N-Trimethylsilyl-N-methylacetamide (HCID 81953)

名称と識別子

優先名称: N-Trimethylsilyl-N-methylacetamide
IUPAC: N-methyl-N-trimethylsilylacetamide
現地名: N-メチル-N-トリメチルシリルアセトアミド
英語名: N-Methyl-N-(trimethylsilyl)acetamide
分子式: C6H15NOSi
分子量: 145.27

名称と別名

N-Methyl-N-(trimethylsilyl)acetamide7449-74-3Acetamide, N-methyl-N-(trimethylsilyl)-N-Trimethylsilyl-N-methylacetamideW0IWF6UKW5EINECS 231-217-0NSC 142435NSC-142435DTXSID0064707RefChem:831201DTXCID2047694231-217-0

名称をさらに表示

N-メチル-N-トリメチルシリルアセトアミドN-メチル-N-(トリメチルシリル)アセトアミドN-(トリメチルシリル)-N-メチルアセトアミドN-メチル-N-TMS-アセトアミドN‐メチル‐N‐(トリメチルシリル)アセトアミドN-メチル-N-トリメチルシルヤセトアミド MSA(N-トリメチルシMSAN-メチルアセトアミド)N-メチル-N-トリメチルシルヤセトアミド MSA(N-トリメチルシMSAN-メチルアセトアミド)MOUSE ALBUMIN[TriMethylsilylating Agent]N-Methyl-N-(trimethylsilyl)amideN-Methyl-N-trimethylsilylacetaminen-methyl-n-(trimethylsilyl)-acetamidAcetamide,N-methyl-N-(trimethylsilyl)-

N-Methyl-N-trimethylsilylacetamideN-Methyl-N-trimethylsilyacetamideN-Methyl-N-TMS-acetamideMFCD00040758N-Methylacetamide, TMS derivatives11925N-Methyl-N-trimethylsilylacetamide (>85%)N-Trimethylsilyl-N-methylacetamide; NSC 142435

データベース識別子

CAS: 7449-74-3
PubChem CID: 81953
DTXSID: DTXSID0064707
UNII: W0IWF6UKW5
EC Number: 231-217-0
Nikkaji: J208.694H

物性

構造計算による物性

極性表面積: 20.3 Å²
水素結合供与体数: 0
水素結合受容体数: 1
回転可能結合数: 1
重原子数: 9
形式電荷: 0
複雑度: 117

実験および物理化学的性質

SpringerMaterials Properties29Si nuclear magnetic resonance spectrum

物理化学的性質

沸点: 159 · 159-161 °C(lit.)
比重(密度): 0.904 g/mL · 0.904 g/mL at 20 °C(lit.)
屈折率: 20 · n20/D 1.439
闪点: 48 °C · 48 °C
貯蔵温度: -20 °C · -20°C
外見: 凍結乾燥粉末
酸解離定数(Pka): -0.11 · -0.11±0.70(Predicted)
色: クリアライトイエロー
比重: 0.906 · 0.906
BRN: 506975 · 506975
InChI: InChI=1S/C6H15NOSi/c1-6(8)7(2)9(3,4)5/h1-5H3
InChIKey: QHUOBLDKFGCVCG-UHFFFAOYSA-N
SMILES: C(N(C)[Si](C)(C)C)(=O)C
CAS データベース: 7449 · 7449-74-3(CAS DataBase Reference)
NISTの化学物質情報: Acetamide, n-methyl-n-(trimethylsilyl)-(7449-74-3)
EPAの化学物質情報: Acetamide, N-methyl-N-(trimethylsilyl)- (7449-74-3)

化学的性質

化学的特性clear light yellow liquid

安全と法規制

GHS分類

GHS Classification · 5 件

This chemical does not meet GHS hazard criteria for 5.9% (1 of 17) of reports.

Danger

H226 (94.1%): Flammable liquid and vapor [Warning Flammable liquids]

P203, P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P305+P354+P338, P317, P318, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 17 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Regulatory Information · 2 件

Chemical: Acetamide, N-methyl-N-(trimethylsilyl)-

Status: Active Update: 13-05-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/33411

Hazard Classes and CategoriesFlam. Liq. 3 (94.1%)

安全データ

F: 10-21
wgk: 3
tsca: TSCA listed
ridadr: UN 1993 3/PG 3
hs_code: 29319090
risk_code: 10-36/37/38
消防法: 危-4-2-III
hazard_code: Xi
safety_code: 37/39-16
hazard_class: 3
packing_group: III
Hazard Classifications: Flam. Liq. 3
ストレージクラス: 3 - Flammable liquids

化学と産業

用途と製造

General Manufacturing InformationAcetamide, N-methyl-N-(trimethylsilyl)-: ACTIVE

応用分野 · 2 件

使用N-Methyl-N-trimethylsilylacetamide may be used as a derivatizing reagent for the following: Quantification of the carbohydrate intermediates in glycation systems using gas chromatography coupled to mass spectrometry technique. Characterization of damaged products of thymine and cytosine formed by the exposure to UV light in a hydrogen peroxide solution using gas chromatography/mass spectrometry with scan mode and selected ion monitoring mode.

一般的な説明N-Methyl-N-trimethylsilylacetamide is a trialkyl-silyl reagent and a versatile derivatizing agent used in gas chromatography (GC).

調製方法 · 1 件

純化方法N-Methyl-N-trimethylsilylacetamide [7449-74-3] M 145.3, b 48 -49o/11mm, 8 4o/13mm, 105-107o/35mm (solid at room temperature), d 4 0.90, n D 1.4379. A likely impurity is Et3N.HCl which can be detected by its odour. If it is completely soluble in *C6H6, then redistil; otherwise dissolve it in this solvent, filter and evaporate first in a vacuum at 12mm, then fractionate; all operations should be carried out in a dry N2 atmosphere. [Klebe et al. J Am Chem Soc 88 3390 1966, Ried & Suarez-Rivero Chem Ber 96 1473 1963, Beilstein 4 IV 4011.]