化工社化工社 化学情報印刷レポート · 研究参考用
ビ尿素
ビ尿素 · 1,2-ジカルバモイルヒドラジン · 1,1'-ヒドラゾビス(ホルムアミド) · ヒドラゾジカルボンアミド · 1,2-ヒドラジンジカルボキサミド · ビウレア · ヒドラジン-1,2-ジカルボアミド · ジ尿素
識別子と物理属性
| CAS No. | 110-21-4 |
|---|---|
| 分子式 | C2H6N4O2 |
| 平均分子量 | 118.1 g/mol |
| 単同位体質量 | 118.04907543 g/mol |
| SMILES | NC(=O)NNC(N)=O |
| InChIKey | ULUZGMIUTMRARO-UHFFFAOYSA-N |
| PubChem CID | 8039 |
| ChEMBL | CHEMBL3188383 |
| EC No. | 203-747-2 |
| DTXSID | DTXSID6024628 |
| 現地名 | ビ尿素 |
化学・物理的性質
| XLogP | -2.1 |
|---|---|
| 極性表面積 | 110 |
| 水素結合供与体数 | 4 |
| 水素結合受容体数 | 2 |
| 回転可能結合数 | 0 |
| 重原子数 | 8 |
| 形式電荷 | 0 |
| 複雑度 | 96.6 |
| 物質分類 | Nitrogen Compounds -> Other Nitrogen Compounds |
| SpringerMaterials Properties | Crystal structure |
| LogP（分配係数） | log Kow = -2.37 /Estimated/ |
| Color/Form | Plates from water |
| 溶解度 | less than 1 mg/mL at 66 °F (NTP, 1992)In water, 238 mg/L at 16 °C硫酸（少量、加温） |
| 融点 | 471 to 473 °F (NTP, 1992)258 °C247-250 °C |
| 蒸気圧 | 0.0000595 [mmHg]5.9X10-5 mm Hg at 25 °C /Estimated/ |
| ヘンリー定数 | Henry's Law constant = 1X10-19 atm-cu m/mol at 25 °C /Estimated/ |
| Physical Description | Biurea is a white powder. (NTP, 1992)White solid[CAMEO] |
| Other Experimental Properties | Hydroxyl radical reaction rate constant = 4.0X10-12 cu cm/molec-sec at 25 °C /Estimated/ |
| 沸点 | 220.6°C (rough estimate) |
| 密度 | 1.6040 |
| 屈折率 | 1.4462 (estimate) |
| 貯蔵条件 | Sealed in dry,Room Temperature |
| pKa（酸解離定数） | 10.06±0.43(Predicted) |
| 外観・状態 | 個体 |
| 色 | ホワイトからオフホワイト |
| CAS データベース | 110-21-4(CAS DataBase Reference) |
| EPAの化学物質情報 | Biurea (110-21-4) |
化学的特性
WHITE POWDER
安全性と法規制
| GHS 分類 | This chemical does not meet GHS hazard criteria for 88.1% (37 of 42) of all reports.WarningH315 (11.9%): Causes skin irritation [Warning Skin corrosion/irritation]P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 42 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| 規制情報 | Chemical: 1,2-Hydrazinedicarboxamide |
| 火災危険 | The flash point of this compound is not available, however it is probably non-flammable. (NTP, 1992) |
| 有害性の概要 | May cause irritation[MSDSonline] |
| 反応性グループ | Amides and Imides |
| Reactivity Profile | BIUREA is chemically classified as an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). |
| Air and Water Reactions | Insoluble in water. |
| Hazard Classes and Categories | Skin Irrit. 2 (11.9%) |
| 消火 | Fires associated with this compound should be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992) |
| 応急処置 | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. |
| 非火災時の漏出対応 | SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then dampen the solid spill material with toluene, then transfer the dampened material to a suitable container. Use absorbent paper dampened with toluene to pick up any remaining material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent-wash all contaminated surfaces with toluene followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. |
| 処分方法 | SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal, aquatic, and plant lifeand conformance with environmental and public health regulations. |
| Preventive Measures | Inhalation of salt dusts should be avoided. /Hydrazine & derivatives/Engineering controls, such as process enclosure or local exhaust ventilation, shall be used when needed to keep concentrations of airborne hydrazines within acceptable levels. Ventilation systems shall be designed to prevent accumulation or recirculation of airborne hydrazines in the workplace environment and to remove hydrazines from the breathing zone of workers. /Hydrazines/ |
| Personal Protective Equipment (PPE) | RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)... Vinyl coated hand protection, natural or reclaimed rubber protection, rubber aprons, and plastic eye and face protection ... used when working with small quantities. Where possibility of gross splashing exists, full protective clothing made of rubber, neoprene or vinyl-coated materials should be worn. For respiratory protection in situations where recommended tolerance limits are ... exceeded, respiratory protective equipment ... must be used. /Hydrazine and derivatives/ |
| Non-Human Toxicity Excerpts | /LABORATORY ANIMALS: Acute Exposure/ /1,2-hydrazinedicarbonamide/ was not irritating to rabbit skin or eyes./LABORATORY ANIMALS: Acute Exposure/ /Sprague-Dawley rats given ip injections of 20 or 200 mg/kg body weight per day for one week displayed/ no change in thyroid function. /No information for controls provided//LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity/ Dogs were fed doses of 50 or 100 g/kg diet 1,1-hydrazoformamide daily for 11 months (approximately 1250 or 2500 mg/kg bw/day). Reduction of the highest dose to 50 g/kg diet after 5 or 7.5 months. Results were increased mortality, renal and bladder calculi, chronic pyelonephritis and pyelitis in both dose groups./LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity/ /Dogs orally exposed to daily doses of 750, 2370 or 7500 ppm in bread as diet for a period of two years/ exhibited no signs of increased tumor incidence. /No information for controls provided.//GENOTOXICITY/ Negative in the following tests: cytogenetic assay and sister chromatid exchange assay in Chinese hamster ovary cells, and Ames test. |
| Populations at Special Risk | Biological half-lives were significantly different among the three acetylation phenotypes (analysis of variance, P < 0.05): 3.94+/-1.70 hours for slow acetylators, 2.25+/-0.37 hours for intermediate acetylators, and 1.86+/-0.67 hours for rapid acetylators. /Hydrazine/ |
| Non-Human Toxicity Values | LD50 Rat oral >2000 mg/kg |
| TSCA 収載状態 | TSCA listed |
| 毒性 | LD50 oral in rat: > 2gm/kg |
| 税関コード | 29280000 |
| 危険文句（R） | 36/37/38 |
| 化審法 | (2)-1748 |
| 安全措置（S） | 24/25 |
| 危険等級 | IRRITANT |
| 有害物質データ | 110-21-4(Hazardous Substances Data) |
用途
使用
Hydrazine-1,2-dicarboxamide is a useful compound in the process of producing protected anode active material particles for rechargeable lithium batteries.
一般的な説明
White powder.
製法・合成法
純化方法
Crystallise the diamide from water, wash the crystals with EtOH then Et2O and dry in vacuum over P2O5. It does not decompose on drying at 110o /48hours. Its solubility in H2O is 1% at 0o. [Andrieth & Mohr Inorg Synth IV 26 1953, Beilstein 3 H 116, 3 I 56, 3 III 229.]