CAS 6976-37-0 Bistris (HCID 81462)

概要

Bis-tris is a buffer substance useful for calibration of glass electrodes and for the preparation of the biochemical and biological buffer solutions; pKa = 6.46 at 25 C. It has a role as a buffer. It is functionally related to a member of tris.

名称と識別子

優先名称: Bistris
IUPAC: 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propane-1,3-diol
現地名: ビス(2-ヒドロキシエチル)アミノトリス(ヒドロキシメチル)メタン
英語名: BIS-Tris
分子式: C8H19NO5
分子量: 209.24

名称と別名

bis-tris6976-37-0Bistris2,2-Bis(hydroxymethyl)-2,2',2''-nitrilotriethanol2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propane-1,3-diol2-(Bis(2-hydroxyethyl)amino)-2-(hydroxymethyl)propane-1,3-diolQ1XC3631CPCHEBI:412501,3-Propanediol, 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)-NSC-24868NSC-1199321,3-Propanediol, 2-(bis(2-hydroxyethyl)amino)-2-(hydroxymethyl)-

名称をさらに表示

ビス(2-ヒドロキシエチル)アミノトリス(ヒドロキシメチル)メタン[ビス(2-ヒドロキシエチル)アミノ]トリス(ヒドロキシメチル)メタンビス(2-ヒドロキシエチル)アミノメチリジントリスメタノール2,2'-[2-ヒドロキシ-1,1-ビス(ヒドロキシメチル)エチルイミノ]ビスエタノールビストリス2-[ビス(2-ヒドロキシエチル)アミノ]-2-(ヒドロキシメチル)-1,3-プロパンジオール2-(ヒドロキシメチル)-2-[ビス(2-ヒドロキシエチル)アミノ]プロパン-1,3-ジオール2-[ビス(2-ヒドロキシエチル)アミノ]-2-(ヒドロキシメチル)プロパン-1,3-ジオール2-(ヒドロキシメチル)-2-[ビス(2-ヒドロキシエチル)アミノ]-1,3-プロパンジオール2,2-ビス(ヒドロキシメチル)-(2,2',2''-ニトリロトリスエタノール)2,2-ビス(ヒドロキシメチル)-2,2′,2″-ニトリロトリエタノールビス(2-ヒドロキシエチル)イミノトリス(ヒドロキシメチル)メタンビスヒドロキシエチルトロメタミン2,2‐ビス(ヒドロキシメチル)‐2,2′,2′′‐ニトリロトリエタノールビス?トリスBIS-TRIS 分子生物学用ビス(2-ヒドロキシエチル)イミノトリス(ヒドロキシメチル)メタン BIS-TRISビス-トリスビス-トリス, 99+%ビス-トリス2-ヒドロキシ-1,1-ビス(ヒドロキシメチル)-N,N-ビス(2-ヒドロキシエチル)エタンアミンBIS(2-HYDROXYETHYL)IMINOTRIS(HYDROXYMETHYL)METHANEBIS(2-HYDROXYETHYL)AMINO-TRIS(HYDROXYMETHYL)METHANEBIS-TRIS BUFFERBIS-HYDROXYETHYL TROMETHAMINEBis-Iris2,2-BIS(HY''BIS-TRIS''BIS-TRIS >99%

2,2-Bis[hydroxymethyl]-2,2',2''-nitrilotriethanolRefChem:569580bis(2-hydroxyethyl)imino-tris(hydroxymethyl)methane2-(bis(2-hydroxyethyl)amino)-2(hydroxymethyl)-1,3-propanediol2,2-BIS(HYDROXYETHYL)-(IMINOTRIS)-(HYDROXYMETHYL)METHANE230-237-7686-880-2Bis(2-hydroxyethyl)aminotris(hydroxymethyl)methane

データベース識別子

CAS: 6976-37-0
PubChem CID: 81462
DTXSID: DTXSID6064537
ChEBI: CHEBI:41250
UNII: Q1XC3631CP
EC Number: 230-237-7、686-880-2
Nikkaji: J135.733F

物性

構造計算による物性

XLogP: -3.3
極性表面積: 104 Å²
水素結合供与体数: 5
水素結合受容体数: 6
回転可能結合数: 8
重原子数: 14
形式電荷: 0
複雑度: 125

実験および物理化学的性質

Chemical ClassesNitrogen Compounds -> Amino Alcohols, Other

Physical Description · 2 件

Liquid

White crystalline powder; [Sigma-Aldrich MSDS]

物理化学的性質

融点: 104 °C · 104 °C(lit.)
沸点: 466.2 · 466.2±40.0 °C(Predicted)
比重(密度): 1.346 · 1.346±0.06 g/cm3(Predicted)
蒸気圧: 0 Pa · 0Pa at 25℃
貯蔵温度: Inert atmosphere,Room Temperature
溶解性: 2 O: · H2O: 1M at20℃、透明、無色
外見: 解決
色: 黄色からオレンジ
臭い (Odor): 無臭
PH: 9 · 9.0-10.1 (20-25℃, 1M in water)
酸解離定数(Pka): 6.5 · 6.5(at 25℃)
由来生物: synthetic
水溶解度: 溶ける
BRN: 2205275 · 2205275
主な用途: 診断アッセイの製造
化粧品成分の機能: バッファリング
InChI: 1S/C8H19NO5/c10-3-1-9(2-4-11)8(5-12,6-13)7-14/h10-14H,1-7H2
InChIKey: OWMVSZAMULFTJU-UHFFFAOYSA-N
SMILES: OCCN(CCO)C(CO)(CO)CO
LogP: -2.26 at · -2.26 at 20℃
CAS データベース: 6976 · 6976-37-0(CAS DataBase Reference)
EPAの化学物質情報: 1 · 1,3-Propanediol, 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)- (6976-37-0)
Absorption: 270 nm · cut-off at 270nm in H2O at 1M

化学的性質

化学的特性White/clear crystalline powder

安全と法規制

GHS分類

GHS Classification · 6 件

This chemical does not meet GHS hazard criteria for 0.7% (2 of 271) of reports.

Danger

H315 (37.6%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 271 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Warning

危険有害性情報

Regulatory Information · 4 件

Chemical: 1,3-Propanediol, 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)-

1,3-Propanediol, 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,3-Propanediol, 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 04-01-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/24579

1,3-Propanediol, 2-bis(2-hydroxyethyl)amino-2-(hydroxymethyl)-: Does not have an individual approval but may be used under an appropriate group standard

Hazards SummaryA skin and strong eye irritant; [Sigma-Aldrich MSDS]

Hazard Classes and Categories · 2 件

Skin Irrit. 2 (37.6%)

Skin Irrit. 2 (100%)

安全データ

F: 10-23
wgk: 3
tsca: TSCA listed
hs_code: 29221980
risk_code: 36/37/38-21/22-20/21/22
hazard_code: Xi,Xn
safety_code: 26-36-36/37/39-22
Hazard Classifications: Eye Irrit. 2
ストレージクラス: 11 - Combustible Solids

化学と産業

薬理情報

MeSH Pharmacological ClassificationA chemical system that functions to control the levels of specific ions in solution. When the level of hydrogen ion in solution is controlled the system is called a pH buffer.

用途と製造

U.S. Production2023: 362,371 lb

Industry UsesNot Known or Reasonably Ascertainable

General Manufacturing Information · 2 件

Pharmaceutical and Medicine Manufacturing

1,3-Propanediol, 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)-: ACTIVE

応用分野 · 2 件

使用It is used as a biological buffer, organic synthesize, chemical & pharmaceutical intermediate. It is suitable for fractionation of hemoglobin.

使用Bis-Tris, also known as bis-Tris methane, is a zwitterionic buffering agent used in biochemistry and molecular biology. It is a bis(2-hydroxyethyl)amine and Tris family buffer. Bis Tris is a common component of many buffer systems for various types of electrophoresis. Bis-Tris may form a complex with some common metals, such as Cu(II) and Pb(II), and formation constants should be taken into account when using this buffer in a solution containing metal ions. Bis-Tris can be used as a substitute for the highly toxic buffer cacodylate.

調製方法

純化方法Crystallise BIS-TRIS from hot 1-butanol and dry it in a vacuum at 25o. N,N-Bis-(2-hydroxyethyl)glycine (BICINE) See in “Amino Acids and Peptides”, Chapter 6.