4-Morpholineethanesulfonic acid (HCID 78165)

概要

2-(N-morpholino)ethanesulfonic acid is an organosulfonic acid and a MES. It is a conjugate acid of a 2-(N-morpholino)ethanesulfonate. It is a tautomer of a 2-(N-morpholiniumyl)ethanesulfonate.

名称と識別子

優先名称: 4-Morpholineethanesulfonic acid
IUPAC: 2-morpholin-4-ylethanesulfonic acid
現地名: MES 分子生物学用
英語名: MES monohydrate
分子式: C6H15NO5S
分子量: 213.25

名称と別名

4432-31-94-Morpholineethanesulfonic acid2-(N-Morpholino)ethanesulfonic acid2-(4-Morpholinyl)ethanesulfonic acid4-Morpholinethanesulfonic acidMorpholineethanesulfonic acid2-morpholin-4-ylethanesulfonic acidMES (buffering agent)Morpholinoethanesulfonic acid2-(morpholin-4-yl)ethanesulfonic acid2GNK67Q0C4CHEBI:39005

名称をさらに表示

MES 分子生物学用MES 一水和物メッシュMES HYDRATEMES.H2OMES 1HYD FREE ACID XTLMORPHOLINOETHANE SULFONIC ACID MONOHYDRATE2-(N-MORPHOLINO)ETHANESULFONIC ACID HYDRATE4-MORPHOLINEETHANESULFONIC ACID MONOHYDRATEMES-HMES-HOMES)MES MonohydMES MONOHYDRATE

NSC-157116DTXSID4063454MES compoundRefChem:461564DTXCID3040306224-632-32-Morpholinoethanesulfonic acidMES

データベース識別子

CAS: 145224-94-8、4432-31-9
PubChem CID: 78165
DTXSID: DTXSID4063454
ChEMBL: CHEMBL1234276
ChEBI: CHEBI:39005
UNII: 2GNK67Q0C4
EC Number: 224-632-3、630-505-7、919-085-9
Nikkaji: J8.725D

物性

構造計算による物性

XLogP: -3.5
極性表面積: 75.2 Å²
水素結合供与体数: 1
水素結合受容体数: 5
回転可能結合数: 3
重原子数: 12
形式電荷: 0
複雑度: 214

実験および物理化学的性質

Chemical ClassesOther Uses -> Biological Buffers

DrugsPharmaceuticals -> Listed in ZINC15

Physical DescriptionColorless solid; [Merck Index] White powder; [Aldrich MSDS]

物理化学的性質

融点: 300 °C · >300 °C(lit.)
比重(密度): 10.66 g/mL · 10.66g/mL
貯蔵温度: Sealed in dry,Room Temperature
溶解性: 2 O: · H2O: 0.5M at20℃、透明
外見: 粉末、結晶またはフレーク
色: 白色から淡黄色および/またはオレンジ色
臭い (Odor): 無臭
PH: 2.5 · 2.5-4.0 (25℃, 0.5M in H2O)
酸解離定数(Pka): 6.1 · 6.1(at 25℃)
由来生物: synthetic
水溶解度: 水に溶ける。
Merck: 14 · 14,5902
BRN: 141319 · 141319
主な用途: 農業診断アッセイの製造一般的な分析微生物学
InChI: InChI=1S/C6H13NO4S.H2O/c8-12(9,10)6-3-7-1-4-11-5-2-7;/h1-6H2,(H,8,9,10);1H2
InChIKey: MIIIXQJBDGSIKL-UHFFFAOYSA-N
SMILES: S(=O)(=O)(O)CCN1CCOCC1.O
CAS データベース: 145224 · 145224-94-8(CAS DataBase Reference)

化学的性質

化学的特性white crystalline powder

安全と法規制

GHS分類

GHS Classification · 6 件

This chemical does not meet GHS hazard criteria for 97.3% (252 of 259) of all reports.

Not Classified

Aggregated GHS information provided per 259 reports by companies from 7 notifications to the ECHA C&L Inventory.

This chemical does not meet GHS hazard criteria for 2.1% (2 of 96) of reports.

Warning

H315 (97.9%): Causes skin irritation [Warning Skin corrosion/irritation]

危険有害性情報

Regulatory Information · 3 件

Chemical: 4-Morpholineethanesulfonic acid

Status: Active Update: 01-12-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/24714

4-Morpholineethanesulfonic acid: Does not have an individual approval but may be used under an appropriate group standard

Hazards SummaryMay cause irritation; [Aldrich MSDS] See Morpholine.

Hazard Classes and Categories · 3 件

Not Classified

Skin Irrit. 2 (100%)

Skin Irrit. 2 (97.9%)

安全データ

wgk: 3
tsca: Yes
rtecs: QE3479500
hs_code: 29349990
risk_code: 36/37/38
hazard_code: Xi
safety_code: 26-36-37/39
ストレージクラス: 11 - Combustible Solids

化学と産業

用途と製造

UsesUsed as a biological buffer; [Merck Index]

General Manufacturing Information4-Morpholineethanesulfonic acid: ACTIVE

応用分野 · 4 件

解説タイラー標準ふるいにおけるふるいの目の大きさを示す単位．目開き0.0029 in(1 in＝2.54 cm)，針金径0.0021 inの200メッシュ(1 in中の目の数に相当)ふるいを基準にし，ふるい比(隣り合うふるいの目開きの比)を1：4√2として標準ふるいが定められている．わが国の単位はJIS Z8801(標準ふるい)に準処し，また日本薬局方もほぼこれに準じており，メッシュ単位は使用しない．

説明MES Monohydrate is a zwitterionic buffer that is not absorbed through cell membranes and is virtually transparent in UV light. MES is a buffering agent used in many biological and biochemical applications. It is also used as a running buffer for denaturing gel electrophoresis. The characteristics of low UV absorptivity, minimal reactivity, stable pH and solubility in water allow MES Monohydrate to be used as a Good's buffer.

使用MES monohydrate is a buffering agent used in biochemistry and molecular biology that was selected and described by Good et al. It is a zwitterionic, morpholinic buffer that is useful for a pH range of 5.5 – 6.7 and commonly used for cell culture media, as a running buffer in electrophoresis, and for protein purification in chromatography. MES lacks the ability to form a complex with most metal ions and is recommended for use as a non-coordinating buffer in solutions with metal ions. MES is often used in buffered culture media for bacteria, yeast, and mammalian cells. It is toxic towards plants at high concentrations, but can be used in culture media at lower concentrations for plants. Due to low ionic mobility, MES is regarded as an excellent buffer for use in capillary electrochromatography. MES is often employed as a substitute for the highly toxic cacodylate, as well as a substitute for the non-zwitterionic buffers citrate and malate. MES complexes with some organotin(IV) molecules that are being explored as antitumor agents.MES free acid or MES free acid monohydrate can be mixed with MES sodium salt to acquire desired pH. Alternatively, MES free acid or MES free acid monohydrate can be titrated with sodium hydroxide to attain desired pH.

一般的な説明buffer substance MES