Dimethyldioctadecylammonium bromide (HCID 77293)

名称と識別子

優先名称: Dimethyldioctadecylammonium bromide
IUPAC: dimethyl(dioctadecyl)azanium bromide
現地名: ジメチルジステアリルアンモニウムブロミド
英語名: Dimethyldioctadecylammonium bromide
分子式: C38H80BrN
分子量: 630.95

名称と別名

Dimethyldioctadecylammonium bromide3700-67-2Distearyldimethylammonium bromidedioctadecyldimethylammonium bromideZ5T47R065ADTXSID60884005RefChem:134337DTXCID701023480223-037-6n,n-dimethyl-n-octadecyloctadecan-1-aminium bromide1-Octadecanaminium, N,N-dimethyl-N-octadecyl-, bromidedimethyl(dioctadecyl)azanium;bromide

名称をさらに表示

ジメチルジステアリルアンモニウムブロミドジオクタデシルジメチルアンモニウムブロミドN,N-ジメチル-N-オクタデシルオクタデカン-1-アミニウム·ブロミドジメチルビス(オクタデシル)アミニウム·ブロミドジオクタデシルジメチルアンモニウム·ブロミドビスオクタデシルジメチルアミニウム·ブロミドジメチルジオクタデシルアンモニウム·ブロミドジオクタデシルジメチルアミニウム·ブロミドジメチルビスオクタデシルアミニウム·ブロミドDODAブロミドジメチルジオクタデシルアミニウム·ブロミドジメチルジステアリルアミニウム·ブロミドジステアリルジメチルアミニウム·ブロミドN,N-ジメチル-N-オクタデシル-1-オクタデカンアミニウム·ブロミドジメチルジオクタデシルアンモニウムブロミド臭化ジメチルジ-N-オクタデシルアンモニウムジメチルジステアリルアンモニウムブロミド臭化ジメチルジ‐N‐オクタデシルアンモニウムジメチルジステアリルアンモニウム=ブロミドジオクタデシルジメチルアミニウム・ブロミドDODABDDADSABDDABDODA(Br)18:0 DDABdioctadecyLERBU Adjuvant 100Dimethyldistearylaminium·bromide

MFCD00041975DISTEARYLDIMONIUM BROMIDEdimethyldioctadecylazanium bromidedistearyl dimethyl ammonium bromideC38H80BrNUNII-Z5T47R065ADSDMAB1-Oct

データベース識別子

CAS: 3700-67-2
PubChem CID: 77293
DTXSID: DTXSID60884005
UNII: Z5T47R065A
EC Number: 223-037-6

物性

構造計算による物性

極性表面積: 0 Å²
水素結合供与体数: 0
水素結合受容体数: 1
回転可能結合数: 34
重原子数: 40
形式電荷: 0
複雑度: 390

実験および物理化学的性質

Chemical ClassesNitrogen Compounds -> Quaternary Amines

Physical DescriptionWhite powder; [Sigma-Aldrich MSDS]

物理化学的性質

融点: 160 °C · ~160 °C
比重(密度): 1.047 · 1.047
屈折率: 1.526 · 1.5260 (estimate)
貯蔵温度: -20 °C · -20°C
溶解性: クロロホルム（微熱）、酢酸エチル（微熱）、ヘキサン（微熱）
外見: 粒状粉末
色: 白い
BRN: 3580323 · 3580323
安定性: 安定。強力な酸化剤とは相容れない。
InChI: InChI=1S/C38H80N.BrH/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-37-39(3,4)38-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-2;/h5-38H2,1-4H3;1H/q+1;/p-1
InChIKey: PSLWZOIUBRXAQW-UHFFFAOYSA-M
SMILES: C(CCCCCCCCCCCCCCCCC)[N+](C)(C)CCCCCCCCCCCCCCCCCC.[Br-]
CAS データベース: 3700 · 3700-67-2(CAS DataBase Reference)
EPAの化学物質情報: 1 · 1-Octadecanaminium, N,N-dimethyl-N-octadecyl-, bromide (3700-67-2)

化学的性質

化学的特性white powder

安全と法規制

GHS分類

GHS Classification · 4 件

Warning

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 59 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Regulatory Information1-Octadecanaminium, N,N-dimethyl-N-octadecyl-, bromide: Does not have an individual approval but may be used under an appropriate group standard

Hazards SummaryCauses zonal hepatitis and changes in blood cell counts in 10-day intermittent intraperitoneal studies of mice; [RTECS] A skin and strong eye irritant; [Sigma-Aldrich MSDS]

Hazard Classes and CategoriesSkin Irrit. 2 (100%)

毒性情報

Adverse EffectsOccupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

安全データ

wgk: 3
tsca: TSCA listed
hs_code: 29211990
risk_code: 36/37/38-43
化審法: (2)-184, (9)-1971 優先評価化学物質
hazard_code: Xi
safety_code: 26-37/39
hazard_class: 9
ストレージクラス: 11 - Combustible Solids

化学と産業

薬理情報

MeSH Pharmacological Classification · 3 件

Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.

Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.

Agents that modify interfacial tension of water; usually substances that have one lipophilic and one hydrophilic group in the molecule; includes soaps, detergents, emulsifiers, dispersing and wetting agents, and several groups of antiseptics.

用途と製造

General Manufacturing Information1-Octadecanaminium, N,N-dimethyl-N-octadecyl-, bromide (1:1): ACTIVE

応用分野 · 2 件

使用Dimethyldioctadecylammonium bromide has been used in a study to assess the interaction of its monolayers with DNA using specular neutron reflection, surface pressure-area isotherms, and Brewster angle microscopy. It has also been used in a study to investigate new adjuvants for use in kill vaccines for bovine viral diarrhea virus (BVDV).

一般的な説明18:0 DDAB is cationic lipid and a quaternary ammonium salt. The hydrocarbon tails are saturated unlike the ionizable lipids.

調製方法 · 1 件

純化方法Crystallise the bromide from acetone, then MeOH [Lukac J Am Chem Soc 106 4387 1984]. Also purify it by chromatography on alumina by washing with *C6H6 and eluting with Me2CO, evaporating and crystallising from MeCN [Swain & Kreevoy J Am Chem Soc 77 1126 1955]. [Beilstein 4 IV 829.]

上流・下流製品情報

上流原料

1-ブロモオクタデカンジメチルアミン

サプライヤー50 社

北京华美互利生物化工010-56205725 · [email protected]

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

南通润丰石油化工有限公司66017690 19952660367 · [email protected]

武汉欣扬瑞和化学科技有限公司13720274133 · [email protected]

ジメチルジステアリルアンモニウムブロミド

基本情報