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化工社化工社 化学情報印刷レポート · 研究参考用
HCID 7845作成日：2026年10月27日

1,3-ブタジエン

1,3-ブタジエン · ブタジエン · エリトレン · trans-1,3-ブタジエン · ジビニル · ビニルエチレン · 1,3-ブタンジエン · エリスレン

https://huagongshe.com/ja/chemical/7845

1,3-ブタジエン の分子構造式

識別子と物理属性

CAS No.106-99-0
分子式C4H6
平均分子量54.09 g/mol
単同位体質量54.04695019 g/mol
SMILESC=CC=C
InChIKeyKAKZBPTYRLMSJV-UHFFFAOYSA-N
PubChem CID7845
ChEMBLCHEMBL537970
ChEBICHEBI:39478
EC No.203-450-8
DTXSIDDTXSID3020203
現地名1,3-ブタジエン

化学・物理的性質

XLogP2
極性表面積0
水素結合供与体数0
水素結合受容体数0
回転可能結合数1
重原子数4
形式電荷0
複雑度21
LogP（分配係数）log Kow = 1.99
臭いMIldly aromatic odorMild aromatic or gasoline-like odor特徴臭
密度0.621 at 68 °F (USCG, 1999) - Less dense than waterwill float0.6149 g/cu cm at 25 °CAbsolute density, gas at 101.325 kPa at 0 °C: 2.428 kg/cu mRelative density, gas at 101.325 kPa at 0 °C (air = 1): 1.878Density, liquid at saturation pressure at 20 °C: 0.621 kg/lCritical density: 0.245 kg/cu mRelative density (water = 1): 0.60.6149 @25 °C0.62 g/mL at 20 °C(lit.)
ViscosityGas at 101.325 kPa at 20 °C: 0.00754 cPLiquid at -40 °C: 0.33 cP
Color/FormColorless gas ... [Note: A liquid below 24 degrees F. Shipped as a liquefied compressed gas]
溶解度Insoluble (NTP, 1992)In water, 735 mg/L at 20 °CSlightly soluble in methanol, ethanolsoluble in organic solvents such as carbon tetrachloridealcohol dissolves about 40 vols at room temp.Soluble in ethanol, ether, benzenevery soluble in acetone0.735 mg/mL at 25 °CSolubility in water, g/100ml: 0.1 (none)水：可溶0.5g/L at 20℃735mg/L(25℃)
CorrosivityNon-corrosive
引火点-105 °F (NTP, 1992)Gas-76 °C c.c.-105 °F (liquid)NA (Gas) -105 °F (Liquid)−105 °F
沸点24.1 °F at 760 mmHg (NTP, 1992)-4.5 °C-4 °C24 °F-4.41 °C @760 [mm Hg]−4.5 °C(lit.)
DecompositionMay decompose explosively when heated above 200 °C/ 1 kbar. ... When heated to decomposition it emits acrid smoke and fumes.
融点-164 °F (NTP, 1992)-108.966 °C-108.9 °C-109 °C-108.91 °C−109 °C(lit.)
蒸気密度1.87 (NTP, 1992) - Heavier than airwill sink (Relative to Air)1.87 (Air = 1)Relative vapor density (air = 1): 1.91.881.9 (15 °C, vs air)
蒸気圧1863 mm Hg ( 21 °C)
屈折率1.4292
貯蔵条件0-6°C
外観・状態無色のガス
色Colorless to Almost colorless
臭気閾値0.23ppm
爆発限界12%
凝固点-108.91℃
比熱容量Cp(liquid): 2.29 J/(g·K), at 25℃
Merck14,1509
BRN605258
ヘンリー定数(x 10-2 atmm3/mol): 6.3 at 25 °C (Hine and Mookerjee, 1975)
安定性安定。非常に可燃性。空気と爆発性混合物を形成する可能性があります。強力な酸化剤、銅、銅合金とは相容れない。安定剤が含まれている場合があります。
InChI1S/C4H6/c1-3-4-2/h3-4H,1-2H2
InChIKeyKAKZBPTYRLMSJV-UHFFFAOYSA-N
SMILESC=CC=C
LogP（分配係数）1.99 at 20℃
CAS データベース106-99-0(CAS DataBase Reference)
EPAの化学物質情報1,3-Butadiene (106-99-0)

化学的特性

Butadiene is a gas, b.p. -4°C.

化学性质

ほとんど生成しないが，熱分解プロセスでは比較的多量に生成する。

安全性と法規制

GHS 分類DangerH220: Extremely flammable gas [Danger Flammable gases]H340: May cause genetic defects [Danger Germ cell mutagenicity]H350: May cause cancer [Danger Carcinogenicity]P203, P210, P222, P280, P318, P377, P381, P403, P405, and P501 (click each P-code to see the statement)This chemical does not meet GHS hazard criteria for 0.1% (2 of 1783) of reports.
規制情報Chemical: 1,3-ButadieneHazard Traits - CarcinogenicityDevelopmental ToxicityGenotoxicityNeurotoxicityReproductive ToxicityRespiratory ToxicityAuthoritative List - ATSDR NeurotoxicantsCA TACsEC Annex VI CMRs - Cat. 1AEC Annex VI CMRs - Cat. 1BIARC Carcinogens - 1IRIS Carcinogens - Carcin.NTP RoC - knownOEHHA RELsProp 65Report - regardless of intended function of ingredient in the product1,3-Butadiene is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,3-Butadiene are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 26-04-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/155701,3-Butadiene: HSNO Approval: HSR000988 Approved with controlsThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)
その他の安全情報IMAP assessments - 1,3-Butadiene: Human health tier II assessment
輸送ラベル（DOT）Flammable Gas
火災危険Behavior in Fire: Vapors heavier than air and may travel a considerable distance to a source of ignition and flashback. Containers may explode in a fire due to polymerization. (USCG, 1999)Extremely flammable. Gas/air mixtures are explosive.
火災の可能性

用途

解説

弱い芳香性を有する引火性の液化しやすい無色の気体．融点－108.92 ℃，沸点－4.41 ℃．爆発範囲2.0～11.5体積％．エタノール，エーテルに可溶，水に不溶．共役した二重結合をもつために化学反応性は高く，とくに重合活性が高いため，貯蔵には重合防止剤および酸化防止剤の添加が必要である．石油化学の重要な原料の一つである．おもにスチレン-ブタジエンゴム(SBR)，アクリロニトリル-ブタジエンゴム(NBR)，ブタジエンゴムなどの合成ゴム，ABS樹脂(アクリロニトリル-ブタジエン-スチレン共重合樹脂)などの樹脂の原料となる．ほかにクロロプレン，アジポニトリル，1,4-ブタンジオールなどの合成原料としても用いられる．スチレンブタジエンゴム(SBR),ブタジエンゴム(BR)合成ゴムラテックス合成原料、スチレンブタジエンアクリロニトリル(ABS)樹脂、スチレンブタジエンメタクリレート(MBS)樹脂合成原料、化成品原料、合成ゴム(SBR,NBRなど)の原料森北出版「化学辞典（第2版）

用途

ポリブタジエン（BR），スチレン-ブタジエンゴム（SBR），ニトリルゴム（NBR），ポリクロロプレンといった合成ゴムや，アクリロニトリル-ブタジエン-スチレン樹脂（ABS樹脂）などの合成樹脂の原料

説明

1,3-Butadiene is a simple conjugated diene. It is a colourless gas with a mild aromatic or gasoline-like odour and incompatible with phenol, chlorine dioxide, copper, and crotonaldehyde. The gas is heavier than air and may travel along the ground; distant ignition is possible. It is an important industrial chemical used as a monomer in the production of synthetic rubber. Most butadiene is polymerised to produce synthetic rubber. While polybutadiene itself is a very soft, almost liquid, material, polymers prepared from mixtures of butadiene with styrene or acrylonitrile, such as ABS, are both tough and elastic. Styrene–butadiene rubber is the material most commonly used for the production of automobile tyres. Smaller amounts of butadiene are used to make nylon via the intermediate adiponitrile, other synthetic rubber materials such as chloroprene, and the solvent sulpholane. Butadiene is used in the industrial production of cyclododecatriene via a trimerisation reaction. 1,3-Butadiene structure

使用

Synthetic elastomers (styrene-butadiene, polybutadiene, neoprene, nitriles), ABS resins, chemical intermediate. 1,3-Butadiene can undergo a four-component coupling reaction with aryl Grignard reagents, and alkyl fluorides in the presence of nickel catalyst to form 1,6-octadiene carbon compound substituted with alkyl and aryl groups at the 3- and 8-positions. 1,3-Butadiene is a useful diene for Diels Alder reaction. It may be used in the synthesis of the following: 1-Silyl-substituted 1,3-butadienes, by [RuHCl(CO)(PCy3)2]-catalyzed silylative coupling of terminal (E)-1,3-dienes with vinylsilanes. Synthetic rubber and thermoplastic resins. Disilylated dimers by reacting with chlorosilanes. Octa-2,7-dien-1-ol via palladium catalyzed-hydrodimerization.

一般的な説明

1,3-Butadiene is a colorless gas with a mild, aromatic, gasoline-like odor. It is shipped as a liquefied gas under its vapor pressure. Contact with the liquid can cause frostbite. It is easily ignited. Its vapors are heavier than air and a flame can flash back to the source of leak very easily. It can asphyxiate by the displacement of air. It must be shipped inhibited as butadiene is liable to polymerization. If polymerization occurs in the container, It may violently rupture. Under prolonged exposure to fire or intense heat the containers may rupture violently and rocket. It is used to make synthetic rubber and plastics, and to make other chemicals.

製法・合成法

製造方法

Butadiene is obtained when n-butenes are dehydrogenated:n-Butenes are mostly obtained from the catalytic cracking operations carried out on various petroleum fractions; thermal cracking processes usually give low yields of butenes. The dehydrogenation of n-butenes is carried out by mixing the feed with steam (which lowers the partial pressures of the reactants) and passing over a catalyst such as mixed calcium/nickel phosphate stabilized with chromium oxide at about 650C.

調製方法

Except for a small amount of butadiene produced by the oxydehydrogenation of n-butane, most of butadiene is produced commercially as a by-product of ethylene production during the steam cracking of hydrocarbon streams. It is separated and purificated from other components by extractive distillation, using acetonitrile and dimethylformamide as solvents.

合成方法

ナフサ分解のC4留分から得られる。抽出溶剤を用いた抽出蒸留法により分離される。エチレンをナフサ分解以外から得ている地域では，ブテンの脱水素，n-ブタンの2段脱水素を行う。また，エタノール脱水素により得られるアセトアルデヒドとエタノールの脱水反応によるブタジエン製造も行われている。

Flammable gas ...Dangerous fire hazard when exposed to heat, flame, or powerful oxidizers. ... Reaction with sodium nitrite forms a spontaneously flammable product. Exothermic reaction with boron trifluoride etherate + phenol.
健康有害性Slight anesthetic effect at high concentrationscauses frostbite from skin contactslight irritation to eyes and nose at high concentrations. (USCG, 1999)
有害性の概要1,3-Butadiene is a chemical made from the processing of petroleum. It is the 36th highest volume chemical produced in the United States. It is a colorless gas with a mild gasoline-like odor. About 75% of the manufactured 1,3-butadiene is used to make synthetic rubber. Synthetic rubber is widely used for tires on cars and trucks. 1,3-Butadiene is also used to make plastics including acrylics. Small amounts are found in gasoline.Motor vehicle exhaust is a constant source of 1,3-butadiene. Although 1,3-butadiene breaks down quickly in the atmosphere, it is usually found in ambient air at low levels in urban and suburban areas. Acute (short-term) exposure to 1,3-butadiene by inhalation in humans results in irritation of the eyes, nasal passages, throat, and lungs. Epidemiological studies have reported a possible association between 1,3- butadiene exposure and cardiovascular diseases. Epidemiological studies of workers in rubber plants have shown an association between 1,3-butadiene exposure and increased incidence of leukemia. Animal studies have reported tumors at various sites from 1,3-butadiene exposure. EPA has classified 1,3- butadiene as carcinogenic to humans by inhalation.Synthetic rubber workers in the past had increased incidence of leukemia attributed to chronic and heavy exposure to 1,3-butadiene. Acutely, it is not very toxic. [Lewis R. Overview of the Rubber Industry and Tire Manufacturing. in Occupational Medicine STAR 14(4): 710, 1999.] In reproductive studies of mice, 1,3-butadiene causes testicular damage. Some animal studies found birth defects after high doses during early pregnancy. [Frazier, p. 277-8] Causes CNS depression at high concentrationsMay have effects on the bone marrow[ICSC] Germ cell mutagens that have shown to increase the mutant frequency in the progeny of exposed mammals. [MAK] The excesses were attributable to both chronic lymphocytic and chronic myelogenous leukemia, with significant exposure-response relationships between cumulative exposure to butadiene and mortality from both leukaemia types. There is sufficient evidence that 1,3-butadiene causes cancer of haematolymphatic organs in studies of styrene-butadiene rubber and butadiene-monomer workers. [IARC Monograph Volume 100F (2012)] Butadienes, stabilized (UN1010) has warning of explosive polymerization[ERG 2016]See 1,3-Butadiene.
輸送番号・ガイド（DOT）1010 116P(inhibited)
反応性グループConjugated DienesPolymerizable Compounds
EC 分類Symbol: F+, TR: 45-46-12S: 53-45Note: D
UN 分類UN Hazard Class: 2.1
Special ReportsUSEPAHealth Assessment Document: 1,3-Butadiene (2002) EPN600/P-98/00lFDHHS/NTPToxicology & Carcinogenesis Studies of 1,3-Butadiene in B6C3F1 Mice Technical Report Series No. 288 (1984) NIH Publication No. 84-2544Toxicology & Carcinogenesis Studies of 1,3-Butadiene in B6C3F1 Mice Technical Report Series No. 434 (1993) NIH Publication No. 93-3165DHHS/National Toxicology ProgramReport on Carcinogens, Thirteenth Edition: 1,3-Butadiene (106-99-0) (2014).. The Report on Carcinogens is an informational scientific and public health document that identifies and discusses substances (including agents, mixtures, or exposure circumstances) that may pose a carcinogenic hazard to human health. 1,3-Butadiene (106-99-0) is listed as known to be a human carcinogen.[Available from, as of February 12, 2015: http://ntp.niehs.nih.gov/go/roc13]HHS/ATSDRToxicological Profile for 1,3-butadiene (September 2012).. Intended to characterize succinctly the toxicological and adverse health effects information for the hazardous substance being described.[HHS/ATSDRToxicological Profile for 1,3-butadiene (September 2012). Available from, as of February 12, 2015: http://www.atsdr.cdc.gov/toxprofiles/index.asp]
消火Excerpt from ERG Guide 116 [Gases - Flammable (Unstable)polymerization hazard]:DO NOT EXTINGUISH A LEAKING GAS FIRE UNLESS LEAK CAN BE STOPPED.SMALL FIRE: Dry chemical or CO2.LARGE FIRE: Water spray or fog. If it can be done safely, move undamaged containers away from the area around the fire.FIRE INVOLVING TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Do not direct water at source of leak or safety devicesicing may occur. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzlesif this is impossible, withdraw from area and let fire burn. (ERG, 2024)Shut off supplyif not possible and no risk to surroundings, let the fire burn itself out. In other cases extinguish with water spray, powder, carbon dioxide, foam. In case of fire: keep cylinder cool by spraying with water.
応急処置措置Fresh air, rest. Refer for medical attention.ON FROSTBITE: rinse with plenty of water, do NOT remove clothes. Refer for medical attention .ON FROSTBITE: rinse with plenty of water. Refer immediately for medical attention.
応急処置EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.SKIN: CAUTION: Exposure of skin to compressed gases may result in freezing of the skin. Treatment for frostbite may be necessary. Remove the victim from the source of contamination. IMMEDIATELY wash affected areas gently with COLD water (and soap, if necessary) while removing and isolating all contaminated clothing. Dry carefully with clean, soft towels. Call a hospital or poison control center IMMEDIATELY even if no symptoms (such as inflammation or irritation) develop. Be prepared to transport the victim to a hospital for treatment after washing the affected area if advised to do so by a physician.INHALATION: IMMEDIATELY leave the contaminated areatake deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be usedif not available, use a level of protection greater than or equal to that advised under Protective Clothing.INGESTION: This compound is a gas, therefore inhalation is the first route of exposure.OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring. Recommendations from the physician will depend upon the specific compound, its chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure. (NTP, 1992)(General first aid procedures)Eye: Frostbite - If eye tissue is frozen, seek medical attention immediatelyif tissue is not frozen, immediately and thoroughly flush the eyes with large amounts of water for at least 15 minutes, occasionally lifting the lower and upper eyelids. If irritation, pain, swelling, lacrimation, or photophobia persist, get medical attention as soon as possible.Skin: Frostbite - Compressed gases may create low temperatures when they expand rapidly. Leaks and uses that allow rapid expansion may cause a frostbite hazard. Wear appropriate personal protective clothing to prevent the skin from becoming frozen.Breathing: Respiratory support
安全保管Store only if stabilized. Fireproof. Cool. Keep in a well-ventilated room. Separated from incompatible materials and food and feedstuffs. See Chemical Dangers. See Physical Dangers. Refer to the manufacturer's instructions for proper storage conditions.
Firefighting Hazards1,3-Butadiene vapors are heavier than air and a flame can flash back to the source of leakage.Floats and boils on water. Flammable visible vapor cloud is produced.
暴露管理・個人防護Biological Exposure Indices (BEI) [ACGIH] - 1,2 Dihydroxy-4-(N-acetylcysteinyl)-butane in urine = 2.5 mg/L at end of shiftMixture of N-1 and N-2-(hydroxybutenyl)valine hemoglobin (Hb) adducts in blood = 2.5 pmol/g Hb sampling time not critical
消火手順If a fire involving 1,3-butadiene becomes uncontrollable or container is exposed to direct flame, evacuate from a radius of 2500 feet.If 1,3-butadiene is on fire or involved in fire: Do not extinguish fire unless flow can be stoppedUse water in flooding quantities as fogCool all affected containers with flooding quantities of water and apply water from as far a distance as possible.Respiratory protection for fire fighting: A self-contained breathing apparatus with a full facepiece operated in pressure-demand or other positive pressure mode.To fight fire, stop flow of gas.For more Fire Fighting Procedures (Complete) data for 1,3-BUTADIENE (7 total), please visit the HSDB record page.
保管条件Outside or detached storage is preferred. Store in a cool, dry, well-ventilated location. Isolate from oxidizing materials.Storage temperature: ambient. Venting: safety relief.MUST BE KEPT INHIBITED DURING STORAGE ... STORAGE IS USUALLY UNDER PRESSURE OR IN INSULATED TANKS BELOW 35 °F.PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/For more Storage Conditions (Complete) data for 1,3-BUTADIENE (7 total), please visit the HSDB record page.
清掃方法Clean up promptly by sweeping or vacuum.Prevent further leakage or spillage if safe to do so. Do not let product enter drains./Accidental release methods/ Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapors can accumulate in low areas.PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. /Chemical Carcinogens/
非火災時の漏出対応Excerpt from ERG Guide 116 [Gases - Flammable (Unstable)polymerization hazard]:ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Stop leak if you can do it without risk. Do not touch or walk through spilled material. Do not direct water at spill or source of leak. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. If possible, turn leaking containers so that gas escapes rather than liquid. Prevent entry into waterways, sewers, basements or confined areas. Isolate area until gas has dispersed. (ERG, 2024)
処分方法SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in air, soil or watereffects on animal, aquatic and plant lifeand conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.Butadiene is a waste chemical stream constituent which may be subjected to ultimate disposal by controlled incineration.PRECAUTIONS FOR "CARCINOGENS": There is no universal method of disposal that has been proved satisfactory for all carcinogenic compounds & specific methods of chem destruction ... published have not been tested on all kinds of carcinogen-containing waste. ... summary of avail methods & recommendations ... /given/ must be treated as guide only. /Chemical Carcinogens/PRECAUTIONS FOR "CARCINOGENS": ... Incineration may be only feasible method for disposal of contaminated laboratory waste from biological expt. However, not all incinerators are suitable for this purpose. The most efficient type ... is probably the gas-fired type, in which a first-stage combustion with a less than stoichiometric air:fuel ratio is followed by a second stage with excess air. Some ... are designed to accept ... aqueous & organic-solvent solutions, otherwise it is necessary ... to absorb soln onto suitable combustible material, such as sawdust. Alternatively, chem destruction may be used, esp when small quantities ... are to be destroyed in laboratory. /Chemical Carcinogens/For more Disposal Methods (Complete) data for 1,3-BUTADIENE (8 total), please visit the HSDB record page.
漏出処分Remove all ignition sources. Evacuate danger area! Consult an expert! Personal protection: self-contained breathing apparatus. Shut off cylinder if possible. Isolate the area until the gas has dispersed. NEVER direct water jet on liquid.
毒性学的情報CDC-ATSDR Toxicological Profile
Cancer SitesHematologic[hemato cancer]
標的器官Cancer, Developmental (effects while organs are developing), Gastrointestinal (Stomach and Intestines, part of the digestive system), Gastrointestinal (Stomach and Intestines, part of the digestive system), Hematological (Blood Forming), Neurological (Nervous System), Reproductive (Producing Children)Eyes, respiratory system, central nervous system, reproductive system
健康影響Breathing high levels of 1,3-butadiene causes central nervous system damage. Chronic exposure may also cause lung damage and kidney, liver, and cardiovascular disease. In addition, 1,3-butadiene is a known human carcinogen. (L990)
生態毒性値TLm Pinperch 71.5 mg/l/24 hr /Conditions of bioassay not specified/
環境中動態TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 40(SRC), determined from a structure estimation method(2), indicates that 1,3-butadiene is expected to have very high mobility in soil(SRC). Volatilization of 1,3-butadiene from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 0.0736 atm-cu m/mole(SRC),calculated from its vapor pressure of 2,052 mm Hg(3) and water solubility of 735 mg/L(4). 1,3-Butadiene is expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(3). Laboratory studies employing pure bacterial cultures isolated from lake and soil samples were shown to degrade 1,3-butadiene to 1,2-epoxybutene(5,6), however it is not clear what the rate of degradation is under environmental conditions(SRC).AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 40(SRC), determined from a structure estimation method(2), indicates that 1,3-butadiene is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 0.0736 atm-cu m/mole(SRC), calculated from its vapor pressure of 2,052 mm Hg(4) and water solubility of 735 mg/L(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 2.2 hours and 2.9 days, respectively(SRC). According to a classification scheme(6), an estimated BCF of 10(SRC), from its log Kow of 1.99(7) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low(SRC). The biodegradation half-life in aerobic waters has been reported as 7 days and the half-life in anaerobic waters was reported as 28 days(8). 1,3-Butadiene is not expected to undergo hydrolysis in the environment due to a lack of hydrolyzable functional groups(3,8). 1,3-Butadiene is an olefin and olefins can degrade in natural waters via photooxidation (with hydroxyl, peroxy and singlet oxygen radicals) with a half-life on the order of 25 days(9).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1,3-butadiene, which has a vapor pressure of 2,052 mm Hg at 25 °C(2), is expected to exist solely as a gas in the ambient atmosphere. Gas-phase 1,3-butadiene is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 6 hours(SRC), calculated from its rate constant of 6.93X10-11 cu cm/molecule-sec at 25 °C(3). Gas-phase 1,3-butadiene is also degraded in the atmosphere by reaction with ozone(SRC)the half-life for this reaction in air is estimated to be 44 hours(SRC), calculated from its rate constant of 6.24X10-18 cu cm/molecule-sec at 25 °C(3). Atmospheric reaction with nitrate radicals is an important night time sink for 1,3-butadiene(4,5)the half-life for this reaction in air is estimated to be 8 hours(SRC), calculated from its rate constant of 1.0X10-13 cu cm/molecule-sec at 25 °C(3). 1,3-Butadiene absorbs at wavelengths >290 nm(3) and, therefore, may be susceptible to direct photolysis by sunlight(SRC).
食品調査値1,3-Butadiene was detected in 6 out of 6 vegetable oils packaged in a butadiene based plastic container at concentrations of 8-9 ppb(1).
有害作用Neurotoxin - Acute solvent syndromeReproductive Toxin - A chemical that is toxic to the reproductive system, including defects in the progeny and injury to male or female reproductive function. Reproductive toxicity includes developmental effects. See Guidelines for Reproductive Toxicity Risk Assessment.IARC Carcinogen - Class 1: International Agency for Research on Cancer classifies chemicals as established human carcinogens.NTP Carcinogen - Known to be a human carcinogen.ACGIH Carcinogen - Suspected Human.
暴露経路The substance can be absorbed into the body by inhalation.inhalation, skin and/or eye contact (liquid)Inhalation (L990)
毒性の概要IDENTIFICATION AND USE: 1,3-Butadiene is a product of incomplete combustion resulting from natural processes and human activity. It is also an industrial chemical used in the production of polymers, polybutadiene, styrene-butadiene rubbers and lattices and nitrile-butadiene rubbers. HUMAN EXPOSURE AND TOXICITY: 1,3-Butadiene can asphyxiate by the displacement of air. An association between exposure to this chemical in the occupational environment and leukemia has been well established. In the largest and most comprehensive study conducted to this date, involving a cohort of workers in multiple plants, mortality due to leukemia increased with estimated cumulative exposure to 1,3-butadiene in styrene-butadiene industrythis association remained after controlling for exposure to styrene and benzene and was strongest in those subgroups with highest potential exposure. An association between 1,3-butadiene and leukemia was observed in an independently conducted case-control study of largely the same population of workers. However, there was no increase in mortality due to leukemia in butadiene monomer production workers who were not concomitantly exposed to some of the other substances present in the styrene-butadiene rubber industry, although there was some limited evidence of an association with mortality due to lymphosarcoma and reticulosarcoma in some subgroups. There is also limited evidence from occupationally exposed populations that 1,3-butadiene is genotoxic in humans, inducing mutagenic and clastogenic damage in somatic cells. ANIMAL STUDIES: Metabolism of 1,3-butadiene appears to be qualitatively similar across species, although there are quantitative differences in the amounts of putatively toxic metabolites formedmice appear to oxidize 1,3-butadiene to the monoepoxide, and subsequently the diepoxide metabolite to a greater extent than humans. This chemical is of low acute toxicity in experimental animals. Longterm exposure to 1,3-butadiene was associated wCertain metabolites of 1,3-butadiene have been shown to bind to DNA and nucleoproteins, forming protein-DNA and DNA-DNA crosslinks. Specifically, 1,2-epoxybutene-3 and diepoxybutane react with guanine to cause crosslinking. (L990, A293)
Signs and SymptomsCough. Headache. Drowsiness.ON CONTACT WITH LIQUID: FROSTBITE.irritation eyes, nose, throatdrowsiness, dizzinessliquid: frostbiteteratogenic, reproductive effects[potential occupational carcinogen]Breathing 1,3-butadiene may cause irritation of the eyes, nose, and throat. High levels of 1,3-butadiene can also cause, blurred vision, nausea, fatigue, headache, decreased blood pressure and pulse rate, and unconsciousness. Skin contact with liquid 1,3-butadiene can cause irritation and frostbite. (L990)
Ongoing Test StatusThe following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical.[Available from: http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=106-99-0]
大気基準This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Butadiene is produced, as an intermediate or a final product, by process units covered under this subpart.Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. 1,3-butadiene is included on this list.... Substances for which a Federal Register notice has been published that included consideration of the serious health effects, including cancer, from ambient air exposure to the substance. 1,3-Butadiene is included on this list.
CERCLA 報告数量Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 10 lb or 4.54 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).
DHS Chemicals of Interest (COI)1,3-Butadiene10000Flammable chemical that can be released at a facility.
州飲料水ガイドライン(NH) NEW HAMPSHIRE 0.019 ug/L
F4.5-31
水環境危害等級（WGK）2
生命健康即時危険濃度2,000 ppm
TSCA 収載状態TSCA listed
RTECS 番号EI9275000
輸送番号（UN）UN 1010 2.1
毒性LC50 (inhalation) for mice 270 gm/m3/2-h, rats 285 gm/m3/4-h (quoted, RTECS, 1985).
PRTR法特定第一種指定化学物質
税関コード29012410
危険文句（R）45-46-12-67-65-63-48/20-36/38-11-62-51/53-38
化審法優先評価化学物質
安衛法有機則 第二種有機溶剤等 変異原性物質
消防法危険物第4類アルコール類
危険表示F+,T,F,N
hazard_noteExtremely Flammable/Carcinogen
安全措置（S）53-45-62-46-36/37-26-61-33-16
危険等級2.1Flam. Gas 1AMuta. 1BPress. Gas Liquefied gas
包装等級II
DOT Classification2.1 (Flammable gas)
特定化学物質特38-314
自然発火温度788 °F
環境リスク評価ブタジエン(106-99-0)
貯蔵分類2A - Gases
有害物質データ106-99-0(Hazardous Substances Data)
危険度評価（NFPA 704基準/消防庁データ）人的[青]=0 火災[赤]=4

使用用途

ブタジエン(1,3-ブタジエン)は石油から製造されており、製造法としてはナフサのクラッキングで副生するC4留分から抽出、精製して製造する抽出法と、ブタンやから脱水素して製造する脱水素法があります。 ブタジエンは主に合成ゴムの原料として用いられています。例えば自動車のタイヤなどに使われるスチレン・ブタジエンゴム(SBR)やブタジエンゴム(BR)などの原料にブタジエンが使われています。その他、ブタジエンはABS樹脂やナイロン66の原料にも使われています。