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化工社化工社 化学情報印刷レポート · 研究参考用
HCID 7580作成日：2026年10月27日

ジフェニルメタン

1-ベンジルベンゼン · 1,1'-メチレンビスベンゼン · ジフェニルメタン · ベンジルベンゼン · メチレンビスベンゼン · ジタン · メチレンジベンゼン · ベンジルフェニル

https://huagongshe.com/ja/chemical/7580

ジフェニルメタン の分子構造式

識別子と物理属性

CAS No.101-81-5
分子式C13H12
平均分子量168.23 g/mol
単同位体質量168.09390038 g/mol
SMILESc1ccc(Cc2ccccc2)cc1
InChIKeyCZZYITDELCSZES-UHFFFAOYSA-N
PubChem CID7580
ChEMBLCHEMBL1796022
ChEBICHEBI:38884
EC No.202-978-6
DTXSIDDTXSID1041891
現地名ジフェニルメタン

化学・物理的性質

XLogP4.1
極性表面積0
水素結合供与体数0
水素結合受容体数0
回転可能結合数2
重原子数13
形式電荷0
複雑度111
物質分類Other Classes -> Aromatic Hydrocarbons
PolymersPolycyclic aromatic hydrocarbon
化粧品Solvent
SpringerMaterials Properties13C nuclear magnetic resonance spectrum
香料Fragrance Ingredient (Diphenylmethane) -> IFRA transparency List
LogP（分配係数）log Kow = 4.144.22
臭いOdor of orangesHarsh herbaceous odor reminiscent of geranium leavesジプロピレングリコール中10.00%。甘い緑の濡れたプラスチックのゼラニウム
密度1.3421 at 10 °C/4 °C (solid)1.0008 at 26 °C/4 °C (liquid)1.008 @25 °C1.006 g/mL at 25 °C (lit.)
Color/FormOrthorhombic needlesLong, colorless needlesLiquid
溶解度In water, 14.1 mg/L at 25 °CIn water, 14.5 mg/LFreely soluble in alcohol, ether, chloroform, hexane, benzeneinsoluble in liquid ammonia>10% in both ethyl ether, ethanol and chloroform.エタノール、エーテル、ベンゼン、クロロホルムに可溶。14.1mg/L(25℃)
引火点130 °C266 °F (130 °C) (CLOSED CUP)>230 °F
沸点264.5 °C264.5 °C @760 [mm Hg]264 °C (lit.)
融点22-24 °C (lit.)
蒸気密度5.79 (vs air)
蒸気圧<1 mm Hg ( 77 °C)
屈折率n20/D 1.577(lit.)
貯蔵条件Store below +30°C.
pKa（酸解離定数）33.5(at 25℃)
外観・状態低融点固体
色無色～淡黄色
比重1.006
においのタイプ緑
爆発限界0.69-8.66%(V)
凝固点24.0 to 26.0 ℃
Merck14,3328
BRN1904982
ヘンリー定数7.7×10-2 mol/(m3Pa) at 25℃, Duchowicz et al. (2020)
誘電率2.6(26℃)
化粧品成分の機能溶媒香料
InChI1S/C13H12/c1-3-7-12(8-4-1)11-13-9-5-2-6-10-13/h1-10H,11H2
InChIKeyCZZYITDELCSZES-UHFFFAOYSA-N
SMILESC(c1ccccc1)c2ccccc2
LogP（分配係数）4.140
CAS データベース101-81-5(CAS DataBase Reference)
NISTの化学物質情報Diphenylmethane(101-81-5)
EPAの化学物質情報Diphenylmethane (101-81-5)

化学的特性

Colorless to pale yellow low melting solid

安全性と法規制

GHS 分類This chemical does not meet GHS hazard criteria for 2.2% (37 of 1665) of reports.WarningH400 (93.4%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]P273, P391, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 1665 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
規制情報Chemical: Benzene, 1,1'-methylenebis-Commission Regulation (EC) No 1565/2000 (Repealed by Com. Implementing Reg. (EU) No 872/2012)Benzene, 1,1'-methylenebis- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Benzene, 1,1'-methylenebis- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 07-03-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/21882Diphenylmethane: Does not have an individual approval but may be used under an appropriate group standard
火災の可能性DIPHENYL AND ITS DERIVATIVES ARE MODERATELY FLAMMABLE ... DANGER OF FIRE IS NEGLIGIBLE @ AMBIENT TEMP BUT INCR @ HIGH TEMP, WHEN MATERIAL IS DISPERSED IN AIR. /DIPHENYL & DERIVATIVES/
有害性の概要May cause irritationNo other information available about toxicity in humansOral LD50 (rat) = 2250 mg/kg[MSDSonline]
NFPA Hazard Classification1 - Materials that, under emergency conditions, can cause significant irritation.1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur.0 - Materials that in themselves are normally stable, even under fire conditions.
Hazard Classes and CategoriesAquatic Acute 1 (93.4%)
Critical Temperature and PressureCritical temperature: 760 deg Kcritical pressure: 2.71X10+6 Pa

用途

解説

ジフェニルメタン．ベンゼンと塩化ベンジルとをフリーデル-クラフツ縮合させると得られる．結晶．融点26～27 ℃，沸点261～262 ℃，158 ℃(5 kPa)．d4201.0008．多くの有機溶媒に可溶．メチレン基の水素はプロトンとして引き抜かれやすく，酸化すればベンゾフェノンとなる．1884年にC.フリーデルとJ.M.クラフツにより，ベンゼンと塩化メチレンから塩化アルミニウムを触媒として合成された。現在用いられる合成法は，塩化ベンジルとベンゼンとのフリーデル=クラフツ反応による。水に不溶，多くの有機溶媒に可溶。酸化クロム(VI)で酸化すればベンゾフェノンとなり，赤熱管を通せば脱水素されフルオレンとなる。

用途

有機合成原料。

天然物の起源

Has apparently not been reported to occur in nature.

使用

Diphenylmethane, is used as an adhesive chemical composition for making flexible laminates for use in food packaging.

使用用途

全ての誘導体が必ずしもジフェニルメタンから合成されるわけではありませんが、ジフェニルメタンの分子骨格はさまざまな物質の部分構造に含まれています。ジフェニルメタン誘導体は、主にはさまざまな色素として活用される物質です。 これらの誘導体はインクや染料の原料として用いられており、ジフェニルメタン誘導体を原料とする染料には、カラーインデックスにおいて41,000番台の番号が割り当てられています。 このほか、ジフェニルメタン誘導体化合物の中には、糖尿病の治療に用いられているものもあります。ヒトSGLT2活性に対する優れた阻害効果を示し、動物における尿中糖排泄を有意に減少させることが報告されているためです。

製法・合成法

製造方法

By interaction of benzyl chloride and benzene in the presence of an acid cata lyst.

純化方法

Sublime it under vacuum, or distil it at 72-75o/0.4mm. Recrystallise it from cold EtOH. It has also been purified by fractional crystallisation from the melt. [Armarego Aust J Chem 13 95 1960, Beilstein 5 II 498, 5 IV 1841.]

Hazardous Reactivities and Incompatibilities
... Can react with oxidizing material.
消火手順/Use/ carbon dioxide /or/ dry chemical /to extinguish fire/.
保管条件/DIPHENYL AND ITS DERIVATIVES/ ... MUST BE STORED IN COOL, WELL-VENTILATED PLACE, FAR FROM OPEN FLAMES & AREAS WHERE DANGER OF FIRE EXISTS. /DIPHENYL & DERIVATIVES/
処分方法SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal and plant lifeand conformance with environmental and public health regulations.SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.
Preventive MeasuresSRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. The completeness of the cleaning procedures should be considered before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at the end of shift, but should remain at employee's place of work for cleaning.
Protective Action Criteria (PAC)6.8 [mg/m3]74 [mg/m3]450 [mg/m3]
Personal Protective Equipment (PPE)IN EVENT OF SPILLAGE OR LEAKAGE OF HOT FLUIDS, APPROVED CHEM CARTRIDGE RESPIRATORS OR MASKS SHOULD BE WORN FOR PROTECTION AGAINST VAPORS. SKIN CONTACT WITH TERPHENYLS AND POSSIBLY WITH DIPHENYL AND DERIVATIVES SHOULD BE AVOIDED BY PROPER HANDLING PROCEDURES. CONTAMINATED CLOTHING MUST BE LAUNDERED BEFORE USE. EYE PROTECTION SHOULD BE WORN IF EYE HAZARD EXISTS. /DIPHENYL & DERIVATIVES/
生態毒性値LC50Species: Leuciscus idus ssp. melanotus (Carp)Concentration: 7500 ug/L for 48 hr /Conditions of bioassay not specified in source examined/ /formulation/
環境中動態TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 9160(SRC), determined from a structure estimation method(2), indicates that 1,1'-methylenebisbenzene is expected to be immobile in soil(SRC). Volatilization of 1,1'-methylenebisbenzene from moist soil surfaces may be an important fate process(SRC) given an estimated Henry's Law constant of 1.3X10-4 atm-cu m/mole(SRC), derived from its vapor pressure, 8.61X10-3 mm Hg(3), and water solubility, 14.1 mg/L(4). However, adsorption to soil is expected to attenuate volatilization(SRC). Biodegradation is expected to be an important fate process in soil. 1,1'-Methylenebisbenzene has been shown to biodegrade readily in river die-away tests(5) and in soil inoculum studies following acclimation(6). A 0% of theoretical BOD using activated sludge in a 2-week Japanese MITI test(7) suggests that biodegradation is not an important environmental fate process in soil(SRC).AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 9160(SRC), determined from a structure estimation method(2), indicates that 1,1'-methylenebisbenzene is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 1.3X10-4 atm-cu m/mole(SRC), derived from its vapor pressure, 8.61X10-3 mm Hg(4), and water solubility, 14.1 mg/L(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 13 hours and 8 days, respectively(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The estimated volatilization half-life from a model pond is 116 days if adsorption is considered(6). According to a classification scheme(7), a measured BCF range of 452 to 1190 in catfish(8), suggests bioconcentration in aquatic organisms is high to very high(SRC). Biodegradation is expected to be an important fate process in water. 1,1'-Methylenebisbenzene has been shown to biodegrade readily in river die-away tests(9) and in soil inoculum studies following acclimation(10). A 0% of theoretical BOD using activated sludge in a 2-week Japanese MITI test(8) suggests that biodegradation is not an important environmental fate process in water(SRC). Hydrolysis is not expected to be an important environmental fate process(SRC) since this compound lacks functional groups that hydrolyze under environmental conditions(3).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1,1'-methylenebisbenzene, which has a vapor pressure of 8.21X10-3 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. However, monitoring data indicates that 1,1'-methylenebisbenzene is found on particulate matter in the ambient atmosphere(3)the source of atmospheric particulate matter containing 1,1'-methylenebisbenzene may be fly ash from municipal incinerators(4,5). Vapor-phase 1,1'-methylenebisbenzene is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 1.5 days(SRC), calculated from its rate constant of 1.1X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(6). Particulate-phase 1,1'-methylenebisbenzene may be removed from the air by wet and dry deposition(SRC). 1,1'-Methylenebisbenzene has a UV absorption band that extends beyond 290 nm(7), therefore, it may be susceptible to direct photolysis by sunlight(SRC).
食品調査値1,1'-Methylenebisbenzene has been detected in the volatile component of baked potato(1).
Effluent ConcentrationsIn a comprehensive survey of wastewater from 4000 industrial and publicly owned treatment works (POTWs) sponsored by the Effluent Guidelines Division of the US EPA, 1,1'-methylenebisbenzene was identified in discharges of the following industrial category (frequency of occurrence, median concentration in ppb): timber products (170.9), paint and ink (334.8), printing and publishing (138.5), coal mining (275.7), organics and plastics (10356.6), plastics and synthetics (128.6), rubber processing (1207.1), pesticides manufacture (1281.4), pharmaceuticals (6204.7), explosives (240.6), electronics (143.8), oil and gas extraction (143.8), organic chemicals (31183.3), publicly owned treatment works (2018.2). The highest effluent concentration was 29,554 ppb in the paint and ink industry(1).
Soil Adsorption/MobilityUsing a structure estimation method based on molecular connectivity indices(1), the Koc of 1,1'-methylenebisbenzene can be estimated to be 9160(SRC). According to a classification scheme(2), this estimated Koc value suggests that 1,1'-methylenebisbenzene is expected to be immobile in soil.
Natural Pollution Sources1,1'-Methylenebisbenzene has been identified as a component in crude oils(1).
Atmospheric ConcentrationsSOURCE DOMINATED: A 1,1'-methylenebisbenzene concentration of 0.59 ng/cu m was detected in the ambient particulate material collected from the atmosphere near the highly industrialized Xigu District, Lanzhou China in March 2003(1).
Human Toxicity Excerpts/HUMAN EXPOSURE STUDIES/ A maximization test was carried out on 25 volunteers. The material was tested at a concn of 8% in petrolatum and produced no sensitization./SIGNS AND SYMPTOMS/ PROBABLE IRRITANT & CNS DEPRESSION HIGH CONCN.
Fish/Seafood Concentrations1,1'-Methylenebisbenzene was identified, but not quantified, in fish in the Great Lakes(1).
Artificial Pollution Sources1,1'-Methylenebisbenzene's production and use in organic synthesis and dyes(1) and in the fragrance industry as both a fixative and scenting agent in soaps(2) may result in its release to the environment through various waste streams(SRC). 1,1'-Methylenebisbenzene is emitted from municipal incinerators in fly ash and may leach from the fly ash in landfills(3).
Environmental BiodegradationAEROBIC: When seeded with a soil inoculum, 1,1'-methylenebisbenzene underwent extensive degradation in 40 days, following a 30 day lag(1). 1,1'-Methylenebisbenzene was completely degraded within 5 days in a river die-away test(2)the study found that, in general, 1,1'-methylenebisbenzene compunds having an unsubstituted phenyl ring undergo rapid primary biodegradation(2). 1,1'-Methylenebisbenzene is degraded by microorganisms isolated from sewage, water, soil, and leaves(3-5). Three metabolic pathways have been identified leading to the initial metabolic product 1,1,1',1'-tetraphenyldimethyl ether, phenylacetic acid, and benzhydrol(3). 1,1'-Methylenebisbenzene, present at 100 mg/L, reached 0% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(6).
Environmental BioconcentrationUsing catfish which were exposed over an 8-week period to 1,1'-methylenebisbenzene concentrations of 0.01 mg/L and 0.1 mg/L, 1,1'-methylenebisbenzene BCF values were measured that ranged from 452 to 1190(1). According to a classification scheme(3), this BCF range suggests the potential for bioconcentration in aquatic organisms is high to very high(SRC).
水環境危害等級（WGK）2
TSCA 収載状態TSCA listed
RTECS 番号DA4976500
輸送番号（UN）UN3077
毒性LD50 orally in Rabbit: 2250 mg/kg LD50 dermal Rabbit > 5000 mg/kg
税関コード29029090
危険文句（R）22
化審法(4)-85
危険表示Xn
安全措置（S）24/25-58-54-44-29
危険等級9Aquatic Acute 1Aquatic Chronic 1
包装等級III
自然発火温度905 °F
貯蔵分類10 - Combustible liquids
有害物質データ101-81-5(Hazardous Substances Data)