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HCID 7903作成日：2026年10月27日

1-ニトロプロパン

1-ニトロプロパン · 1ニトロプロパン · 1‐ニトロプロパン · 1-NP · ai3-02264 · n-C3H7NO2 · 1-Nitropro · 1-Nitropan

https://huagongshe.com/ja/chemical/7903

1-ニトロプロパン の分子構造式

識別子と物理属性

CAS No.108-03-2
分子式C3H7NO2
平均分子量89.09 g/mol
単同位体質量89.04767846 g/mol
SMILESCCC[N+](=O)[O-]
InChIKeyJSZOAYXJRCEYSX-UHFFFAOYSA-N
PubChem CID7903
ChEMBLCHEMBL1449933
ChEBICHEBI:76261
EC No.203-544-9
DTXSIDDTXSID1020980
現地名1-ニトロプロパン

化学・物理的性質

XLogP0.9
極性表面積45.8
水素結合供与体数0
水素結合受容体数2
回転可能結合数1
重原子数6
形式電荷0
複雑度47.2
物質分類Nitrogen Compounds -> Nitros, AliphaticFlammable agents - 3rd degree
pHpH = 6.0 for a 0.01 M aqueous solution at 25 °C6.0 (0.9g/l, H2O, 20℃)
SpringerMaterials PropertiesBoiling point
LogP（分配係数）log Kow = 0.87
臭いSomewhat disagreeable odorMild, fruity odor
密度0.9934 at 77 °F (USCG, 1999) - Less dense than waterwill float0.9961 g/cu cm at 25 °CRelative density (water = 1): 0.990.9961 @25 °C1.000.998 g/mL at 25 °C(lit.)
Viscosity0.790 cP at 25 °C
Color/FormLiquidColorless liquid
溶解度Slightly soluble (NTP, 1992)In water, 1.50X10+4 mg/L at 25 °CSlightly soluble in water (1.4 mL/100 mL)Slightly soluble in waterMiscible with ethanol, ethyl ethersoluble in chloroformSolubility in water, g/100ml: 1.414g/リットル1.40g/100mL
引火点93 °F (NTP, 1992)36 °C36 °C, 96 °F (closed cup)93 °F (34 °C) - open cup120 °F open cup (commercial grade)
沸点270 °F at 760 mmHg (NTP, 1992)131.2 °C132 °C269 °F131.1 °C @760 [mm Hg]
DecompositionHazardous decomposition products formed under fire conditions: Carbon oxides, nitrogen oxides (NOx).When heated to decomposition it emits toxic fumes of /nitrogen oxides/.
融点-108 °C
蒸気密度3.1 (vs air)
蒸気圧7.5 mm Hg ( 20 °C)
屈折率n20/D 1.401(lit.)
貯蔵条件Store below +30°C.
外観・状態液体
pKa（酸解離定数）pK1:8.98 (25°C)
色クリア
爆発限界2.2-11.0%(V)
比熱容量Cp(gas): 1.17 J/(g·K), at 25℃
Merck14,6626
BRN506236
ヘンリー定数6.11 at 25 °C (static headspace-GC, Welke et al., 1998)
誘電率23.239999999999998
安定性安定。可燃性。強塩基、強酸化剤とは相容れない。
化粧品成分の機能溶媒
InChI1S/C3H7NO2/c1-2-3-4(5)6/h2-3H2,1H3
InChIKeyJSZOAYXJRCEYSX-UHFFFAOYSA-N
SMILESCCC[N+]([O-])=O
LogP（分配係数）0.79 at 22℃
表面張力29.4mN/m at 20°C
CAS データベース108-03-2(CAS DataBase Reference)
NISTの化学物質情報Propane, 1-nitro-(108-03-2)
EPAの化学物質情報1-Nitropropane (108-03-2)

化学的特性

Colorless liquid.Soluble in water 1.4 mL/100 mL (20C); solubility of water in 1-nitropropane 0.5 cc/100 cc (20C).

安全性と法規制

GHS 分類WarningH226: Flammable liquid and vapor [Warning Flammable liquids]P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P317, P321, P330, P362+P364, P370+P378, P403+P235, and P501 (click each P-code to see the statement)DangerH226 (100%): Flammable liquid and vapor [Warning Flammable liquids]P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P316, P317, P321, P330, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)
規制情報Chemical: Propane, 1-nitro-Propane, 1-nitro- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Propane, 1-nitro- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 20-09-2012 https://echa.europa.eu/registration-dossier/-/registered-dossier/11705Propane, 1-nitro-: HSNO Approval: HSR001078 Approved with controlsThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)
輸送ラベル（DOT）Flammable Liquid
火災危険Special Hazards of Combustion Products: Combustion products include toxic oxides of nitrogen along with carbon monoxide.Flammable. Above 36 °C explosive vapour/air mixtures may be formed.
火災の可能性Flammable, moderate fire risk ... .Very dangerous fire hazard when exposed to heat, open flame or oxidizers.
健康有害性Inhalation causes headache, dizziness, nausea, vomiting, diarrhea, restlessness, muscular uncoordination and irritation of the respiratory tract. Contact causes irritation of the eyes and skin. Ingestion may cause headache, dizziness, nausea, vomiting, restlessness and muscular uncoordination. (USCG, 1999)
有害性の概要A hepatotoxin in animals after oral administration or inhalation[ACGIH] An eye and respiratory tract irritant[ICSC] Volunteers tolerated 100 ppm for 8 hours

用途

用途

溶剤、合成中間体

用途

溶剤、有機合成原料。

解説

ニトロプロパン， 1-ニトロプロパン 化学式 CH3(CH2)2NO2 。無色の液体，沸点 131.6℃。酢酸セルロース，ビニル系樹脂などの溶剤として用いられる

説明

1-Nitropropane (1-NP), a representative small nitro-alkane, is widely used as an industrial solvent and a fuel additive in automobiles and aircraft engines. The improvement effects of 1-NP on fuel combustion demonstrate that 1-NP served as an initiator can rapidly produce a large number of reactive radicals, which significantly increases the fuel conversion rate. In addition, among the small nitro-alkanes, the molecular structure of 1-NP endows it with a higher specific impulse. It provides the possibilities for its application as propellant in long-range rocket systems[1].

使用

The solvent of 1-Nitropropane is mainly used coatings, inks and separation processes.

製法・合成法

調製方法

1-Nitropropane is produced by vapor-phase nitration of propane with nitric acid (Baker and Bollmeier 1978) or by the vapor-phase nitration of butanol (HSDB 1988).

純化方法

Purify it as for nitromethane. [Beilstein 1 IV 229.]

150 ppm caused irritation of the nose and throat
A weak inducer of methemoglobinemia
[CHEMINFO] Causes CNS depression and anesthesia in lethal concentration animal studies
[ChemIDplus] See 2-Nitropropane.
輸送番号・ガイド（DOT）2608 129
反応性グループNitro, Nitroso, Nitrate, and Nitrite Compounds, Organic
EC 分類Symbol: XnR: 10-20/21/22S: (2)-9
UN 分類UN Hazard Class: 3UN Pack Group: III
TSCA 要件Section 8(a) of TSCA requires manufacturers of this chemical substance to report preliminary assessment information concerned with production, exposure, and use to EPA as cited in the preamble in 51 FR 41329. Effective date: 1/26/94Reporting date: 3/28/94.Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. 1-Nitropropane is included on this list. Effective date: 1/26/94Sunset date: 6/30/98.
Reactivity AlertsHighly Flammable
消火Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]:Use powder, foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.
応急処置措置Fresh air, rest. Refer for medical attention.Remove contaminated clothes. Rinse and then wash skin with water and soap.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Give one or two glasses of water to drink. Refer for medical attention .
応急処置EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.(General first aid procedures)
安全保管Fireproof. Separated from strong oxidants and strong bases.
暴露管理・個人防護2.0 [ppm]
消火手順Use water spray, dry chemical, or carbon dioxide. Use water spray to keep fire-exposed containers cool. Fight fire from protected location or maximum possible distance. / Nitropropanes/To fight fire, use alcohol foam, CO2, dry chemical, water spray.Alcohol foam. Water may be ineffective.Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary. Further information: Use water spray to cool unopened containers.
保管条件Store in a cool, dry, well-ventilated location. Separate from amines, acids, alkalies, oxidizing materials, metal oxides, and combustibles. Outside or detached storage is preferred. /Nitropropanes/Store in containers tightly closed. Outdoor or isolated storage is preferable. Indoor storage needs standard combustible liquid storage.Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Storage class (TRGS 510): 3: Flammable liquids.
清掃方法After covering the spills with soda ash, mix and spray with water. Scoop into a bucket of water and leave it stand for 2 hr. Neutralize with 6 M HCl ...If liquid ... is spilled or leaked ... 1. Remove all ignition sources. 2. Ventilate area of spill or leak. 3. For small quantities, absorb on paper towels and burn in a suitable combustion chamber which allows burning in an unconfined condition and is equipped with appropriate effluent gas cleaning device. Large quantities can be collected, diluted in fuel oil, and atomized in suitable combustion chamber equipped with an appropriate effluent gas cleaning device. Liquid 1-nitropropane should not be allowed to enter a confined space, such as a sewer, because of the possibility of an explosion.ACCIDENTAL RELEASE MEASURESPersonal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Methods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations.
非火災時の漏出対応Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]:
処分方法SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in air, soil or watereffects on animal, aquatic and plant lifeand conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.Liquid ... may be disposed of by diluting in fuel oil and atomizing in a suitable combustion chamber equipped with an appropriate effluent gas cleaning device.Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent and remove to safe place.Product: Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Contaminated packaging: Dispose of as unused product.
漏出処分Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
Preventive MeasuresGloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.ACCIDENTAL RELEASE MEASURESPersonal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains.SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.SRP: Contaminated protective clothing should be segregated in a manner such that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. The completeness of the cleaning procedures should be considered before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at the end of shift, but should remain at employee's place of work for cleaning.For more Preventive Measures (Complete) data for 1-Nitropropane (12 total), please visit the HSDB record page.
標的器官Eyes, central nervous system, liver, kidneys
環境中動態TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 36(SRC), determined from a structure estimation method(2), indicates that 1-nitropropane is expected to have very high mobility(SRC). The pKa of 1-nitropropane is 8.98(3), indicating that this compound will exist partially in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Volatilization of 1-nitropropane from moist soil surfaces is expected to be an important fate process(SRC) given a Henry's Law constant of 8.7X10-5 atm-cu m/mole(3). 1-Nitropropane is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 10.1 mm Hg at 25 °C(5). Using the Closed Bottle test, 45% degradation in 4 weeks using an activated sludge inoculum(6) suggests that biodegradation may be an important environmental fate process in soil(SRC).AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 36(SRC), determined from a structure estimation method(2), indicates that 1-nitropropane is not expected to adsorb to suspended solids and sediment(SRC). Volatilization of the neutral species from water surfaces is expected(3) based upon a Henry's Law constant of 8.70X10-5 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 12 hrs and 7 days, respectively(SRC). A pKa of 8.98(5) indicates 1-nitropropane will exist partially in the anion form at pH values of 5 to 9 and, therefore, volatilization from water surfaces is not expected to be an important fate process for the ionized species(SRC). According to a classification scheme(6), a BCF of 1.3(7) indicates that bioconcentration in aquatic organisms is low(SRC). Using the Closed Bottle test, 45% degradation in 4 weeks using an activated sludge inoculum(7) suggests that biodegradation may be an important environmental fate process in water(SRC).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1-nitropropane, which has a vapor pressure of 10.1 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 1-nitropropane is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 37 days(SRC), calculated from its rate constant of 4.40X10-13 cu cm/molecule-sec at 25 °C(3). 1-Nitropropane does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).
有害作用Neurotoxin - Other CNS neurotoxin
暴露経路The substance can be absorbed into the body by inhalation and by ingestion.inhalation, ingestion, skin and/or eye contact
毒性の概要IDENTIFICATION AND USE: 1-Nitropropane (1-NP) is a colorless liquid. 1-NP is used as a rocket propellant, gasoline additive, and in chemical syntheses. HUMAN STUDIES: Anorexia, nausea, vomiting, and intermittent diarrhea and headaches occurred in men exposed at 20 to 45 ppm of 1-NP during a dipping processes. Additionally, human exposure to 1-NP concentrations exceeding 100 ppm reportedly causes eye irritation in humans. ANIMAL STUDIES: Exposures at 5,000 ppm of 1-NP for 3 hr killed rabbits and guinea pigs. However, concentration of 10,000 ppm for 1 hr was not lethal. Signs of 1-NP exposure included conjunctival irritation, lacrimation, slow respiration with some rales, incoordination, ataxia, and weakness. Rats treated with 1-NP at 1 mmol/kg bw three times per week for 16 weeks had only slightly reduced body weight, and after 26 weeks (termination of treatment), they regained their body weight. One benign liver tumor was observed in these rats. Hepatotoxic symptoms were also observed. There have been numerous studies on the mutagenic activity of 1-NP in Salmonella typhimurium (Ames test). 1-NP was not mutagenic in multiple strains of S. typhimurium with or without the addition of various microsomal metabolic activating systems. The effects of DNA repair synthesis were also studied in numerous mammalian cell lines derived from humans, mice, hamsters, and rats, but 1-NP was not active. An additional study examined liver cell lines that possess cytochrome P450 metabolic capability versus V79 cells that lack this capability. 1-NP was completely inactive in the liver cell lines but did induce mutations and micronuclei in V79 cells.
Signs and SymptomsHeadache. Nausea. Vomiting.Redness.Further see Inhalation.irritation eyesheadache, nausea, vomiting, diarrheaIn Animals: liver, kidney damage
Ongoing Test StatusThe following link will take the user to the National Toxicology Program (NTP) Test Status of Agents Search page, which tabulates the results and current status of tests such as "Short-Term Toxicity Studies", "Long-term Carcinogenicity Studies", "Developmental Studies", "Genetic Toxicology Studies", etc., performed with this chemical. Testing status for 1-nitropropane is available.[Available from, as of February 1, 2019: https://ntpsearch.niehs.nih.gov/?e=True&ContentType=Testing+Status]EPA has released the Interactive Chemical Safety for Sustainability (iCSS) Dashboard. The iCSS Dashboard provides an interactive tool to explore rapid, automated (or in vitro high-throughput) chemical screening data generated by the Toxicity Forecaster (ToxCast) project and the federal Toxicity Testing in the 21st century (Tox21) collaboration. /The title compound was tested by ToxCast and/or Tox21 assays/[USEPAICSS Dashboard ApplicationAvailable from, as of February 4, 2019: http://actor.epa.gov/dashboard/]
Soil Adsorption/MobilityUsing a structure estimation method based on molecular connectivity indices(1), the Koc of 1-nitropropane can be estimated to be 36(SRC). According to a classification scheme(2), this estimated Koc value suggests that 1-nitropropane is expected to have very high mobility in soil. The pKa of 1-nitropropane is 8.98(3), indicating that this compound will exist partially in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4).
TSCA Test Submissions1-Nitropropane was evaluated for repeat-dose toxicity when orally administered to male and female Sprague-Dawley rats (5/sex/group) at dose levels of 0, 10, 30, and 100 mg/kg/day for 28 consecutive days. Two additional groups (5/sex/group) received the vehicle alone or 100 mg/kg/day of 1-nitropropane and were maintained for observation an additional 14 days post-treatment. One mortality was reported among the high-dose males on day 27, after developing severe clinical signs of hunched posture, lethargy, and ataxis. Animals receiving 100 mg/kg/day were seen to have increased salivation with red/brown staining around the mouth after treatment on day 15, and two females from this group developed a hunched posture on day 28 (prior to final dosing). Decreased bodyweight gain and food intake were noted for high-dose males, but these parameters were comparable to controls in females from this group and animals from other treatment groups. Necropsy performed on the early mortality revealed dark kidneys, thickening of the forestomach, and sloughing of the glandular epithelium. The organ weight data revealed that 100 mg/kg animals had statistically significant increases in absolute and relative brain weights with no corresponding microscopic changes. No effects were seen in animals from the 10 or 30 mg/kg groups, nor from the additional 100 mg/kg/day group, held for observation and recovery. The NOEL for the conditions of this study was determined to be 30 mg/kg/day.Radio-labeled ((14)C) 1-Nitropropane was evaluated for skin absorption when applied to the shaved, intact dorsal skin of 2 female rhesus monkeys (weight and age not stated). The test material was applied as a solution (15.28 mg (14)C-1-nitropropane in 300 uL alcohol) then covered with an occlusive patch. The patch was removed after 12 hours and the skin was wiped with soap/acetone swabs. Swabs and patches were extracted with acetone and alcohol, then the swabs combusted to (14)CO2 and water. Both the extracts and combustion products were assayed for radioactivity. Blood samples, urine, and feces were collected at various time intervals for 72 hours following treatment, while the test site and 2 small areas of adjacent untreated skin (approximately 1.13 sq cm) were excised after 72 hours and examined histologically. All samples were analyzed for radioactivity. The 2 monkeys (PH0140 and PH0142) showed no signs of toxicity, and food and water consumption were normal. Within 72 hours, 0.204% and 0.405% (PH0140 and PH0142, respectively) of the applied dose was recovered from urine and feces, with an average of 94.8% of that for both animals being excreted in the urine. The skin from the application sites as well as adjacent skin samples contained 0.043% and 0.102% of the total dose. The swabs and patches accounted for 0.115% and 0.064% of the total dose while negligible amounts of radioactivity were detected in blood samples from either monkey. It was reported that 99.583% and 99.389% (PH0140 and PH0142, respectively) of the dose remained unrecovered due to the high volatility of the test material as well as the carrier.
Human Toxicity Excerpts/SIGNS AND SYMPTOMS/ ... Industrial experience with 1-nitropropane has been virtually without incidenta few field reports of warning symptoms such as headache and nausea resulting from prolonged exposure to excessive amounts have been made, but these appear well in advance of systemic injury ... ./SIGNS AND SYMPTOMS/ Potential symptoms of overexposure are eye irritation, headache, nausea, vomiting and diarrhea./SIGNS AND SYMPTOMS/ The chemical may produce... injury to the liver and kidneys in exposed humans. High concentrations of the chemical also may produce methemoglobinemia with cyanosis. 1-Nitropropane vapors also are damaging to the lungs. 1-Nitropropane is, however, more acutely irritating to mucous membranes than 2-nitropropane./SIGNS AND SYMPTOMS/ Anorexia, nausea, vomiting, and intermittent diarrhea and headaches occurred in men exposed at 20 to 45 ppm of nitropropane during a dipping processes. These symptoms ceased when methyl ethyl ketone was substituted. Additionally, human exposure to 1-NP concentrations exceeding 100 ppm reportedly causes eye irritation in humans./GENOTOXICITY/ The effects of DNA repair synthesis were also studied in numerous mammalian cell lines derived from humans, mice, hamsters, and rats, but 1-NP was not active. An additional study examined liver cell lines that possess cytochrome P450 metabolic capability versus V79 cells that lack this capability. 1-NP was completely inactive in the liver cell lines but did induce mutations and micronuclei in V79 cells.
Artificial Pollution Sources1-Nitropropane's production and use as a solvent for cellulose acetate, vinyl resins, lacquers, synthetic rubbers, fats, oils, and dyes and other organic materials, an intermediate(1), as a gasoline additive(2) and an ingredient in rocket propellant(1,2) may result in its release to the environment through various waste streams(SRC).
Environmental BiodegradationAEROBIC: When 1-nitropropane was incubated with activated sludge, 23.3% mineralization occurred in 5 days(1). During a closed bottle biodegradability test, using a municipal sewage plant effluent innoculum, 45% degradation of 1-nitropropane occurred within 28 days(1). Aerobic C14 studies performed with soil microorganisms resulted in 4.6% conversion to CO2 in 35 days(1). During this time 21.2% was lost as volatile products(1).ANAEROBIC: Anaerobic C14 studies performed with soil microorganisms resulted in 3.0% conversion to CO2(1). During this time, 35.7% was lost as volatile products(1).
大気基準This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Nitropropane is produced, as an intermediate or a final product, by process units covered under this subpart. /Nitropropane/
職業暴露区分（OEB）A
職業暴露限界（OEL）TWA: 25 ppm (90 mg/m3)
水環境危害等級（WGK）1
生命健康即時危険濃度1,000 ppm
TSCA 収載状態TSCA listed
RTECS 番号TZ5075000
輸送番号（UN）UN 2608 3/PG 3
毒性LD50 orally in Rabbit: 455 mg/kg LD50 dermal Rabbit > 2000 mg/kg
税関コード29042000
危険文句（R）10-20/21/22
化審法(2)-3738
安衛法57,57-2
消防法危-4-2-III
危険表示Xn
安全措置（S）9-24/25
危険等級3Acute Tox. 3 InhalationAcute Tox. 4 DermalAcute Tox. 4 OralFlam. Liq. 3
包装等級III
自然発火温度788 °F
貯蔵分類3 - Flammable liquids
有害物質データ108-03-2(Hazardous Substances Data)