エチレン グリコール モノ-n-ブチル エーテル アセタート

Fire Extinguishing Agents Not to Be Used: Water may be ineffective.

Use water spray, powder, alcohol-resistant foam, carbon dioxide.

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Give one or two glasses of water to drink. Do NOT induce vomiting. Refer for medical attention .

Excerpt from NIOSH Pocket Guide for 2-Butoxyethanol acetate:

(General first aid procedures)

Use water in flooding quantities as fog. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use alcohol foam, dry chemical or carbon dioxide. Keep run-off water out of sewers and water sources.

"Alcohol" foam

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a POTW is acceptable only after review by the governing authority. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must meet Hazardous Material Criteria for disposal.

Ventilation. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent and remove to safe place. (Extra personal protection: filter respirator for organic gases and vapors.)

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without undue personnel hazard. Personnel protection. Avoid breathing vapors Keep upwind. ... Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water.

The worker should immediately wash the skin when it becomes contaminated.

Work clothing that becomes wet should be immediately removed due to its flammability hazard (i.e., for liquids with a flash point <100 °F).

LC50; Species: Leuciscus idus (Golden orfe); Conditions: static bioassay; Concentration: 80 mg/L for 48 hr.

LC50; Species: Oncorhynchus mykiss (Rainbow trout, young fish); Conditions: serial dilution of eight concentrations of the test substance, 16 + or -1 °C, pH 8 + or -0.3, water hardness 250 + or -25 mg/L CaCO3, with a 12-hour light/dark photo period; Concentration: 28.3 mg/L for 96 hr

EC50; Species: Daphnia magna (Water flea); Conditions: static, 21 °C, pH 5.1-8.1, oxygen 2.9-8.1 mg/L; Concentration: 37 mg/L for 48 hr (95% confidence interval: 29-48 mg/L); Effect: immobility

EC50; Species: Daphnia magna (Water flea, neonate); Conditions: serial dilution, 20 + or -2 °C, pH 7.8 + or -0.2, water hardness 250 + or -20 mg/L CaCO3; Concentration: 67.5 mg/L for 48 hr; Effect: immobilization

For more Ecotoxicity Values (Complete) data for ETHYLENE GLYCOL MONOBUTYL ETHER ACETATE (6 total), please visit the HSDB record page.

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 15(SRC), determined from a water solubility of 9000 mg/L(2) and a regression-derived equation(3), indicates that ethylene glycol monobutyl ether acetate is expected to have very high mobility in soil(SRC). Volatilization of ethylene glycol monobutyl ether acetate from moist soil surfaces is expected to be an important fate process(SRC) given a Henry's Law constant of 5.46X10-6 atm-cu m/mole(4). Ethylene glycol monobutyl ether acetate is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 0.375 mm Hg(5). Biodegradation of ethylene glycol monobutyl ether acetate is expected based on a screening study were 90% was degraded in 28 days(6).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 15(SRC), determined from a water solubility of 9000 mg/L(2) and a regression-derived equation(3), indicates that ethylene glycol monobutyl ether acetate is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon a Henry's Law constant of 5.46X10-6 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 9 and 70 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 4(SRC), from its water solubility(2) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Estimated hydrolysis half-lives for ethylene glycol monobutyl ether acetate are 300 and 30 days at pHs 7 and 8, respectively(6). Biodegradation of ethylene glycol monobutyl ether acetate is expected based on a screening study were 90% was degraded in 28 days(7).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), ethylene glycol monobutyl ether acetate, which has a vapor pressure of 0.375 mm Hg at 20 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase ethylene glycol monobutyl ether acetate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 18 hrs(SRC), calculated from its rate constant of 2.1X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Ethylene glycol monobutyl ether acetate contains chromophores that absorb at wavelengths >290 nm(4) and therefore may be susceptible to direct photolysis by sunlight(SRC).

The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

inhalation, skin absorption, ingestion, skin and/or eye contact

/AQUATIC SPECIES/ DeVillers et al. (2003) have tested the toxicity of EGBEA on Ceriodaphnia dubia according to the draft of the method AFNOR NF T90-376 (equivalent to the OECD guideline No 211). An EC10 of 30.4 mg/L has been determined after seven days. One daphnid was disposed per container, in ten replicates. The parental mortality and the number of offspring per living parent were used as endpoints. Other test conditions are shown here: eight concentrations plus control were tested at a temperature of 23 +/- 1 °C and pH = 8-9, DO = 8.1-8.3 mg/L and water hardness was 200 +/- 40 mg/L (CaCO3). An analytical monitoring was performed but results were expressed based on nominal concentrations. The 95% confidence interval for the EC10 ranged between 9.89 and 37.73 mg/L. A NOEC (16.4 mg/L) and an EC20 (30.7 mg/L) have also been calculated in another report but methods used for calculation tend to give a preference to the EC10 value.

/AQUATIC SPECIES/ Toxicity tests /in algae. for EGBEA are summarized /in the table/. Test 1 has been performed ... on the algae Scenedesmus subspicatus. The norm DIN 38412/9 was followed. The effects of five concentrations (25, 50, 100, 250 and 500 mg/L) plus one control were measured after 72 and 96 hours. Temperature and pH were respectively 24.8 °C and 7.6-8. No effect was detected at any concentration tested. A NOEC of 300 mg/L was determined in test 2. This test was performed according to the norm ISO 8692: "Water quality - fresh water and algal growth inhibition test with Scenedesmus subspicatus and Selenestrum capricornutum". Test conditions were as follow: incubation occurred on a shaking table under constant temperature (approximately 23 °C) and light. Each test was performed on three replicate batches at each concentration and at each control batch. The cell densities were determined using an electronic particle counter after 24, 48 and 72 hours and the inhibition of growth was estimated as the average growth rate expressed as a percentage of the control growth rate. EC50 was calculated by means of probit analysis and NOEC was determined by using a software (TOXSTAT). It can also be noticed that although the solutions were analysed, toxicity results were based on nominal concentrations.

Cough. Headache. Dizziness. Drowsiness. Nausea.

MAY BE ABSORBED! Redness. Dry skin.

Redness.

Burning sensation in the throat and chest. Vomiting. Further see Inhalation.

irritation eyes, skin, nose, throat; hemolysis, hematuria (blood in the urine); central nervous system depression, headache; vomiting

The emission rate of ethylene glycol monobutyl ether acetate into the atmosphere from painting operations at an automotive assembly plant in Janesville, WI was estimated to be 3.5 gallons/hr(1). Samples collected from paint spray booths used in the automotive industry contained ethylene glycol monobutyl ether acetate at unreported concentrations(2).

The rate constant for the vapor-phase reaction of ethylene glycol monobutyl ether acetate with photochemically-produced hydroxyl radicals has been estimated as 2.1X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 18 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). A base-catalyzed second-order hydrolysis rate constant of 0.26 L/mole-sec(SRC) was estimated using a structure estimation method(2); this corresponds to half-lives of 300 and 30 days at pH values of 7 and 8, respectively(2). Ethylene glycol monobutyl ether acetate contains chromophores that absorb at wavelengths >290 nm(3) and therefore may be susceptible to direct photolysis by sunlight(SRC).

/HUMAN EXPOSURE STUDIES/ Individual exposure to 2-butoxyethanol acetate was measured by personal air sampling and biological monitoring of urine from 19 employees during an 8-hour workday in four silk-screen printing installations. The samples were analyzed by gas chromatography. Urine was quantitatively collected from each subject two or three times during the day. 2-Butoxyethanol acetate was detected in the personal air samples of 5 individuals at an average concentration of 0.44 ppm ... The detection limit was 0.015 ppm in air. Free 2-butoxyacetic acid was detected in the urine of 12 individuals, at an average concentration of 8 uM (0.132 mg/L).

/HUMAN EXPOSURE STUDIES/ 2-Butoxyethanol acetate was used to evaluate a noninvasive human method and an in vitro cytotoxicity method as alternatives to the rabbit skin test for primary irritant effects human method included measurements of cutaneous blood flow values (CBFV) by laser Doppler flowmetry before and after patch application on the forearm; some experiments used 100% test substances (75 mg/sq cm) applied for 48 hours and measured 12 hours later, and other experiments used 10% solutions of test substances (7.5 mg/cu m) applied for 3 hours and measured 1, 24, 48, and 72 hours later. Cutaneous blood flow values (CBFV) obtained in the two series of experiments (10% for 3 hours and 100% for 48 hours) resulted in a ranking of 2, which is the minimal mean erythema needed to classify substances as skin irritants. The CBFV in humans correlated very well (r=0.99) with erythema scores obtained on rabbits.

/SIGNS AND SYMPTOMS/ The effects /of alkyl derivatives of ethylene glycol/ ...upon the CNS include headache, drowsiness, weakness, slurred speech, recrudescent stuttering, staggering gait, tremor, and blurred vision. Changes of personality are often noted ...these changes are such that the patient, in the absence of an accurate occupational history, may be treated for schizophrenia or narcolepsy. In acute poisoning with the thylene glycol monoalkyl ethers, there is ...renal injury: albuminuria and hematuria. /Ethylene glycol monoalkyl ethers/

/SIGNS AND SYMPTOMS/ 1. Central nervous depression, although probably less prominent than with ethylene glycol. 2. No hypocalcemic tetany or metabolic acidosis with the possible exception of poisonings due to ethylene glycol monomethyl ether. 3. Nausea, vomiting, and sometimes diarrhea. 4. Prominent headache. Later abdominal and lumbar pain and costovertebral angle tenderness. 5. Transient polyuria & then oliguria, progressing to anuria. 6. Acute renal failure ... 7. Less critical pathological lesions may appear in brain, lung, liver, meninges and heart. 8. Observations in animals suggest the remote possibility of pulmonary edema, intravascular hemolysis & bone marrow depression, at least with some ether derivatives of ethylene and diethylene glycols. ... /Ethylene glycol (Group B compounds)/

This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Ethylene glycol monobutyl ether acetate is produced, as an intermediate or final product, by process units covered under this subpart.

CIR ingredient: Butoxyethyl Acetate

Used as a solvent for lacquers, paints, enamels, resins, polymers, inks, and oils; [HSDB]

Painting (Solvents) [Category: Paint]

High-boiling solvent for nitrocellulose lacquers, epoxy resins, multicolor lacquers; film-coalescing aid for polyvinyl acetate latex.

Solvent (paints, resins)

Solvent in printing inks

Purity: the purities were all > or = to 98% w/w. Impurities: ethylene di (acetate) (CAS 111-55-7) < 1% w/w water ~ 0.1% w/w; 2-butoxyethanol (CAS 111-76-2) ~ 0.05% w/w. The remaining 2% or less is very dependent on the purity of the alcohol source and will contain a mixture of alcohols and acetates of homologues. It is thought that there is not any one which is predominant. Additives: It is reported that a food approved antioxidant has been added at a level below that requiring to be declared.

2023: 10,000,000 - <25,000,000 lb

(1972) 6.1X10+9 g

Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#1254]

Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#1255]

Ethanol, 2-butoxy-, acetate is listed as a High Production Volume (HPV) chemical (65FR81686). Chemicals listed as HPV were produced in or imported into the U.S. in >1 million pounds in 1990 and/or 1994. The HPV list is based on the 1990 Inventory Update Rule. (IUR) (40 CFR part 710 subpart B; 51FR21438).

For more U.S. Production (Complete) data for ETHYLENE GLYCOL MONOBUTYL ETHER ACETATE (7 total), please visit the HSDB record page.

Reaction of ethylene glycol monobutyl ether and acetic acid (esterification)

2-Butoxyethanol acetate is predominantly produced by treatment of 2-butoxyethanol with acetic acid. Treatment with acetic acid anhydride or acetic acid chloride are secondary, minor methods of production.

Ethylene glycol esters are produced from reaction of ethylene oxide and an appropriate acid and are used also as solvents. Use of a suitable catalyst can influence the outcome of the reaction so as to produce monoesters (sodium acetate) or diesters (sulfuric acid). Glycol monoethers can be converted to the corresponding ether esters by the usual methods. /Ethylene glycol esters/

Miscellaneous Manufacturing

Ethanol, 2-butoxy-, 1-acetate: ACTIVE