of unreasonable adverse effects.Active ingredient (AI): Glycolic acidAI Status: The active ingredient is no longer contained in any registered pesticide products ... "cancelled."
Chemical Dangers	Reacts with strong oxidants, cyanides and sulfides. Reacts violently with aluminium, zinc and tin. This generates fire and explosion hazard. The solution in water is a medium strong acid.
Packaging and Labelling	Do not transport with food and feedstuffs.
Toxic Combustion Products	Hazardous decomposition prod ucts formed under fire conditions. - Carbon oxides
消火	Use water spray, powder, foam, carbon dioxide.
応急処置措置	Half-upright position. Fresh air, rest. Refer for medical attention.First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention .
安全保管	Separated from strong oxidants, metals, sulfides, cyanides, strong bases and food and feedstuffs. Dry.
Firefighting Hazards	Emits toxic fumes under fire conditions. /99% Glycolic acid/
消火手順	Suitable extinguishing media: Use water spray, alcohol - resistant foam, dry chemical or carbon dioxide.Special protective equipment for firefighters Wear self contained breathing apparatus for fire fighting if necessary.Use water spray, powder, foam, carbon dioxide.
保管条件	Separated from strong oxidants, metals, sulfides, cyanides, strong bases and food and feedstuffs. Dry.Keep container tightly closed in a dry and well - ventilated place.Do not contaminate water, food, or feed by storage ... . Store out of reach of children.
清掃方法	Accidental Release Measures. Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions: Do not let product enter drains. Methods and materials for containment and clean up: Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.Do not contaminate water, food, or feed by ... disposal. ... Do not re-use empty container. Wrap empty bottle and put in trash or recycle. /5% Glycolic acid/Neutralize spills with lime or soda ash. /70% Glycolic acid/
処分方法	SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal and plant lifeand conformance with environmental and public health regulations.SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.Waste Treatment Methods. Product: Offer surplus and non - recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipp ed with an afterburner and scrubber. Contaminated packaging: Dispose of as unused product.
漏出処分	Personal protection: chemical protection suit including self-contained breathing apparatus. Sweep spilled substance into covered containers.
Preventive Measures	SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.SRP: Contaminated protective clothing should be segregated in a manner such that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. The completeness of the cleaning procedures should be considered before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at the end of shift, but should remain at employee's place of work for cleaning.SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants. Ensure that the local ventilation moves the contaminant away from the worker.When chemicals containing glycolic acid are used on a daily basis, protection for the skin and eyes is advised to prevent localized irritation. Child-proof packaging is available to prevent children from ingesting these products. Overall, the evidence indicates there is minimal risk of adverse health effects from glycolic acid during the normal use of commercially available cleaning products.For more Preventive Measures (Complete) data for HYDROXYACETIC ACID (14 total), please visit the HSDB record page.
Eye Prevention	Wear safety goggles or eye protection in combination with breathing protection.
Fire Prevention	NO open flames.
Treatment	Chronic Exposure: In some patients with primary hyperoxaluria type 1, pyridoxine treatment (vitamin B6) may decrease oxalate excretion and prevent kidney stone formation. Acute Exposure: EYES: irrigate opened eyes for several minutes under running water. INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice.
相互作用	The effect of 0.35 to 0.8 mmol/kg glycolic acid and 1.0 to 4.4 mmol/kg sodium glycolate on cyclopropane-epinephrine induced cardiac arrhythmias was examined using dogs. Doses of 0.35 to 0.5 mmol/kg glycolic acid increased the duration of arrhythmias in the 13 dogs tested, whereas doses >0.5 mmol/kg decreased or totally eliminated the arrhythmias in each of 11 dogs. Depression was observed for many of the dogs at higher doses. Sodium glycolate was much less effective in decreasing the arrhythmias, with 3 mmol/kg being required and its action being transient.... This study was performed in order to determine whether short-term dermal treatment with glycolic acid, a representative alpha-hydroxy acid (AHA), can enhance the damaging effects of UV light. The duration of the effect of AHAs on the sensitivity of skin to UV light was also examined. ... The backs of 29 Caucasian subjects were treated, once daily, 6 days per week with either 10% glycolic acid (pH 3.5) or placebo in a randomized double-blinded study. At the end of 4 weeks, sites within each treated area were exposed to 1.5 MED of UV light, determined on previously untreated skin. Specimens were obtained for enumeration of sunburn cells (SBCs) in the first group of subjects (n = 16), whereas cyclobutyl pyrimidine dimers (CPDs) in DNA were determined in the second group (n = 13). The minimal erythema dose (MED) in each site was also determined in the first group of subjects. Sunburn cells and MEDs were re-evaluated in the first group 1 week after discontinuing AHA applications. ... Glycolic acid caused enhanced sensitivity to UV light measured as increased SBC induction and lowered MEDs. Cyclobutyl pyrimidine dimers were elevated but not to a statistically significant level. No differences in SBCs or MEDs were evident after a week of discontinued treatments...Hairless mice were irradiated thrice weekly for 10 weeks with UVB. In the 10-week postirradiation period, the mice were treated topically five times per week with tretinoin (0.05%), glycolic acid (10%), benzalkonium chloride (1.0%), sodium lauryl sulfate (5%), croton oil (5%) and the water - propylene glycol vehicle... Tretinoin-treated skin had increased amounts of collagen and type III procollagen whereas irritant- and peeling agent-treated skins were similar to vehicle-treated controls.Glycolic acid, a depressant antagonizing the convulsant action of strychnine in spinal cord of cats.For more Interactions (Complete) data for HYDROXYACETIC ACID (11 total), please visit the HSDB record page.
健康影響	Glycolic acid metabolizes to oxalic acid, which reacts with calcium and forms calcium oxalate crystals in the kidney. This can cause kidney injury, leading to acute kidney failure. (L1023) Chronically high levels of glycolic acid are associated with the inborn error of metabolism known as Type I primary hyperoxaluria. Oxalate stones in primary hyperoxaluria tend to be severe, resulting in relatively early kidney damage (before age 20), which impairs the excretion of oxalate leading to a further acceleration in accumulation of oxalate in the body. After the development of renal failure patients may develop oxalate deposits in the bones, joints and bone marrow. Severe cases may develop haematological problems such as anaemia and thrombocytopaenia. The deposition of oxalate in the body is sometimes called "oxalosis" to be distinguished from "oxaluria" which refers to oxalate in the urine.
生態毒性値	LC50Species: Pimephales promelas (Fathead minnows)Conditions: staticConcentration: 164 mg/L for 96 hr (nominal)EC50Species: Pseudokirchneriella subcapitata (Green algae)Concentration: 21.6 mg/L for 72 hrEffect: biomassConcentration: 44.0 mg/L for 72 hrEffect: growth rateSpecies: Lepomis sp. (sunfish)Concentration: 93 mg/L for 48 hr /Conditions of bioassay not specified in source examined/ /70% purity/For more Ecotoxicity Values (Complete) data for HYDROXYACETIC ACID (8 total), please visit the HSDB record page.
環境中動態	TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 0.14(SRC), determined from a log Kow of -1.11(2) and a regression-derived equation(3), indicates that hydroxyacetic acid is expected to have very high mobility in soil(SRC). The pKa of hydroxyacetic acid is 3.6(4), indicating that this compound will exist almost entirely in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5). Volatilization of hydroxyacetic acid from moist soil surfaces is not expected to be an important fate process because the compound exists as an anion and ions do not volatilize. Hydroxyacetic acid is not expected to volatilize from dry soil surfaces(SRC) based upon an extrapolated vapor pressure of 0.02 mm Hg at 25 °C(6). Utilizing the Japanese MITI test, 86% of the Theoretical BOD was reached in 2 weeks(7) indicating that biodegradation is an important environmental fate process in soil(SRC).AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 0.14(SRC), determined from a log Kow of -1.11(2) and a regression-derived equation(3), indicates that hydroxyacetic acid is not expected to adsorb to suspended solids and sediment(SRC). A pKa of 3.6(4) indicates hydroxyacetic acid will exist almost entirely in the anion form at pH values of 5 to 9 and, therefore, volatilization from water surfaces is not expected to be an important fate process(SRC). According to a classification scheme(5), an estimated BCF of 3(SRC), from its log Kow(2) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Utilizing the Japanese MITI test, 86% of the Theoretical BOD was reached in 2 weeks(6) indicating that biodegradation is an important environmental fate process in water(SRC).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), hydroxyacetic acid, which has an extrapolated vapor pressure of 0.02 mm Hg at 25 °C (2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase hydroxyacetic acid is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 3.4 days(SRC), calculated from its estimated rate constant of 3.1X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Hydroxyacetic acid does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).
有害作用	Nephrotoxin - The chemical is potentially toxic to the kidneys in the occupational setting.
暴露経路	The substance can be absorbed into the body by inhalation and by ingestion.Oral (L1909)dermal (L1909)
毒性の概要	Based on the available information included in this report, the CIR Expert Panel concludes that Glycolic and Lactic Acid, their common salts and their simple esters, are safe for use in cosmetic products at concentrations less than or equal to 10%, at final formulation pH greater than or equal to 3.5, when formulated to avoid increasing sun sensitivity or when directions for use include the daily use of sun protection. These ingredients are safe for use in salon products at concentrations less than or equal to 30%, at final formulation pH greater than or equal to 3.0, in products designed for brief, discontinuous use followed by thorough rinsing from the skin, when applied by trained professionals, and when application is accompanied by directions for the daily use of sun protection...Glycolic Acid...Safe for use in cosmetics, with qualificationsIDENTIFICATION AND USE: Hydroxyacetic (glycolic) acid is an odorless, colorless and translucent solid. The primary uses of hydroxyacetic acid are in cleaning and metal processing. Other specialized applications include biomedical uses, printed wire board flux, adhesives, textiles, hydrogen sulfide abatement, tanning, oil well acidification, and biodegradable polymers and copolymers for absorbable sutures and drug delivery systems. It is also used in skin care products as exfolliant and keratolytic. HUMAN EXPOSURE AND TOXICITY: Inhalation may cause irritation of mucous membranes with upper respiratory and bronchial irritation. Skin contact may cause severe skin irritation with discomfort or rash. Higher or prolonged exposure may cause skin burns or ulceration. Eye contact may cause eye corrosion with corneal or conjunctival ulceration. Permanent eye damage can occur. Ingestion may cause corrosion of mucous membranes with stomach discomfort, nausea, and prostration. Kidney damage or fatality may occur from gross overexposure. ANIMAL TOXICITY STUDIES: A basal diet with 3% glycolic acid for 3 weeks in rats resulted in a high incidence of oxalate urolithiasis (mostly in the kidneys, but some animals also had uroliths in the ureter and urinary bladder. Also, fine crystalline depositions were present throughout the cortex and medulla and clusters of concretions were on the surface or embedded in the renal papilla. In dogs given daily oral doses of 1000 mg glycolic acid for 35 days, no abnormal secretions of oxalic acid were found and no damage to the gastroenteric tract or kidneys was reported. In other experiment, rats were administered up to 600 mg/kg/day of the test substance by gavage for 90 days. Two deaths occurred in males at 600 mg/kg/day. Decreased mean body weight, overall body weight gain, food consumption, and food efficiency occurred in males and females of the 300 and 600 mg/kg/day groups. Microscopic findings of oxalate crystal nephrosis and unilateral hydronephrosis, and hyperplasia of the transitional epithelium of the renal pelvis were also observed (in males only) at these dose levels. No organ weight, gross or microscopic findings indicative of systemic toxicity were observed in female rats exposed to 300 or 600 mg/kg/day. The developmental toxicity of glycolic acid was assessed in rats over days 7-21 of gestation. Groups of mated female rats were gavaged at daily dose levels of up to 600 mg/kg. Clear evidence of maternal toxicity was demonstrated at 600 mg/kg. There was marked evidence of developmental toxicity at 600 mg/kg. Mean fetal weight was statistically significantly reduced while the incidences of skeletal (ribs, vertebra, and sternebra) malformations and variations were statistically significantly increased. Glycolic acid was not found to be genotoxic based on negative Ames test with and without activation using Salmonella typhimurium TA98, TA100, TA1535, TA1537, and TA1538. ECOTOXICITY STUDIES: Green Algae were exposed to glycolic acid for 72 hours. At the end of the exposure period, a control replicate and samples from the test concentrations exhibiting a 50% or greater inhibition of cell counts were selected for a recovery test and exposed to nutrient medium for an additional 144 hours. The effects upon growth rate and biomass were found to be algistatic. Fathead minnows were exposed to glycolic acid for 96 hours under static conditions. All deaths occurred within 24 hours. Daphnia magna were exposed to glycolic acid for 48 hours under static conditions. There were no sublethal effects observed in the surviving daphnids.Glycolic acid's toxicity is due to its metabolism to oxalic acid. Glycolic and oxalic acid, along with excess lactic acid, are responsible for the anion gap metabolic acidosis. Oxalic acid readily precipitates with calcium to form insoluble calcium oxalate crystals. Tissue injury is caused by widespread deposition of oxalate crystals and the toxic effects of glycolic acid. (A612, A613)
生態毒性抜粋	/AQUATIC SPECIES/ /Green algae (Pseudokirchnerie lla subcapitata3 replicates/concentration) were exposed to /glycolic acid/ at mean measured concentrations of 7.52, 14.5, 30.3, 54.6 and 73.6 mg/L for 72 hours. At the end of the 72-hour exposure period, a control replicate and samples from the test concentrations exhibiting a 50% or greater inhibition of cell counts were selected for a recovery test and exposed to nutrient medium for an additional 144 hours. The effects upon growth rate and biomass were found to be algistatic. 72-hr EC50 (growth) = 44.0 mg/L72-hr EC50 (biomass) = 21.6 mg/L/AQUATIC SPECIES/ Fathead minnows (Pimephales promelas10/concentration) were exposed to /glycolic acid/ at nominal concentrations of 0.0064, 0. 0081, 0.010, 0.013, 0.016 or 0.020% (v/v) for 96 hours under static conditions. All deaths occurred within 24 hours. 96-hr LC50 = 164 mg/L./AQUATIC SPECIES/ Water fleas (Daphnia magna5/replicate, 4 replicates/concentration) were exposed to /glycolic acid/ at nominal concentrations of 0, 25, 50, 100, 200, 400 or 800 mg/L for 48 hours under static conditions. There were no sublethal effects observed in the surviving daphnids. 48-hr EC50 = 141 mg/L.
Plant Concentrations	Plants containing hydroxyacetic acid(1).[Table#5288]
Signs and Symptoms	Cough. Shortness of breath. Sore throat.Redness. Pain. Serious skin burns.Redness. Pain. Blurred vision. Severe deep burns.Abdominal pain. Burning sensation. Shock or collapse.Glycolic acid is a strong irritant. Accumulation of glycolic acid and its metabolite, oxalic acid, causes tachycardia, hypertension, hyperventilation, and metabolic acidosis. (L1023, L1909)
Ongoing Test Status	EPA has released the first beta version (version 0.5) of the Interactive Chemical Safety for Sustainability (iCSS) Dashboard. The beta version of the iCSS Dashboard provides an interactive tool to explore rapid, automated (or in vitro high-throughput) chemical screening data generated by the Toxicity Forecaster (ToxCast) project and the federal Toxicity Testing in the 21st century (Tox21) collaboration. /The title compound was tested by ToxCast and/or Tox21 assaysSee the data in Chemical Explorer/[USEPAICSS Dashboard ApplicationAvailable from, as of June 27, 2014: http://actor.epa.gov/dashboard/]The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical.[Available from, as of June 30, 2014: http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=79-14-1]
F	3-10
水環境危害等級（WGK）	3
TSCA 収載状態	TSCA listed
税関コード	3907998090
化審法	新規公示化学物質（2011年3月31日以前届出）
貯蔵分類	11 - Combustible Solids

用途

解説

グリコール酸の重縮合あるいはグリコリドの開環重合によって合成されるもっとも代表的な生分解性合成高分子，－[OCH2CO]n－．ポリグリコリドともいう．手術用の吸収性縫合糸として用いられている．

使用

medical device

一般的な説明

Biodegradable and biocompatible PGA could be potentially useful for bone regeneration. High molecular weight polyglycolide (PGA) can be prepared by ring opening polymerization of diglycolide in the presence of diphenyl bismuth bromide.