化工社化工社 化学情報印刷レポート · 研究参考用
フェニルエーテル
フェニルエーテル · 1,1'-オキシビス[ベンゼン] · オキシビスベンゼン · ジフェニルエーテル · 1,1'-オキシビスベンゼン · ゲラニウムクリスタル · フェノキシベンゼン · ジフェニルオキシド
識別子と物理属性
| CAS No. | 101-84-8 |
|---|---|
| 分子式 | C12H10O |
| 平均分子量 | 170.21 g/mol |
| 単同位体質量 | 170.07316494 g/mol |
| SMILES | c1ccc(Oc2ccccc2)cc1 |
| InChIKey | USIUVYZYUHIAEV-UHFFFAOYSA-N |
| PubChem CID | 7583 |
| ChEMBL | CHEMBL38934 |
| ChEBI | CHEBI:39258 |
| EC No. | 202-981-2 |
| DTXSID | DTXSID9021847 |
| 現地名 | フェニルエーテル |
化学・物理的性質
| XLogP | 4.2 |
|---|---|
| 極性表面積 | 9.2 |
| 水素結合供与体数 | 0 |
| 水素結合受容体数 | 1 |
| 回転可能結合数 | 2 |
| 重原子数 | 13 |
| 形式電荷 | 0 |
| 複雑度 | 116 |
| LogP（分配係数） | log Kow = 4.21 |
| 臭い | Geranium-like odor弱いゼラニウム。 |
| 密度 | 1.07 at 80.6 °F (USCG, 1999) - Denser than waterwill sink1.0661 g/cu cm at 30 °CPercent in saturated air: 0.0028Density of saturated air: 1.0014 (Air = 1)Relative density (water = 1): 1.081.071-1.0751.073 g/mL at 25 °C(lit.) |
| Viscosity | 3.4909X10-3 Pa-sec at melting point |
| Color/Form | Colorless crystals or liquidColorless, crystalline solid or liquid (above 82 degrees F) |
| 溶解度 | Insoluble (NTP, 1992)In water, 18 mg/L at 25 °CSoluble in ethanol, ether, benzene, acetic acidslightly soluble in chloroform0.018 mg/mL at 25 °CSolubility in water, g/100ml: 0.002 (very poor)Insoluble in water, soluble in oilsアルコール: 可溶(lit.)不溶性 |
| 引火点 | 239 °F (NTP, 1992)[ACGIH] 115 °C239 °F (115 °C) (Closed cup)115 °C (Closed cup)96.11 °C (Open cup)115 °C c.c.>230 °F |
| 沸点 | 496.27 °F at 760 mmHg (NTP, 1992)258 °C258.00 to 259.00 °C. @ 760.00 mm Hg257 °C259 °C498 °F259 °C(lit.) |
| Decomposition | When heated to decomposition it emits acrid smoke and irritating fumes. |
| 融点 | 80.3 °F (NTP, 1992)26.865 °C37 - 39 °C28 °C82 °F26 °C |
| 蒸気密度 | 5.86 (Air = 1)Relative vapor density (air = 1): 5.9>5.86 (25 °C, vs air) |
| 臭気閾値 | Odor Threshold Low: 0.0012 [ppm]Reported odor threshold0.1 ppm |
| 蒸気圧 | <1 mm Hg ( 20 °C) |
| 屈折率 | n20/D 1.579(lit.) |
| FEMA | 3667 | DIPHENYL ETHER |
| 貯蔵条件 | Store below +30°C. |
| 外観・状態 | 無色の液体 |
| 色 | White or Colorless to Almost white or Almost colorless |
| 比重 | 1.073 |
| 爆発限界 | 0.8-1.5%(V) |
| 臭気閾値 | 0.1ppm |
| 由来生物 | synthetic |
| においのタイプ | 緑 |
| 凝固点 | 27℃ |
| 比熱容量 | Cp(crystal): 1.27 J/(g·K), at 25℃ |
| JECFA Number | 1255 |
| Merck | 14,7288 |
| BRN | 1364620 |
| ヘンリー定数 | 2.13 at 20 °C (approximate - calculated from water solubility and vapor pressure) |
| 誘電率 | 3.7(30℃) |
| 化粧品成分の機能 | 香料 |
| InChI | 1S/C12H10O/c1-3-7-11(8-4-1)13-12-9-5-2-6-10-12/h1-10H |
| InChIKey | USIUVYZYUHIAEV-UHFFFAOYSA-N |
| SMILES | O(c1ccccc1)c2ccccc2 |
| LogP（分配係数） | 4.21 at 25℃ |
| CAS データベース | 101-84-8(CAS DataBase Reference) |
| NISTの化学物質情報 | Diphenyl ether(101-84-8) |
| EPAの化学物質情報 | Phenyl ether (101-84-8) |
化学的特性
Diphenyl Ether has not been observed in nature. It is a colorless liquid or a crystalline solid (mp 26.8°C) with an odor reminiscent of geranium leaves. Diphenyl ether is obtained as a by-product in the production of phenol by high-pressure hydrolysis of chlorobenzene. Because of its stability and low price, diphenyl ether is used in large quantities in soap perfumes.
安全性と法規制
| GHS 分類 | This chemical does not meet GHS hazard criteria for 0.5% (12 of 2199) of reports.WarningH319 (84.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]H400 (16.1%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]H410 (10.3%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]H411 (78.8%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]P264+P265, P273, P280, P305+P351+P338, P337+P317, P391, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 2199 reports by companies from 45 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Reported as not meeting GHS hazard criteria per 12 of 2199 reports by companies.There are 44 notifications provided by 2187 of 2199 reports by companies with hazard statement code(s).Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. |
|---|---|
| 規制情報 | Chemical: Benzene, 1,1'-oxybis-Commission Regulation (EC) No 1565/2000 (Repealed by Com. Implementing Reg. (EU) No 872/2012)Benzene, 1,1'-oxybis- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Benzene, 1,1'-oxybis- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 04-08-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/14971Status: Active Update: 07-10-2016 https://echa.europa.eu/registration-dossier/-/registered-dossier/18130Diphenyl ether: Does not have an individual approval but may be used under an appropriate group standard |
| 輸送ラベル（DOT） | Class 9 |
| 火災危険 | This chemical is combustible. (NTP, 1992) |
| 火災の可能性 | Combustible when exposed to heat or flame. |
| 健康有害性 | Inhalation may cause nausea because of disagreeable odor. Contact of liquid with eyes causes mild irritation. Prolonged exposure of skin to liquid causes reddening and irritation. Ingestion produces nausea. (USCG, 1999) |
| 有害性の概要 | . . . industrial experience has shown no evidence that phenyl ether, either as liquid mist or vapor, was a human health hazard under ordinary conditions of manufacture, handling, or use. Controlling workplace concentration below 1 ppm has been recommended to prevent the disagreeable odor and nausea in some workers. Damage to the liver and other organs has been documented in acute feeding studies of experimental animalsLD50 = 4 g/kg for rats and guinea pigs[ACGIH] An irritant of the eyes and respiratory tract[ICSC] |
| 反応性グループ | EthersHydrocarbons, Aromatic |
| UN 分類 | UN Hazard Class: 9UN Pack Group: III |
| TSCA 要件 | Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Diphenyl oxide is included on this list. Effective date: 4/13/89Sunset date: 6/30/98. |
| OSHA Standards | Permissible Exposure Limit: Table Z-1 8-hr Time Weighted Avg: 1 ppm (7 mg/cu m). /Vapor/ |
| Reactivity Profile | DIPHENYL OXIDE can react with oxidizing materials. (NTP, 1992). A vigorous reaction occurred between the ether and chlorosulfuric acid. |
| 大気基準 | This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Diphenyl oxide is produced, as an intermediate or a final product, by process units covered under this subpart. |
| 消火 | Fire Extinguishing Agents Not to Be Used: Water or foam may cause frothing.Fire Extinguishing Agents: Dry chemical, carbon dioxide (USCG, 1999)Use water spray, powder, foam, carbon dioxide. |
| 応急処置措置 | Fresh air, rest.Remove contaminated clothes. Rinse and then wash skin with water and soap.Rinse with plenty of water for several minutes (remove contact lenses if easily possible).Rinse mouth. |
| 応急処置 | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.INHALATION: IMMEDIATELY leave the contaminated areatake deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be usedif not available, use a level of protection greater than or equal to that advised under Protective Clothing.INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)(General first aid procedures)Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.Skin: Soap wash promptly - If this chemical contacts the skin, promptly wash the contaminated skin with soap and water. If this chemical penetrates the clothing, promptly remove the clothing and wash the skin with soap and water. Get medical attention promptly.Breathing: Respiratory support |
| 安全保管 | Separated from strong oxidants. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing. |
| 暴露管理・個人防護 | 1.0 [ppm] |
| 消火手順 | Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible.Dry chemical, carbon dioxide. Water or foam may cause frothing. |
| 保管条件 | Conditions for safe storage, including any incompatibilities. Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Non Combustible Solids. |
| 清掃方法 | Accidental release measures: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Avoid breathing dust.Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.Methods and materials for containment and cleaning up: Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal. |
| 非火災時の漏出対応 | SMALL SPILLS AND LEAKAGE: If you spill this chemical, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with alcohol followed by washing with a strong soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.STORAGE PRECAUTIONS: You should store this chemical under refrigerated temperatures, and keep it away from oxidizing materials. (NTP, 1992) |
| 処分方法 | SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in air, soil or watereffects on animal, aquatic and plant lifeand conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.Product: Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Contaminated packaging: Dispose of as unused product.Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal. |
| 漏出処分 | Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. If solid: sweep spilled substance into containers. If appropriate, moisten first to prevent dusting. Then store and dispose of according to local regulations. |
| Preventive Measures | Precautions for safe handling: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Further processing of solid materials may result in the formation of combustible dusts. The potential for combustible dust formation should be taken into consideration before additional processing occurs. Provide appropriate exhaust ventilation at places where dust is formed.Appropriate engineering controls: Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary.For more Preventive Measures (Complete) data for DIPHENYL ETHER (9 total), please visit the HSDB record page. |
| 体内負荷 | As part of the USEPA's National Human Adipose Tissue Survey (NHATS), diphenyl ether was detected in 40 of 44 composite adipose tissue collected for fiscal year 1982(1). |
| 標的器官 | Eyes, skin, respiratory system |
| 生態毒性値 | LC50Species: Daphnia magna (Water Flea) age < or =24 hrConditions: freshwater, static, 22 °C, pH 7.4-9.4, dissolved oxygen 6.5-9.1 mg/LConcentration: 1400 ug/L for 24 hr (95% confidence limit: 1100-1900 ug/L) /> or =80% purity/Concentration: 670 ug/L for 48 hr (95% confidence limit: 110-1100 ug/L) /> or =80% purity/Species: Cyprinodon variegatus (Sheepshead Minnow) age 14-28 dph, juvenile, length 8-15 mmConditions: saltwater, staticConcentration: 2400 ug/L for 24 hr (95% confidence limit: 1800-3200 ug/L) /> or =80% purity/Concentration: 2400 ug/L for 48 hr (95% confidence limit: 1800-3200 ug/L) /> or =80% purity/For more Ecotoxicity Values (Complete) data for DIPHENYL ETHER (6 total), please visit the HSDB record page. |
| 環境中動態 | TERRESTRIAL FATE: Based on a classification scheme(1), a Koc value of 1950(2), indicates that diphenyl ether is expected to have low mobility in soil(SRC). Volatilization of diphenyl ether from moist soil surfaces may be an important fate process(SRC) given its Henry's Law constant estimated as 2.8X10-4 atm-cu m/mole(SRC) based upon its vapor pressure, 2.25X10-2 mm Hg(3), and water solubility, 18 mg/L(4). Diphenyl ether is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 2.25X10-2 mm Hg at 25 °C(3). A 6.3% of theoretical BOD using activated sludge in the Japanese MITI test(5) suggests that biodegradation is not an important environmental fate process in soil(SRC).AQUATIC FATE: Based on a classification scheme(1), a Koc value of 1950(2), indicates that diphenyl ether is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces may be expected(3) based upon an estimated Henry's Law constant of 2.8X10-4 atm-cu m/mole(SRC) derived from its vapor pressure, 2.25X10-2 mm Hg(4), and water solubility, 18 mg/L(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 4 hours and 6 days, respectively(SRC). According to a classification scheme(6), experimental BCF values of 195, 470 and 590, suggest that bioconcentration in aquatic organisms is moderate to high(SRC). A 6.3% of theoretical BOD using activated sludge in the Japanese MITI test(5) suggests that biodegradation is not an important environmental fate process in water(SRC).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), diphenyl ether, which has a vapor pressure of 2.25X10-2 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase diphenyl ether is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 3 days(SRC), calculated from its rate constant of 9.8X10-12 cu cm/molecule-sec at 25 °C(3). Diphenyl ether contains chromophores that absorb at wavelengths >290 nm(4) and, therefore, may be susceptible to direct photolysis by sunlight(SRC). |
| 食品調査値 | Diphenyl ether has been qualitatively detected in the volatile aroma components of roasted beef(1). |
| 有害作用 | Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation. |
| 暴露経路 | inhalation, skin and/or eye contact |
| 毒性の概要 | IDENTIFICATION AND USE: Diphenyl ether exists as a colorless crystalline solid or liquid with a unpleasant odor. It is insoluble in water and soluble in ether, benzene and acetic acid. The odor is extremely unpleasant. It is used in large quantities in soap perfumes and its main application is as a heat transfer medium (eutectic mixture with diphenyl) and as a chemical intermediate for reactions such as halogenation, acylation, alkylationit is also used as a dye carrier. Employed as a processing aid in the production of polyesters. HUMAN EXPOSURE AND TOXICITY: Contact with a commercial product containing diphenyl ether has caused burning of the eyes, irritation of the respiratory tract, and severe nausea along with skin irritation. Oral exposure to a commercial product containing this chemical has caused severe degenerative changes in the liver and kidney. Prolonged exposure of skin to liquid causes reddening and irritation. Occupational exposure to diphenyl ether occurs through dermal contact and inhalation of vapor. Its use in various soap, detergent, creams, lotion, and perfume formulations results in general population exposure through inhalation and dermal contact. Diphenyl ether was detected in collected composite adipose tissue. ANIMAL STUDIES: In acute oral exposures of diphenyl ether to rats, injury to the liver, spleen, kidney, thyroid and intestinal tract was observed. Undiluted diphenyl ether is irritating to rabbit skin. Erythema and exfoliation of skin was noted. |
| Plant Concentrations | Diphenyl ether reportedly occurs in lemon balm oil(1). |
| Signs and Symptoms | Sore throat. Cough.Redness.Redness. Pain.irritation eyes, nose, skinnausea |
| Ongoing Test Status | EPA has released the first beta version (version 0.5) of the Interactive Chemical Safety for Sustainability (iCSS) Dashboard. The beta version of the iCSS Dashboard provides an interactive tool to explore rapid, automated (or in vitro high-throughput) chemical screening data generated by the Toxicity Forecaster (ToxCast) project and the federal Toxicity Testing in the 21st century (Tox21) collaboration. /The title compound was tested by ToxCast and/or Tox21 assaysClick on the "Chemical Explorer" button on the tool bar to see the data./[USEPAICSS Dashboard ApplicationAvailable from, as of April 22, 2015: http://actor.epa.gov/dashboard/] |
| Effluent Concentrations | Diphenyl ether has been detected at concentrations > 100 ppb in 1 of 63 effluents collected from chemical manufacturing plants across the US(1). Wastewater samples collected from a small specialty chemicals manufacturing plant on the Pawtuxet River (RI) during 1975 and 1976 contained diphenyl ether concentrations ranging from 0.01 to 0.20 ppm(2,3). In Delaware diphenyl ether was present in digested and dewatered sludge obtained from a Georgetown WWTP in July 2000 at trace amounts and in digested and dewatered sludge obtained from a Willmington WWTP October 2002 at concentration of 99.6 ug/g(4). Diphenyl ether has been identified in advanced waste water treatment facility samples collected from Orange County, CA (Jan-Feb 1976)(5).Diphenyl ether was listed as 57 of the 99 most frequently detected compounds at US hazardous waste sites monitored for 2 years prior to 1989(1). The compound has been detected in wastewater effluents from municipal waste water treatment facilities(2,3), textile finishing plants(4), organic chemical and plastic manufacturing plants, soap and detergent facilities, and electronic facilities(5). Diphenyl ether is reportedly released to the atmosphere in emissions from combustion, phthalic anhydride manufacture, and turbine engines(6). The detection of diphenyl ether in river water samples adjacent to hazardous waste disposal areas in Niagara Falls, NY indicates that leaching is a source of environmental contamination(7). Possible sources of release to environmental waters include spent heat exchange chemicals and byproduct from phenol manufacture(8). |
| 職業暴露区分（OEB） | B |
| 職業暴露限界（OEL） | TWA: 1 ppm (7 mg/m3) |
| 水環境危害等級（WGK） | 2 |
| 生命健康即時危険濃度 | 100 ppm |
| TSCA 収載状態 | TSCA listed |
| RTECS 番号 | KN8970000 |
| 輸送番号（UN） | UN 3077 9/PG 3 |
| 毒性 | LD50 orally in Rabbit: 2450 mg/kg LD50 dermal Rabbit > 7940 mg/kg |
| PRTR法 | 第一種指定化学物質 |
| 税関コード | 2909 30 10 |
| 危険文句（R） | 51/53-36/37/38-39/23/24/25-23/24/25-36/38-36 |
| 化審法 | (3)-650 |
| 安衛法 | 57,57-2 |
| 危険表示 | N,Xi,T |
| 安全措置（S） | 60-61-57-37/39-26-45-36/37 |
| 危険等級 | 9Aquatic Acute 1Aquatic Chronic 2Eye Irrit. 2 |
| 包装等級 | III |
| 自然発火温度 | 610 °C |
| 貯蔵分類 | 11 - Combustible Solids |
| 有害物質データ | 101-84-8(Hazardous Substances Data) |
用途
解説
C12H10O(170.21)．C6H5OC6H5．フェニルエーテルともいう．フェノールとクロロベンゼンをアルカリの存在下，高温加圧下に縮合させると得られる．ゼラニウム油の香りをもつ板状晶．融点28 ℃，沸点259 ℃．d204 1.074．n20D 1.5809．多くの有機溶媒に可溶，水に不溶．安価な香料の調合に用いられる．[CAS 101-84-8]森北出版「化学辞典（第2版）
用途
石けん用の香料、熱媒体
説明
Diphenyl ether (diphenyl oxide) is a colorless liquid with a floral odor. It is a white, crystalline solid at temperatures below 80ºF (27ºC). It has low volatility, low solubility in water, and is stable at high temperatures. Avoid contact with oxidizing materials. Liquid diphenyl oxide is used primarily in industry. It is used in the industrial setting as a heat transfer fluid. It is the major component of Dowtherm A® (an eutectic mixture of phenyl ether and biphenyl) and further as a chemical intermediate in the production of surface-active agents and hightemperature lubricants, and in perfumery due to its geranium-like odour (ACG99b). It is also used as a chemical intermediate in the manufacture of surfactants and fire retardants. Diphenyl oxide (DPO) is manufactured using the direct phenol method.
天然物の起源
Reported found in muscat grapes, grilled beef, green tea, potato chips, buckwheat, Bourbon vanilla and lemon balm.
使用
Phenyl Ether is an Impurity of Propofol (P829750).
一般的な説明
Colorless liquid with a mild pleasant odor. May float or sink in water. Freezing point is 81°F.
一般的な説明
Diphenyl ether occurs, e.g., in lemon balm oil. The compound forms colorless crystals that possess a geranium-like aroma. Diphenyl ether is formed as a byproduct in the high-pressure hydrolysis of chlorobenzene. Because of its high thermal stability, a eutectic mixture of diphenyl ether and biphenyl is employed as a heat transfer medium. Diphenyl ether is the starting material for organic intermediates and is used as a fragrance component. The compound is also employed as a processing aid in the production of polyesters; several polybromine derivatives of diphenyl ether are used as fire retardants.
使用用途
ジフェニルエーテルの主な使用用途は、農医薬原料、熱媒原料、香料原料、反応溶媒、特殊樹脂原料などです。特に中心となるものとして、石鹸用の香料、熱媒体、殺虫剤の原料などが挙げられます。例えば、とジフェニルエーテルの3:7混合物は、熱交換媒体、高沸点溶媒として広く用いられています。これは、この混合物が15℃から257℃までの広い範囲で液体として存在するためです。 また、ジフェニルエーテルにアルコキシ基が結合した物質は、ジフェニルエーテル殺虫剤として用いられます。ジフェニルエーテル殺虫剤であるメソプレンは、カやハエを対象とした防疫用殺虫剤、ペットのノミやシラミ駆除剤として利用される物質です。
製法・合成法
製造方法
By heating potassium phenolate with bromobenzene or with chlorobenzene at elevated temperatures.
純化方法
Crystallise the ether from 90% EtOH. Melt it, wash it with 3M NaOH and water, dry it with CaCl2 and fractionally distil it under reduced pressure. Fractionally recrystallise it from its melt and store over P2O5. [Beilstein 6 IV 562.]